TDMS Study 05201-06 Pathology Tables
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27
CHRONIC STUDY
Facility: Battelle Northwest
Chemical CAS #: 0098-00-0000
Lock Date: 01/26/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 11 12 15 8
Natural Death 5 3 2 2
Accidently Killed 1 1
Survivors
Terminal Sacrifice 34 33 32 40
Other 1
Animals Examined Microscopically 50 49 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (49) (48) (50)
Angiectasis 1 (2%)
Inflammation 1 (2%)
Gallbladder (43) (45) (47) (41)
Degeneration, Hyaline 1 (2%)
Inflammation, Suppurative 2 (4%)
Intestine Large, Rectum (49) (45) (49) (48)
Inflammation, Suppurative 1 (2%)
Metaplasia, Squamous 1 (2%)
Intestine Small, Duodenum (47) (46) (48) (48)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Jejunum (45) (46) (48) (48)
Peyer's Patch, Hyperplasia 1 (2%)
Intestine Small, Ileum (45) (47) (48) (48)
Peyer's Patch, Hyperplasia 1 (2%) 1 (2%)
Liver (50) (49) (49) (49)
Basophilic Focus 2 (4%)
Clear Cell Focus 2 (4%)
Degeneration, Fatty 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Eosinophilic Focus 14 (28%) 19 (39%) 20 (41%) 8 (16%)
Hematopoietic Cell Proliferation 1 (2%) 5 (10%) 5 (10%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Chronic 4 (8%) 4 (8%) 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%) 2 (4%)
Karyomegaly 1 (2%)
Necrosis 2 (4%) 1 (2%) 4 (8%) 2 (4%)
Pigmentation, Bile 1 (2%)
Regeneration 1 (2%)
Bile Duct, Cyst 1 (2%)
Centrilobular, Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (15) (6) (11) (10)
Angiectasis 1 (10%)
Inflammation, Chronic 1 (7%) 1 (10%)
Fat, Hemorrhage 1 (9%) 1 (10%)
Fat, Necrosis 13 (87%) 6 (100%) 8 (73%) 7 (70%)
Oral Mucosa (1)
Pharyngeal, Hyperplasia 1 (100%)
Pancreas (50) (48) (49) (49)
Atrophy 7 (14%) 3 (6%) 5 (10%) 9 (18%)
Cytoplasmic Alteration 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Hypertrophy 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 1 (2%)
Duct, Cyst 1 (2%)
Stomach, Forestomach (50) (48) (49) (49)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Suppurative 2 (4%) 1 (2%)
Ulcer 3 (6%) 1 (2%)
Epithelium, Hyperplasia 2 (4%) 8 (17%) 6 (12%) 3 (6%)
Stomach, Glandular (50) (46) (49) (48)
Inflammation, Suppurative 2 (4%) 2 (4%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Inflammation 1 (100%)
Heart (50) (49) (49) (50)
Cardiomyopathy 36 (72%) 40 (82%) 46 (94%) 42 (84%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50) (49)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hyperplasia 2 (4%)
Hypertrophy 4 (8%) 1 (2%) 3 (6%) 3 (6%)
Adrenal Medulla (48) (48) (49) (49)
Hyperplasia 4 (8%) 1 (2%) 2 (4%) 4 (8%)
Islets, Pancreatic (49) (48) (49) (49)
Hyperplasia 2 (4%) 1 (2%) 2 (4%)
Parathyroid Gland (32) (32) (29) (26)
Hyperplasia 1 (3%)
Pituitary Gland (48) (48) (48) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Angiectasis 1 (2%)
Hemorrhage 1 (2%)
Pars Distalis, Angiectasis 1 (2%) 1 (2%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 15 (31%) 17 (35%) 15 (31%) 17 (35%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (50) (49) (49) (49)
Inflammation 1 (2%)
Follicular Cell, Cyst 1 (2%)
Follicular Cell, Hyperplasia 17 (34%) 21 (43%) 17 (35%) 30 (61%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (49) (48) (49)
Angiectasis 2 (4%) 1 (2%)
Atrophy 4 (8%) 3 (6%) 1 (2%) 2 (4%)
Cyst 14 (28%) 14 (29%) 18 (38%) 15 (31%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Thrombosis 1 (2%)
Corpus Luteum, Hemorrhage 1 (2%)
Corpus Luteum, Hyperplasia 1 (2%)
Germinal Epithelium, Hyperplasia 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Uterus (50) (49) (49) (49)
Angiectasis 3 (6%) 4 (8%) 2 (4%)
Hemorrhage 1 (2%) 1 (2%)
Hydrometra 5 (10%) 5 (10%) 4 (8%) 3 (6%)
Hyperplasia, Cystic 4 (8%) 3 (6%) 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Thrombosis 1 (2%) 2 (4%) 1 (2%)
Endometrium, Hyperplasia 1 (2%) 1 (2%)
Endometrium, Metaplasia 1 (2%)
Myometrium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (49) (49)
Hyperplasia 1 (2%) 1 (2%)
Lymph Node (6) (4) (5) (4)
Angiectasis 4 (67%) 3 (75%) 2 (40%)
Necrosis 1 (17%)
Renal, Hyperplasia 1 (25%) 1 (20%)
Lymph Node, Bronchial (33) (27) (30) (37)
Hyperplasia 1 (3%) 1 (4%) 1 (3%) 2 (5%)
Lymph Node, Mandibular (36) (40) (43) (40)
Hyperplasia 1 (3%) 2 (5%) 2 (5%)
Infiltration Cellular, Mast Cell 1 (2%)
Lymph Node, Mesenteric (48) (47) (47) (46)
Angiectasis 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Lymph Node, Mediastinal (41) (34) (40) (40)
Hyperplasia 4 (10%) 1 (3%) 3 (8%) 2 (5%)
Spleen (50) (48) (49) (49)
Hematopoietic Cell Proliferation 11 (22%) 11 (23%) 12 (24%) 17 (35%)
Hyperplasia, Lymphoid 8 (16%) 8 (17%) 4 (8%) 5 (10%)
Thymus (42) (40) (46) (38)
Angiectasis 1 (3%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (49) (50)
Hyperplasia 2 (4%) 1 (2%) 2 (4%)
Skin (50) (49) (49) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Angiectasis 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation, Focal,
Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49) (50) (50)
Fibrous Osteodystrophy 16 (32%) 19 (39%) 15 (30%) 22 (44%)
Fracture 1 (2%)
Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (49) (49)
Gliosis 1 (2%)
Necrosis 2 (4%) 1 (2%)
Meninges, Infiltration Cellular, Mononuclear
Cell 4 (8%) 4 (8%) 2 (4%) 4 (8%)
Peripheral Nerve (1)
Degeneration 1 (100%)
Spinal Cord (2) (2) (1)
Degeneration 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (49) (50) (49)
Hyperplasia 5 (10%) 9 (18%) 3 (6%) 5 (10%)
Inflammation, Suppurative 3 (6%) 1 (2%)
Epiglottis, Metaplasia, Squamous 1 (2%)
Lung (50) (49) (49) (50)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Histiocyte 3 (6%) 5 (10%) 2 (4%) 3 (6%)
Inflammation, Chronic, Focal 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 1 (2%) 2 (4%)
Mediastinum, Inflammation, Chronic 1 (2%) 1 (2%)
Nose (50) (48) (49) (50)
Inflammation, Suppurative 5 (10%) 12 (25%) 25 (51%) 42 (84%)
Glands, Hyperplasia 33 (69%) 46 (94%) 47 (94%)
Glands, Metaplasia, Squamous 1 (2%) 1 (2%) 34 (69%) 46 (92%)
Lateral Wall, Metaplasia, Squamous 3 (6%) 14 (29%) 16 (33%) 36 (72%)
Lateral Wall, Necrosis 4 (8%) 1 (2%)
Olfactory Epithelium, Atrophy 2 (4%) 35 (73%) 49 (100%) 50 (100%)
Olfactory Epithelium, Degeneration, Hyaline 7 (14%) 14 (29%) 28 (57%) 45 (90%)
Olfactory Epithelium, Metaplasia 31 (65%) 49 (100%) 49 (98%)
Respiratory Epithelium, Degeneration, Hyaline 19 (38%) 44 (92%) 49 (100%) 48 (96%)
Respiratory Epithelium, Hyperplasia, Polypoid 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 9 (19%) 21 (43%) 39 (78%)
Respiratory Epithelium, Necrosis 2 (4%) 3 (6%)
Respiratory Epithelium, Regeneration 9 (18%) 13 (26%)
Trachea (50) (48) (49) (48)
Metaplasia, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (49) (49) (50)
Cataract 2 (4%) 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 2 (4%)
Cornea, Degeneration 3 (6%) 1 (2%) 4 (8%) 26 (52%)
Cornea, Fibrosis 1 (2%)
Cornea, Hyperplasia 2 (4%) 4 (8%) 7 (14%)
Cornea, Inflammation, Chronic Active 1 (2%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (48) (49) (49)
Metaplasia, Osseous 1 (2%) 3 (6%) 2 (4%) 4 (8%)
Mineralization 1 (2%)
Nephropathy 41 (82%) 35 (73%) 40 (82%) 39 (80%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 11 10 14 8
Natural Death 5 4 6 4
Survivors
Terminal Sacrifice 34 36 30 38
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (42) (42) (43)
Degeneration, Hyaline 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Intestine Large, Rectum (48) (47) (46) (46)
Anus, Inflammation, Chronic Active 1 (2%)
Intestine Large, Cecum (48) (47) (46) (48)
Serosa, Inflammation, Chronic 1 (2%)
Intestine Small, Duodenum (48) (48) (46) (47)
Peyer's Patch, Hyperplasia 1 (2%)
Intestine Small, Ileum (46) (48) (46) (47)
Peyer's Patch, Hyperplasia 1 (2%)
Liver (50) (50) (49) (50)
Angiectasis 2 (4%)
Basophilic Focus 5 (10%)
Clear Cell Focus 3 (6%) 3 (6%) 1 (2%)
Degeneration, Cystic 1 (2%)
Degeneration, Fatty 5 (10%) 1 (2%) 1 (2%)
Eosinophilic Focus 13 (26%) 18 (36%) 12 (24%) 14 (28%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 2 (4%)
Necrosis 2 (4%) 4 (8%) 6 (12%) 2 (4%)
Vacuolization Cytoplasmic 1 (2%) 3 (6%)
Bile Duct, Cyst 1 (2%) 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Centrilobular, Degeneration 1 (2%)
Centrilobular, Necrosis 1 (2%)
Mesentery (7) (4) (7) (3)
Fat, Necrosis 7 (100%) 4 (100%) 6 (86%) 3 (100%)
Pancreas (50) (49) (48) (49)
Atrophy 7 (14%) 3 (6%) 4 (8%) 10 (20%)
Hypertrophy 1 (2%) 2 (4%)
Inflammation, Chronic, Focal 1 (2%)
Duct, Cyst 1 (2%) 1 (2%)
Salivary Glands (50) (49) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hyperplasia 1 (2%)
Inflammation, Chronic 1 (2%)
Duct, Hyperplasia 1 (2%)
Stomach, Forestomach (50) (49) (50) (50)
Diverticulum 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Ulcer 1 (2%)
Epithelium, Hyperplasia 2 (4%) 5 (10%) 2 (4%) 5 (10%)
Stomach, Glandular (50) (48) (47) (48)
Inflammation, Suppurative 1 (2%) 2 (4%) 2 (4%)
Necrosis 2 (4%) 1 (2%)
Tooth (2) (1) (1)
Developmental Malformation 1 (50%)
Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Inflammation 1 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 46 (92%) 47 (94%) 43 (86%) 45 (90%)
Atrium, Thrombosis 1 (2%)
Ventricle, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (49) (48)
Hyperplasia 1 (2%) 1 (2%) 5 (10%) 2 (4%)
Hypertrophy 35 (70%) 37 (76%) 31 (63%) 28 (58%)
Capsule, Hyperplasia 1 (2%)
Adrenal Medulla (50) (49) (48) (48)
Hyperplasia 1 (2%)
Islets, Pancreatic (50) (49) (48) (48)
Hyperplasia 9 (18%) 7 (14%) 10 (21%) 5 (10%)
Pituitary Gland (50) (48) (48) (49)
Pars Distalis, Hyperplasia 3 (6%) 4 (8%) 1 (2%) 2 (4%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (50) (49) (49) (48)
Follicular Cell, Hyperplasia 8 (16%) 9 (18%) 6 (12%) 13 (27%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (49) (50)
Hyperplasia 2 (4%)
Inflammation, Chronic 2 (4%) 1 (2%) 2 (4%)
Mineralization 1 (2%)
Spermatocele 2 (4%)
Penis (2)
Inflammation 1 (50%)
Preputial Gland (50) (49) (49) (50)
Cyst 3 (6%) 3 (6%) 2 (4%) 6 (12%)
Inflammation 3 (6%) 1 (2%) 2 (4%)
Prostate (49) (48) (48) (49)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Seminal Vesicle (50) (48) (46) (49)
Inflammation 1 (2%)
Testes (50) (50) (49) (50)
Angiectasis 1 (2%)
Atrophy 4 (8%) 3 (6%) 5 (10%) 2 (4%)
Degeneration 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%)
Mineralization 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (49) (50)
Hyperplasia 2 (4%) 2 (4%) 1 (2%)
Lymph Node, Bronchial (27) (22) (27) (28)
Hyperplasia 2 (7%)
Lymph Node, Mandibular (28) (33) (23) (28)
Hyperplasia 1 (4%)
Lymph Node, Mesenteric (50) (46) (46) (47)
Angiectasis 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 2 (4%) 3 (6%)
Lymph Node, Mediastinal (40) (39) (38) (31)
Hematopoietic Cell Proliferation 1 (3%)
Hyperplasia 2 (5%) 1 (3%) 1 (3%)
Spleen (50) (49) (49) (50)
Angiectasis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hematopoietic Cell Proliferation 7 (14%) 12 (24%) 11 (22%) 9 (18%)
Hyperplasia, Lymphoid 2 (4%)
Thymus (35) (31) (36) (36)
Epithelial Cell, Hyperplasia 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (48) (49)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic 2 (4%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Prepuce, Inflammation, Chronic Active 3 (6%) 2 (4%) 3 (6%) 2 (4%)
Subcutaneous Tissue, Inflammation, Chronic
Active 2 (4%) 1 (2%)
Subcutaneous Tissue, Inflammation, Focal,
Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 2 (4%)
Hyperostosis 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50)
Cyst Epithelial Inclusion 1 (2%)
Meninges, Infiltration Cellular, Mononuclear
Cell 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (49) (48)
Hyperplasia 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Lung (50) (50) (49) (50)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 2 (4%)
Infiltration Cellular, Histiocyte 4 (8%) 4 (8%) 5 (10%) 7 (14%)
Inflammation, Chronic, Focal 1 (2%)
Alveolar Epithelium, Hyperplasia 5 (10%) 2 (4%) 2 (4%) 2 (4%)
Mediastinum, Angiectasis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nose (50) (49) (49) (50)
Inflammation, Suppurative 7 (14%) 11 (22%) 27 (55%) 28 (56%)
Glands, Hyperplasia 10 (20%) 48 (98%) 46 (92%)
Glands, Metaplasia, Squamous 6 (12%) 35 (71%) 47 (94%)
Lateral Wall, Metaplasia, Squamous 9 (18%) 10 (20%) 20 (40%)
Lateral Wall, Necrosis 3 (6%)
Olfactory Epithelium, Atrophy 3 (6%) 15 (31%) 49 (100%) 50 (100%)
Olfactory Epithelium, Degeneration, Hyaline 2 (4%) 3 (6%) 21 (43%) 39 (78%)
Olfactory Epithelium, Metaplasia 12 (24%) 49 (100%) 50 (100%)
Respiratory Epithelium, Degeneration, Hyaline 5 (10%) 18 (37%) 42 (86%) 45 (90%)
Respiratory Epithelium, Hyperplasia, Polypoid 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%) 10 (20%) 20 (40%)
Respiratory Epithelium, Necrosis 1 (2%) 1 (2%)
Respiratory Epithelium, Regeneration 1 (2%) 13 (27%) 21 (42%)
Trachea (50) (48) (48) (49)
Metaplasia, Squamous 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (48) (49) (49)
Cataract 2 (4%) 1 (2%) 3 (6%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Cornea, Dysplasia 1 (2%)
Cornea, Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Cornea, Inflammation, Chronic Active 1 (2%)
Retina, Atrophy 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (49) (50)
Amyloid Deposition 1 (2%)
Cyst 1 (2%) 3 (6%)
Hydronephrosis 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Metaplasia, Osseous 3 (6%) 4 (8%) 4 (8%)
Mineralization 1 (2%)
Nephropathy 49 (98%) 48 (98%) 43 (88%) 47 (94%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Degeneration 1 (2%) 48 (96%)
Renal Tubule, Hyperplasia 1 (2%) 3 (6%) 3 (6%)
Renal Tubule, Hypertrophy 1 (2%) 1 (2%)
Urinary Bladder (50) (47) (47) (50)
Inflammation, Chronic Active 3 (6%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27
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B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Necrosis 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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