TDMS Study 05201-05 Pathology Tables
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:12:30
2 YEAR CHRONIC FINAL #2
Facility: Battelle Northwest
Chemical CAS #: 0098-00-0000
Lock Date: 01/26/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 23 21 24 32
Natural Death 1 3 3 2
Survivors
Terminal Sacrifice 26 25 22 16
Natural Death 1
Other 1
Animals Examined Microscopically 50 50 49 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (47) (48) (48)
Intestine Large, Rectum (50) (47) (47) (49)
Fibroma 1 (2%)
Leiomyosarcoma 1 (2%)
Intestine Large, Cecum (49) (47) (46) (48)
Intestine Small, Duodenum (50) (49) (47) (49)
Intestine Small, Jejunum (49) (47) (47) (48)
Adenocarcinoma 1 (2%)
Intestine Small, Ileum (49) (47) (46) (48)
Liver (50) (49) (49) (50)
Hepatocellular Adenoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 2 (4%)
Mesentery (15) (8) (11) (7)
Carcinoma, Metastatic, Kidney 1 (13%)
Sarcoma Stromal, Metastatic, Uterus 1 (14%)
Oral Mucosa (1) (1) (1)
Pharyngeal, Squamous Cell Papilloma 1 (100%)
Pancreas (49) (49) (48) (50)
Carcinoma, Metastatic, Kidney 1 (2%)
Salivary Glands (49) (50) (49) (50)
Stomach, Forestomach (50) (50) (49) (50)
Leiomyosarcoma 1 (2%)
Stomach, Glandular (50) (49) (49) (50)
Tongue (1) (4) (1) (3)
Squamous Cell Carcinoma 1 (25%) 1 (33%)
Squamous Cell Papilloma 2 (50%) 1 (33%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (49) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (48) (50)
Adenoma 2 (4%) 2 (4%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Adrenal Medulla (50) (50) (48) (50)
Histiocytic Sarcoma 1 (2%)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 4 (8%) 5 (10%) 2 (4%) 5 (10%)
Bilateral, Pheochromocytoma Benign 2 (4%) 2 (4%) 2 (4%)
Islets, Pancreatic (49) (48) (48) (50)
Adenoma 1 (2%) 3 (6%)
Carcinoma 1 (2%) 1 (2%)
Parathyroid Gland (46) (43) (44) (46)
Adenoma 1 (2%)
Pituitary Gland (50) (49) (48) (50)
Pars Distalis, Adenoma 38 (76%) 35 (71%) 34 (71%) 35 (70%)
Thyroid Gland (49) (49) (47) (48)
C-Cell, Adenoma 7 (14%) 5 (10%) 6 (13%) 5 (10%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 2 (4%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (44) (45) (46) (45)
Adenoma 3 (7%) 2 (4%) 2 (4%) 7 (16%)
Carcinoma 3 (7%) 2 (4%) 1 (2%)
Bilateral, Adenoma 1 (2%)
Bilateral, Carcinoma 1 (2%)
Ovary (50) (50) (49) (50)
Granulosa Cell Tumor Benign 1 (2%) 1 (2%)
Sertoli Cell Tumor Benign 1 (2%)
Uterus (50) (50) (49) (50)
Adenoma 1 (2%)
Page 3
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Leiomyosarcoma, Metastatic, Intestine Large,
Rectum 1 (2%)
Polyp Stromal 5 (10%) 9 (18%) 6 (12%) 2 (4%)
Polyp Stromal, Multiple 1 (2%)
Sarcoma Stromal 2 (4%)
Schwannoma Malignant 2 (4%) 1 (2%)
Vagina (1) (3)
Leiomyosarcoma, Metastatic, Intestine Large,
Rectum 1 (33%)
Polyp 1 (33%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (48) (48) (50)
Lymph Node (4) (5) (8) (11)
Lymph Node, Bronchial (37) (30) (40) (25)
Carcinoma, Metastatic, Thyroid Gland 1 (3%)
Histiocytic Sarcoma 1 (4%)
Lymph Node, Mandibular (46) (46) (46) (42)
Lymph Node, Mesenteric (50) (50) (49) (50)
Carcinoma, Metastatic, Kidney 1 (2%)
Lymph Node, Mediastinal (43) (37) (45) (40)
Carcinoma, Metastatic, Kidney 1 (3%)
Spleen (49) (49) (49) (50)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma 1 (2%)
Thymus (47) (44) (44) (43)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (49) (50)
Adenoma 1 (2%)
Carcinoma 7 (14%) 2 (4%) 2 (4%) 5 (10%)
Carcinoma, Multiple 2 (4%) 1 (2%)
Fibroadenoma 17 (34%) 17 (35%) 19 (39%) 14 (28%)
Fibroadenoma, Multiple 2 (4%) 7 (14%) 6 (12%) 6 (12%)
Skin (50) (50) (48) (50)
Keratoacanthoma 1 (2%) 2 (4%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49) (50)
Fibroma 1 (2%)
Osteosarcoma 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50)
Astrocytoma Malignant 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (49) (49)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lung (50) (50) (49) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 2 (4%)
Mediastinum, Osteosarcoma, Metastatic, Bone 1 (2%)
Nose (49) (50) (48) (49)
Lateral Wall, Adenoma 1 (2%)
Respiratory Epithelium, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (49) (50)
Histiocytic Sarcoma 1 (2%)
Renal Tubule, Adenoma 2 (4%)
Renal Tubule, Carcinoma 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (49) (49) (49) (50)
Leiomyosarcoma, Metastatic, Intestine Large,
Rectum 1 (2%)
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NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Transitional Epithelium, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(49) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leukemia Mononuclear 21 (42%) 19 (38%) 18 (37%) 29 (58%)
Lymphoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 49 49 49
Total Primary Neoplasms 127 119 120 131
Total Animals with Benign Neoplasms 48 47 46 43
Total Benign Neoplasms 88 87 87 88
Total Animals with Malignant Neoplasms 31 28 32 36
Total Malignant Neoplasms 39 32 33 43
Total Animals with Metastatic Neoplasms 1 2 3 1
Total Metastatic Neoplasm 3 5 10 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 34 43 31 43
Natural Death 8 2 10 7
Survivors
Natural Death 1
Terminal Sacrifice 7 5 9
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (50) (48) (47)
Intestine Large, Cecum (46) (49) (44) (45)
Intestine Small, Duodenum (50) (50) (50) (49)
Intestine Small, Jejunum (46) (50) (43) (44)
Carcinoma 1 (2%)
Intestine Small, Ileum (47) (49) (43) (45)
Liver (50) (50) (50) (50)
Hepatocellular Adenoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 2 (4%)
Mesentery (11) (13) (9) (26)
Oral Mucosa (1) (1) (1) (1)
Pharyngeal, Squamous Cell Papilloma 1 (100%)
Pancreas (50) (50) (50) (49)
Adenoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Kidney 1 (2%)
Salivary Glands (47) (50) (49) (49)
Histiocytic Sarcoma 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (50) (49)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Carcinoma, Metastatic, Kidney 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma, Metastatic, Kidney 1 (2%)
Bilateral, Adenoma 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Carcinoma, Metastatic, Kidney 1 (2%)
Pheochromocytoma Malignant 1 (2%) 2 (4%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 11 (22%) 13 (26%) 12 (24%) 6 (12%)
Bilateral, Pheochromocytoma Benign 8 (16%) 14 (28%) 10 (20%) 20 (40%)
Islets, Pancreatic (50) (50) (50) (49)
Adenoma 3 (6%) 2 (4%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Parathyroid Gland (49) (45) (50) (49)
Adenoma 1 (2%)
Pituitary Gland (50) (50) (48) (50)
Pars Distalis, Adenoma 36 (72%) 37 (74%) 39 (81%) 31 (62%)
Thyroid Gland (49) (49) (49) (47)
C-Cell, Adenoma 5 (10%) 6 (12%) 5 (10%)
C-Cell, Carcinoma 1 (2%) 1 (2%)
Follicular Cell, Adenoma 2 (4%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (1) (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (49) (50) (49) (50)
Adenoma 2 (4%) 3 (6%) 2 (4%) 2 (4%)
Carcinoma 3 (6%) 2 (4%) 5 (10%) 2 (4%)
Schwannoma Malignant 1 (2%)
Bilateral, Carcinoma 1 (2%)
Prostate (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Seminal Vesicle (49) (49) (46) (47)
Adenoma 1 (2%)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 28 (56%) 27 (54%) 27 (54%) 18 (36%)
Interstitial Cell, Adenoma 7 (14%) 8 (16%) 10 (20%) 14 (28%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (49)
Lymph Node (10) (8) (10) (12)
Lymph Node, Bronchial (39) (28) (33) (22)
Carcinoma, Metastatic, Kidney 1 (3%)
Lymph Node, Mandibular (44) (42) (48) (46)
Lymph Node, Mesenteric (48) (50) (50) (45)
Carcinoma, Metastatic, Kidney 1 (2%)
Lymph Node, Mediastinal (45) (47) (46) (44)
Carcinoma, Metastatic, Kidney 1 (2%)
Spleen (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Thymus (43) (40) (41) (38)
Thymoma Benign 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (30) (25) (29) (27)
Carcinoma 2 (7%)
Carcinoma, Multiple 1 (3%)
Fibroadenoma 2 (7%) 1 (4%) 5 (17%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%) 3 (6%)
Basal Cell Carcinoma 2 (4%) 1 (2%)
Keratoacanthoma 5 (10%) 1 (2%) 7 (14%) 4 (8%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 2 (4%)
Sebaceous Gland, Carcinoma 2 (4%)
Subcutaneous Tissue, Fibroma 4 (8%) 2 (4%) 5 (10%) 1 (2%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteoma 1 (2%)
Turbinate, Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Meningioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Carcinoma, Metastatic, Kidney 1 (2%)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Nose (50) (50) (50) (50)
Lateral Wall, Adenoma 1 (2%)
Respiratory Epithelium, Adenoma 1 (2%)
Respiratory Epithelium, Carcinoma 1 (2%)
Respiratory Epithelium, Squamous Cell
Carcinoma 3 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1) (3)
Adenoma 1 (100%)
Carcinoma 1 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lipoma 1 (2%)
Nephroblastoma 1 (2%)
Stromal Nephroma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%) 2 (4%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Page 11
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%)
Leukemia Mononuclear 29 (58%) 31 (62%) 28 (56%) 15 (30%)
Mesothelioma Malignant 3 (6%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 05201-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 50 50
Total Primary Neoplasms 161 166 189 125
Total Animals with Benign Neoplasms 47 50 49 47
Total Benign Neoplasms 115 126 139 98
Total Animals with Malignant Neoplasms 35 35 34 26
Total Malignant Neoplasms 46 40 50 27
Total Animals with Metastatic Neoplasms 4
Total Metastatic Neoplasm 11
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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