TDMS Study 05201-05 Pathology Tables
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11 2 YEAR CHRONIC FINAL #2 Facility: Battelle Northwest Chemical CAS #: 0098-00-0000 Lock Date: 01/26/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 23 21 24 32 Natural Death 1 3 3 2 Survivors Terminal Sacrifice 26 25 22 16 Natural Death 1 Other 1 Animals Examined Microscopically 50 50 49 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (50) (47) (48) (48) Parasite Metazoan 2 (4%) 3 (6%) 2 (4%) 3 (6%) Intestine Large, Rectum (50) (47) (47) (49) Parasite Metazoan 4 (8%) 3 (6%) 3 (6%) 3 (6%) Intestine Large, Cecum (49) (47) (46) (48) Parasite Metazoan 5 (10%) 4 (9%) 8 (17%) 4 (8%) Intestine Small, Ileum (49) (47) (46) (48) Parasite Metazoan 1 (2%) Liver (50) (49) (49) (50) Angiectasis 3 (6%) 2 (4%) 3 (6%) 5 (10%) Basophilic Focus 30 (60%) 31 (63%) 34 (69%) 22 (44%) Clear Cell Focus 5 (10%) 6 (12%) 6 (12%) 3 (6%) Cyst 1 (2%) Degeneration, Cystic 1 (2%) 1 (2%) Degeneration, Fatty 13 (26%) 9 (18%) 10 (20%) 17 (34%) Eosinophilic Focus 3 (6%) 2 (4%) 4 (8%) 1 (2%) Hematopoietic Cell Proliferation 1 (2%) Hepatodiaphragmatic Nodule 4 (8%) 7 (14%) 6 (12%) 4 (8%) Infiltration Cellular, Histiocyte 1 (2%) Inflammation, Granulomatous 1 (2%) Mixed Cell Focus 9 (18%) 13 (27%) 9 (18%) 8 (16%) Necrosis 1 (2%) 1 (2%) 2 (4%) Regeneration 1 (2%) 1 (2%) Thrombosis 1 (2%) Vacuolization Cytoplasmic, Focal 1 (2%) Bile Duct, Hyperplasia 6 (12%) 7 (14%) 6 (12%) 7 (14%) Centrilobular, Necrosis 6 (12%) 6 (12%) 8 (16%) 9 (18%) Mesentery (15) (8) (11) (7) Fat, Hemorrhage 1 (7%) Fat, Necrosis 13 (87%) 7 (88%) 11 (100%) 6 (86%) Oral Mucosa (1) (1) (1) Pharyngeal, Hyperplasia, Squamous 1 (100%) 1 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Pancreas (49) (49) (48) (50) Atrophy 10 (20%) 11 (22%) 11 (23%) 11 (22%) Basophilic Focus 4 (8%) 1 (2%) 1 (2%) 1 (2%) Hyperplasia 1 (2%) 1 (2%) Metaplasia, Hepatocyte 1 (2%) Salivary Glands (49) (50) (49) (50) Atrophy 1 (2%) Necrosis 1 (2%) Stomach, Forestomach (50) (50) (49) (50) Hyperplasia, Squamous 1 (2%) 1 (2%) Inflammation, Acute 1 (2%) Mineralization 1 (2%) Necrosis 5 (10%) 6 (12%) 5 (10%) 12 (24%) Stomach, Glandular (50) (49) (49) (50) Mineralization 2 (4%) 2 (4%) 1 (2%) 1 (2%) Necrosis 1 (2%) 2 (4%) 3 (6%) 7 (14%) Tongue (1) (4) (1) (3) Hyperplasia, Squamous 1 (33%) Tooth (1) (1) Degeneration 1 (100%) Pulp, Necrosis 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) Aorta, Mineralization 1 (100%) Heart (50) (50) (49) (50) Cardiomyopathy 29 (58%) 24 (48%) 23 (47%) 19 (38%) Artery, Mineralization 1 (2%) Atrium, Thrombosis 3 (6%) 3 (6%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (48) (50) Angiectasis 1 (2%) 1 (2%) Degeneration, Cystic 1 (2%) Hyperplasia 19 (38%) 22 (44%) 21 (44%) 23 (46%) Hypertrophy 2 (4%) 4 (8%) 6 (13%) 2 (4%) Necrosis 4 (8%) 1 (2%) 1 (2%) Vacuolization Cytoplasmic 5 (10%) 3 (6%) 3 (6%) 8 (16%) Adrenal Medulla (50) (50) (48) (50) Hyperplasia 12 (24%) 7 (14%) 10 (21%) 14 (28%) Islets, Pancreatic (49) (48) (48) (50) Hyperplasia 2 (4%) Parathyroid Gland (46) (43) (44) (46) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Hyperplasia 1 (2%) 1 (2%) 1 (2%) 1 (2%) Pituitary Gland (50) (49) (48) (50) Cyst 1 (2%) Pars Distalis, Angiectasis 3 (6%) Pars Distalis, Hyperplasia 8 (16%) 10 (20%) 7 (15%) 9 (18%) Thyroid Gland (49) (49) (47) (48) C-Cell, Hyperplasia 40 (82%) 41 (84%) 35 (74%) 39 (81%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (44) (45) (46) (45) Hyperplasia 1 (2%) 5 (11%) 2 (4%) 1 (2%) Inflammation, Chronic Active 2 (5%) 3 (7%) 1 (2%) Ovary (50) (50) (49) (50) Cyst 3 (6%) 5 (10%) 6 (12%) 7 (14%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (48) (48) (50) Hyperplasia, Histiocytic 2 (4%) 1 (2%) 1 (2%) Lymph Node (4) (5) (8) (11) Renal, Ectasia 1 (9%) Renal, Hemorrhage 1 (20%) 1 (13%) 1 (9%) Renal, Pigmentation 1 (13%) Lymph Node, Mesenteric (50) (50) (49) (50) Hemorrhage 1 (2%) Lymph Node, Mediastinal (43) (37) (45) (40) Hemorrhage 1 (2%) 1 (3%) Spleen (49) (49) (49) (50) Accessory Spleen 2 (4%) 1 (2%) Fibrosis 5 (10%) 3 (6%) 3 (6%) 5 (10%) Hematopoietic Cell Proliferation 2 (4%) 4 (8%) 2 (4%) 5 (10%) Hemorrhage 1 (2%) 1 (2%) Hyperplasia, Focal 1 (2%) Inflammation, Granulomatous 1 (2%) 1 (2%) Metaplasia, Lipocyte 1 (2%) Necrosis 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (49) (49) (50) Galactocele 3 (6%) 2 (4%) 1 (2%) 5 (10%) Hyperplasia, Atypical 1 (2%) Necrosis 1 (2%) Skin (50) (50) (48) (50) Cyst Epithelial Inclusion 1 (2%) Hyperkeratosis 1 (2%) Inflammation, Chronic Active 2 (4%) Subcutaneous Tissue, Necrosis 1 (2%) Tail, Hyperkeratosis 1 (2%) Tail, Inflammation, Chronic Active 5 (10%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (49) (50) Fibrous Osteodystrophy 1 (2%) 1 (2%) Hyperostosis 8 (16%) 14 (28%) 12 (24%) 6 (12%) Inflammation, Chronic 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (49) (49) (49) Epiglottis, Metaplasia, Squamous 1 (2%) Lung (50) (50) (49) (50) Foreign Body 1 (2%) Infiltration Cellular, Histiocyte 2 (4%) Inflammation, Granulomatous 1 (2%) 2 (4%) 3 (6%) Inflammation, Suppurative 1 (2%) Mineralization 1 (2%) Alveolar Epithelium, Hyperplasia 9 (18%) 16 (32%) 13 (27%) 12 (24%) Mediastinum, Inflammation, Granulomatous 1 (2%) Perivascular, Infiltration Cellular, Mononuclear Cell 1 (2%) Nose (49) (50) (48) (49) Inflammation, Suppurative 4 (8%) 1 (2%) 5 (10%) 23 (47%) Thrombosis 7 (14%) 3 (6%) 6 (13%) 5 (10%) Glands, Hyperplasia 24 (50%) 46 (94%) Lateral Wall, Hyperplasia 39 (78%) 48 (100%) 49 (100%) Lateral Wall, Metaplasia, Squamous 1 (2%) 24 (49%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Olfactory Epithelium, Atrophy 6 (12%) 44 (92%) 49 (100%) Olfactory Epithelium, Degeneration, Hyaline 43 (88%) 50 (100%) 47 (98%) 48 (98%) Olfactory Epithelium, Fibrosis 16 (33%) 31 (63%) Olfactory Epithelium, Hyperplasia 31 (65%) 41 (84%) Olfactory Epithelium, Metaplasia 5 (10%) 37 (77%) 48 (98%) Respiratory Epithelium, Degeneration, Hyaline 23 (47%) 39 (78%) 45 (94%) 6 (12%) Respiratory Epithelium, Hyperplasia 18 (36%) 40 (83%) 49 (100%) Respiratory Epithelium, Metaplasia, Squamous 2 (4%) 10 (20%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (1) (1) Cataract 1 (100%) 1 (100%) Retina, Atrophy 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (49) (49) (50) Cyst 1 (2%) Hydronephrosis 1 (2%) Infarct 2 (4%) 1 (2%) Infiltration Cellular, Histiocyte 1 (2%) Mineralization 1 (2%) Nephropathy 47 (94%) 45 (92%) 47 (96%) 47 (94%) Renal Tubule, Hyperplasia 2 (4%) Urinary Bladder (49) (49) (49) (50) Transitional Epithelium, Hyperplasia 2 (4%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 34 43 31 43 Natural Death 8 2 10 7 Survivors Natural Death 1 Terminal Sacrifice 7 5 9 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (50) (48) (49) (50) Inflammation, Suppurative 1 (2%) Intestine Large, Colon (49) (50) (48) (47) Mineralization 1 (2%) 9 (19%) Parasite Metazoan 3 (6%) 4 (8%) 6 (13%) 5 (11%) Intestine Large, Rectum (47) (50) (48) (47) Mineralization 2 (4%) Parasite Metazoan 1 (2%) 3 (6%) 4 (8%) 1 (2%) Intestine Large, Cecum (46) (49) (44) (45) Parasite Metazoan 2 (4%) 2 (4%) 8 (18%) 4 (9%) Intestine Small, Duodenum (50) (50) (50) (49) Inflammation, Suppurative 1 (2%) 1 (2%) Intestine Small, Ileum (47) (49) (43) (45) Inflammation, Suppurative 1 (2%) Mineralization 1 (2%) Parasite Metazoan 1 (2%) 1 (2%) Liver (50) (50) (50) (50) Angiectasis 6 (12%) 2 (4%) 3 (6%) 4 (8%) Basophilic Focus 9 (18%) 12 (24%) 27 (54%) 31 (62%) Clear Cell Focus 5 (10%) 1 (2%) 4 (8%) Cyst 2 (4%) Degeneration, Cystic 12 (24%) 18 (36%) 12 (24%) 9 (18%) Degeneration, Fatty 5 (10%) 9 (18%) 3 (6%) 7 (14%) Eosinophilic Focus 4 (8%) 2 (4%) 3 (6%) 4 (8%) Hepatodiaphragmatic Nodule 1 (2%) 4 (8%) 6 (12%) Mixed Cell Focus 1 (2%) 2 (4%) 2 (4%) Necrosis 2 (4%) 2 (4%) Regeneration 1 (2%) 3 (6%) 2 (4%) Tension Lipidosis 1 (2%) Vacuolization Cytoplasmic, Focal 1 (2%) Bile Duct, Hyperplasia 28 (56%) 31 (62%) 30 (60%) 13 (26%) Centrilobular, Necrosis 12 (24%) 17 (34%) 15 (30%) 8 (16%) Mesentery (11) (13) (9) (26) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Pigmentation 1 (11%) Thrombosis 1 (4%) Artery, Inflammation, Chronic Active 3 (12%) Artery, Mineralization 2 (15%) 22 (85%) Fat, Hemorrhage 2 (15%) 1 (11%) 2 (8%) Fat, Necrosis 10 (91%) 6 (46%) 7 (78%) 4 (15%) Oral Mucosa (1) (1) (1) (1) Gingival, Inflammation, Chronic Active 1 (100%) Pharyngeal, Hyperplasia 1 (100%) Pancreas (50) (50) (50) (49) Atrophy 22 (44%) 22 (44%) 23 (46%) 17 (35%) Basophilic Focus 3 (6%) 1 (2%) 2 (4%) 1 (2%) Hyperplasia 5 (10%) 2 (4%) 2 (4%) Artery, Inflammation 1 (2%) 5 (10%) Artery, Mineralization 1 (2%) 3 (6%) Salivary Glands (47) (50) (49) (49) Atrophy 1 (2%) 1 (2%) Inflammation, Chronic Active 1 (2%) Stomach, Forestomach (50) (50) (50) (50) Hyperplasia, Squamous 1 (2%) Inflammation, Acute 1 (2%) 1 (2%) Mineralization 1 (2%) 2 (4%) 2 (4%) 12 (24%) Necrosis 9 (18%) 6 (12%) 10 (20%) 6 (12%) Stomach, Glandular (50) (50) (50) (49) Mineralization 2 (4%) 2 (4%) 3 (6%) 32 (65%) Necrosis 7 (14%) 3 (6%) 4 (8%) 4 (8%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (2) (2) (3) (31) Aorta, Mineralization 2 (100%) 2 (100%) 2 (67%) 31 (100%) Heart (50) (50) (50) (50) Cardiomyopathy 38 (76%) 32 (64%) 40 (80%) 42 (84%) Inflammation, Suppurative 1 (2%) Artery, Mineralization 2 (4%) 2 (4%) 2 (4%) 29 (58%) Atrium, Thrombosis 3 (6%) 6 (12%) 1 (2%) 3 (6%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Hyperplasia 15 (30%) 19 (38%) 20 (40%) 24 (48%) Hypertrophy 3 (6%) 3 (6%) 1 (2%) 4 (8%) Necrosis 2 (4%) 1 (2%) Vacuolization Cytoplasmic 4 (8%) 3 (6%) 4 (8%) 8 (16%) Adrenal Medulla (50) (50) (50) (50) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Hyperplasia 30 (60%) 17 (34%) 24 (48%) 19 (38%) Islets, Pancreatic (50) (50) (50) (49) Hyperplasia 1 (2%) Parathyroid Gland (49) (45) (50) (49) Hyperplasia 9 (18%) 5 (11%) 12 (24%) 39 (80%) Necrosis 1 (2%) Pituitary Gland (50) (50) (48) (50) Mineralization 1 (2%) Pars Distalis, Angiectasis 1 (2%) Pars Distalis, Hemorrhage 1 (2%) Pars Distalis, Hyperplasia 4 (8%) 8 (16%) 3 (6%) 11 (22%) Pars Intermedia, Hyperplasia 1 (2%) Thyroid Gland (49) (49) (49) (47) C-Cell, Hyperplasia 27 (55%) 33 (67%) 30 (61%) 21 (45%) Follicular Cell, Hyperplasia 1 (2%) 1 (2%) 2 (4%) 2 (4%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (49) (50) (49) (50) Hyperplasia 1 (2%) 1 (2%) Inflammation, Chronic Active 1 (2%) 2 (4%) 4 (8%) Prostate (50) (50) (50) (50) Hyperplasia 7 (14%) 3 (6%) 5 (10%) Inflammation, Chronic Active 9 (18%) 8 (16%) 3 (6%) 5 (10%) Seminal Vesicle (49) (49) (46) (47) Inflammation, Suppurative 1 (2%) Mineralization 1 (2%) 3 (6%) Testes (50) (50) (50) (50) Atrophy 1 (2%) 1 (2%) 3 (6%) 5 (10%) Artery, Inflammation, Chronic Active 3 (6%) 1 (2%) 4 (8%) 8 (16%) Interstitial Cell, Hyperplasia 4 (8%) 6 (12%) 4 (8%) 7 (14%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (49) Necrosis 2 (4%) Lymph Node (10) (8) (10) (12) Ectasia 1 (8%) Iliac, Ectasia 1 (8%) Renal, Ectasia 4 (33%) a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Renal, Hemorrhage 1 (10%) 1 (10%) 3 (25%) Lymph Node, Mandibular (44) (42) (48) (46) Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%) Lymph Node, Mediastinal (45) (47) (46) (44) Hemorrhage 2 (5%) Spleen (50) (50) (50) (50) Accessory Spleen 3 (6%) 1 (2%) Angiectasis 1 (2%) Fibrosis 14 (28%) 13 (26%) 10 (20%) 12 (24%) Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 2 (4%) 4 (8%) Hemorrhage 3 (6%) Hyperplasia, Focal 1 (2%) 1 (2%) Necrosis 2 (4%) 2 (4%) 3 (6%) 2 (4%) Thymus (43) (40) (41) (38) Cyst 1 (3%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (30) (25) (29) (27) Degeneration 1 (3%) 1 (3%) Galactocele 6 (20%) 2 (8%) 6 (21%) 7 (26%) Skin (50) (50) (50) (50) Cyst Epithelial Inclusion 2 (4%) Fibrosis, Focal 1 (2%) Inflammation, Acute 2 (4%) Inflammation, Chronic Active 1 (2%) 2 (4%) 2 (4%) 2 (4%) Inflammation, Granulomatous 1 (2%) Mineralization 1 (2%) Necrosis 1 (2%) Subcutaneous Tissue, Edema 1 (2%) Tail, Hyperkeratosis 1 (2%) Tail, Inflammation, Chronic Active 1 (2%) 2 (4%) 6 (12%) 18 (36%) Tail, Subcutaneous Tissue, Thrombosis 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Fibrous Osteodystrophy 2 (4%) 5 (10%) 6 (12%) 34 (68%) Fracture 1 (2%) Hyperostosis 5 (10%) 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Necrosis 2 (4%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Foreign Body 1 (2%) Hemorrhage 1 (2%) 1 (2%) Inflammation, Granulomatous 1 (2%) Inflammation, Suppurative 1 (2%) Metaplasia, Osseous 1 (2%) 1 (2%) Metaplasia, Squamous 1 (2%) Mineralization 1 (2%) 2 (4%) 2 (4%) 24 (48%) Thrombosis 1 (2%) 1 (2%) Alveolar Epithelium, Hyperplasia 12 (24%) 7 (14%) 5 (10%) 8 (16%) Artery, Mediastinum, Mineralization 1 (2%) 2 (4%) 2 (4%) 26 (52%) Mediastinum, Inflammation, Suppurative 1 (2%) Perivascular, Infiltration Cellular, Mononuclear Cell 1 (2%) Nose (50) (50) (50) (50) Inflammation, Suppurative 3 (6%) 6 (12%) 17 (34%) 44 (88%) Thrombosis 10 (20%) 15 (30%) 11 (22%) 2 (4%) Glands, Hyperplasia 22 (44%) 49 (98%) Lateral Wall, Hyperplasia 1 (2%) 49 (98%) 50 (100%) 50 (100%) Lateral Wall, Metaplasia, Squamous 1 (2%) 1 (2%) 8 (16%) 33 (66%) Lateral Wall, Necrosis 1 (2%) Nasopharyngeal Duct, Inflammation, Acute 1 (2%) Olfactory Epithelium, Atrophy 1 (2%) 12 (24%) 47 (94%) 50 (100%) Olfactory Epithelium, Degeneration, Hyaline 42 (84%) 48 (96%) 50 (100%) 47 (94%) Olfactory Epithelium, Fibrosis 1 (2%) 26 (52%) 40 (80%) Olfactory Epithelium, Hyperplasia 1 (2%) 42 (84%) 40 (80%) Olfactory Epithelium, Metaplasia 1 (2%) 8 (16%) 37 (74%) 49 (98%) Respiratory Epithelium, Degeneration, Hyaline 12 (24%) 14 (28%) 45 (90%) 3 (6%) Respiratory Epithelium, Hyperplasia 26 (52%) 50 (100%) 50 (100%) Respiratory Epithelium, Metaplasia, Squamous 3 (6%) 26 (52%) Trachea (49) (50) (50) (50) Inflammation, Suppurative 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (3) (1) (3) Cataract 1 (33%) 1 (100%) 1 (33%) Inflammation, Chronic Active 2 (67%) 1 (33%) Retina, Atrophy 1 (33%) 1 (33%) a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - CONT Harderian Gland (1) (1) Hyperplasia 1 (100%) Inflammation, Chronic Active 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Cyst 1 (2%) 3 (6%) 4 (8%) Hydronephrosis 2 (4%) Hyperplasia, Oncocytic 1 (2%) Infarct 1 (2%) 2 (4%) 1 (2%) Mineralization 2 (4%) 2 (4%) 2 (4%) 28 (56%) Nephropathy 50 (100%) 49 (98%) 50 (100%) 50 (100%) STROMAL HYPERPLASIA 1 (2%) Papilla, Necrosis 1 (2%) Renal Tubule, Hyperplasia 5 (10%) 5 (10%) 2 (4%) 6 (12%) Urinary Bladder (50) (50) (50) (50) Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%) Necrosis 1 (2%) Transitional Epithelium, Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 12 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------