TDMS Study 05201-05 Pathology Tables
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11
2 YEAR CHRONIC FINAL #2
Facility: Battelle Northwest
Chemical CAS #: 0098-00-0000
Lock Date: 01/26/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 23 21 24 32
Natural Death 1 3 3 2
Survivors
Terminal Sacrifice 26 25 22 16
Natural Death 1
Other 1
Animals Examined Microscopically 50 50 49 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (47) (48) (48)
Parasite Metazoan 2 (4%) 3 (6%) 2 (4%) 3 (6%)
Intestine Large, Rectum (50) (47) (47) (49)
Parasite Metazoan 4 (8%) 3 (6%) 3 (6%) 3 (6%)
Intestine Large, Cecum (49) (47) (46) (48)
Parasite Metazoan 5 (10%) 4 (9%) 8 (17%) 4 (8%)
Intestine Small, Ileum (49) (47) (46) (48)
Parasite Metazoan 1 (2%)
Liver (50) (49) (49) (50)
Angiectasis 3 (6%) 2 (4%) 3 (6%) 5 (10%)
Basophilic Focus 30 (60%) 31 (63%) 34 (69%) 22 (44%)
Clear Cell Focus 5 (10%) 6 (12%) 6 (12%) 3 (6%)
Cyst 1 (2%)
Degeneration, Cystic 1 (2%) 1 (2%)
Degeneration, Fatty 13 (26%) 9 (18%) 10 (20%) 17 (34%)
Eosinophilic Focus 3 (6%) 2 (4%) 4 (8%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 4 (8%) 7 (14%) 6 (12%) 4 (8%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Granulomatous 1 (2%)
Mixed Cell Focus 9 (18%) 13 (27%) 9 (18%) 8 (16%)
Necrosis 1 (2%) 1 (2%) 2 (4%)
Regeneration 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bile Duct, Hyperplasia 6 (12%) 7 (14%) 6 (12%) 7 (14%)
Centrilobular, Necrosis 6 (12%) 6 (12%) 8 (16%) 9 (18%)
Mesentery (15) (8) (11) (7)
Fat, Hemorrhage 1 (7%)
Fat, Necrosis 13 (87%) 7 (88%) 11 (100%) 6 (86%)
Oral Mucosa (1) (1) (1)
Pharyngeal, Hyperplasia, Squamous 1 (100%) 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (49) (49) (48) (50)
Atrophy 10 (20%) 11 (22%) 11 (23%) 11 (22%)
Basophilic Focus 4 (8%) 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Metaplasia, Hepatocyte 1 (2%)
Salivary Glands (49) (50) (49) (50)
Atrophy 1 (2%)
Necrosis 1 (2%)
Stomach, Forestomach (50) (50) (49) (50)
Hyperplasia, Squamous 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Mineralization 1 (2%)
Necrosis 5 (10%) 6 (12%) 5 (10%) 12 (24%)
Stomach, Glandular (50) (49) (49) (50)
Mineralization 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Necrosis 1 (2%) 2 (4%) 3 (6%) 7 (14%)
Tongue (1) (4) (1) (3)
Hyperplasia, Squamous 1 (33%)
Tooth (1) (1)
Degeneration 1 (100%)
Pulp, Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Mineralization 1 (100%)
Heart (50) (50) (49) (50)
Cardiomyopathy 29 (58%) 24 (48%) 23 (47%) 19 (38%)
Artery, Mineralization 1 (2%)
Atrium, Thrombosis 3 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (48) (50)
Angiectasis 1 (2%) 1 (2%)
Degeneration, Cystic 1 (2%)
Hyperplasia 19 (38%) 22 (44%) 21 (44%) 23 (46%)
Hypertrophy 2 (4%) 4 (8%) 6 (13%) 2 (4%)
Necrosis 4 (8%) 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 5 (10%) 3 (6%) 3 (6%) 8 (16%)
Adrenal Medulla (50) (50) (48) (50)
Hyperplasia 12 (24%) 7 (14%) 10 (21%) 14 (28%)
Islets, Pancreatic (49) (48) (48) (50)
Hyperplasia 2 (4%)
Parathyroid Gland (46) (43) (44) (46)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (50) (49) (48) (50)
Cyst 1 (2%)
Pars Distalis, Angiectasis 3 (6%)
Pars Distalis, Hyperplasia 8 (16%) 10 (20%) 7 (15%) 9 (18%)
Thyroid Gland (49) (49) (47) (48)
C-Cell, Hyperplasia 40 (82%) 41 (84%) 35 (74%) 39 (81%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (44) (45) (46) (45)
Hyperplasia 1 (2%) 5 (11%) 2 (4%) 1 (2%)
Inflammation, Chronic Active 2 (5%) 3 (7%) 1 (2%)
Ovary (50) (50) (49) (50)
Cyst 3 (6%) 5 (10%) 6 (12%) 7 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (48) (48) (50)
Hyperplasia, Histiocytic 2 (4%) 1 (2%) 1 (2%)
Lymph Node (4) (5) (8) (11)
Renal, Ectasia 1 (9%)
Renal, Hemorrhage 1 (20%) 1 (13%) 1 (9%)
Renal, Pigmentation 1 (13%)
Lymph Node, Mesenteric (50) (50) (49) (50)
Hemorrhage 1 (2%)
Lymph Node, Mediastinal (43) (37) (45) (40)
Hemorrhage 1 (2%) 1 (3%)
Spleen (49) (49) (49) (50)
Accessory Spleen 2 (4%) 1 (2%)
Fibrosis 5 (10%) 3 (6%) 3 (6%) 5 (10%)
Hematopoietic Cell Proliferation 2 (4%) 4 (8%) 2 (4%) 5 (10%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Metaplasia, Lipocyte 1 (2%)
Necrosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (49) (50)
Galactocele 3 (6%) 2 (4%) 1 (2%) 5 (10%)
Hyperplasia, Atypical 1 (2%)
Necrosis 1 (2%)
Skin (50) (50) (48) (50)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic Active 2 (4%)
Subcutaneous Tissue, Necrosis 1 (2%)
Tail, Hyperkeratosis 1 (2%)
Tail, Inflammation, Chronic Active 5 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49) (50)
Fibrous Osteodystrophy 1 (2%) 1 (2%)
Hyperostosis 8 (16%) 14 (28%) 12 (24%) 6 (12%)
Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (49) (49)
Epiglottis, Metaplasia, Squamous 1 (2%)
Lung (50) (50) (49) (50)
Foreign Body 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%)
Inflammation, Granulomatous 1 (2%) 2 (4%) 3 (6%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
Alveolar Epithelium, Hyperplasia 9 (18%) 16 (32%) 13 (27%) 12 (24%)
Mediastinum, Inflammation, Granulomatous 1 (2%)
Perivascular, Infiltration Cellular,
Mononuclear Cell 1 (2%)
Nose (49) (50) (48) (49)
Inflammation, Suppurative 4 (8%) 1 (2%) 5 (10%) 23 (47%)
Thrombosis 7 (14%) 3 (6%) 6 (13%) 5 (10%)
Glands, Hyperplasia 24 (50%) 46 (94%)
Lateral Wall, Hyperplasia 39 (78%) 48 (100%) 49 (100%)
Lateral Wall, Metaplasia, Squamous 1 (2%) 24 (49%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Olfactory Epithelium, Atrophy 6 (12%) 44 (92%) 49 (100%)
Olfactory Epithelium, Degeneration, Hyaline 43 (88%) 50 (100%) 47 (98%) 48 (98%)
Olfactory Epithelium, Fibrosis 16 (33%) 31 (63%)
Olfactory Epithelium, Hyperplasia 31 (65%) 41 (84%)
Olfactory Epithelium, Metaplasia 5 (10%) 37 (77%) 48 (98%)
Respiratory Epithelium, Degeneration, Hyaline 23 (47%) 39 (78%) 45 (94%) 6 (12%)
Respiratory Epithelium, Hyperplasia 18 (36%) 40 (83%) 49 (100%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%) 10 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (1)
Cataract 1 (100%) 1 (100%)
Retina, Atrophy 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (49) (50)
Cyst 1 (2%)
Hydronephrosis 1 (2%)
Infarct 2 (4%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Mineralization 1 (2%)
Nephropathy 47 (94%) 45 (92%) 47 (96%) 47 (94%)
Renal Tubule, Hyperplasia 2 (4%)
Urinary Bladder (49) (49) (49) (50)
Transitional Epithelium, Hyperplasia 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 34 43 31 43
Natural Death 8 2 10 7
Survivors
Natural Death 1
Terminal Sacrifice 7 5 9
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (48) (49) (50)
Inflammation, Suppurative 1 (2%)
Intestine Large, Colon (49) (50) (48) (47)
Mineralization 1 (2%) 9 (19%)
Parasite Metazoan 3 (6%) 4 (8%) 6 (13%) 5 (11%)
Intestine Large, Rectum (47) (50) (48) (47)
Mineralization 2 (4%)
Parasite Metazoan 1 (2%) 3 (6%) 4 (8%) 1 (2%)
Intestine Large, Cecum (46) (49) (44) (45)
Parasite Metazoan 2 (4%) 2 (4%) 8 (18%) 4 (9%)
Intestine Small, Duodenum (50) (50) (50) (49)
Inflammation, Suppurative 1 (2%) 1 (2%)
Intestine Small, Ileum (47) (49) (43) (45)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
Parasite Metazoan 1 (2%) 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 6 (12%) 2 (4%) 3 (6%) 4 (8%)
Basophilic Focus 9 (18%) 12 (24%) 27 (54%) 31 (62%)
Clear Cell Focus 5 (10%) 1 (2%) 4 (8%)
Cyst 2 (4%)
Degeneration, Cystic 12 (24%) 18 (36%) 12 (24%) 9 (18%)
Degeneration, Fatty 5 (10%) 9 (18%) 3 (6%) 7 (14%)
Eosinophilic Focus 4 (8%) 2 (4%) 3 (6%) 4 (8%)
Hepatodiaphragmatic Nodule 1 (2%) 4 (8%) 6 (12%)
Mixed Cell Focus 1 (2%) 2 (4%) 2 (4%)
Necrosis 2 (4%) 2 (4%)
Regeneration 1 (2%) 3 (6%) 2 (4%)
Tension Lipidosis 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bile Duct, Hyperplasia 28 (56%) 31 (62%) 30 (60%) 13 (26%)
Centrilobular, Necrosis 12 (24%) 17 (34%) 15 (30%) 8 (16%)
Mesentery (11) (13) (9) (26)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pigmentation 1 (11%)
Thrombosis 1 (4%)
Artery, Inflammation, Chronic Active 3 (12%)
Artery, Mineralization 2 (15%) 22 (85%)
Fat, Hemorrhage 2 (15%) 1 (11%) 2 (8%)
Fat, Necrosis 10 (91%) 6 (46%) 7 (78%) 4 (15%)
Oral Mucosa (1) (1) (1) (1)
Gingival, Inflammation, Chronic Active 1 (100%)
Pharyngeal, Hyperplasia 1 (100%)
Pancreas (50) (50) (50) (49)
Atrophy 22 (44%) 22 (44%) 23 (46%) 17 (35%)
Basophilic Focus 3 (6%) 1 (2%) 2 (4%) 1 (2%)
Hyperplasia 5 (10%) 2 (4%) 2 (4%)
Artery, Inflammation 1 (2%) 5 (10%)
Artery, Mineralization 1 (2%) 3 (6%)
Salivary Glands (47) (50) (49) (49)
Atrophy 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Hyperplasia, Squamous 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Mineralization 1 (2%) 2 (4%) 2 (4%) 12 (24%)
Necrosis 9 (18%) 6 (12%) 10 (20%) 6 (12%)
Stomach, Glandular (50) (50) (50) (49)
Mineralization 2 (4%) 2 (4%) 3 (6%) 32 (65%)
Necrosis 7 (14%) 3 (6%) 4 (8%) 4 (8%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2) (2) (3) (31)
Aorta, Mineralization 2 (100%) 2 (100%) 2 (67%) 31 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 38 (76%) 32 (64%) 40 (80%) 42 (84%)
Inflammation, Suppurative 1 (2%)
Artery, Mineralization 2 (4%) 2 (4%) 2 (4%) 29 (58%)
Atrium, Thrombosis 3 (6%) 6 (12%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Hyperplasia 15 (30%) 19 (38%) 20 (40%) 24 (48%)
Hypertrophy 3 (6%) 3 (6%) 1 (2%) 4 (8%)
Necrosis 2 (4%) 1 (2%)
Vacuolization Cytoplasmic 4 (8%) 3 (6%) 4 (8%) 8 (16%)
Adrenal Medulla (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 30 (60%) 17 (34%) 24 (48%) 19 (38%)
Islets, Pancreatic (50) (50) (50) (49)
Hyperplasia 1 (2%)
Parathyroid Gland (49) (45) (50) (49)
Hyperplasia 9 (18%) 5 (11%) 12 (24%) 39 (80%)
Necrosis 1 (2%)
Pituitary Gland (50) (50) (48) (50)
Mineralization 1 (2%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 4 (8%) 8 (16%) 3 (6%) 11 (22%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (49) (49) (49) (47)
C-Cell, Hyperplasia 27 (55%) 33 (67%) 30 (61%) 21 (45%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (49) (50) (49) (50)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 4 (8%)
Prostate (50) (50) (50) (50)
Hyperplasia 7 (14%) 3 (6%) 5 (10%)
Inflammation, Chronic Active 9 (18%) 8 (16%) 3 (6%) 5 (10%)
Seminal Vesicle (49) (49) (46) (47)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%) 3 (6%)
Testes (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%) 3 (6%) 5 (10%)
Artery, Inflammation, Chronic Active 3 (6%) 1 (2%) 4 (8%) 8 (16%)
Interstitial Cell, Hyperplasia 4 (8%) 6 (12%) 4 (8%) 7 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (49)
Necrosis 2 (4%)
Lymph Node (10) (8) (10) (12)
Ectasia 1 (8%)
Iliac, Ectasia 1 (8%)
Renal, Ectasia 4 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Renal, Hemorrhage 1 (10%) 1 (10%) 3 (25%)
Lymph Node, Mandibular (44) (42) (48) (46)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%)
Lymph Node, Mediastinal (45) (47) (46) (44)
Hemorrhage 2 (5%)
Spleen (50) (50) (50) (50)
Accessory Spleen 3 (6%) 1 (2%)
Angiectasis 1 (2%)
Fibrosis 14 (28%) 13 (26%) 10 (20%) 12 (24%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 2 (4%) 4 (8%)
Hemorrhage 3 (6%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Necrosis 2 (4%) 2 (4%) 3 (6%) 2 (4%)
Thymus (43) (40) (41) (38)
Cyst 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (30) (25) (29) (27)
Degeneration 1 (3%) 1 (3%)
Galactocele 6 (20%) 2 (8%) 6 (21%) 7 (26%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 2 (4%)
Fibrosis, Focal 1 (2%)
Inflammation, Acute 2 (4%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
Tail, Hyperkeratosis 1 (2%)
Tail, Inflammation, Chronic Active 1 (2%) 2 (4%) 6 (12%) 18 (36%)
Tail, Subcutaneous Tissue, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 2 (4%) 5 (10%) 6 (12%) 34 (68%)
Fracture 1 (2%)
Hyperostosis 5 (10%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Necrosis 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Foreign Body 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Metaplasia, Squamous 1 (2%)
Mineralization 1 (2%) 2 (4%) 2 (4%) 24 (48%)
Thrombosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 12 (24%) 7 (14%) 5 (10%) 8 (16%)
Artery, Mediastinum, Mineralization 1 (2%) 2 (4%) 2 (4%) 26 (52%)
Mediastinum, Inflammation, Suppurative 1 (2%)
Perivascular, Infiltration Cellular,
Mononuclear Cell 1 (2%)
Nose (50) (50) (50) (50)
Inflammation, Suppurative 3 (6%) 6 (12%) 17 (34%) 44 (88%)
Thrombosis 10 (20%) 15 (30%) 11 (22%) 2 (4%)
Glands, Hyperplasia 22 (44%) 49 (98%)
Lateral Wall, Hyperplasia 1 (2%) 49 (98%) 50 (100%) 50 (100%)
Lateral Wall, Metaplasia, Squamous 1 (2%) 1 (2%) 8 (16%) 33 (66%)
Lateral Wall, Necrosis 1 (2%)
Nasopharyngeal Duct, Inflammation, Acute 1 (2%)
Olfactory Epithelium, Atrophy 1 (2%) 12 (24%) 47 (94%) 50 (100%)
Olfactory Epithelium, Degeneration, Hyaline 42 (84%) 48 (96%) 50 (100%) 47 (94%)
Olfactory Epithelium, Fibrosis 1 (2%) 26 (52%) 40 (80%)
Olfactory Epithelium, Hyperplasia 1 (2%) 42 (84%) 40 (80%)
Olfactory Epithelium, Metaplasia 1 (2%) 8 (16%) 37 (74%) 49 (98%)
Respiratory Epithelium, Degeneration, Hyaline 12 (24%) 14 (28%) 45 (90%) 3 (6%)
Respiratory Epithelium, Hyperplasia 26 (52%) 50 (100%) 50 (100%)
Respiratory Epithelium, Metaplasia, Squamous 3 (6%) 26 (52%)
Trachea (49) (50) (50) (50)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (1) (3)
Cataract 1 (33%) 1 (100%) 1 (33%)
Inflammation, Chronic Active 2 (67%) 1 (33%)
Retina, Atrophy 1 (33%) 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:07:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Harderian Gland (1) (1)
Hyperplasia 1 (100%)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 1 (2%) 3 (6%) 4 (8%)
Hydronephrosis 2 (4%)
Hyperplasia, Oncocytic 1 (2%)
Infarct 1 (2%) 2 (4%) 1 (2%)
Mineralization 2 (4%) 2 (4%) 2 (4%) 28 (56%)
Nephropathy 50 (100%) 49 (98%) 50 (100%) 50 (100%)
STROMAL HYPERPLASIA 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Hyperplasia 5 (10%) 5 (10%) 2 (4%) 6 (12%)
Urinary Bladder (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Necrosis 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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