TDMS Study 05201-06 Pathology Tables
NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 CHRONIC STUDY Facility: Battelle Northwest Chemical CAS #: 0098-00-0000 Lock Date: 01/26/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 3| 3| 3| 4| 3| 9| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 3| | 7| 4| 4| 4| 7| 4| 5| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 5| 9| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + A + + + + M + + + M + + A + + + M + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| Anus, Squamous Cell Carcinoma | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + M + A + + + + + + + + + + + + + + + + + +| Polyp Adenomatous | | __________________________________________________________________________| Intestine Small, Jejunum | + + + M + + A + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + A A + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | X | Histiocytic Sarcoma | X | Lymphoma Malignant | X | __________________________________________________________________________| Mesentery | + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + I + + + + + M +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + M + + M + M M + + + + + M M + + M + M + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + I M + + + + + + + + + + +| Pars Distalis, Adenoma | X X X | Pars Intermedia, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 3| 3| 3| 4| 3| 9| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 3| | 7| 4| 4| 4| 7| 4| 5| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 5| 9| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + M + + + M + + + + + + M + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | | Histiocytic Sarcoma | X | Luteoma | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leiomyoma | X | Leiomyosarcoma | | Lymphoma Malignant | | Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node | | Pancreatic, Lymphoma Malignant | | Renal, Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + M + M I + + M + + + + + M + M + + + + + M| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Mandibular | M + + + M + + + + + + M M + M M + M + M + M + + +| Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + I + + M + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + M + + + M + + + + + + + M + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Thymus | + + + M + + + M + + + + + M + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | X | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 3| 3| 3| 4| 3| 9| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 3| | 7| 4| 4| 4| 7| 4| 5| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 5| 9| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Bone | | Marrow | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Histiocytic Sarcoma | | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X| Alveolar/Bronchiolar Carcinoma | X X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | X | Lymphoma Malignant | X | Sarcoma, Metastatic, Skin | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Pleura | + | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Harderian Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | | __________________________________________________________________________| Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3| | | 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + A + + + + + + + + + + + A + + + + + + + + +| 43 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Anus, Squamous Cell Carcinoma | X | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + + + + + + + + + + + A + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 | Polyp Adenomatous | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + + + + + + + + + + + A + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + + + + + + + + + A + + + + + + + + +| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X X X X | 8 | Hepatocellular Carcinoma, Multiple | | 1 | Hepatocellular Adenoma | X X | 5 | Hepatocellular Adenoma, Multiple | X | 2 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X X | 3 | __________________________________________________________________________|____________| Mesentery | + + + + + | 15 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | M M M + + + M + M M + + + + + + + + M + + M + + M| 32 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3| | | 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Adenoma | X X X X | 7 | Pars Intermedia, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | X | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + M + + + + + + + M + M + + + I + + + +| 43 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cystadenoma | X X | 2 | Histiocytic Sarcoma | X | 2 | Luteoma | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 2 | Leiomyoma | | 1 | Leiomyosarcoma | X | 1 | Lymphoma Malignant | X | 1 | Polyp Stromal | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 2 | __________________________________________________________________________|____________| Lymph Node | + + + + + +| 6 | Pancreatic, Lymphoma Malignant | X | 1 | Renal, Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M M M M + M M + + + + + M + + M + + + M + + + M +| 33 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + M + + M + + + + + M + + + + M + + + + + + +| 36 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant | X X | 3 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + M + + M + + + M + M + + + + M + + M + + + +| 41 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3| | | 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X X | 4 | __________________________________________________________________________|____________| Thymus | + M + + + + M + + + + M + + + + + + M M + + + + +| 42 | Lymphoma Malignant | X X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma, Metastatic, Bone | | | Marrow | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Meninges, Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 2 | Alveolar/Bronchiolar Carcinoma | X | 4 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 2 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X | 2 | Sarcoma, Metastatic, Skin | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Pleura | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Harderian Gland | + + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3| | | 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | Adenoma | X X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X X X X X | 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7| DAY ON TEST | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3| | 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + M + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + M + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | X X | Lymphoma Malignant | X X| __________________________________________________________________________| Mesentery | + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + A| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| Capsule, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + M + + + + + + + + + + + + + + +| Lymphoma Malignant | X| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M M + + + + + + + + + + + M M + + + M + M M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| Pars Distalis, Adenoma | X X X X | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7| DAY ON TEST | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3| | 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + M + + + + + + + I + M + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Cystadenoma | X | Lymphoma Malignant | X| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | Lymphoma Malignant | X| Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node | + +| Iliac, Lymphoma Malignant | X| __________________________________________________________________________| Lymph Node, Bronchial | M + M + + M + M + + M + M + M M + + M + M + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Lymphoma Malignant | X| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + + + M M + + + + + + + + M + +| Carcinoma, Metastatic, Harderian | | Gland | | Lymphoma Malignant | X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| __________________________________________________________________________| Lymph Node, Mediastinal | + M + + + M + M M M + + + M + + + + M M + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Lymphoma Malignant | X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | | Lymphoma Malignant | X X| __________________________________________________________________________| Thymus | + + M + + + + M M + + + M + + + M + + + M + + +| Lymphoma Malignant | X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7| DAY ON TEST | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3| | 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X| Alveolar/Bronchiolar Carcinoma | X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Carcinoma, Metastatic, Harderian | | Gland | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | X| Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Harderian Gland | + | Adenoma | | Carcinoma | X | __________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + A + + + + + + + + I + + +| Lymphoma Malignant | X| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7| DAY ON TEST | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3| | 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Lymphoma Malignant | X X| _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3| | | 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + M + + + + M + + + + A + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + A + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatocellular Carcinoma | X X X X X X | 12 | Hepatocellular Carcinoma, Multiple | X X | 3 | Hepatocellular Adenoma | X X | 5 | Hepatocellular Adenoma, Multiple | | 2 | Lymphoma Malignant | | 2 | __________________________________________________________________________|____________| Mesentery | + + + | 6 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | Capsule, Adenoma | X X | 2 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________|____________| Parathyroid Gland | M M M + I + + M + + + M M + + + + M + + M + + + +| 32 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3| | | 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Adenoma | X X X| 7 | Pars Intermedia, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Follicular Cell, Adenoma | | 1 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + M M + + + + + + M + + + M + + + + M| 41 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | Cystadenoma | | 1 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangioma | | 1 | Lymphoma Malignant | | 1 | Polyp Stromal | X X | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node | + + | 4 | Iliac, Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + M + M M M M + + M M M + + + M + M + + M + +| 27 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + M + + + + + + + M + + + + + + + + M + M| 40 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | Lymphoma Malignant | | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + A + + + +| 47 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + + + + M + M M + + + + + M M + M + + + + +| 34 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3| | | 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 3 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + I + + + + M M + + + + + +| 40 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma | X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Adenoma | X | 4 | Alveolar/Bronchiolar Carcinoma | | 3 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 1 | Carcinoma, Metastatic, Harderian | | | Gland | X | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant | | 1 | Mediastinum, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3| | | 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Harderian Gland | + + + + | 5 | Adenoma | X X | 2 | Carcinoma | X | 2 | __________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + I + +| 45 | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8| | 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + A| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + A| Hepatocellular Carcinoma | X X X X | Hepatocellular Adenoma | X X X | Hepatocholangiocarcinoma | | Lymphoma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Mesentery | + + + + + + | Hemangiosarcoma | X | Hepatocholangiocarcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| Lymphoma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + A| Lymphoma Malignant | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A| Squamous Cell Carcinoma | X | Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Tooth | | Adamantinoma Malignant | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + A| Sarcoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8| | 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + M + + M + I + + M + M M + + + M M M + + + + M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| Pars Distalis, Adenoma | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| Bilateral, Follicular Cell, Adenoma | | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M M + I I M + + + + + + + + + + M M + + M + M M A| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + A| Cystadenoma | X X X | Granulosa Cell Tumor Benign | X | Lymphoma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | Yolk Sac Carcinoma | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + A| Histiocytic Sarcoma | X | Polyp Stromal | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Lymph Node | + + + | Iliac, Lymphoma Malignant | | Renal, Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Bronchial | + + M M + M + + M M M + + M M + + + M + M + + + A| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Lymphoma Malignant | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + M + + M + + + + + + + M + + + + A| Lymphoma Malignant | X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + A| Lymphoma Malignant | X X | __________________________________________________________________________| Lymph Node, Mediastinal | + M + + + M + + + + + + + + M + + + + + + + + + A| Alveolar/Bronchiolar Carcinoma, | | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8| | 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Metastatic, Lung | | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Lymphoma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A| Hemangiosarcoma | X | Lymphoma Malignant | X X | __________________________________________________________________________| Thymus | + + + + + + + + + M + + + + + + + + + + M + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Lymphoma Malignant | X X | Sarcoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| Carcinoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + A| Subcutaneous Tissue, Hemangioma, | | Multiple | | Subcutaneous Tissue, Hemangiosarcoma | | Subcutaneous Tissue, Histiocytic | | Sarcoma | X | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Sarcoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + A| Lymphoma Malignant | X | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + A| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Carcinoma | X | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8| | 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Carcinoma, Metastatic, Mammary Gland | X | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Lymphoma Malignant | X X | Sarcoma, Metastatic, Uncertain | | Primary Site | | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | Mediastinum, | | Hepatocholangiocarcinoma, | | Metastatic, Liver | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + A| Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + A| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + A| Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | Sarcoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A| Hepatocholangiocarcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | X | Lymphoma Malignant | X X | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X | Lymphoma Malignant | X X | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0| | | 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + M + + + + + + + + + + A + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatocellular Carcinoma | X | 5 | Hepatocellular Adenoma | X X X X X X | 9 | Hepatocholangiocarcinoma | X | 1 | Lymphoma Malignant | | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | __________________________________________________________________________|____________| Mesentery | + + + + + | 11 | Hemangiosarcoma | | 1 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 2 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Squamous Cell Carcinoma | | 1 | Squamous Cell Papilloma | X X | 3 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Tooth | + + | 2 | Adamantinoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0| | | 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | I + M + + + + M + M + M + + + + + M M M + M + M +| 29 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 | Pars Distalis, Adenoma | X X | 4 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Bilateral, Follicular Cell, Adenoma | X | 1 | Follicular Cell, Adenoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + + + + + + + M + M + + I M + M + M + + + + M| 31 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 | Cystadenoma | | 3 | Granulosa Cell Tumor Benign | X | 2 | Lymphoma Malignant | | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | Yolk Sac Carcinoma | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | Polyp Stromal | X X X | 4 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | + + | 5 | Iliac, Lymphoma Malignant | X | 1 | Renal, Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + M M M + + + + + M M + + M + + M + + + M| 30 | Alveolar/Bronchiolar Carcinoma, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0| | | 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Metastatic, Lung | X | 1 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant | X | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + M + + + M| 43 | Lymphoma Malignant | X | 3 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 | Lymphoma Malignant | X | 3 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + M + + + + + + + M + + + + M M + + + M + M + +| 40 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant | | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | X | 2 | Lymphoma Malignant | X X X | 5 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + M + + + + M + + + + +| 46 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | Lymphoma Malignant | | 2 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Subcutaneous Tissue, Hemangioma, | | | Multiple | X | 1 | Subcutaneous Tissue, Hemangiosarcoma | X X | 2 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | | 1 | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0| | | 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skeletal Muscle | +| 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Adenoma | X X X X X | 8 | Alveolar/Bronchiolar Carcinoma | X X | 3 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 1 | Carcinoma, Metastatic, Mammary Gland | | 1 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant | | 2 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | Mediastinum, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | X | 1 | Mediastinum, | | | Hepatocholangiocarcinoma, | | | Metastatic, Liver | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | __________________________________________________________________________|____________| Harderian Gland | + + + +| 6 | Adenoma | X X X | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0| | | 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | | 2 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X| 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | X X X | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| | 4| 4| 4| 4| 4| 3| 4| 5| 4| 4| 4| 9| 4| 2| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + M + + + + + + + M M + + + A| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A| Lymphoma Malignant | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A| Lymphoma Malignant | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X | Lymphoma Malignant | X | __________________________________________________________________________| Mesentery | + + + + | Lymphoma Malignant | | Sarcoma, Metastatic, Skin | X | __________________________________________________________________________| Oral Mucosa | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + M + M M + + + M + M I + + M + + + M + M + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Pars Distalis, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| | 4| 4| 4| 4| 4| 3| 4| 5| 4| 4| 4| 9| 4| 2| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + M + + M + M + M + + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X | Luteoma | X | Lymphoma Malignant | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Lymphoma Malignant | | Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant | | __________________________________________________________________________| Lymph Node | + | Lymphoma Malignant | | Iliac, Lymphoma Malignant | X | Pancreatic, Lymphoma Malignant | | Renal, Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + M + + + + + + + + M + + + + + + M M +| Lymphoma Malignant | X X | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + M + + + M + + + + + + + + + + M + M +| Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + M + +| Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + M + M M M + + M + M + + + + + + + + + + M| Lymphoma Malignant | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Lymphoma Malignant | X X | __________________________________________________________________________| Thymus | + + + + + + + M M M + + + + + + M + M + + + + M +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangioma | X | Subcutaneous Tissue, Hemangiosarcoma | | Subcutaneous Tissue, Sarcoma | X | Subcutaneous Tissue, Sarcoma, | | Multiple | X | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| | 4| 4| 4| 4| 4| 3| 4| 5| 4| 4| 4| 9| 4| 2| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | __________________________________________________________________________| Skeletal Muscle | + | Sarcoma, Metastatic, Skin | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Harderian | | Gland | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | | Sarcoma, Metastatic, Skin | X | Mediastinum, Sarcoma, Metastatic, | | Skin | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + A| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Harderian Gland | + + + + +| Adenoma | X X X X| Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + M A + + + + + + M M + + + + + I +| 41 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X X | 6 | Hepatocellular Carcinoma, Multiple | X | 2 | Hepatocellular Adenoma | X X X | 5 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Mesentery | + + + + + + | 10 | Lymphoma Malignant | X | 1 | Sarcoma, Metastatic, Skin | | 1 | __________________________________________________________________________|____________| Oral Mucosa | + | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Capsule, Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M M + I I M M + + + M M M M M + M + M + + M| 26 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 1 | Pars Distalis, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Follicular Cell, Adenoma | X | 5 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + M + + + + + M + + + M + + M + + + M + + + + +| 41 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Cystadenoma | X | 2 | Luteoma | | 1 | Lymphoma Malignant | X X X | 3 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + I + + + + + +| 49 | Adenocarcinoma | | 1 | Lymphoma Malignant | X | 1 | Polyp Stromal | X X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Lymph Node | + + +| 4 | Lymphoma Malignant | X X| 2 | Iliac, Lymphoma Malignant | X | 2 | Pancreatic, Lymphoma Malignant | X X | 2 | Renal, Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + M + M + + M M + M M + + M + + + + M + + + +| 37 | Lymphoma Malignant | X X X | 5 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + M + + + + + M + + M + + M M + + + + +| 40 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + M + + + + + + +| 46 | Lymphoma Malignant | X X X | 4 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + M + + + + + A + M + + + + + + + + + + + + +| 40 | Lymphoma Malignant | X X X X | 6 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hemangioma | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant | X X X X | 6 | __________________________________________________________________________|____________| Thymus | M + M + + + + + + A + M + + + + + M + M + + + + +| 38 | Lymphoma Malignant | X X X | 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Hemangioma | | 1 | Subcutaneous Tissue, Hemangiosarcoma | X | 1 | Subcutaneous Tissue, Sarcoma | | 1 | Subcutaneous Tissue, Sarcoma, | | | Multiple | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | X | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Sarcoma, Metastatic, Skin | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma | X | 1 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 3 | Lymphoma Malignant | X | 1 | Sarcoma, Metastatic, Skin | | 1 | Mediastinum, Sarcoma, Metastatic, | | | Skin | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Harderian Gland | + | 6 | Adenoma | X | 5 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X X X X| 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 8| 9| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 5| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + A + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatoblastoma | | Hepatocellular Carcinoma | X X X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X| Hepatocellular Adenoma, Multiple | X X X X X X | __________________________________________________________________________| Mesentery | + + + + | __________________________________________________________________________| Oral Mucosa | | Pharyngeal, Squamous Cell Carcinoma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + | Odontoma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Capsule, Adenoma | X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + M + M + M M + + M + M + M + + + M + M M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Nose | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 8| 9| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 5| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Lymphoma Malignant | X | Iliac, Lymphoma Malignant | X | Pancreatic, Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Bronchial | + M M M + + + + M M + + + + M + + + M + M M + + M| Lymphoma Malignant | X X | __________________________________________________________________________| Lymph Node, Mandibular | M + I + + + M + + + + M M M M + + M + + + M M + +| Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + M M M + + M + +| Lymphoma Malignant | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | __________________________________________________________________________| Thymus | + + + + + + + M M M + M + + + M + + + + M M + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Sarcoma, | | Multiple | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Maxilla, Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Schwannoma Malignant, | | Metastatic, Nose | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X X| _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 8| 9| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 5| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Carcinoma, Metastatic, Harderian | | Gland | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | | Schwannoma Malignant, Metastatic, | | Nose | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Harderian Gland | + | Adenoma | X | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3| | | 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + M + + + A + + + + + + M + + + + + + + A + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + I + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + A + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + I + + A + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatoblastoma | X | 1 | Hepatocellular Carcinoma | X X X X X X X X | 13 | Hepatocellular Carcinoma, Multiple | X | 2 | Hepatocellular Adenoma | X X X | 7 | Hepatocellular Adenoma, Multiple | | 6 | __________________________________________________________________________|____________| Mesentery | + + + | 7 | __________________________________________________________________________|____________| Oral Mucosa | + | 1 | Pharyngeal, Squamous Cell Carcinoma | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Tooth | + | 2 | Odontoma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 2 | Capsule, Adenoma | X X | 4 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + M M + + M + M + + + M + M M + +| 32 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Schwannoma Malignant, Metastatic, | | | Nose | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3| | | 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leiomyoma | X | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + | 2 | Lymphoma Malignant | | 1 | Iliac, Lymphoma Malignant | | 1 | Pancreatic, Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + M + + M + M M + M M M M M M + + + + M M +| 27 | Lymphoma Malignant | | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + M M + M + + M + M M M M M + M + + + + M +| 28 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 2 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + M M M + + + + + + + + I + + M +| 40 | Lymphoma Malignant | | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 3 | __________________________________________________________________________|____________| Thymus | + + + M + + + + + + M + + M M M M + + + + + + M +| 35 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M + M M M M M M M M M M M| 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Sarcoma, | | | Multiple | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3| | | 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Maxilla, Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Meninges, Schwannoma Malignant, | | | Metastatic, Nose | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X X X X | 14 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 2 | Alveolar/Bronchiolar Carcinoma | X X X | 3 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 1 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 2 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | Schwannoma Malignant, Metastatic, | | | Nose | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Harderian Gland | + + + | 4 | Adenoma | X X | 3 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3| | | 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Lymphoma Malignant | X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 2| 7| 7| 7| 6| 5| 7| 7| 2| 6| 7| 7| 7| DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 8| 3| 0| 3| 3| 8| 3| 3| 3| 6| 9| 3| 3| 7| 3| 3| 3| 3| | 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 3| 3| 7| 3| 3| 3| 5| 8| 3| 3| 0| 2| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + M + + + M + + + + + M + + + + + M + A + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| Carcinoma | X | Lymphoma Malignant | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| Lymphoma Malignant | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X X X X| Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X | Hepatocholangiocarcinoma | X | __________________________________________________________________________| Mesentery | + + | Lymphoma Malignant | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + M + + + +| Lymphoma Malignant | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Tooth | | Odontoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + A + + + +| Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + M M + M + + + M M + M + I M M + M + + A + M M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 2| 7| 7| 7| 6| 5| 7| 7| 2| 6| 7| 7| 7| DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 8| 3| 0| 3| 3| 8| 3| 3| 3| 6| 9| 3| 3| 7| 3| 3| 3| 3| | 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 3| 3| 7| 3| 3| 3| 5| 8| 3| 3| 0| 2| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Prostate | M + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Lymph Node | | Renal, Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + M + + + + M + + + + M + M M M A + M M M| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + M + + + + M A + M + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + M + + + +| Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + M + M + M + + M M + + + + + + A + + + +| Lymphoma Malignant | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + M + + + +| Lymphoma Malignant | | __________________________________________________________________________| Thymus | + + + + + + I + + M + + + M M + M M M M A + M + M| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M + M M M M M M M M +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Subcutaneous Tissue, Hemangioma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + A + + + +| _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 2| 7| 7| 7| 6| 5| 7| 7| 2| 6| 7| 7| 7| DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 8| 3| 0| 3| 3| 8| 3| 3| 3| 6| 9| 3| 3| 7| 3| 3| 3| 3| | 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 3| 3| 7| 3| 3| 3| 5| 8| 3| 3| 0| 2| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X X X X| Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | X X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | | Mediastinum, | | Hepatocholangiocarcinoma, | | Metastatic, Liver | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Harderian Gland | + + + + | Adenoma | X X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | __________________________________________________________________________| Urinary Bladder | + + + + + + M + + + + + + + + + + + + + A + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3| | | 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + M + M + + + + + + A + + + + + + +| 42 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + M A + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + A + + + + + + +| 47 | Carcinoma | | 1 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X X X X | 5 | Hepatocellular Carcinoma | X X X X X X X X X X | 17 | Hepatocellular Carcinoma, Multiple | | 2 | Hepatocellular Adenoma | X X X X X X X X | 12 | Hepatocellular Adenoma, Multiple | | 1 | Hepatocholangiocarcinoma | | 1 | __________________________________________________________________________|____________| Mesentery | + + | 4 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | __________________________________________________________________________|____________| Tooth | + | 1 | Odontoma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Capsule, Adenoma | X | 2 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3| | | 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + M M + + + + + M + + + + + + + M| 32 | __________________________________________________________________________|____________| Pituitary Gland | + I + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Penis | + | 2 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | + + | 2 | Renal, Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M M M M M + M + M M M M M + M M M M + + M + + + M| 22 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + + M + + M M M + + M + M + M M + M M M| 33 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + M + + + +| 46 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + M M M + + + + + + + + + + + + M + + M +| 39 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Thymus | + M + + M + + + + M + + M M + + M + M + + + + M +| 31 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3| | | 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangioma | X | 1 | Subcutaneous Tissue, Hemangioma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X X X | 15 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | X X X X | 7 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 4 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant | X | 1 | Mediastinum, | | | Hepatocholangiocarcinoma, | | | Metastatic, Liver | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | __________________________________________________________________________|____________| Harderian Gland | | 4 | Adenoma | | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3| | | 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Lymphoma Malignant | X X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 4| 7| 4| 4| 7| 4| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 5| 7| 5| 7| 7| 7| 4| 7| DAY ON TEST | 0| 3| 5| 9| 3| 8| 6| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 4| 1| 3| 3| 3| 3| 7| 3| | 0| 3| 5| 7| 3| 8| 9| 3| 0| 3| 3| 3| 3| 2| 3| 7| 3| 8| 2| 2| 3| 3| 3| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | A + + + + + A + + + + + + + + + + + M A + + + M +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + A + + + A +| __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + A + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + A + + + + + + + + + + + + A + + + A +| Carcinoma | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + A + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X X X | Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X | Lymphoma Malignant | X | __________________________________________________________________________| Mesentery | + + + + | Hemangioma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + M + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | A + + + + + + + + + + + + + + + + + + A + + + + +| Sarcoma | X | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + M + M M + + + + + M M + + + + M + M + + + M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 4| 7| 4| 4| 7| 4| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 5| 7| 5| 7| 7| 7| 4| 7| DAY ON TEST | 0| 3| 5| 9| 3| 8| 6| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 4| 1| 3| 3| 3| 3| 7| 3| | 0| 3| 5| 7| 3| 8| 9| 3| 0| 3| 3| 3| 3| 2| 3| 7| 3| 8| 2| 2| 3| 3| 3| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Seminal Vesicle | A + + + + + A + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Renal, Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Bronchial | M + M + M M M + M + + + M + + M + + + + M + + + M| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________________________________________| Lymph Node, Mandibular | M M + M M + M M + M + + + M M + + M + + + M + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + A + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mediastinal | M + M M M + + + + + + + + + + + M M M M + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant | X | __________________________________________________________________________| Thymus | M + + M + + M + + + + M M + M + + M + M + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M + M M M M M + M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Subcutaneous Tissue, Hemangiosarcoma | X | Subcutaneous Tissue, Histiocytic | | Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X | Alveolar/Bronchiolar Adenoma, | | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 4| 7| 4| 4| 7| 4| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 5| 7| 5| 7| 7| 7| 4| 7| DAY ON TEST | 0| 3| 5| 9| 3| 8| 6| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 4| 1| 3| 3| 3| 3| 7| 3| | 0| 3| 5| 7| 3| 8| 9| 3| 0| 3| 3| 3| 3| 2| 3| 7| 3| 8| 2| 2| 3| 3| 3| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Multiple | X| Alveolar/Bronchiolar Carcinoma | X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Harderian Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | A + + + + + I + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 5| | DAY ON TEST | 6| 6| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 8| | | 5| 5| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 4| 4| 1| 4| 4| 4| 4| 6| 4| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + A + + M + + + + + + + + + + M +| 42 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + M + + + A + + + + + + M + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| 45 | Carcinoma | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hepatocellular Carcinoma | X X X X X | 11 | Hepatocellular Carcinoma, Multiple | X | 3 | Hepatocellular Adenoma | X | 5 | Hepatocellular Adenoma, Multiple | X X X X| 5 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Mesentery | + + + | 7 | Hemangioma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 | Sarcoma | | 1 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Pheochromocytoma Malignant | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Adenoma | X X | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + M M + M + M M + M + + + + + + + + M + M +| 32 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + A M + + + + + + + + + + + + + +| 48 | Pars Distalis, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Follicular Cell, Adenoma | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 50 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 5| | DAY ON TEST | 6| 6| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 8| | | 5| 5| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 4| 4| 1| 4| 4| 4| 4| 6| 4| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + A + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Testes | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | | 1 | Renal, Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + + M M + M M M M + + + + + M M M + M M M| 27 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M M M + M + M M M M M M + + + + M M + M M M M + +| 23 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + M + M + + + + + + + M + + + + + + +| 46 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + A + + + M + M + M + + + + + + +| 38 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + M + + A + + + M M + M + + + + + + + M| 36 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 2 | __________________________________________________________________________|____________| Skin | + + + M + + + + + A + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma | X | 1 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 51 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 5| | DAY ON TEST | 6| 6| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 8| | | 5| 5| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 4| 4| 1| 4| 4| 4| 4| 6| 4| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Adenoma | X X X | 9 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | X X X X | 7 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 3 | Mediastinum, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Harderian Gland | + + + + | 5 | Adenoma | X X X X | 5 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X X | 2 | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| 1| | 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 4| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + + + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + M + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X | Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + M + + + + + + + + A + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | Capsule, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + M + + + + + + + + A + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + + + M M + M M M + + M + + M M + + + M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + M + + + + + + A + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| 1| | 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 4| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Pancreatic, Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Bronchial | + M M M + + M + M M + + + M + M M + + + + M M + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Lymph Node, Mandibular | M M + M + + + + + M M M + M M M M + + A + M + + M| __________________________________________________________________________| Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Lymph Node, Mediastinal | + + + M + + + + + + M + + + M M M + + + + M + M M| Lymphoma Malignant | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Thymus | + + + M M + + + + + M M M + + + M + + + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Schwannoma | | Malignant | X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Hemangiosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meningioma Benign | | __________________________________________________________________________| Spinal Cord | + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + M + + + + + + A + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | X X X X X | Carcinoma, Metastatic, Harderian | | _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3| 1| | 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 4| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Gland | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Mediastinum, | | Hepatocholangiocarcinoma, | | Metastatic, Liver | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Harderian Gland | + | Adenoma | | Carcinoma | X | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | Renal Tubule, Adenoma | X X | Renal Tubule, Carcinoma | | Renal Tubule, Carcinoma, Multiple | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 8| 3| 9| 3| 3| 8| 3| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 8| | | 3| 4| 4| 6| 4| 4| 2| 4| 0| 4| 4| 2| 4| 4| 4| 9| 4| 6| 4| 4| 4| 4| 7| 4| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + M + + A + + + + + M + + A + M + + + + + + +| 43 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | M + + + + M A + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + A + + + + + + +| 47 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + A + A + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + + + + + A + A + + + + + + +| 47 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 3 | Hepatocellular Carcinoma | X X X X X X X X X X| 12 | Hepatocellular Carcinoma, Multiple | X | 1 | Hepatocellular Adenoma | X X X X X X X| 11 | Hepatocellular Adenoma, Multiple | X | 2 | __________________________________________________________________________|____________| Mesentery | + | 3 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Capsule, Adenoma | X | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 | __________________________________________________________________________|____________| Parathyroid Gland | M + M + + + + + + + + + + M + + M + + + + + + + +| 35 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 56 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 8| 3| 9| 3| 3| 8| 3| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 8| | | 3| 4| 4| 6| 4| 4| 2| 4| 0| 4| 4| 2| 4| 4| 4| 9| 4| 6| 4| 4| 4| 4| 7| 4| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | | 1 | Pancreatic, Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M M + M M M M + M + + + + + + M + + M + M + + M| 28 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + M + + M + M + + + + + + M + M + M + M M + +| 28 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + M + M M M M M M + M + + + M + M + M + + + + +| 31 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Thymus | M + + + M + + M + + + + I + + M + + + + + + M + M| 36 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | Subcutaneous Tissue, Schwannoma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Hemangiosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Meningioma Benign | X | 1 | __________________________________________________________________________|____________| Spinal Cord | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 57 NTP Experiment-Test: 05201-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 5| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 8| 3| 9| 3| 3| 8| 3| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 8| | | 3| 4| 4| 6| 4| 4| 2| 4| 0| 4| 4| 2| 4| 4| 4| 9| 4| 6| 4| 4| 4| 4| 7| 4| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X| 12 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 2 | Alveolar/Bronchiolar Carcinoma | X X X | 8 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X | 4 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Mediastinum, | | | Hepatocholangiocarcinoma, | | | Metastatic, Liver | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Harderian Gland | + + | 3 | Adenoma | X X | 2 | Carcinoma | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Renal Tubule, Adenoma | | 2 | Renal Tubule, Carcinoma | X | 1 | Renal Tubule, Carcinoma, Multiple | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 58 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------