TDMS Study 05201-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest FURFURYL ALCOHOL DATE: 03/25/97
EXPERIMENT: 05201 TEST: 05 TIME: 20:34:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-15315 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56224C
PATHOLOGIST: GRUMBEIN, S. CAS: 0098-00-0000
------------------------------------------------------------------------------------------------------------------------------------
CHRONIC
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest FURFURYL ALCOHOL DATE: 03/25/97
EXPERIMENT: 05201 TEST: 05 TIME: 20:34:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-15315 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56224C
PATHOLOGIST: GRUMBEIN, S. CAS: 0098-00-0000
FURFURYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 42 CENSORED DEATHS 0 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 302 333 351 382 469 490 507 522 525 532 |
| 536 561 572 574 578 581 591 595 599 599 |
| 606 609 617 624 648 657 664 665 679 681 |
| 684 685 685 686 690 693 696 696 702 715 |
| 717 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 45 CENSORED DEATHS 0 TERMINAL 5 |
| |
| UNCENSORED DEATHS |
| 399 462 477 477 490 490 490 491 525 543 |
| 555 560 571 578 578 581 601 604 606 609 |
| 609 609 616 616 622 623 627 637 637 644 |
| 652 660 678 686 686 689 689 691 693 694 |
| 705 716 721 726 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 8.0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 41 CENSORED DEATHS 0 TERMINAL 9 |
| |
| UNCENSORED DEATHS |
| 428 473 478 483 492 505 519 525 536 546 |
| 547 554 559 571 572 580 585 588 592 597 |
| 616 621 635 639 646 652 665 666 666 670 |
| 671 679 688 692 693 700 708 708 708 716 |
| 730 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FURFURYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 32.0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 50 CENSORED DEATHS 0 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 347 421 469 472 476 497 521 522 526 532 |
| 555 568 580 580 581 581 583 585 594 599 |
| 601 604 606 609 609 610 610 612 613 615 |
| 622 622 623 631 637 637 637 638 638 638 |
| 649 650 651 651 664 668 674 681 682 693 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FURFURYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 94.0 92.0 90.0 78.0 60.0 44.0 16.0 |
| | |
| | |
|2.0 PPM | 100.0 100.0 100.0 100.0 98.0 92.0 80.0 64.0 36.0 10.0 |
| | |
| | |
|8.0 PPM | 100.0 100.0 100.0 100.0 100.0 92.0 82.0 60.0 46.0 18.0 |
| | |
| | |
|32.0 PPM | 100.0 100.0 100.0 98.0 96.0 90.0 80.0 56.0 10.0 0.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 2.0 PPM 8.0 PPM 32.0 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 16.0% 10.0% 18.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.597 P=0.915N P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 595.8 607.6 607.3 593.3 |
|NATURAL DEATHS (C) | (16.6) (12.3) (12.6) ( 9.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 618.1 620.3 630.3 593.3 |
|(STANDARD ERROR) | (15.7) (12.3) (12.4) ( 9.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
FURFURYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 98 456 470 477 478 573 581 581 599 604 |
| 609 609 616 627 631 652 661 673 693 707 |
| 707 707 707 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 428 469 497 506 535 547 571 581 603 628 |
| 637 651 651 676 677 679 690 693 707 708 |
| 716 721 727 732 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 8.0 PPM |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 518 522 546 547 547 563 589 595 606 609 |
| 616 623 627 628 639 652 658 670 679 679 |
| 693 694 694 700 715 729 732 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FURFURYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 32.0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 34 CENSORED DEATHS 0 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 302 429 438 478 497 518 518 525 526 560 |
| 581 597 599 616 621 632 638 639 642 658 |
| 665 670 671 686 689 693 706 707 711 712 |
| 712 715 721 733 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FURFURYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 98.0 98.0 98.0 98.0 90.0 90.0 80.0 66.0 52.0 |
| | |
| | |
|2.0 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 90.0 82.0 74.0 52.0 |
| | |
| | |
|8.0 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 95.9 83.7 65.3 44.9 |
| | |
| | |
|32.0 PPM | 100.0 100.0 100.0 98.0 98.0 92.0 82.0 74.0 58.0 32.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 2.0 PPM 8.0 PPM 32.0 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 52.0% 52.0% 44.9% 32.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.028 P=0.982N P=0.681 P=0.094 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 593.2 626.3 632.2 611.9 |
|NATURAL DEATHS (C) | (27.0) (18.3) (12.3) (17.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 666.9 682.8 678.4 651.3 |
|(STANDARD ERROR) | (16.3) (11.6) (10.0) (14.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
FURFURYL ALCOHOL
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
2.0 PPM = 2
8.0 PPM = 3
32.0 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 4 2 3
| 1 1 4 2 43 2 3
| 1 1 1 4 2432
| 1 1 223
90 + 14 13 3
| 14 1 3
| 22 1 143
| 1132
80 + 11232
| 1 3314
| 2112
| 11
P 70 + 33
E | 13 12
R | 3 112
C | 33
E 60 + 113
N | 4433
T | 121133
| 221 31
S 50 + 44 11
U | 22 1 1
R | 22 131
V | 22 11
I 40 + 44 2 2
V | 2 233
A | 4 4 2 223
L | 11
30 + 223
| 11 3
| 44 11
| 22131
20 + 44 22 3 3
| 2 11 3
| 21 1
| 4 4
10 + 44 2 2
| 44
| 44
| 44
0 + 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 55 obs hidden.
FURFURYL ALCOHOL
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
2.0 PPM = 2
8.0 PPM = 3
32.0 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 4 2 3
| 1 4 2 12 3 3
| 44 1211 2 2 3 33
| 4 4 2 2
90 + 1 4 4 2 2 31
| 2 311 3
P | 4 44 21 12
E | 4 4 311 2
R 80 + 4 4 33 22
C | 4 4 33 2 2
E | 41131 2 2
N | 44113
T 70 + 4 13 1
| 44 1 1 2 2
S | 3 131 1 2
U | 4 4 33 1 12
R 60 + 4 4 3 3 22
V | 44 33
I | 4 4 1 12 2
V | 44 1 1
A 50 + 3 3 3
L | 4 4
| 44 3
|
40 +
| 44
| 4 4
| 4
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 29 obs hidden.