TDMS Study 05200-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest NITROMETHANE DATE: 04/04/96
EXPERIMENT: 05200 TEST: 05 TIME: 05:46:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-75189 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C61927
PATHOLOGIST: R. MILLER R. RENNE CAS: 75-52-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest NITROMETHANE DATE: 04/04/96
EXPERIMENT: 05200 TEST: 05 TIME: 05:46:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-75189 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C61927
PATHOLOGIST: R. MILLER R. RENNE CAS: 75-52-5
NITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 242 411 490 491 504 512 528 537 552 565 |
| 569 580 590 592 600 611 611 612 623 626 |
| 644 644 660 664 664 670 673 681 684 692 |
| 708 719 720 720 725 727 730 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 94 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 34 CENSORED DEATHS 0 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 292 397 427 439 490 492 515 520 523 524 |
| 574 581 586 588 593 601 604 606 607 608 |
| 609 616 636 642 646 650 664 665 665 670 |
| 677 686 692 714 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 188 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 36 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 395 471 492 499 509 518 552 560 561 568 |
| 580 590 608 611 621 621 624 629 631 638 |
| 638 639 643 650 650 650 665 677 678 678 |
| 681 684 692 707 720 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 375 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 42 CENSORED DEATHS 0 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 405 428 444 480 495 516 544 551 571 573 |
| 588 590 595 607 608 612 617 630 634 636 |
| 638 643 650 650 656 660 664 675 681 681 |
| 683 688 692 692 698 698 700 700 705 709 |
| 719 732 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.0 98.0 96.0 96.0 84.0 70.0 50.0 26.0 |
| | |
| | |
|94 PPM | 100.0 100.0 100.0 98.0 96.0 92.0 80.0 66.0 42.0 32.0 |
| | |
| | |
|188 PPM | 100.0 100.0 100.0 100.0 98.0 96.0 88.0 76.0 46.0 28.0 |
| | |
| | |
|375 PPM | 100.0 100.0 100.0 100.0 98.0 92.0 86.0 74.0 46.0 16.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 94 PPM 188 PPM 375 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 26.0% 32.0% 28.0% 16.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.378 P=1.000N P=1.000N P=0.361 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 610.0 582.3 612.7 622.3 |
|NATURAL DEATHS (C) | (16.6) (16.1) (12.6) (12.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 642.0 630.5 646.4 640.0 |
|(STANDARD ERROR) | (14.5) (14.8) (11.9) (12.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 454 519 519 539 544 565 573 585 600 604 |
| 630 631 631 650 658 681 691 691 713 714 |
| 726 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 94 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 31 CENSORED DEATHS 0 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 428 435 473 488 495 512 520 551 561 576 |
| 579 580 586 588 600 606 621 623 636 662 |
| 664 665 667 672 680 691 698 700 720 727 |
| 730 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 188 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 432 440 468 491 508 512 513 545 619 638 |
| 646 650 657 665 670 686 691 698 705 712 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 375 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 387 425 492 496 550 552 594 597 600 604 |
| 604 607 634 636 642 651 660 665 665 670 |
| 672 676 684 709 712 720 720 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 98.0 90.0 80.0 70.0 56.0 |
| | |
| | |
|94 PPM | 100.0 100.0 100.0 100.0 100.0 94.0 86.0 70.0 56.0 38.0 |
| | |
| | |
|188 PPM | 100.0 100.0 100.0 100.0 100.0 94.0 84.0 84.0 72.0 60.0 |
| | |
| | |
|375 PPM | 100.0 100.0 100.0 100.0 96.0 96.0 92.0 78.0 62.0 46.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 94 PPM 188 PPM 375 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.0% 38.0% 60.0% 46.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.780 P=0.083 P=0.900N P=0.404 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 620.2 604.3 597.3 615.7 |
|NATURAL DEATHS (C) | (16.4) (15.4) (21.6) (16.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 683.4 653.2 678.7 669.7 |
|(STANDARD ERROR) | (10.7) (13.0) (12.8) (12.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NITROMETHANE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
94 PPM = 2
188 PPM = 3
375 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
112 +
|
|
| 1 1 2 241 4 3
P 96 + 2 1 2424 34113
E | 2 421131
R | 2 1 211433
C | 1 1313
E 80 + 2 1114 3
N | 12 1 33
T | 2 11413
| 22433
S 64 + 11133
U | 22 141
R | 2 213 1
V | 224 11
I 48 + 2 2111
V | 22411
A | 2221 11
L | 22 32
32 + 443211 2
| 1 1
| 444
| 44 4
16 + 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 99 obs hidden.
NITROMETHANE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
94 PPM = 2
188 PPM = 3
375 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 4 2 1
| 4 422 1 1
96 + 4 2 32 4
| 32 23 1 1
| 22 3 114
| 2 32 1 1
88 + 2 2 4 11 4
| 3 2 32 1 1 44
P | 32 2 1 1 3
E | 2 2 11 3 3
R 80 + 1 1 33
C | 11
E | 22 4 4 33
N | 1 13 3
T 72 + 2 2 4411 33
| 22 441 3 1
S | 2 2 4 4 11
U | 33
R 64 + 2 2 1331
V | 2 24 33
I | 1 1 3
V | 44
A 56 + 2244 1 1
L | 4 4
| 2 2
| 22 44
48 + 22
| 4 4
| 2 2
| 22
40 + 2 2
| 2
|
|
32 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 17 obs hidden.