TDMS Study 05200-05 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
NITROMETHANE
NTP Experiment-Test: 05200-05 Report: PEIRPT09
Study Type: CHRONIC Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 75-52-5
Lock Date: 06/22/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 2| 3| 4| 9| 3| 3| 3| 3| 3| 1| 0| 1| 3| 3| 1| 3| 2| 3| 1| 3| 3| 3| 7|
| 4| 4| 7| 4| 4| 1| 5| 4| 5| 4| 5| 9| 4| 3| 4| 5| 4| 4| 6| 9| 9| 3| 3| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Degeneration, Cystic | 2 |
Degeneration, Fatty | 1 3 3 3 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X X X X |
Inflammation, Granulomatous | |
Mixed Cell Focus | X X X X|
Necrosis | |
Regeneration | 2 |
Bile Duct, Hyperplasia | 1 1 1 2 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 3 2 2 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 2 2 2 2 1 2 |
Basophilic Focus | X |
Hyperplasia | 2 |
Artery, Inflammation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Necrosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 1 2 1 1 1 1 1 2 1 1 2 2 2 2 1 2 2 1 1 1 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 2| 3| 4| 9| 3| 3| 3| 3| 3| 1| 0| 1| 3| 3| 1| 3| 2| 3| 1| 3| 3| 3| 7|
| 4| 4| 7| 4| 4| 1| 5| 4| 5| 4| 5| 9| 4| 3| 4| 5| 4| 4| 6| 9| 9| 3| 3| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 1 2 1 |
Hypertrophy | 2 1 1 1 2 3 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 2 2 1 1 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 1 2 4 1 2 1 2 3 1 1 3 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Lymph Node | + + M |
Iliac, Pigmentation | |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Thrombosis | |
__________________________________________________________________________|
Thymus | M + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 2| 3| 4| 9| 3| 3| 3| 3| 3| 1| 0| 1| 3| 3| 1| 3| 2| 3| 1| 3| 3| 3| 7|
| 4| 4| 7| 4| 4| 1| 5| 4| 5| 4| 5| 9| 4| 3| 4| 5| 4| 4| 6| 9| 9| 3| 3| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 |
Hyperplasia, Atypical | 1 4 2 1 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 2 2 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 |
Degeneration | 3 |
__________________________________________________________________________|
Harderian Gland | + + |
Hemorrhage | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy | 2 3 2 2 3 1 2 2 1 1 2 1 2 2 3 2 2 2 1 2 2 3 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| |
DAY ON TEST | 5| 9| 5| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 8| 5| 3| 3| 6| 3| 8| 3| 3| |
| 0| 1| 4| 3| 4| 5| 4| 5| 0| 3| 1| 5| 1| 0| 3| 3| 1| 8| 5| 5| 5| 4| 5| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 41 |
Clear Cell Focus | X X X X X | 6 |
Degeneration, Cystic | | 1 2.0|
Degeneration, Fatty | 3 4 2 2 3 | 9 2.7|
Eosinophilic Focus | X | 2 |
Hepatodiaphragmatic Nodule | X | 7 |
Inflammation, Granulomatous | 3 | 1 3.0|
Mixed Cell Focus | X X X X X X X X| 12 |
Necrosis | 3 | 1 3.0|
Regeneration | 2 | 2 2.0|
Bile Duct, Hyperplasia | 1 2 2 3 2 | 10 1.6|
Centrilobular, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 10 |
Fat, Necrosis | 2 2 2 | 7 2.3|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 3 1 1 2 2 2 1 1 1 1| 20 1.6|
Basophilic Focus | | 1 |
Hyperplasia | | 1 2.0|
Artery, Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 3 2 | 2 2.5|
Necrosis | 3 2 2 | 4 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 1.0|
Necrosis | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| |
DAY ON TEST | 5| 9| 5| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 8| 5| 3| 3| 6| 3| 8| 3| 3| |
| 0| 1| 4| 3| 4| 5| 4| 5| 0| 3| 1| 5| 1| 0| 3| 3| 1| 8| 5| 5| 5| 4| 5| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 3 2 2 2 1 2 2 1 1 1 1 1 1 1 1 2| 42 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 | 6 1.3|
Hypertrophy | 2 2 1 3 2 2 2 3 | 16 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 4 | 3 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 2 3 1 2 2 1 | 13 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 2 2 1 2 1 1 | 41 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + + + + M| 47 |
Inflammation, Chronic Active | | 4 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 7 |
Iliac, Pigmentation | 2 | 1 2.0|
Renal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| |
DAY ON TEST | 5| 9| 5| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 8| 5| 3| 3| 6| 3| 8| 3| 3| |
| 0| 1| 4| 3| 4| 5| 4| 5| 0| 3| 1| 5| 1| 0| 3| 3| 1| 8| 5| 5| 5| 4| 5| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 2 2.0|
Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 3 2 | 3 2.3|
Hyperplasia, Atypical | 2 2 1 1 3 1 | 12 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Hydrocephalus | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 3 | 2 2.5|
Alveolar Epithelium, Hyperplasia | 2 4 | 6 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 1 | 4 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 1 | 5 1.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| |
DAY ON TEST | 5| 9| 5| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 8| 5| 3| 3| 6| 3| 8| 3| 3| |
| 0| 1| 4| 3| 4| 5| 4| 5| 0| 3| 1| 5| 1| 0| 3| 3| 1| 8| 5| 5| 5| 4| 5| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 2.0|
Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 3 | 1 3.0|
Nephropathy | 2 2 2 2 3 2 2 2 1 2 3 3 2 2 2 2 1 2 2 2 2 2 2 2 2| 49 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 5| 7| 7| 6| 7| 6| 6| 6| 6| 5| 7| 7| 7| 7| 6| 6| 5| 7| 4|
DAY ON TEST | 6| 3| 3| 8| 6| 3| 8| 3| 3| 9| 3| 0| 2| 6| 6| 2| 3| 2| 3| 3| 0| 6| 8| 3| 8|
| 2| 5| 5| 0| 1| 5| 8| 5| 3| 8| 3| 0| 3| 4| 5| 0| 5| 0| 3| 3| 6| 7| 6| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
94 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Degeneration, Fatty | 1 3 2 1 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X X X X X X X X X X |
Bile Duct, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Fat, Necrosis | 2 2 2 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 3 1 1 2 1 2 1|
Basophilic Focus | X |
Metaplasia, Hepatocyte | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Basophilic Focus | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Necrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
Necrosis | |
__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 1 2 2 2 1 1 1 1 2 1 1 1|
Artery, Mineralization | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 1 2 2 1 2 2 2 1 |
Hypertrophy | 3 3 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 5| 7| 7| 6| 7| 6| 6| 6| 6| 5| 7| 7| 7| 7| 6| 6| 5| 7| 4|
DAY ON TEST | 6| 3| 3| 8| 6| 3| 8| 3| 3| 9| 3| 0| 2| 6| 6| 2| 3| 2| 3| 3| 0| 6| 8| 3| 8|
| 2| 5| 5| 0| 1| 5| 8| 5| 3| 8| 3| 0| 3| 4| 5| 0| 5| 0| 3| 3| 6| 7| 6| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
94 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Pars Distalis, Hyperplasia | 2 1 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 2 1 2 3 2 3 3 2 1 2 2 1 2 3 2 2 2 3 1 4 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + M + +|
Inflammation, Chronic Active | 2 2 2 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Lymph Node | + + + |
Pancreatic, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 3|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 1 |
Hyperplasia, Atypical | 1 1 1 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 5| 7| 7| 6| 7| 6| 6| 6| 6| 5| 7| 7| 7| 7| 6| 6| 5| 7| 4|
DAY ON TEST | 6| 3| 3| 8| 6| 3| 8| 3| 3| 9| 3| 0| 2| 6| 6| 2| 3| 2| 3| 3| 0| 6| 8| 3| 8|
| 2| 5| 5| 0| 1| 5| 8| 5| 3| 8| 3| 0| 3| 4| 5| 0| 5| 0| 3| 3| 6| 7| 6| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
94 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic Active | 2 |
Inflammation, Granulomatous | |
Sebaceous Gland, Hypertrophy | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 1 |
Hemorrhage | |
Inflammation, Chronic Active | 1 |
Mineralization | 2 |
Alveolar Epithelium, Hyperplasia | 2 4 1 2 2 2 1 1 |
Artery, Mediastinum, Mineralization | 3 |
Bronchiole, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 2 |
Inflammation, Suppurative | 2 |
Thrombosis | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 5| 7| 7| 6| 7| 6| 6| 6| 6| 5| 7| 7| 7| 7| 6| 6| 5| 7| 4|
DAY ON TEST | 6| 3| 3| 8| 6| 3| 8| 3| 3| 9| 3| 0| 2| 6| 6| 2| 3| 2| 3| 3| 0| 6| 8| 3| 8|
| 2| 5| 5| 0| 1| 5| 8| 5| 3| 8| 3| 0| 3| 4| 5| 0| 5| 0| 3| 3| 6| 7| 6| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
94 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 |
Nephropathy | 2 2 2 2 1 2 2 2 2 2 2 3 2 2 2 4 3 2 2 2 2 2 3 3 2|
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 4| 7| 4| 5| 4| 7| 4| 6| 7| 7| 7| 6| 6| 5| 5| 7| 5| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 9| 3| 7| 8| 2| 3| 3| 2| 3| 0| 2| 3| 9| 7| 1| 3| 7| 7| 3| |
| 5| 3| 3| 4| 1| 4| 5| 4| 3| 0| 8| 3| 5| 1| 5| 0| 7| 6| 1| 9| 2| 3| 6| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
94 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 42 |
Clear Cell Focus | X X X X X X X | 9 |
Degeneration, Fatty | 1 3 2 | 7 1.9|
Eosinophilic Focus | X X | 2 |
Hepatodiaphragmatic Nodule | X X X | 4 |
Mixed Cell Focus | X X X X X| 15 |
Bile Duct, Hyperplasia | 1 1 2 | 7 1.1|
__________________________________________________________________________|____________|
Mesentery | + + + + | 11 |
Fat, Necrosis | 2 1 3 2 | 10 2.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 2 3 1 2 | 15 1.6|
Basophilic Focus | X | 2 |
Metaplasia, Hepatocyte | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
Basophilic Focus | X | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 3.0|
Necrosis | 2 2 3| 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 3.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 1 1 2 1 1 2 3 1 2 2 1 | 31 1.6|
Artery, Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 4| 7| 4| 5| 4| 7| 4| 6| 7| 7| 7| 6| 6| 5| 5| 7| 5| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 9| 3| 7| 8| 2| 3| 3| 2| 3| 0| 2| 3| 9| 7| 1| 3| 7| 7| 3| |
| 5| 3| 3| 4| 1| 4| 5| 4| 3| 0| 8| 3| 5| 1| 5| 0| 7| 6| 1| 9| 2| 3| 6| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
94 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia | 2 2 1 2 2 1 | 15 1.7|
Hypertrophy | 3 1 2 2 2 2 2 | 12 2.1|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 4 1 4 3 | 8 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 3 3 2 1 2 2 1 1 2 1 1 1 1 3 2 1 2 1 2 2 2 3 2| 47 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + M + + + + +| 46 |
Inflammation, Chronic Active | 3 | 6 2.2|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 3.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 6 |
Pancreatic, Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + M + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Hemorrhage | | 3 2.3|
Inflammation, Granulomatous | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 4| 7| 4| 5| 4| 7| 4| 6| 7| 7| 7| 6| 6| 5| 5| 7| 5| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 9| 3| 7| 8| 2| 3| 3| 2| 3| 0| 2| 3| 9| 7| 1| 3| 7| 7| 3| |
| 5| 3| 3| 4| 1| 4| 5| 4| 3| 0| 8| 3| 5| 1| 5| 0| 7| 6| 1| 9| 2| 3| 6| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
94 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 | 3 3.0|
Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 1 1.0|
Hyperplasia, Atypical | 2 1 1 1 1 1 1 2 | 17 1.2|
Inflammation, Granulomatous | 3 | 1 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 1 | 1 1.0|
Inflammation, Chronic Active | 3 | 2 2.5|
Inflammation, Granulomatous | 3 | 1 3.0|
Sebaceous Gland, Hypertrophy | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 3.0|
Hyperostosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 2.0|
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Squamous | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | | 1 1.0|
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 1 | 2 1.0|
Mineralization | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 2 2 | 11 1.9|
Artery, Mediastinum, Mineralization | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 4| 7| 4| 5| 4| 7| 4| 6| 7| 7| 7| 6| 6| 5| 5| 7| 5| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 3| 9| 3| 7| 8| 2| 3| 3| 2| 3| 0| 2| 3| 9| 7| 1| 3| 7| 7| 3| |
| 5| 3| 3| 4| 1| 4| 5| 4| 3| 0| 8| 3| 5| 1| 5| 0| 7| 6| 1| 9| 2| 3| 6| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
94 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Bronchiole, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 3 1.7|
Inflammation, Suppurative | 2 | 2 2.0|
Thrombosis | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 2 | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Degeneration | 3 | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 4.0|
Nephropathy | 3 3 2 2 1 2 1 3 1 2 1 2 2 2 2 2 1 1 1 2 2 3 2 3| 49 2.1|
Renal Tubule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 5| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 9| 3| 3| 4| 3| 1| 6| 5| 1| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 8|
| 1| 3| 5| 5| 5| 2| 5| 7| 9| 4| 2| 8| 5| 3| 4| 4| 3| 4| 5| 8| 4| 5| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
188 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X |
Degeneration, Cystic | 1 |
Degeneration, Fatty | 3 2 2 2 2 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X X X X X X X X|
Bile Duct, Hyperplasia | 2 1 1 2 1 1 2 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Necrosis | 2 2 2 1 3 2 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 2 2 4 2 |
Basophilic Focus | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Hyperplasia, Squamous | 3 |
Inflammation, Acute | 2 3|
Necrosis | 3 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3|
Mineralization | 1 |
Necrosis | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 1 1 1 2 2 1 2 2 1 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 1 2 |
Hypertrophy | 3 3 2 2 1 1 2 3 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 5| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 9| 3| 3| 4| 3| 1| 6| 5| 1| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 8|
| 1| 3| 5| 5| 5| 2| 5| 7| 9| 4| 2| 8| 5| 3| 4| 4| 3| 4| 5| 8| 4| 5| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
188 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 1 2 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 2 2 2 2 3 2 1 1 1 2 2 1 2 2 3 2 3 1 3 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Inflammation, Chronic Active | 3 1 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 2 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 1 |
__________________________________________________________________________|
Lymph Node | + + + + |
Pancreatic, Hemorrhage | 2 |
Renal, Hemorrhage | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1 |
__________________________________________________________________________|
Thymus | + M M + + + + + + M + + + + + + + + + + + + + I M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 3 |
Hyperplasia, Atypical | 1 1 1 2 2 2 |
Hyperplasia | 3 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 5| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 9| 3| 3| 4| 3| 1| 6| 5| 1| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 8|
| 1| 3| 5| 5| 5| 2| 5| 7| 9| 4| 2| 8| 5| 3| 4| 4| 3| 4| 5| 8| 4| 5| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
188 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vulva, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | |
Femur, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | 2 4 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 3 3 1 2 1 2 4 2 3 2 3 3 2 3 2 1 2 3 2 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 4| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 3| 0| 3| 3| 4| 9| 3| 3| 3| 3| 7| 1| 4| 3| 3| 3| 5| 3| 3| 3| |
| 5| 5| 4| 8| 4| 3| 5| 5| 4| 6| 1| 5| 3| 3| 5| 0| 3| 0| 4| 5| 3| 0| 8| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 4 1.5|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 41 |
Clear Cell Focus | X X X X X X| 9 |
Degeneration, Cystic | | 1 1.0|
Degeneration, Fatty | 4 2 2 | 8 2.4|
Eosinophilic Focus | X | 1 |
Hepatodiaphragmatic Nodule | X X | 3 |
Mixed Cell Focus | X X X | 11 |
Bile Duct, Hyperplasia | 1 1 1 2 | 12 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 12 |
Fat, Necrosis | 3 3 2 2 | 10 2.2|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 1 1 1 1 1 1 2 1 2 2 1 | 20 1.6|
Basophilic Focus | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | X | 1 |
Hyperplasia, Squamous | | 1 3.0|
Inflammation, Acute | 3 3 | 4 2.8|
Necrosis | 4 3 2 | 5 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 3.0|
Mineralization | | 1 1.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 1 2 1 1 2 1 1 1 2 2 1 2 2| 34 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 4| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 3| 0| 3| 3| 4| 9| 3| 3| 3| 3| 7| 1| 4| 3| 3| 3| 5| 3| 3| 3| |
| 5| 5| 4| 8| 4| 3| 5| 5| 4| 6| 1| 5| 3| 3| 5| 0| 3| 0| 4| 5| 3| 0| 8| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 1 1| 12 1.3|
Hypertrophy | 3 2 1 2 2 3| 14 2.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 2 | 9 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 2 1 1 3 2 3 4| 9 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 2 1 2 1 3 2 1 3 1 2 2 2 3 3 1 1 2 2 2 1 2 1 3| 49 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + + + M + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | 2 | 4 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3| 5 2.6|
Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 9 |
Pancreatic, Hemorrhage | | 1 2.0|
Renal, Hemorrhage | 3 | 1 3.0|
Renal, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + + + + + + + + + + + + + + M + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Infiltration Cellular, Plasma Cell | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 4| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 3| 0| 3| 3| 4| 9| 3| 3| 3| 3| 7| 1| 4| 3| 3| 3| 5| 3| 3| 3| |
| 5| 5| 4| 8| 4| 3| 5| 5| 4| 6| 1| 5| 3| 3| 5| 0| 3| 0| 4| 5| 3| 0| 8| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 2 | 4 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 3 | 3 2.7|
Hyperplasia, Atypical | 1 2 1 1 2 1 2 1| 14 1.4|
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + M + + + + + + M + + + + + + +| 48 |
Vulva, Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis | 3 | 1 3.0|
Femur, Hyperostosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 | 1 4.0|
Hemorrhage | 2| 1 2.0|
Inflammation, Chronic Active | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 1 1 2| 7 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 2 1.5|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 2 | 6 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 4| 7| |
DAY ON TEST | 3| 3| 3| 0| 3| 3| 0| 3| 3| 4| 9| 3| 3| 3| 3| 7| 1| 4| 3| 3| 3| 5| 3| 3| 3| |
| 5| 5| 4| 8| 4| 3| 5| 5| 4| 6| 1| 5| 3| 3| 5| 0| 3| 0| 4| 5| 3| 0| 8| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 2 2 1 1 2 3 4 2 2 1 1 2 2 3 2 2 2 3 3 2 2 2 1 3| 48 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 7| 6| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 0| 7| 4| 3| 3| 2| 5| 3| 3| 1| 3| 3| 3| 3| 0| 5| 3| 7| 3| 3| 3| 3| 0| 2|
| 7| 7| 2| 2| 4| 6| 5| 1| 4| 5| 2| 4| 3| 3| 4| 4| 2| 4| 6| 4| 4| 4| 3| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Degeneration, Fatty | 1 3 3 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Granulomatous | 3 |
Mixed Cell Focus | X X X X X X X X|
Necrosis | 2 |
Bile Duct, Hyperplasia | 2 2 2 1 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 3 2 2 3 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 2 2 2 2 3 2 2 2 1 1|
Basophilic Focus | X |
Hyperplasia | |
Artery, Inflammation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Mineralization | |
Necrosis | 2 3 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 3 1 1 1 1 1 2 1 1 1 2 2 2 1 2 1 1 2|
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia | 1 2 1 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 7| 6| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 0| 7| 4| 3| 3| 2| 5| 3| 3| 1| 3| 3| 3| 3| 0| 5| 3| 7| 3| 3| 3| 3| 0| 2|
| 7| 7| 2| 2| 4| 6| 5| 1| 4| 5| 2| 4| 3| 3| 4| 4| 2| 4| 6| 4| 4| 4| 3| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy | 2 1 2 3 1 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 2 2 2 1 1 1 2 2 3 1 2 2 2 2 1 4 1 2 1 2 3 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + M + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 2 2 |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Pigmentation | 2 |
Pancreatic, Infiltration Cellular, | |
Eosinophil | 3 |
Pancreatic, Inflammation, | |
Granulomatous | 3 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + M + + + + + + + +|
Infiltration Cellular, Eosinophil | 3 |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + M + + +|
Hemorrhage | |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Eosinophil | 3 |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 7| 6| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 0| 7| 4| 3| 3| 2| 5| 3| 3| 1| 3| 3| 3| 3| 0| 5| 3| 7| 3| 3| 3| 3| 0| 2|
| 7| 7| 2| 2| 4| 6| 5| 1| 4| 5| 2| 4| 3| 3| 4| 4| 2| 4| 6| 4| 4| 4| 3| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 3 2 2 |
Hyperplasia, Atypical | 2 2 3 2 1 2 2 1 3 1 1 |
Hyperplasia, Lobular | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + M + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Multifocal | |
Hemorrhage | |
Inflammation, Chronic Active | 3 |
Alveolar Epithelium, Hyperplasia | 2 1 2 2 |
Artery, Mediastinum, Inflammation | |
Bronchiole, Metaplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + +|
Cataract | 3|
Degeneration | 4 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 7| 6| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 0| 7| 4| 3| 3| 2| 5| 3| 3| 1| 3| 3| 3| 3| 0| 5| 3| 7| 3| 3| 3| 3| 0| 2|
| 7| 7| 2| 2| 4| 6| 5| 1| 4| 5| 2| 4| 3| 3| 4| 4| 2| 4| 6| 4| 4| 4| 3| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retina, Atrophy | 2|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Nephropathy | 2 3 4 1 2 2 3 2 2 3 2 3 4 2 2 1 3 2 2 3 3 2 2 2|
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 7| 6| 6| 5| 6| 7| 3| 7| 6| 7| 6| 7| 7| 7| 6| 7| 4| 7| 5| 7| |
DAY ON TEST | 6| 3| 9| 3| 3| 3| 8| 7| 5| 6| 2| 8| 3| 0| 3| 0| 3| 3| 3| 6| 3| 9| 3| 9| 3| |
| 5| 5| 6| 3| 3| 4| 4| 0| 0| 5| 0| 7| 3| 0| 5| 4| 5| 3| 3| 0| 4| 2| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + I + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 3 | 5 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 41 |
Clear Cell Focus | X X X X X X | 7 |
Degeneration, Fatty | 1 3 | 5 2.2|
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | X X | 5 |
Inflammation, Granulomatous | | 1 3.0|
Mixed Cell Focus | X X X X X X X X X | 17 |
Necrosis | | 1 2.0|
Bile Duct, Hyperplasia | 1 2 1 | 9 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + +| 14 |
Fat, Necrosis | 3 3 1 3 3 2| 11 2.5|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 2 1 1 4 2 3 1 | 24 1.7|
Basophilic Focus | | 1 |
Hyperplasia | 2 | 1 2.0|
Artery, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 1.0|
Mineralization | 2 | 1 2.0|
Necrosis | 2 2 | 6 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1| 1 1.0|
Necrosis | | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 3 2 1 1 2 2 2 2 2 1 1 1 1 2 1 2 1 2| 39 1.5|
Atrium, Thrombosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 7| 6| 6| 5| 6| 7| 3| 7| 6| 7| 6| 7| 7| 7| 6| 7| 4| 7| 5| 7| |
DAY ON TEST | 6| 3| 9| 3| 3| 3| 8| 7| 5| 6| 2| 8| 3| 0| 3| 0| 3| 3| 3| 6| 3| 9| 3| 9| 3| |
| 5| 5| 6| 3| 3| 4| 4| 0| 0| 5| 0| 7| 3| 0| 5| 4| 5| 3| 3| 0| 4| 2| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Hyperplasia | 2 1 2 1 1 | 13 1.5|
Hypertrophy | 2 2 2 2 2 2 1| 12 1.8|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 3 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 1 1| 8 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + M +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 3 3 1 3 2 4 | 9 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 2 3 3 4 1 2 3 2 3 1 3 2 2 3 1 1 1 3| 42 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 4.0|
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 3 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Iliac, Pigmentation | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Eosinophil | | 1 3.0|
Pancreatic, Inflammation, | | |
Granulomatous | | 1 3.0|
Renal, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 7| 6| 6| 5| 6| 7| 3| 7| 6| 7| 6| 7| 7| 7| 6| 7| 4| 7| 5| 7| |
DAY ON TEST | 6| 3| 9| 3| 3| 3| 8| 7| 5| 6| 2| 8| 3| 0| 3| 0| 3| 3| 3| 6| 3| 9| 3| 9| 3| |
| 5| 5| 6| 3| 3| 4| 4| 0| 0| 5| 0| 7| 3| 0| 5| 4| 5| 3| 3| 0| 4| 2| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Infiltration Cellular, Eosinophil | | 1 3.0|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Eosinophil | | 1 3.0|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + M M + + + + + + + + + + + M +| 46 |
Hemorrhage | 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + M +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 1 3 3 | 7 2.3|
Hyperplasia, Atypical | 1 2 1 1 | 15 1.7|
Hyperplasia, Lobular | 2 | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Metaplasia, Squamous | 1 | 2 1.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Multifocal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 7| 6| 6| 5| 6| 7| 3| 7| 6| 7| 6| 7| 7| 7| 6| 7| 4| 7| 5| 7| |
DAY ON TEST | 6| 3| 9| 3| 3| 3| 8| 7| 5| 6| 2| 8| 3| 0| 3| 0| 3| 3| 3| 6| 3| 9| 3| 9| 3| |
| 5| 5| 6| 3| 3| 4| 4| 0| 0| 5| 0| 7| 3| 0| 5| 4| 5| 3| 3| 0| 4| 2| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | 1 | 1 1.0|
Inflammation, Chronic Active | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 3 2 3 | 7 2.1|
Artery, Mediastinum, Inflammation | 2 | 1 2.0|
Bronchiole, Metaplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Cataract | 4 3 | 3 3.3|
Degeneration | | 1 4.0|
Retina, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 3.0|
Nephropathy | 1 2 1 2 2 3 3 2 2 3 3 1 3 2 2 1 2 3 3 4 2 2 2 2 3| 49 2.3|
Renal Tubule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 6| 5| 5| 7| 5| 5| 5| 7| 7| 4| 6| 4| 5| 7| 7|
DAY ON TEST | 0| 3| 9| 2| 2| 6| 1| 3| 1| 3| 1| 8| 6| 3| 9| 9| 1| 3| 3| 9| 6| 9| 5| 1| 3|
| 4| 3| 2| 0| 3| 4| 1| 3| 1| 4| 2| 0| 9| 5| 2| 0| 2| 5| 0| 0| 0| 1| 2| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X|
Clear Cell Focus | X X |
Degeneration, Cystic | 3 3 1 2 2 2|
Degeneration, Fatty | 2 1 3 2 2 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X X X X X |
Necrosis | 3 |
Regeneration | 2 |
Bile Duct, Hyperplasia | 2 1 1 2 2 3 3 2 2 1 2 2 1 1 1 2 2 1 2 2 1 1|
Centrilobular, Necrosis | 3 2 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + +|
Fat, Necrosis | 2 3 2 2 2 2|
__________________________________________________________________________|
Oral Mucosa | |
Pharyngeal, Hyperplasia, Squamous | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 1 3 2 2 2 1 2 4 1 3 |
Hyperplasia | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 2 |
Necrosis | 2 3 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Necrosis | 2 1 |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 3 2 3 2 1 3 1 2 1 2 2 2 2 2 2 1 1 3 2|
Atrium, Thrombosis | 4 3 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 6| 5| 5| 7| 5| 5| 5| 7| 7| 4| 6| 4| 5| 7| 7|
DAY ON TEST | 0| 3| 9| 2| 2| 6| 1| 3| 1| 3| 1| 8| 6| 3| 9| 9| 1| 3| 3| 9| 6| 9| 5| 1| 3|
| 4| 3| 2| 0| 3| 4| 1| 3| 1| 4| 2| 0| 9| 5| 2| 0| 2| 5| 0| 0| 0| 1| 2| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 2 2 2 2 2 1 2|
Hypertrophy | 2 2 |
Necrosis | 3 |
Vacuolization Cytoplasmic | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 3 3 3 2 1|
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 2 2 2 1 2 1 2 1 1 1 1 1 1 1 1|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 3 2 2 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 |
Interstitial Cell, Hyperplasia | 1 1 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 |
Thrombosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Pancreatic, Inflammation, | |
Granulomatous | 3 |
Renal, Infiltration Cellular, Plasma | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 6| 5| 5| 7| 5| 5| 5| 7| 7| 4| 6| 4| 5| 7| 7|
DAY ON TEST | 0| 3| 9| 2| 2| 6| 1| 3| 1| 3| 1| 8| 6| 3| 9| 9| 1| 3| 3| 9| 6| 9| 5| 1| 3|
| 4| 3| 2| 0| 3| 4| 1| 3| 1| 4| 2| 0| 9| 5| 2| 0| 2| 5| 0| 0| 0| 1| 2| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cell | 2|
Renal, Inflammation, Granulomatous | 2 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Infiltration Cellular, Plasma Cell | 2 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 3 3 1 3|
Hematopoietic Cell Proliferation | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + M + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M + M M + M + + M + M + M M + M + M + M +|
Galactocele | 3 |
Hyperplasia, Atypical | |
Hyperplasia | |
Duct, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hyperkeratosis | 4 |
Inflammation, Chronic Active | 3 |
Inflammation, Granulomatous | 2 |
Prepuce, Inflammation, Acute | 2 |
Subcutaneous Tissue, Cyst Epithelial | |
Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 1 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 6| 5| 5| 7| 5| 5| 5| 7| 7| 4| 6| 4| 5| 7| 7|
DAY ON TEST | 0| 3| 9| 2| 2| 6| 1| 3| 1| 3| 1| 8| 6| 3| 9| 9| 1| 3| 3| 9| 6| 9| 5| 1| 3|
| 4| 3| 2| 0| 3| 4| 1| 3| 1| 4| 2| 0| 9| 5| 2| 0| 2| 5| 0| 0| 0| 1| 2| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Chronic | 3 |
Congestion | 4 |
Hemorrhage | |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 1 1 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Inflammation, Suppurative | 1 1 1 1 2 2|
Thrombosis | 2 1 4 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Degeneration | 2 1 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Nephropathy | 2 4 4 4 2 2 4 3 2 3 3 2 2 4 2 4 3 4 3 1 2 2 2 4 4|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 6| 2| 7| 6| 5| 7| 7| 6| 6| 4| 6| 7| 7| 5| 6| 5| 6| |
DAY ON TEST | 3| 2| 3| 8| 3| 3| 6| 2| 8| 4| 3| 0| 3| 3| 0| 4| 2| 1| 7| 3| 2| 2| 7| 6| 4| |
| 3| 7| 4| 4| 5| 5| 4| 5| 1| 2| 5| 0| 7| 5| 8| 4| 6| 1| 3| 3| 0| 8| 0| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | X X X X X X X X X| 16 |
Clear Cell Focus | X | 3 |
Degeneration, Cystic | 2 2 2 2 2 3 2 3 3 1 2 3 2 | 19 2.2|
Degeneration, Fatty | 2 | 6 2.0|
Eosinophilic Focus | X | 2 |
Hepatodiaphragmatic Nodule | X X | 4 |
Mixed Cell Focus | X X | 7 |
Necrosis | | 1 3.0|
Regeneration | 3 | 2 2.5|
Bile Duct, Hyperplasia | 1 3 1 2 2 2 2 2 2 3 2 3 3 2 1 3 2 1 1 2 2 1| 44 1.8|
Centrilobular, Necrosis | 2 3 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 15 |
Fat, Necrosis | 2 2 2 3 2 2 | 12 2.2|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Pharyngeal, Hyperplasia, Squamous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 1 2 2 1 1 4 3 2 1 4 2 1 3 2 | 27 2.1|
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 2 | 3 2.0|
Necrosis | 3 2 | 6 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 1 | 1 1.0|
Necrosis | 2 | 3 1.7|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 6| 2| 7| 6| 5| 7| 7| 6| 6| 4| 6| 7| 7| 5| 6| 5| 6| |
DAY ON TEST | 3| 2| 3| 8| 3| 3| 6| 2| 8| 4| 3| 0| 3| 3| 0| 4| 2| 1| 7| 3| 2| 2| 7| 6| 4| |
| 3| 7| 4| 4| 5| 5| 4| 5| 1| 2| 5| 0| 7| 5| 8| 4| 6| 1| 3| 3| 0| 8| 0| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 2 2 2 2 2 3 2 1 2 1 1 2 2 2 2 2 4 3 4 1 1 2 2| 45 2.0|
Atrium, Thrombosis | 2 2 3 | 5 2.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3 2 1 2 2 1 2 1 1 2 2| 24 1.8|
Hypertrophy | 2 2 2 2 | 6 2.0|
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 2 2 2 2 2 4 3 3 3 | 20 2.4|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + M + + + +| 47 |
Hyperplasia | 3 1 2 | 8 2.1|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 3 3 2 | 7 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 4 1 1 2 2 2 1 2 1 2 3 1 1 2 1 | 34 1.6|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | +| 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 7 2.1|
Inflammation, Suppurative | 4 3 2 | 4 2.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 4 | 4 3.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 6| 2| 7| 6| 5| 7| 7| 6| 6| 4| 6| 7| 7| 5| 6| 5| 6| |
DAY ON TEST | 3| 2| 3| 8| 3| 3| 6| 2| 8| 4| 3| 0| 3| 3| 0| 4| 2| 1| 7| 3| 2| 2| 7| 6| 4| |
| 3| 7| 4| 4| 5| 5| 4| 5| 1| 2| 5| 0| 7| 5| 8| 4| 6| 1| 3| 3| 0| 8| 0| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | 1 1 1 1 2 2 1 1 1| 17 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 3 | 2 3.0|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + +| 17 |
Pancreatic, Inflammation, | | |
Granulomatous | | 1 3.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | | 1 2.0|
Renal, Inflammation, Granulomatous | | 1 2.0|
Renal, Pigmentation | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Plasma Cell | | 1 2.0|
Inflammation, Granulomatous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 2 3 4 3 3 2 | 14 2.6|
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + M| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + M + + M M + + + M + M M M M + + M +| 28 |
Galactocele | 3 | 2 3.0|
Hyperplasia, Atypical | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
Duct, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 2 3.5|
Hyperkeratosis | 2 4 | 3 3.3|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Granulomatous | 2 | 2 2.0|
Prepuce, Inflammation, Acute | 2 | 2 2.0|
Subcutaneous Tissue, Cyst Epithelial | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 6| 2| 7| 6| 5| 7| 7| 6| 6| 4| 6| 7| 7| 5| 6| 5| 6| |
DAY ON TEST | 3| 2| 3| 8| 3| 3| 6| 2| 8| 4| 3| 0| 3| 3| 0| 4| 2| 1| 7| 3| 2| 2| 7| 6| 4| |
| 3| 7| 4| 4| 5| 5| 4| 5| 1| 2| 5| 0| 7| 5| 8| 4| 6| 1| 3| 3| 0| 8| 0| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inclusion | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Hydrocephalus | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion, Chronic | | 1 3.0|
Congestion | | 1 4.0|
Hemorrhage | 1 | 1 1.0|
Inflammation, Chronic Active | 2 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | | 4 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 | 4 1.0|
Inflammation, Suppurative | 1 1 1 1 | 10 1.2|
Thrombosis | 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Degeneration | | 2 1.5|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 | 2 2.0|
Nephropathy | 4 3 3 4 3 4 2 4 3 1 3 2 2 3 3 2 4 1 3 3 3 2 2 2 3| 50 2.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 6| 4| 6| 4| 6| 7| 7| 5| 5| 7| 6| 6| 7| 6| 2| 7| 6| 6| 6| 4|
DAY ON TEST | 3| 0| 1| 1| 3| 3| 3| 6| 9| 5| 3| 3| 9| 2| 3| 6| 0| 3| 0| 9| 3| 4| 4| 7| 9|
| 4| 7| 5| 6| 5| 6| 9| 5| 0| 0| 3| 5| 3| 0| 5| 4| 6| 5| 9| 2| 5| 2| 6| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
94 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 4 |
Necrosis | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 4 |
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | X X |
Cyst | 2 |
Degeneration, Cystic | 3 2 2 2 2 1 1 |
Degeneration, Fatty | 4 3 2 |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | |
Mixed Cell Focus | X X X X |
Necrosis | 1 |
Bile Duct, Hyperplasia | 1 3 1 2 2 1 2 2 3 1 1 2 2 2 1 1 2 2 2 2 2 3 2|
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Infiltration Cellular | 4 |
Artery, Inflammation | |
Artery, Mineralization | 3 |
Fat, Hemorrhage | |
Fat, Necrosis | 2 2 2 |
__________________________________________________________________________|
Oral Mucosa | + + |
Gingival, Hyperplasia | 3 |
Gingival, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 3 4 2 1 4 3 2 4|
Basophilic Focus | X |
Hyperplasia, Focal | |
Hyperplasia | 3 |
Artery, Inflammation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 4 3 2 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 6| 4| 6| 4| 6| 7| 7| 5| 5| 7| 6| 6| 7| 6| 2| 7| 6| 6| 6| 4|
DAY ON TEST | 3| 0| 1| 1| 3| 3| 3| 6| 9| 5| 3| 3| 9| 2| 3| 6| 0| 3| 0| 9| 3| 4| 4| 7| 9|
| 4| 7| 5| 6| 5| 6| 9| 5| 0| 0| 3| 5| 3| 0| 5| 4| 6| 5| 9| 2| 5| 2| 6| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
94 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Acute | 2 |
Necrosis | 2 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 |
Necrosis | 3 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
Foreign Body | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 2 1 2 1 1 2 2 3 2 1 1 4 1 3 3 2 2 1 2 2 2|
Artery, Mineralization | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 4 |
Hyperplasia | 2 1 2 1 1 2 1 2 1 2 |
Hypertrophy | 2 3 1 2 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 1 1 2 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + M + + + + + + + + + M +|
Pars Distalis, Hyperplasia | 2 3 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 3 1 2 1 1 1 1 1 1 1 2 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation, Chronic Active | 2 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 2 2 3 |
Inflammation, Suppurative | 3 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 6| 4| 6| 4| 6| 7| 7| 5| 5| 7| 6| 6| 7| 6| 2| 7| 6| 6| 6| 4|
DAY ON TEST | 3| 0| 1| 1| 3| 3| 3| 6| 9| 5| 3| 3| 9| 2| 3| 6| 0| 3| 0| 9| 3| 4| 4| 7| 9|
| 4| 7| 5| 6| 5| 6| 9| 5| 0| 0| 3| 5| 3| 0| 5| 4| 6| 5| 9| 2| 5| 2| 6| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
94 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 4 |
Artery, Inflammation | 2 3 |
Interstitial Cell, Hyperplasia | 1 1 1 2 1 1 1 1 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Thrombosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Renal, Hemorrhage | |
Renal, Inflammation, Granulomatous | 3 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation, Acute | 2 |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + M + M + + + + + + + + + M + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 2 2 3 3 2 3 2 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + M + + + +|
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M + + M + M + M M M M + + M + M M + + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + M|
Cyst | |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 3 |
Inflammation, Granulomatous | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 1 |
Hyperostosis | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 6| 4| 6| 4| 6| 7| 7| 5| 5| 7| 6| 6| 7| 6| 2| 7| 6| 6| 6| 4|
DAY ON TEST | 3| 0| 1| 1| 3| 3| 3| 6| 9| 5| 3| 3| 9| 2| 3| 6| 0| 3| 0| 9| 3| 4| 4| 7| 9|
| 4| 7| 5| 6| 5| 6| 9| 5| 0| 0| 3| 5| 3| 0| 5| 4| 6| 5| 9| 2| 5| 2| 6| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
94 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | 1 1 3 4 1 2 |
Artery, Mediastinum, Inflammation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | 2 |
Thrombosis | 2 1 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Olfactory Epithelium, Foreign Body | |
Olfactory Epithelium, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Nephropathy | 4 4 2 2 4 4 3 3 3 3 4 3 2 1 3 4 4 2 2 1 4 3 3 3 2|
Artery, Inflammation | |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 5| 6| 5| 5| 4| 7| 6| 5| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 3| 6| 7| |
DAY ON TEST | 0| 2| 6| 8| 7| 7| 8| 8| 2| 3| 0| 2| 3| 3| 3| 8| 1| 3| 3| 0| 3| 3| 9| 9| 3| |
| 1| 4| 5| 6| 4| 0| 1| 8| 7| 3| 4| 3| 4| 4| 4| 6| 4| 3| 3| 8| 4| 3| 7| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
94 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 4.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 3 2.0|
Basophilic Focus | X X X X X X X X X X X | 19 |
Clear Cell Focus | X X X | 5 |
Cyst | 2 | 2 2.0|
Degeneration, Cystic | 2 1 2 2 2 4 2 3| 15 2.1|
Degeneration, Fatty | 2 3 2 | 6 2.7|
Eosinophilic Focus | X X | 4 |
Hepatodiaphragmatic Nodule | X X X X | 4 |
Mixed Cell Focus | X X | 6 |
Necrosis | 1 | 2 1.0|
Bile Duct, Hyperplasia | 1 2 1 1 1 1 3 1 2 1 3 1 2 2 3 2 1 1 2 1| 43 1.7|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 13 |
Infiltration Cellular | | 1 4.0|
Artery, Inflammation | 4 3 | 2 3.5|
Artery, Mineralization | 3 | 2 3.0|
Fat, Hemorrhage | 3 | 1 3.0|
Fat, Necrosis | 2 2 3 2 | 7 2.1|
__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
Gingival, Hyperplasia | | 1 3.0|
Gingival, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 3 2 1 2 1 1 2 2 3 3 2 2 2 2 3| 28 2.4|
Basophilic Focus | X X | 3 |
Hyperplasia, Focal | 3 | 1 3.0|
Hyperplasia | 3 3 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 5| 6| 5| 5| 4| 7| 6| 5| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 3| 6| 7| |
DAY ON TEST | 0| 2| 6| 8| 7| 7| 8| 8| 2| 3| 0| 2| 3| 3| 3| 8| 1| 3| 3| 0| 3| 3| 9| 9| 3| |
| 1| 4| 5| 6| 4| 0| 1| 8| 7| 3| 4| 3| 4| 4| 4| 6| 4| 3| 3| 8| 4| 3| 7| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
94 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Artery, Inflammation | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | | 3 3.0|
Inflammation, Acute | 2 | 2 2.0|
Necrosis | 3 | 4 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 2 1| 4 2.5|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + +| 2 |
Foreign Body | X| 1 |
Inflammation, Chronic Active | 3 1| 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1 1 1 3 1 3 3 1 2 3 2 2 3 1 2 1 2 3 2 2 2| 49 1.8|
Artery, Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 3 3.3|
Hyperplasia | 2 1 2 2 2 1 2 2 2| 19 1.6|
Hypertrophy | 2 2 2 1 1 | 10 1.8|
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 1 2 1 1 2 1 1 2 1 1 2 1 | 23 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Hyperplasia | 2 1 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 2 1 1 1 1 2 2 1 3 1 2 1 1 2 2 2 1 1| 37 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 5| 6| 5| 5| 4| 7| 6| 5| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 3| 6| 7| |
DAY ON TEST | 0| 2| 6| 8| 7| 7| 8| 8| 2| 3| 0| 2| 3| 3| 3| 8| 1| 3| 3| 0| 3| 3| 9| 9| 3| |
| 1| 4| 5| 6| 4| 0| 1| 8| 7| 3| 4| 3| 4| 4| 4| 6| 4| 3| 3| 8| 4| 3| 7| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
94 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Inflammation, Chronic Active | 2 | 3 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 2 3 2 | 9 2.4|
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 3 4 3 | 7 3.4|
Artery, Inflammation | 3 3 | 4 2.8|
Interstitial Cell, Hyperplasia | 1 2 1 1 1 2 1 1 | 17 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 13 |
Renal, Hemorrhage | 3 | 1 3.0|
Renal, Inflammation, Granulomatous | | 1 3.0|
Renal, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + M + + +| 48 |
Infiltration Cellular, Plasma Cell | 3 4 3 | 3 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + M + + + M +| 45 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 3 3 2 3 3 2 3 2 2 2 | 20 2.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M + + + + M + + + + + + + + + M + + + + + + + + +| 45 |
Artery, Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 5| 6| 5| 5| 4| 7| 6| 5| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 3| 6| 7| |
DAY ON TEST | 0| 2| 6| 8| 7| 7| 8| 8| 2| 3| 0| 2| 3| 3| 3| 8| 1| 3| 3| 0| 3| 3| 9| 9| 3| |
| 1| 4| 5| 6| 4| 0| 1| 8| 7| 3| 4| 3| 4| 4| 4| 6| 4| 3| 3| 8| 4| 3| 7| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
94 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + M + M + + + M + + + M + + M M + + + M M +| 27 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 | 1 3.0|
Hyperkeratosis | 3 3 | 3 2.7|
Inflammation, Chronic Active | 2 3 | 3 2.7|
Inflammation, Granulomatous | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 | 3 2.3|
Hyperostosis | 3 | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Inflammation, Chronic Active | 3 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 1 2 | 8 1.9|
Artery, Mediastinum, Inflammation | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | 1 2 | 3 1.7|
Thrombosis | | 3 1.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Olfactory Epithelium, Foreign Body | X | 1 |
Olfactory Epithelium, Inflammation, | | |
Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 5| 6| 5| 5| 4| 7| 6| 5| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 3| 6| 7| |
DAY ON TEST | 0| 2| 6| 8| 7| 7| 8| 8| 2| 3| 0| 2| 3| 3| 3| 8| 1| 3| 3| 0| 3| 3| 9| 9| 3| |
| 1| 4| 5| 6| 4| 0| 1| 8| 7| 3| 4| 3| 4| 4| 4| 6| 4| 3| 3| 8| 4| 3| 7| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
94 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Degeneration | 3 | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 2.0|
Nephropathy | 3 2 3 3 4 3 4 2 1 3 3 1 3 4 3 2 4 3 3 3 4 4 2 2 4| 50 2.9|
Artery, Inflammation | 2 | 1 2.0|
Renal Tubule, Hyperplasia | 3 4 | 3 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 5| 5| 4| 7| 7| 6| 6| 7| 3| 6| 6| 4| 6| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 3| 5| 2| 6| 6| 9| 9| 3| 2| 8| 4| 3| 9| 3| 9| 7| 7| 2| 5| 3| 3| 3| 0| 5|
| 1| 3| 0| 9| 0| 1| 0| 9| 4| 0| 1| 3| 4| 5| 8| 2| 1| 8| 4| 2| 3| 4| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
188 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X|
Clear Cell Focus | X X X X X X X |
Cyst | 2 |
Degeneration, Cystic | 2 2 3 2 2 2 |
Degeneration, Fatty | 2 |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X |
Inflammation, Suppurative | 3 |
Mixed Cell Focus | X X X |
Necrosis | 3 |
Regeneration | |
Thrombosis | 4 |
Bile Duct, Hyperplasia | 3 2 3 2 2 3 3 2 2 3 2 2 1 2 1 2 3 3 1 2 2 1|
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Artery, Mineralization | 4 |
Fat, Necrosis | 2 2 2 2 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 1 1 2 2 2 3 2 1 4 3 3 1 2 1 2 2 |
Basophilic Focus | X X |
Hyperplasia | 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Hyperplasia, Squamous | |
Mineralization | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Mineralization | 3 |
Necrosis | |
__________________________________________________________________________|
Tooth | + + + |
Developmental Malformation | 2 |
Inflammation, Chronic Active | 3 3 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 5| 5| 4| 7| 7| 6| 6| 7| 3| 6| 6| 4| 6| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 3| 5| 2| 6| 6| 9| 9| 3| 2| 8| 4| 3| 9| 3| 9| 7| 7| 2| 5| 3| 3| 3| 0| 5|
| 1| 3| 0| 9| 0| 1| 0| 9| 4| 0| 1| 3| 4| 5| 8| 2| 1| 8| 4| 2| 3| 4| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
188 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 4 1 3 2 2 1 2 3 3 1 2 2 1 2 2 3 2 3 3 2|
Artery, Mineralization | 4 |
Atrium, Thrombosis | 3 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 2 2 2 3 1 |
Hypertrophy | 2 3 2 2 3 2 |
Necrosis | 2 |
Thrombosis | |
Vacuolization Cytoplasmic | 2 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 3 2 1 1 1 2 3 2 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 3 3 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1|
Follicular Cell, Hyperplasia | 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 3 |
Interstitial Cell, Hyperplasia | 1 2 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 5| 5| 4| 7| 7| 6| 6| 7| 3| 6| 6| 4| 6| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 3| 5| 2| 6| 6| 9| 9| 3| 2| 8| 4| 3| 9| 3| 9| 7| 7| 2| 5| 3| 3| 3| 0| 5|
| 1| 3| 0| 9| 0| 1| 0| 9| 4| 0| 1| 3| 4| 5| 8| 2| 1| 8| 4| 2| 3| 4| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
188 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + +|
Renal, Hemorrhage | |
Renal, Pigmentation | 2|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Plasma Cell | 3 3 3 4 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + M +|
Hemorrhage | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 3 3 3 2 2 2 3 3 2 2 2 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + M + + + + M + M M + M + + M + + + M +|
Galactocele | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Granulomatous | |
Prepuce, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 4 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Hemorrhage | 2 |
Inflammation, Chronic | |
Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2|
Metaplasia, Osseous | 1 |
Mineralization | 4 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 5| 5| 4| 7| 7| 6| 6| 7| 3| 6| 6| 4| 6| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 3| 5| 2| 6| 6| 9| 9| 3| 2| 8| 4| 3| 9| 3| 9| 7| 7| 2| 5| 3| 3| 3| 0| 5|
| 1| 3| 0| 9| 0| 1| 0| 9| 4| 0| 1| 3| 4| 5| 8| 2| 1| 8| 4| 2| 3| 4| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
188 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 1 2 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic Active | 2 2 2 |
Inflammation, Suppurative | |
Thrombosis | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Mineralization | 4 |
Nephropathy | 3 2 4 3 3 2 3 3 3 4 4 4 4 2 3 4 2 3 2 3 4 4 3 4 4|
Pelvis, Dilatation | 2 |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 6| 6| 6| 6| 7| 6| 7| 6| 6| 5| 6| 4| 7| 5| 7| 7| 6| 5| 6| |
DAY ON TEST | 3| 8| 3| 8| 3| 3| 5| 3| 2| 3| 3| 1| 3| 0| 3| 6| 7| 9| 3| 0| 2| 3| 7| 1| 6| |
| 3| 4| 3| 0| 4| 5| 0| 9| 1| 1| 5| 1| 5| 8| 8| 8| 7| 2| 3| 9| 8| 5| 8| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X | 20 |
Clear Cell Focus | X X X | 10 |
Cyst | | 1 2.0|
Degeneration, Cystic | 2 3 2 1 2 2 2 3 2 2 | 16 2.1|
Degeneration, Fatty | 3 | 2 2.5|
Eosinophilic Focus | X X | 4 |
Hepatodiaphragmatic Nodule | X| 2 |
Inflammation, Suppurative | | 1 3.0|
Mixed Cell Focus | X X X X X X | 9 |
Necrosis | | 1 3.0|
Regeneration | 2 | 1 2.0|
Thrombosis | | 1 4.0|
Bile Duct, Hyperplasia | 1 1 2 2 3 2 4 3 2 1 2 1 1 2 3 2 2 1 1 2 1 1 2 2 3| 47 2.0|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 10 |
Artery, Mineralization | | 1 4.0|
Fat, Necrosis | 3 2 2 3 | 9 2.3|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 3 3 3 1 2 1 3 2 3 2 1 2 4 3| 34 2.2|
Basophilic Focus | X X X X X| 7 |
Hyperplasia | 2 3 2 2 | 5 2.2|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | X | 1 |
Hyperplasia, Squamous | 3 | 1 3.0|
Mineralization | | 1 3.0|
Necrosis | 4 2 | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 6| 6| 6| 6| 7| 6| 7| 6| 6| 5| 6| 4| 7| 5| 7| 7| 6| 5| 6| |
DAY ON TEST | 3| 8| 3| 8| 3| 3| 5| 3| 2| 3| 3| 1| 3| 0| 3| 6| 7| 9| 3| 0| 2| 3| 7| 1| 6| |
| 3| 4| 3| 0| 4| 5| 0| 9| 1| 1| 5| 1| 5| 8| 8| 8| 7| 2| 3| 9| 8| 5| 8| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | 2 | 2 2.5|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 3 |
Developmental Malformation | | 1 2.0|
Inflammation, Chronic Active | | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 2 2 2 1 1 2 2 3 2 3 2 2 3 2 2 1 3 3 3 1 2| 47 2.1|
Artery, Mineralization | | 1 4.0|
Atrium, Thrombosis | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Hyperplasia | 2 1 1 1 1 2 1 2 1 1 2 2 1 2 1 2| 22 1.6|
Hypertrophy | 2 1 2 2 1 | 11 2.0|
Necrosis | 1 | 2 1.5|
Thrombosis | 3 | 1 3.0|
Vacuolization Cytoplasmic | 2 | 4 2.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 4 1 2 2 1 2 1 2 3 2 2 2 1 2| 27 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 2 4 | 5 2.6|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 2 1 2 2 | 9 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 4 1 1 1 1 3 1 2 1 1 1 1 1 2 2 3 1 2| 34 1.4|
Follicular Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 6| 6| 6| 6| 7| 6| 7| 6| 6| 5| 6| 4| 7| 5| 7| 7| 6| 5| 6| |
DAY ON TEST | 3| 8| 3| 8| 3| 3| 5| 3| 2| 3| 3| 1| 3| 0| 3| 6| 7| 9| 3| 0| 2| 3| 7| 1| 6| |
| 3| 4| 3| 0| 4| 5| 0| 9| 1| 1| 5| 1| 5| 8| 8| 8| 7| 2| 3| 9| 8| 5| 8| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 3 | 3 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 2 3.0|
Inflammation, Suppurative | 3 | 3 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 5 2.6|
Interstitial Cell, Hyperplasia | 1 1 1 1 1| 12 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + +| 17 |
Renal, Hemorrhage | 2 2 | 2 2.0|
Renal, Pigmentation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Plasma Cell | | 5 3.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 3 4 3 2 2 4 3 2 3 2| 26 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + + + + + M + + M M M + + + + M M + M + M M| 31 |
Galactocele | 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Granulomatous | 2 2 | 2 2.0|
Prepuce, Inflammation, Acute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 3 4 | 4 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 6| 6| 6| 6| 7| 6| 7| 6| 6| 5| 6| 4| 7| 5| 7| 7| 6| 5| 6| |
DAY ON TEST | 3| 8| 3| 8| 3| 3| 5| 3| 2| 3| 3| 1| 3| 0| 3| 6| 7| 9| 3| 0| 2| 3| 7| 1| 6| |
| 3| 4| 3| 0| 4| 5| 0| 9| 1| 1| 5| 1| 5| 8| 8| 8| 7| 2| 3| 9| 8| 5| 8| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
188 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 3 | 1 3.0|
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 2| 1 2.0|
Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
Mineralization | | 1 4.0|
Alveolar Epithelium, Hyperplasia | 2 2 2 2 2 1 | 10 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X| 3 |
Inflammation, Chronic Active | | 3 2.0|
Inflammation, Suppurative | 2 1 1| 3 1.3|
Thrombosis | 2 2 2 | 5 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 3 | 1 3.0|
Mineralization | 2 | 2 3.0|
Nephropathy | 4 4 3 2 3 4 4 2 2 4 3 4 3 2 4 2 4 2 3 2 4 3 4 2 3| 50 3.1|
Pelvis, Dilatation | | 1 2.0|
Renal Tubule, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 7| 5| 5| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| 5| 4| 7| 7| 6| 7| 7| 6| 5| 4| 6|
DAY ON TEST | 0| 4| 9| 6| 9| 3| 3| 8| 0| 7| 8| 8| 9| 3| 8| 0| 3| 3| 6| 3| 3| 4| 7| 4| 5|
| 0| 4| 0| 4| 8| 5| 8| 1| 7| 5| 1| 8| 2| 3| 8| 5| 3| 4| 0| 3| 4| 3| 3| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X |
Degeneration, Cystic | 3 1 2 2 4 1 2 3 3 1 2 1 1 |
Degeneration, Fatty | 1 2 1 |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X X X X |
Necrosis | |
Regeneration | 3 |
Bile Duct, Hyperplasia | 1 2 2 1 2 2 1 2 2 3 1 1 2 2 2 1 2 1 1 1 2 2 2|
Centrilobular, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Hemorrhage | |
Fat, Necrosis | 2 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 3 2 3 1 3 2 2 2 2 3 2 1 1 |
Basophilic Focus | X X X |
Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Inflammation, Acute | 2 3 3 2 |
Necrosis | 2 4 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Inflammation, Chronic | |
Necrosis | 1 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 3 1 2 3 3 1 2 3 3 3 2 1 1 3 2 3 2 3 1 1 2|
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 7| 5| 5| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| 5| 4| 7| 7| 6| 7| 7| 6| 5| 4| 6|
DAY ON TEST | 0| 4| 9| 6| 9| 3| 3| 8| 0| 7| 8| 8| 9| 3| 8| 0| 3| 3| 6| 3| 3| 4| 7| 4| 5|
| 0| 4| 0| 4| 8| 5| 8| 1| 7| 5| 1| 8| 2| 3| 8| 5| 3| 4| 0| 3| 4| 3| 3| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Atrophy | 3 4 |
Hyperplasia | 2 1 1 2 1 1 2 1 2 2 1 1|
Hypertrophy | 2 2 2 |
Necrosis | |
Vacuolization Cytoplasmic | 4 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 3 2 2 1 2 2 2 1 2 1 |
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + I + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 1 1 1 1 2 1 1 1 2 1 1 1 2 3 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 2 |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 2 3 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 1 2 1 3 |
Inflammation, Suppurative | 4 2 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
Artery, Inflammation | 2 |
Interstitial Cell, Hyperplasia | 1 1 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 7| 5| 5| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| 5| 4| 7| 7| 6| 7| 7| 6| 5| 4| 6|
DAY ON TEST | 0| 4| 9| 6| 9| 3| 3| 8| 0| 7| 8| 8| 9| 3| 8| 0| 3| 3| 6| 3| 3| 4| 7| 4| 5|
| 0| 4| 0| 4| 8| 5| 8| 1| 7| 5| 1| 8| 2| 3| 8| 5| 3| 4| 0| 3| 4| 3| 3| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + |
Renal, Hemorrhage | 2 |
Renal, Infiltration Cellular, Plasma | |
Cell | |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hemorrhage | 2 |
Inflammation, Granulomatous | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 4 3 3 3 3 2|
Hematopoietic Cell Proliferation | 2 |
Necrosis | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + M + + + + M M + M M M M M + + M M + + + M +|
Galactocele | |
Hyperplasia, Atypical | 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic Active | |
Inflammation, Granulomatous | 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 |
Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | 2 2|
__________________________________________________________________________|
Peripheral Nerve | + |
Radicular Neuropathy | 3 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
_____________________________________________________________________________________________________________________
| 7| 5| 5| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| 5| 4| 7| 7| 6| 7| 7| 6| 5| 4| 6|
DAY ON TEST | 0| 4| 9| 6| 9| 3| 3| 8| 0| 7| 8| 8| 9| 3| 8| 0| 3| 3| 6| 3| 3| 4| 7| 4| 5|
| 0| 4| 0| 4| 8| 5| 8| 1| 7| 5| 1| 8| 2| 3| 8| 5| 3| 4| 0| 3| 4| 3| 3| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
375 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic Active | 1 |
Inflammation, Suppurative | 2 |
Thrombosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 4 3 4 2 4 3 4 4 3 3 4 4 4 3 3 2 4 4 3 4 2 3 3 2 3|
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 7| 5| 6| 6| 6| 5| 4| |
DAY ON TEST | 1| 0| 8| 3| 9| 5| 3| 9| 0| 1| 3| 3| 2| 1| 1| 8| 3| 0| 0| 5| 3| 9| 5| 7| 9| |
| 6| 9| 3| 0| 5| 6| 4| 8| 0| 2| 5| 2| 8| 7| 9| 0| 4| 8| 5| 1| 6| 2| 0| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | X | 1 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 | 3 2.0|
Basophilic Focus | X X X X X X X X | 23 |
Clear Cell Focus | X | 6 |
Degeneration, Cystic | 3 2 4 2 2 2 2 1 2 | 22 2.1|
Degeneration, Fatty | 3 1 3 2 1 | 8 1.8|
Eosinophilic Focus | X | 3 |
Hepatodiaphragmatic Nodule | X | 2 |
Mixed Cell Focus | X X X | 7 |
Necrosis | 2 2 | 2 2.0|
Regeneration | 4 | 2 3.5|
Bile Duct, Hyperplasia | 1 3 2 3 2 3 1 1 2 2 3 1 2 1 3 1 1 2 1 1 | 43 1.7|
Centrilobular, Necrosis | 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + +| 8 |
Fat, Hemorrhage | 2 | 1 2.0|
Fat, Necrosis | 2 3 | 6 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 4 1 2 2 2 1 2 3 3 1 1 2 2 1 2 | 32 2.0|
Basophilic Focus | | 3 |
Hyperplasia | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | | 1 3.0|
Inflammation, Acute | 3 4 2 2 | 8 2.6|
Necrosis | 2 2 4 4 2| 9 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 2 | 2 2.5|
Inflammation, Chronic | 2 | 1 2.0|
Necrosis | 2 3 | 3 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 7| 5| 6| 6| 6| 5| 4| |
DAY ON TEST | 1| 0| 8| 3| 9| 5| 3| 9| 0| 1| 3| 3| 2| 1| 1| 8| 3| 0| 0| 5| 3| 9| 5| 7| 9| |
| 6| 9| 3| 0| 5| 6| 4| 8| 0| 2| 5| 2| 8| 7| 9| 0| 4| 8| 5| 1| 6| 2| 0| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 2 2 2 2 1 3 1 1 2 1 2 3 1 2 3 2 2 2 3 2 3 2 2| 47 2.1|
Atrium, Thrombosis | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Atrophy | | 2 3.5|
Hyperplasia | 2 2 2 2 1 1 1 3 2 2 | 22 1.6|
Hypertrophy | 2 1 2 2 1 | 8 1.8|
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 | 3 2.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 2 2 2 1 2 3 | 22 1.8|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Hyperplasia | 2 2 3 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 3 2 2 2 1| 8 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 3 1 1 2 2 2 1 1 1 2 1 1 1 1 1 1 4 1 3 1| 41 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 2 3.0|
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 1 4.0|
Inflammation, Chronic Active | 3 3 3 | 9 2.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 3 | 8 2.1|
Inflammation, Suppurative | 3 3 | 6 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 7| 5| 6| 6| 6| 5| 4| |
DAY ON TEST | 1| 0| 8| 3| 9| 5| 3| 9| 0| 1| 3| 3| 2| 1| 1| 8| 3| 0| 0| 5| 3| 9| 5| 7| 9| |
| 6| 9| 3| 0| 5| 6| 4| 8| 0| 2| 5| 2| 8| 7| 9| 0| 4| 8| 5| 1| 6| 2| 0| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 4 2 3 | 6 3.0|
Artery, Inflammation | 2 2 | 3 2.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 2 1 | 16 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2| 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 13 |
Renal, Hemorrhage | 1 | 2 1.5|
Renal, Infiltration Cellular, Plasma | | |
Cell | 2 | 1 2.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + M + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + + + + + + + M + + + +| 47 |
Hemorrhage | | 1 2.0|
Inflammation, Granulomatous | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 3 2 3 3 1 4 3 2 2 3 | 19 2.8|
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + M + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + M + + M M M + M + + M + + + M M + + + M| 28 |
Galactocele | 2 4 2 | 3 2.7|
Hyperplasia, Atypical | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 4 | 1 4.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Inflammation, Granulomatous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05200-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NITROMETHANE Date: 06/15/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:33:35
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 7| 5| 6| 6| 6| 5| 4| |
DAY ON TEST | 1| 0| 8| 3| 9| 5| 3| 9| 0| 1| 3| 3| 2| 1| 1| 8| 3| 0| 0| 5| 3| 9| 5| 7| 9| |
| 6| 9| 3| 0| 5| 6| 4| 8| 0| 2| 5| 2| 8| 7| 9| 0| 4| 8| 5| 1| 6| 2| 0| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
375 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Hyperostosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Hydrocephalus | | 2 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Radicular Neuropathy | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 3 1 | 9 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
Inflammation, Chronic Active | 2 | 2 1.5|
Inflammation, Suppurative | 1 1 2 2 | 5 1.6|
Thrombosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 1 | 1 1.0|
Retina, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 4 4 3 4 2 3 3 3 3 4 2 4 1 4 4 2 4 4 3 3 4 3 4 3 2| 50 3.2|
Renal Tubule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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