TDMS Study 05200-05 Pathology Tables
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:29
Facility: Battelle Northwest
Chemical CAS #: 75-52-5
Lock Date: 06/22/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 5 5 2 2
Moribund Sacrifice 17 26 18 25
Survivors
Terminal Sacrifice 28 19 30 23
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Intestine Large, Cecum (50) (50) (50) (50)
Intestine Small, Duodenum (50) (50) (50) (50)
Intestine Small, Jejunum (50) (50) (50) (50)
Intestine Small, Ileum (50) (50) (50) (50)
Liver (50) (50) (50) (50)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (10) (11) (12) (14)
Carcinoma, Metastatic, Islets, Pancreatic 1 (9%)
Carcinoma, Metastatic, Urinary Bladder 1 (7%)
Histiocytic Sarcoma 1 (7%)
Oral Mucosa (1) (1) (1)
Pharyngeal, Squamous Cell Papilloma 1 (100%) 1 (100%) 1 (100%)
Pancreas (50) (50) (50) (50)
Carcinoma, Metastatic, Urinary Bladder 1 (2%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Stomach, Glandular (50) (50) (50) (50)
Tongue (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adrenal Medulla (49) (50) (49) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 1 (2%) 2 (4%) 2 (4%)
Bilateral, Pheochromocytoma Benign 1 (2%) 2 (4%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 3 (6%) 1 (2%)
Carcinoma 1 (2%)
Parathyroid Gland (50) (49) (50) (48)
Adenoma 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Adenoma 33 (66%) 36 (72%) 39 (78%) 40 (80%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (50) (50) (50) (49)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 8 (16%) 9 (18%) 7 (14%) 10 (20%)
C-Cell, Carcinoma 2 (4%) 3 (6%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (46) (47) (48)
Adenoma 6 (13%) 4 (9%) 5 (11%) 2 (4%)
Carcinoma 1 (2%) 3 (6%)
Histiocytic Sarcoma 1 (2%)
Bilateral, Adenoma 1 (2%) 1 (2%)
Ovary (50) (50) (50) (50)
Granulosa Cell Tumor Benign 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Uterus (50) (50) (50) (50)
Leiomyoma 1 (2%)
Polyp Stromal 5 (10%) 11 (22%) 6 (12%) 5 (10%)
Polyp Stromal, Multiple 1 (2%) 1 (2%)
Sarcoma Stromal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Lymph Node (7) (6) (9) (3)
Lymph Node, Bronchial (48) (49) (47) (48)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lymph Node, Mandibular (49) (48) (48) (47)
Lymph Node, Mesenteric (50) (50) (49) (50)
Lymph Node, Mediastinal (48) (49) (50) (46)
Spleen (50) (49) (50) (50)
Thymus (48) (47) (45) (48)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenoma 2 (4%) 2 (4%)
Carcinoma 2 (4%) 4 (8%) 1 (2%) 10 (20%)
Carcinoma, Multiple 3 (6%) 1 (2%)
Fibroadenoma 10 (20%) 15 (30%) 19 (38%) 22 (44%)
Fibroadenoma, Multiple 9 (18%) 6 (12%) 14 (28%) 14 (28%)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Skin (50) (50) (48) (49)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 2 (4%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
Subcutaneous Tissue, Pinna, Amelanotic
Melanoma, Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (2) (1)
Carcinoma, Metastatic, Urinary Bladder 1 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Benign 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (49)
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Nose (50) (50) (50) (50)
Trachea (50) (50) (50) (50)
Carcinoma, Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3)
Zymbal's Gland (1) (1) (1)
Carcinoma 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Carcinoma, Metastatic, Urinary Bladder 1 (2%)
Lipoma 1 (2%)
Mesenchymal Tumor Malignant 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (49) (50)
Histiocytic Sarcoma 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
Transitional Epithelium, Papilloma 2 (4%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 22 (44%) 13 (26%) 14 (28%) 9 (18%)
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50) *(50)
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 50 50
Total Primary Neoplasms 114 116 127 135
Total Animals with Benign Neoplasms 44 47 48 49
Total Benign Neoplasms 83 90 103 104
Total Animals with Malignant Neoplasms 28 21 20 27
Total Malignant Neoplasms 31 26 24 31
Total Animals with Metastatic Neoplasms 2 3 2 2
Total Metastatic Neoplasm 2 5 2 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 33 31 34 39
Natural Death 4 3 2 3
Survivors
Terminal Sacrifice 13 16 14 8
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Intestine Large, Rectum (50) (49) (50) (49)
Intestine Large, Cecum (50) (50) (50) (50)
Intestine Small, Duodenum (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Intestine Small, Ileum (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Liver (50) (50) (50) (50)
Cholangiocarcinoma 1 (2%)
Hepatocellular Carcinoma 2 (4%)
Hepatocellular Adenoma 1 (2%) 1 (2%) 2 (4%)
Hepatocellular Adenoma, Multiple 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mesentery (15) (13) (10) (8)
Oral Mucosa (1) (2) (1)
Pharyngeal, Squamous Cell Papilloma 1 (50%) 1 (100%)
Pancreas (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Tongue (1) (1)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Carcinoma 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Pheochromocytoma Malignant 1 (2%) 2 (4%) 2 (4%)
Pheochromocytoma Benign 11 (22%) 12 (24%) 15 (30%) 14 (28%)
Bilateral, Pheochromocytoma Malignant 1 (2%)
Bilateral, Pheochromocytoma Benign 5 (10%) 8 (16%) 6 (12%) 5 (10%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 8 (16%) 9 (18%) 4 (8%) 1 (2%)
Carcinoma 1 (2%) 1 (2%) 3 (6%) 5 (10%)
Parathyroid Gland (47) (49) (49) (48)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (50) (47) (50) (49)
Histiocytic Sarcoma 1 (2%)
Pars Distalis, Adenoma 38 (76%) 36 (77%) 32 (64%) 39 (80%)
Pars Intermedia, Adenoma 1 (2%) 2 (4%)
Thyroid Gland (50) (50) (50) (50)
Bilateral, C-Cell, Carcinoma 1 (2%)
C-Cell, Adenoma 8 (16%) 5 (10%) 8 (16%) 8 (16%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 3 (6%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (50) (50) (50) (50)
Adenoma 4 (8%) 3 (6%) 3 (6%) 3 (6%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Prostate (50) (50) (50) (50)
Page 9
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Seminal Vesicle (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 22 (44%) 23 (46%) 27 (54%) 16 (32%)
Interstitial Cell, Adenoma 16 (32%) 11 (22%) 13 (26%) 15 (30%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymph Node (17) (13) (17) (13)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (8%)
Iliac, Histiocytic Sarcoma 1 (8%)
Renal, Histiocytic Sarcoma 1 (8%)
Lymph Node, Bronchial (48) (48) (48) (47)
Osteosarcoma, Metastatic, Bone 1 (2%)
Lymph Node, Mandibular (48) (48) (48) (49)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (50) (50) (48) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mediastinal (50) (45) (50) (47)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (50) (50) (50)
Fibroma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (45) (45) (48) (46)
Histiocytic Sarcoma 1 (2%)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (28) (27) (31) (28)
Fibroadenoma 1 (4%) 1 (4%) 1 (3%) 2 (7%)
Skin (50) (49) (50) (50)
Basal Cell Carcinoma 2 (4%)
Keratoacanthoma 6 (12%) 2 (4%) 2 (4%) 1 (2%)
Keratoacanthoma, Multiple 1 (2%)
Squamous Cell Carcinoma 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Squamous Cell Papilloma 3 (6%)
Sebaceous Gland, Adenoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 3 (6%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 3 (6%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Osteosarcoma 1 (2%)
Page 10
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Sarcoma 2 (4%)
Subcutaneous Tissue, Schwannoma Malignant 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Osteoma 1 (2%)
Osteosarcoma 1 (2%)
Skeletal Muscle (2) (1) (1)
Histiocytic Sarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Granular Cell Tumor Benign 1 (2%)
Oligodendroglioma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (4%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 2 (4%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Nose (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1)
Zymbal's Gland (2) (1)
Carcinoma 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lipoma 1 (2%)
Renal Tubule, Adenoma 3 (6%) 2 (4%) 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leukemia Mononuclear 35 (70%) 27 (54%) 33 (66%) 25 (50%)
Mesothelioma Malignant 1 (2%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 05200-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NITROMETHANE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:30:29
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 94 PPM 188 PPM 375 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 49 50 49
Total Primary Neoplasms 174 167 171 163
Total Animals with Benign Neoplasms 50 45 50 47
Total Benign Neoplasms 128 124 121 119
Total Animals with Malignant Neoplasms 40 35 39 33
Total Malignant Neoplasms 46 43 50 44
Total Animals with Metastatic Neoplasms 2 3 1 1
Total Metastatic Neoplasm 2 5 1 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
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