TDMS Study 05201-06 Pathology Tables
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 CHRONIC STUDY Facility: Battelle Northwest Chemical CAS #: 0098-00-0000 Lock Date: 01/26/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 3| 3| 3| 4| 3| 9| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 3| | 7| 4| 4| 4| 7| 4| 5| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 5| 9| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 | __________________________________________________________________________| Gallbladder | + + + + + + A + + + + M + + + M + + A + + + M + +| Degeneration, Hyaline | 2 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + M + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + M + + A + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + A A + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | | Eosinophilic Focus | X X X X X | Hematopoietic Cell Proliferation | | Inflammation, Focal, Granulomatous | 3 | Necrosis | 1 | __________________________________________________________________________| Mesentery | + + + + + + + + + +| Inflammation, Chronic | | Fat, Necrosis | 2 4 3 3 2 2 2 3 2| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 1 1 | Hyperplasia, Lymphoid | | Hypertrophy | | Inflammation, Chronic, Focal | 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| Mineralization | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypertrophy | 1 1 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + I + + + + + M +| Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + M + + M + M M + + + + + M M + + M + M + + M| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 3| 3| 3| 4| 3| 9| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 3| | 7| 4| 4| 4| 7| 4| 5| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 5| 9| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + I M + + + + + + + + + + +| Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 1 1 4 4 2 2 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | Follicular Cell, Cyst | 2 | Follicular Cell, Hyperplasia | 1 2 1 2 1 1 2 1 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + M + + + M + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Cyst | 1 1 3 2 2 2 2 2 2| Infiltration Cellular, Mononuclear | | Cell | | Corpus Luteum, Hemorrhage | | Germinal Epithelium, Hyperplasia | | Interstitial Cell, Hyperplasia | 1 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 | Hydrometra | 3 | Hyperplasia, Cystic | 3 4 2 | Inflammation, Suppurative | | Thrombosis | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | Angiectasis | | Necrosis | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + M + M I + + M + + + + + M + M + + + + + M| Hyperplasia | | __________________________________________________________________________| Lymph Node, Mandibular | M + + + M + + + + + + M M + M M + M + M + M + + +| Hyperplasia | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + I + + M + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + M + + + M + + + + + + + M + + + + + +| Hyperplasia | 4 4 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 2 2 2 2 2 2 | Hyperplasia, Lymphoid | 2 2 2 | __________________________________________________________________________| Thymus | + + + M + + + M + + + + + M + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 3| 3| 3| 4| 3| 9| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 3| | 7| 4| 4| 4| 7| 4| 5| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 5| 9| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Subcutaneous Tissue, Angiectasis | 3 | Subcutaneous Tissue, Hemorrhage | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 2 1 1 1 2 2 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Infiltration Cellular, | | Mononuclear Cell | 1 1 2 | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 | Epiglottis, Metaplasia, Squamous | 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | Infiltration Cellular, Histiocyte | 4 3 | Inflammation, Chronic, Focal | | Alveolar Epithelium, Hyperplasia | 2 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 1 | Glands, Metaplasia, Squamous | | Lateral Wall, Metaplasia, Squamous | | Olfactory Epithelium, Atrophy | 1 1 | Olfactory Epithelium, Degeneration, | | Hyaline | 1 1 2 2 | Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 2 2 1 1 1 1 1 | Respiratory Epithelium, Metaplasia, | | Squamous | | __________________________________________________________________________| Pleura | + | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 3| 3| 3| 4| 3| 9| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 3| | 7| 4| 4| 4| 7| 4| 5| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 5| 9| 5| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Cornea, Degeneration | 1 1| Cornea, Fibrosis | 2 | Cornea, Hyperplasia | 1 1 | Cornea, Inflammation, Chronic Active | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Osseous | | Nephropathy | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1| __________________________________________________________________________| Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3| | | 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | | 1 1.0| __________________________________________________________________________|____________| Gallbladder | + + + A + + + + + + + + + + + A + + + + + + + + +| 43 | Degeneration, Hyaline | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + + + + + + + + + + + A + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + + + + + + + + + + + A + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + + + + + + + + + A + + + + + + + + +| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Fatty | 2 | 1 2.0| Eosinophilic Focus | X X X X X X X X X | 14 | Hematopoietic Cell Proliferation | 4 | 1 4.0| Inflammation, Focal, Granulomatous | | 1 3.0| Necrosis | 1 | 2 1.0| __________________________________________________________________________|____________| Mesentery | + + + + + | 15 | Inflammation, Chronic | 4 | 1 4.0| Fat, Necrosis | 4 4 1 4 | 13 2.8| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 2 1 | 7 1.4| Hyperplasia, Lymphoid | 2 | 1 2.0| Hypertrophy | 1 | 1 1.0| Inflammation, Chronic, Focal | | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | 1 | 2 1.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1| 36 1.1| Mineralization | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hypertrophy | 1 | 4 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3| | | 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | 1 1 1 | 4 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 | 2 1.5| __________________________________________________________________________|____________| Parathyroid Gland | M M M + + + M + M M + + + + + + + + M + + M + + M| 32 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Cyst | 2 | 1 2.0| Pars Distalis, Hyperplasia | 1 2 1 2 1 1 3 2| 15 1.9| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 1 | 1 1.0| Follicular Cell, Cyst | | 1 2.0| Follicular Cell, Hyperplasia | 1 1 1 1 1 2 1 | 17 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + M + + + + + + + M + M + + + I + + + +| 43 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 2 2| 4 2.0| Cyst | 2 2 1 1 2 | 14 1.8| Infiltration Cellular, Mononuclear | | | Cell | 2 | 1 2.0| Corpus Luteum, Hemorrhage | 2 | 1 2.0| Germinal Epithelium, Hyperplasia | 4 | 1 4.0| Interstitial Cell, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 3 | 3 2.3| Hydrometra | 3 2 3 2 | 5 2.6| Hyperplasia, Cystic | 2 | 4 2.8| Inflammation, Suppurative | 4 | 1 4.0| Thrombosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + +| 6 | Angiectasis | 4 3 3 4| 4 3.5| Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | M M M M + M M + + + + + M + + M + + + M + + + M +| 33 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3| | | 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + M + + M + + + + + M + + + + M + + + + + + +| 36 | Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + M + + M + + + M + M + + + + M + + M + + + +| 41 | Hyperplasia | 3 | 4 3.5| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 2 2 3 | 11 2.2| Hyperplasia, Lymphoid | 2 2 2 2 2| 8 2.0| __________________________________________________________________________|____________| Thymus | + M + + + + M + + + + M + + + + + + M M + + + + +| 42 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 4 | 1 4.0| Subcutaneous Tissue, Angiectasis | | 1 3.0| Subcutaneous Tissue, Hemorrhage | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 2 4 1 1 1 2 3 2| 16 1.8| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Meninges, Infiltration Cellular, | | | Mononuclear Cell | 1 | 4 1.3| __________________________________________________________________________|____________| Spinal Cord | + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Hyperplasia | 1 2 3 | 5 1.6| Epiglottis, Metaplasia, Squamous | | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | 2 | 1 2.0| Infiltration Cellular, Histiocyte | 1 | 3 2.7| Inflammation, Chronic, Focal | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | | 2 1.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 1 1 | 5 1.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3| | | 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Glands, Metaplasia, Squamous | 1 | 1 1.0| Lateral Wall, Metaplasia, Squamous | 1 1 1 | 3 1.0| Olfactory Epithelium, Atrophy | | 2 1.0| Olfactory Epithelium, Degeneration, | | | Hyaline | 1 1 1 | 7 1.3| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 2 2 2 2 2 1 1 2| 19 1.4| Respiratory Epithelium, Metaplasia, | | | Squamous | 1 | 1 1.0| __________________________________________________________________________|____________| Pleura | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | Cataract | 1 1 | 2 1.0| Cornea, Degeneration | 1 | 3 1.0| Cornea, Fibrosis | | 1 2.0| Cornea, Hyperplasia | | 2 1.0| Cornea, Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Harderian Gland | + + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Metaplasia, Osseous | 1 | 1 1.0| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 41 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7| DAY ON TEST | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3| | 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + A + + + + + + + + + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + M + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + M + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + +| Peyer's Patch, Hyperplasia | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | | Eosinophilic Focus | X X X X X X X X X| Inflammation, Chronic | 3 2 | Inflammation, Focal, Granulomatous | 1 | Necrosis | 2 | Pigmentation, Bile | | Bile Duct, Cyst | | Centrilobular, Necrosis | | __________________________________________________________________________| Mesentery | + + + | Fat, Necrosis | 3 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 | Cytoplasmic Alteration | 1 | Hyperplasia, Lymphoid | 2 | Inflammation, Chronic, Focal | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mast Cell | | Inflammation, Suppurative | 1 | Ulcer | 1| Epithelium, Hyperplasia | 2 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + A| Inflammation, Suppurative | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Inflammation | 3 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7| DAY ON TEST | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3| | 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Hyperplasia | 1 1 | Hypertrophy | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + M + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | + M M + + + + + + + + + + + M M + + + M + M M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Hyperplasia | 1 1 1 1 1 1 1 1 2| Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 2 1 1 1 1 1 1 3 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + M + + + + + + + I + M + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 | Atrophy | 4 2 4 | Cyst | 4 3 4 4 | Hemorrhage | 4 | Hyperplasia, Lymphoid | | Inflammation, Chronic | | Thrombosis | 4 | Corpus Luteum, Hyperplasia | 3 | Interstitial Cell, Hyperplasia | 2 4 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hydrometra | 4 2| Hyperplasia, Cystic | 2 4 3 | Inflammation, Suppurative | | Thrombosis | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + +| Angiectasis | 4 | Renal, Hyperplasia | | __________________________________________________________________________| Lymph Node, Bronchial | M + M + + M + M + + M + M + M M + + M + M + + +| Hyperplasia | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + + + M M + + + + + + + + M + +| _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7| DAY ON TEST | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3| | 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hyperplasia | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Hyperplasia | 4 | __________________________________________________________________________| Lymph Node, Mediastinal | + M + + + M + M M M + + + M + + + + M M + + + +| Hyperplasia | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 4 2 2 2 2 2 2 | Hyperplasia, Lymphoid | 2 2 2 | __________________________________________________________________________| Thymus | + + M + + + + M M + + + M + + + M + + + M + + +| Angiectasis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 1 1 1 3 1 1 2 1 | Fracture | X | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 1 | Meninges, Infiltration Cellular, | | Mononuclear Cell | 1 1 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 2 1 1 1| Inflammation, Suppurative | 1 1| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 | Infiltration Cellular, Histiocyte | 3 2 2 | Mediastinum, Inflammation, Chronic | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 1 1 1 1 2 1 | Glands, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 | Glands, Metaplasia, Squamous | | Lateral Wall, Metaplasia, Squamous | 1 1 1 1 1 1 1 4 | Olfactory Epithelium, Atrophy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 | Olfactory Epithelium, Degeneration, | | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7| DAY ON TEST | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3| | 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Hyaline | 1 1 1 1 1 1 | Olfactory Epithelium, Metaplasia | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 | Respiratory Epithelium, Degeneration,| | Hyaline | 2 1 1 2 1 1 2 2 1 1 1 1 2 1 1 2 2 2 2 1 2 2| Respiratory Epithelium, Metaplasia, | | Squamous | 1 1 1 1 4 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | | Inflammation, Acute | 1 | Inflammation, Chronic | | Cornea, Degeneration | 1 | __________________________________________________________________________| Harderian Gland | + | __________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Osseous | 1 1 | Nephropathy | 2 1 1 1 2 1 1 1 1 1 1 2 1 1 1 2 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + A + + + + + + + + I + + +| _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3| | | 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + M + + + + M + + + + A + + + +| 45 | Inflammation, Suppurative | 1 1 | 2 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + A + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 | Peyer's Patch, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Degeneration, Fatty | 4 | 1 4.0| Eosinophilic Focus | X X X X X X X X X X | 19 | Inflammation, Chronic | 2 2 | 4 2.3| Inflammation, Focal, Granulomatous | 1 | 2 1.0| Necrosis | | 1 2.0| Pigmentation, Bile | 2 | 1 2.0| Bile Duct, Cyst | 1 | 1 1.0| Centrilobular, Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + | 6 | Fat, Necrosis | 2 2 2 | 6 2.2| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Atrophy | 1 4 | 3 2.0| Cytoplasmic Alteration | | 1 1.0| Hyperplasia, Lymphoid | | 1 2.0| Inflammation, Chronic, Focal | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Infiltration Cellular, Mast Cell | 3 | 1 3.0| Inflammation, Suppurative | 2 | 2 1.5| Ulcer | 2 1 | 3 1.3| Epithelium, Hyperplasia | 4 1 1 4 4 3 | 8 2.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 | Inflammation, Suppurative | 2 1 | 2 1.5| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | Inflammation | | 1 3.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3| | | 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 1 | 1 1.0| Hyperplasia | | 2 1.0| Hypertrophy | 1| 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Parathyroid Gland | M M M + I + + M + + + M M + + + + M + + M + + + +| 32 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 | Pars Distalis, Angiectasis | 3 | 1 3.0| Pars Distalis, Hyperplasia | 2 2 2 3 2 1 1 2 | 17 1.5| Pars Intermedia, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Follicular Cell, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 1 1 | 21 1.2| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + M M + + + + + + M + + + M + + + + M| 41 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 2 | 2 3.0| Atrophy | | 3 3.3| Cyst | 1 2 4 1 2 2 4 2 4 1 | 14 2.7| Hemorrhage | | 1 4.0| Hyperplasia, Lymphoid | 4 | 1 4.0| Inflammation, Chronic | 2 | 1 2.0| Thrombosis | | 1 4.0| Corpus Luteum, Hyperplasia | | 1 3.0| Interstitial Cell, Hyperplasia | | 2 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | 4 | 1 4.0| Hydrometra | 2 3 4 | 5 3.0| Hyperplasia, Cystic | | 3 3.0| Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3| | | 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Thrombosis | 3 4 | 2 3.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | + + | 4 | Angiectasis | 3 3 | 3 3.3| Renal, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + M + M M M M + + M M M + + + M + M + + M + +| 27 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + M + + + + + + + M + + + + + + + + M + M| 40 | Hyperplasia | 3 | 2 3.5| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + A + + + +| 47 | Angiectasis | | 1 3.0| Hyperplasia | 4 | 2 4.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + + + + M + M M + + + + + M M + M + + + + +| 34 | Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Hematopoietic Cell Proliferation | 2 2 2 | 11 2.2| Hyperplasia, Lymphoid | 2 2 2 4 2 | 8 2.3| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + I + + + + M M + + + + + +| 40 | Angiectasis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2| 2 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrous Osteodystrophy | 2 2 1 2 2 1 2 2 1 1| 19 1.5| Fracture | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Necrosis | 2 | 2 1.5| Meninges, Infiltration Cellular, | | | Mononuclear Cell | 1 | 4 1.3| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3| | | 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 1 1 | 9 1.1| Inflammation, Suppurative | 1 | 3 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | | 1 1.0| Infiltration Cellular, Histiocyte | 2 3 | 5 2.4| Mediastinum, Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Inflammation, Suppurative | 1 1 1 1 | 12 1.1| Glands, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1| 33 1.1| Glands, Metaplasia, Squamous | 1 | 1 1.0| Lateral Wall, Metaplasia, Squamous | 1 2 1 2 1 1| 14 1.4| Olfactory Epithelium, Atrophy | 1 2 1 1 2 1 1 1 1 1 1 1 1 1 2 3 1 2| 35 1.2| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 1 1 1 4 1 2 2| 14 1.4| Olfactory Epithelium, Metaplasia | 1 2 1 1 2 1 1 1 1 1 1 1 1 2 1 2| 31 1.2| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 2 2 1 1 1 1 2 1 1 1 2 1 1 1 2 1 1 2 2 2 2| 44 1.5| Respiratory Epithelium, Metaplasia, | | | Squamous | 4 1 2 1 | 9 1.8| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cataract | 2 | 1 2.0| Inflammation, Acute | | 1 1.0| Inflammation, Chronic | 4 | 1 4.0| Cornea, Degeneration | | 1 1.0| __________________________________________________________________________|____________| Harderian Gland | + + + + | 5 | __________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Metaplasia, Osseous | 1 | 3 1.0| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1| 35 1.1| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + I + +| 45 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8| | 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + A| Angiectasis | | __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A| Metaplasia, Squamous | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A| Inflammation, Chronic | 4 | Necrosis | 3 | Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A| Peyer's Patch, Hyperplasia | 4 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A| Peyer's Patch, Hyperplasia | 4 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + A| Degeneration, Fatty | | Eosinophilic Focus | X X X X X X X X X | Hematopoietic Cell Proliferation | 1 2 | Inflammation, Chronic | 2 | Karyomegaly | 2 | Necrosis | 2 | Regeneration | | __________________________________________________________________________| Mesentery | + + + + + + | Fat, Hemorrhage | 1 | Fat, Necrosis | 3 2 2 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| Atrophy | 1 2 | Hypertrophy | 1 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A| Inflammation, Suppurative | 1 | Epithelium, Hyperplasia | 2 2 2 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A| Inflammation, Suppurative | 1 1 | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + A| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8| | 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Hypertrophy | 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | + M + + M + I + + M + M M + + + M M M + + + + M M| Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| Hemorrhage | 4 | Pars Distalis, Hyperplasia | 2 1 2 1 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| Follicular Cell, Hyperplasia | 2 1 2 1 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M M + I I M + + + + + + + + + + M M + + M + M M A| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + A| Angiectasis | | Atrophy | | Cyst | 2 2 4 4 1 4 2 2 2 | Inflammation, Suppurative | 4 | Interstitial Cell, Hyperplasia | 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + A| Angiectasis | 2 | Hemorrhage | | Hydrometra | 4 4 4 | Hyperplasia, Cystic | | Inflammation, Chronic | 3 | Thrombosis | 4 | Endometrium, Hyperplasia | 4 | Myometrium, Hyperplasia | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node | + + + | Angiectasis | 4 | Renal, Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Bronchial | + + M M + M + + M M M + + M M + + + M + M + + + A| Hyperplasia | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + M + + M + + + + + + + M + + + + A| Infiltration Cellular, Mast Cell | | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8| | 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + A| Hyperplasia | 4 | __________________________________________________________________________| Lymph Node, Mediastinal | + M + + + M + + + + + + + + M + + + + + + + + + A| Hyperplasia | 2 4 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A| Hematopoietic Cell Proliferation | 2 2 2 3 2 3 | Hyperplasia, Lymphoid | 2 2 | __________________________________________________________________________| Thymus | + + + + + + + + + M + + + + + + + + + + M + + + +| Angiectasis | 2 | Hyperplasia, Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| Hyperplasia | 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + A| Hemorrhage | | Inflammation, Chronic Active | | Subcutaneous Tissue, Angiectasis | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 1 1 1 2 2 1 1 | Hyperostosis | | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + A| Necrosis | 1 | Meninges, Infiltration Cellular, | | Mononuclear Cell | | __________________________________________________________________________| Peripheral Nerve | + | Degeneration | 1 | __________________________________________________________________________| Spinal Cord | + | Degeneration | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + A| Hemorrhage | | Infiltration Cellular, Histiocyte | 2 | Alveolar Epithelium, Hyperplasia | | Mediastinum, Inflammation, Chronic | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + A| _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8| | 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammation, Suppurative | 2 1 1 1 2 2 1 2 1 2 2 1 2 | Glands, Hyperplasia | 2 3 3 4 3 3 2 4 2 2 4 3 2 3 4 4 3 3 4 2 4 3 3 | Glands, Metaplasia, Squamous | 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 | Lateral Wall, Metaplasia, Squamous | 1 1 1 2 1 2 1 | Lateral Wall, Necrosis | | Olfactory Epithelium, Atrophy | 2 3 3 4 3 3 2 4 2 3 3 4 4 2 3 4 4 3 3 4 2 4 3 3 | Olfactory Epithelium, Degeneration, | | Hyaline | 2 1 2 2 2 2 2 1 3 1 2 1 4 1 | Olfactory Epithelium, Metaplasia | 2 3 3 4 3 3 2 4 2 3 3 4 4 2 3 4 4 3 3 4 2 4 3 3 | Respiratory Epithelium, Degeneration,| | Hyaline | 2 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 2 | Respiratory Epithelium, Metaplasia, | | Squamous | 3 1 2 2 1 2 2 1 2 1 | Respiratory Epithelium, Necrosis | | Respiratory Epithelium, Regeneration | 1 1 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + A| Metaplasia, Squamous | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + A| Inflammation, Chronic Active | | Cornea, Degeneration | 2 2 | Cornea, Hyperplasia | 1 2 | Cornea, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A| Metaplasia, Osseous | 2 1 | Mineralization | | Nephropathy | 1 1 2 1 1 1 1 2 1 3 1 1 1 1 1 1 1 2 1 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0| | | 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Angiectasis | 4 | 1 4.0| __________________________________________________________________________|____________| Gallbladder | + + + + + + + M + + + + + + + + + + A + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Metaplasia, Squamous | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | Inflammation, Chronic | | 1 4.0| Necrosis | | 1 3.0| Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | Peyer's Patch, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | Peyer's Patch, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Degeneration, Fatty | 2| 1 2.0| Eosinophilic Focus | X X X X X X X X X X X | 20 | Hematopoietic Cell Proliferation | 1 1 2 | 5 1.4| Inflammation, Chronic | 2 2 1 | 4 1.8| Karyomegaly | | 1 2.0| Necrosis | 1 2 1 | 4 1.5| Regeneration | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + + + | 11 | Fat, Hemorrhage | | 1 1.0| Fat, Necrosis | 4 2 4 4 | 8 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 2 1 3 | 5 1.8| Hypertrophy | | 2 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | | 1 1.0| Epithelium, Hyperplasia | 1 2 | 6 1.7| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | | 2 1.0| __________________________________________________________________________|____________| Tooth | + + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0| | | 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 | 46 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | | 1 2.0| Hypertrophy | 1 3 | 3 1.7| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Parathyroid Gland | I + M + + + + M + M + M + + + + + M M M + M + M +| 29 | Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 | Hemorrhage | | 1 4.0| Pars Distalis, Hyperplasia | 3 2 2 1 2 2 1 1 1 1 | 15 1.6| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Follicular Cell, Hyperplasia | 1 1 2 3 1 1 2 1 1 | 17 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + + + + + + + M + M + + I M + M + M + + + + M| 31 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 | Angiectasis | 2 | 1 2.0| Atrophy | 2 | 1 2.0| Cyst | 2 1 1 1 2 2 4 1 2 | 18 2.2| Inflammation, Suppurative | | 1 4.0| Interstitial Cell, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 2 4 2 | 4 2.5| Hemorrhage | 4 | 1 4.0| Hydrometra | 4 | 4 4.0| Hyperplasia, Cystic | 3 4 | 2 3.5| Inflammation, Chronic | | 1 3.0| Thrombosis | | 1 4.0| Endometrium, Hyperplasia | | 1 4.0| Myometrium, Hyperplasia | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0| | | 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + | 5 | Angiectasis | 4 | 2 4.0| Renal, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + M M M + + + + + M M + + M + + M + + + M| 30 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + M + + + M| 43 | Infiltration Cellular, Mast Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 | Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + M + + + + + + + M + + + + M M + + + M + M + +| 40 | Hyperplasia | 3 | 3 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 2 2 2 2 2| 12 2.2| Hyperplasia, Lymphoid | 2 2 | 4 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + M + + + + M + + + + +| 46 | Angiectasis | | 1 2.0| Hyperplasia, Lymphoid | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | 2 | 1 2.0| Inflammation, Chronic Active | 4 | 1 4.0| Subcutaneous Tissue, Angiectasis | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 2 1 1 2 1 1 1 | 15 1.3| Hyperostosis | 2 | 1 2.0| __________________________________________________________________________|____________| Skeletal Muscle | +| 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Necrosis | | 1 1.0| Meninges, Infiltration Cellular, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0| | | 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Mononuclear Cell | 2 2 | 2 2.0| __________________________________________________________________________|____________| Peripheral Nerve | | 1 | Degeneration | | 1 1.0| __________________________________________________________________________|____________| Spinal Cord | + | 2 | Degeneration | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 3 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | 3 | 1 3.0| Infiltration Cellular, Histiocyte | 2 | 2 2.0| Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| Mediastinum, Inflammation, Chronic | 1 | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 2 1 1 2 1 1 1 2 2 1 3 1 | 25 1.5| Glands, Hyperplasia | 2 3 3 3 2 2 2 3 3 1 4 3 4 2 1 3 2 2 3 1 2 2 4| 46 2.8| Glands, Metaplasia, Squamous | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 34 1.1| Lateral Wall, Metaplasia, Squamous | 1 1 3 1 1 2 3 1 1 | 16 1.4| Lateral Wall, Necrosis | 1 3 1 2 | 4 1.8| Olfactory Epithelium, Atrophy | 2 3 3 3 2 2 2 3 3 3 2 4 3 4 2 3 3 3 2 3 3 2 3 3 4| 49 3.0| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 2 2 1 2 1 1 2 2 2 1 2 1 3| 28 1.8| Olfactory Epithelium, Metaplasia | 2 3 3 3 2 2 2 3 3 3 2 4 3 4 2 3 3 3 2 3 3 2 3 3 4| 49 3.0| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 2 2 1 2 1 1 2 1 1 2| 49 1.3| Respiratory Epithelium, Metaplasia, | | | Squamous | 1 2 1 1 3 2 1 1 2 3 1 | 21 1.7| Respiratory Epithelium, Necrosis | 3 2 | 2 2.5| Respiratory Epithelium, Regeneration | 1 1 1 1 1 | 9 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Metaplasia, Squamous | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 1 4| 2 2.5| Cornea, Degeneration | 1 1 | 4 1.5| Cornea, Hyperplasia | 1 1 | 4 1.3| Cornea, Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0| | | 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + + +| 6 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Metaplasia, Osseous | | 2 1.5| Mineralization | 2 | 1 2.0| Nephropathy | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 3 1 1| 40 1.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| | 4| 4| 4| 4| 4| 3| 4| 5| 4| 4| 4| 9| 4| 2| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + M + + + + + + + M M + + + A| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Clear Cell Focus | X | Degeneration, Fatty | | Eosinophilic Focus | X X X X X X X | Hematopoietic Cell Proliferation | 1 2 3 | Infiltration Cellular, Mixed Cell | 4 | Inflammation, Chronic | | Necrosis | | __________________________________________________________________________| Mesentery | + + + + | Angiectasis | 4 | Inflammation, Chronic | | Fat, Hemorrhage | | Fat, Necrosis | 2 2 | __________________________________________________________________________| Oral Mucosa | | Pharyngeal, Hyperplasia | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 4 1 | Hypertrophy | 2 | Duct, Cyst | 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 2 | Epithelium, Hyperplasia | 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | Hypertrophy | 1 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| | 4| 4| 4| 4| 4| 3| 4| 5| 4| 4| 4| 9| 4| 2| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + M M + + + M + M I + + M + + + M + M + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Pars Distalis, Angiectasis | 4| Pars Distalis, Hyperplasia | 4 2 3 1 1 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 2 3 1 2 2 1 1 2 1 3 2 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + M + + M + M + M + + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Cyst | 1 2 2 1 2 1 1 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hydrometra | | Inflammation, Suppurative | 2 | Endometrium, Hyperplasia | 3 | Endometrium, Metaplasia | 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + M + + + + + + + + M + + + + + + M M +| Hyperplasia | 2 2 | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + M + + + M + + + + + + + + + + M + M +| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + M + +| Angiectasis | | Hematopoietic Cell Proliferation | | Hyperplasia | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + M + M M M + + M + M + + + + + + + + + + M| Hyperplasia | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 3 2 3 2 2 2 2 | Hyperplasia, Lymphoid | 2 2 | __________________________________________________________________________| Thymus | + + + + + + + M M M + + + + + + M + M + + + + M +| Hyperplasia, Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| | 4| 4| 4| 4| 4| 3| 4| 5| 4| 4| 4| 9| 4| 2| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Subcutaneous Tissue, Hemorrhage | | Subcutaneous Tissue, Inflammation, | | Focal, Granulomatous | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 1 1 3 2 2 3 2 2 1 1 1 1 | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Gliosis | 2 | Meninges, Infiltration Cellular, | | Mononuclear Cell | 2 1 2| __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 | Inflammation, Suppurative | 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 3 | Inflammation, Chronic, Focal | | Pigmentation, Hemosiderin | 2 | Alveolar Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 3 2 3 2 2 1 2 2 2 1 2 1 2 2 2 2 3 2 2| Glands, Hyperplasia | 4 3 4 2 3 3 3 4 2 3 1 2 3 1 3 3 4 3 3 4 4 3 4 2| Glands, Metaplasia, Squamous | 1 2 2 1 2 1 1 2 1 2 2 2 2 1 1 2 2 1 2 1 1 2 1| Lateral Wall, Metaplasia, Squamous | 2 1 3 3 1 1 2 1 2 1 2 3 1 2 3 2 3 1 2 1| Lateral Wall, Necrosis | | Olfactory Epithelium, Atrophy | 4 4 4 3 3 3 4 4 2 4 2 2 4 3 4 4 4 4 4 3 4 4 3 4 3| Olfactory Epithelium, Degeneration, | | Hyaline | 4 2 2 3 2 2 2 1 2 2 2 1 3 2 2 1 3 3 3 2 3 2| Olfactory Epithelium, Metaplasia | 4 4 4 3 3 4 4 2 4 2 2 4 3 3 4 4 4 4 3 4 4 3 4 3| Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 2 2 1 1 1 1 1 1 2 1 1 1 1 3 2 1 2 1 2 1 1 1| Respiratory Epithelium, Hyperplasia, | | Polypoid | | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| | 4| 4| 4| 4| 4| 3| 4| 5| 4| 4| 4| 9| 4| 2| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Respiratory Epithelium, Metaplasia, | | Squamous | 2 1 4 2 1 1 2 1 2 1 3 3 1 1 2 3 2 3 1 2 | Respiratory Epithelium, Necrosis | | Respiratory Epithelium, Regeneration | 1 1 1 1| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + A| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | 2| Cornea, Degeneration | 4 1 2 2 2 2 2 1 1 2 1 1 2 2 3 | Cornea, Hyperplasia | 1 1 1 1 | Cornea, Inflammation, Chronic Active | 2 1 | __________________________________________________________________________| Harderian Gland | + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Osseous | 1 1 | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + M A + + + + + + M M + + + + + I +| 41 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Basophilic Focus | X | 2 | Clear Cell Focus | X | 2 | Degeneration, Fatty | 1 | 1 1.0| Eosinophilic Focus | X| 8 | Hematopoietic Cell Proliferation | 3 2 | 5 2.2| Infiltration Cellular, Mixed Cell | | 1 4.0| Inflammation, Chronic | 2 | 1 2.0| Necrosis | 1 2 | 2 1.5| __________________________________________________________________________|____________| Mesentery | + + + + + + | 10 | Angiectasis | | 1 4.0| Inflammation, Chronic | 3 | 1 3.0| Fat, Hemorrhage | 3 | 1 3.0| Fat, Necrosis | 2 2 2 2 2 | 7 2.0| __________________________________________________________________________|____________| Oral Mucosa | + | 1 | Pharyngeal, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Atrophy | 1 4 1 1 1| 9 1.7| Hypertrophy | | 1 2.0| Duct, Cyst | | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Ulcer | | 1 2.0| Epithelium, Hyperplasia | 2 2 | 3 2.7| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Hypertrophy | 1 | 3 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 | 4 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M M + I I M M + + + M M M M M + M + M + + M| 26 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Angiectasis | | 1 2.0| Pars Distalis, Angiectasis | | 1 4.0| Pars Distalis, Hyperplasia | 2 3 2 3 1 1 2 1 3 1| 17 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Follicular Cell, Hyperplasia | 1 1 1 1 4 2 1 1 1 1 2 1 1 2 1 2 1| 30 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + M + + + + + M + + + M + + M + + + M + + + + +| 41 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Atrophy | 2 | 2 2.0| Cyst | 2 3 1 3 4 2 1 1 | 15 1.8| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + I + + + + + +| 49 | Angiectasis | 2 4 | 2 3.0| Hydrometra | 2 2 3 | 3 2.3| Inflammation, Suppurative | | 1 2.0| Endometrium, Hyperplasia | | 1 3.0| Endometrium, Metaplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + +| 4 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + M + M + + M M + M M + + M + + + + M + + + +| 37 | Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + M + + + + + M + + M + + M M + + + + +| 40 | Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + M + + + + + + +| 46 | Angiectasis | 2 1 | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hematopoietic Cell Proliferation | 3 | 1 3.0| Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + M + + + + + A + M + + + + + + + + + + + + +| 40 | Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 3 2 2 4 2 2 | 17 2.3| Hyperplasia, Lymphoid | 2 2 4| 5 2.4| __________________________________________________________________________|____________| Thymus | M + M + + + + + + A + M + + + + + M + M + + + + +| 38 | Hyperplasia, Lymphoid | 4| 1 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 2 1.5| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 4 | 1 4.0| Subcutaneous Tissue, Hemorrhage | 1 | 1 1.0| Subcutaneous Tissue, Inflammation, | | | Focal, Granulomatous | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 2 2 1 2 2 1 1 1 2 | 22 1.6| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Gliosis | | 1 2.0| Meninges, Infiltration Cellular, | | | Mononuclear Cell | 1 | 4 1.5| __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 1 1 | 5 1.0| Inflammation, Suppurative | | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Histiocyte | 1 2 | 3 2.0| Inflammation, Chronic, Focal | 1 | 1 1.0| Pigmentation, Hemosiderin | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolar Epithelium, Hyperplasia | 1 | 2 1.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 2 2 2 2 2 2 3 1 3 2 2 2 3 3 1 3 2 1 1 1 3 2| 42 2.0| Glands, Hyperplasia | 3 3 4 3 4 4 3 4 3 4 4 3 3 3 4 3 3 4 3 1 2 3 4| 47 3.1| Glands, Metaplasia, Squamous | 1 2 1 1 1 2 2 1 1 2 2 3 3 2 1 1 2 1 1 1 1 1 2| 46 1.5| Lateral Wall, Metaplasia, Squamous | 2 2 1 2 2 2 2 3 3 2 2 2 1 1 1 2| 36 1.9| Lateral Wall, Necrosis | 2 | 1 2.0| Olfactory Epithelium, Atrophy | 4 4 3 4 4 4 3 4 4 3 4 4 3 4 4 4 4 4 4 4 4 3 3 4 4| 50 3.6| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 3 2 2 3 2 2 1 1 2 2 4 3 2 2 3 2 2 3 1 2 2 2| 46 2.2| Olfactory Epithelium, Metaplasia | 4 4 3 4 4 4 3 4 4 3 4 4 3 4 4 4 4 3 4 4 4 3 3 4 4| 49 3.6| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 2 2 1 2 2 1 2 1 1 1 1 1 1 2 1 2 2 2 1 1 2 2 1| 48 1.4| Respiratory Epithelium, Hyperplasia, | | | Polypoid | 1| 1 1.0| Respiratory Epithelium, Metaplasia, | | | Squamous | 2 2 1 1 2 2 2 2 3 2 3 3 3 1 1 2 2 1 2| 39 1.9| Respiratory Epithelium, Necrosis | 2 1 1 | 3 1.3| Respiratory Epithelium, Regeneration | 1 1 2 1 1 1 2 1 1 | 13 1.2| __________________________________________________________________________|____________| Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cataract | | 1 2.0| Cornea, Degeneration | 2 1 3 3 1 3 3 2 2 3 2 | 26 2.0| Cornea, Hyperplasia | 1 1 1 | 7 1.0| Cornea, Inflammation, Chronic Active | 2 | 3 1.7| __________________________________________________________________________|____________| Harderian Gland | + | 6 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Metaplasia, Osseous | 1 1 | 4 1.0| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 8| 9| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 5| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + M| Anus, Inflammation, Chronic Active | 4 | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| Serosa, Inflammation, Chronic | 2 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + A + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 2 2| Eosinophilic Focus | X X X X X X X X X X | Hematopoietic Cell Proliferation | 2 | Inflammation, Chronic | | Necrosis | | Bile Duct, Cyst | 4 | __________________________________________________________________________| Mesentery | + + + + | Fat, Necrosis | 2 2 2 2 | __________________________________________________________________________| Oral Mucosa | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1 1 1 1| Hypertrophy | 1 | Duct, Cyst | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Necrosis | | __________________________________________________________________________| Tooth | + | Developmental Malformation | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Atrium, Thrombosis | 3 | Ventricle, Thrombosis | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Hypertrophy | 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 3 1| _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 8| 9| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 5| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 2 1 1 1 2 | __________________________________________________________________________| Parathyroid Gland | + + M + M + M M + + M + M + M + + + M + M M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 1 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 1 | Spermatocele | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 1 2| Inflammation | 2 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Bronchial | + M M M + + + + M M + + + + M + + + M + M M + + M| __________________________________________________________________________| Lymph Node, Mandibular | M + I + + + M + + + + M M M M + + M + + + M M + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 | __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + M M M + + M + +| Hyperplasia | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 | __________________________________________________________________________| Thymus | + + + + + + + M M M + M + + + M + + + + M M + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 4 2 | Mineralization | 2 | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 8| 9| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 5| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Prepuce, Inflammation, Chronic Active| 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Meninges, Infiltration Cellular, | | Mononuclear Cell | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | Inflammation, Suppurative | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | | Alveolar Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 3 1 1 | Olfactory Epithelium, Atrophy | 1 | Olfactory Epithelium, Degeneration, | | Hyaline | 2 | Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 1 | Respiratory Epithelium, Necrosis | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Squamous | 1 1 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | 2 | Inflammation, Chronic Active | | Cornea, Hyperplasia | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 1 | Hydronephrosis | 2 | Inflammation, Chronic Active | | Metaplasia, Osseous | 2| Nephropathy | 1 1 1 2 1 1 1 2 2 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1| Renal Tubule, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 8| 9| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 5| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3| | | 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + M + + + A + + + + + + M + + + + + + + A + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + I + + + + + + + + + + + + + + + + + + + + + +| 48 | Anus, Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 | Serosa, Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + A + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + I + + A + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Fatty | 1 1 2| 5 1.6| Eosinophilic Focus | X X X | 13 | Hematopoietic Cell Proliferation | 1 | 2 1.5| Inflammation, Chronic | 2 | 1 2.0| Necrosis | 2 3 | 2 2.5| Bile Duct, Cyst | | 1 4.0| __________________________________________________________________________|____________| Mesentery | + + + | 7 | Fat, Necrosis | 3 2 4 | 7 2.4| __________________________________________________________________________|____________| Oral Mucosa | + | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 | 7 1.0| Hypertrophy | | 1 1.0| Duct, Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 | 1 1.0| Necrosis | 1 1 | 2 1.0| __________________________________________________________________________|____________| Tooth | + | 2 | Developmental Malformation | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.0| Atrium, Thrombosis | | 1 3.0| Ventricle, Thrombosis | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3| | | 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 1 1.0| Hypertrophy | 1 2 1 1 1 2 1 1 1 2 1 1 1 3 1 3 1| 35 1.3| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 2 | 9 1.3| __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + M M + + M + M + + + M + M M + +| 32 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Hyperplasia | 1 | 3 1.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Hyperplasia | 1 1 1 1 2| 8 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 2 1.5| Spermatocele | 2 2 | 2 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 3 1.7| Inflammation | 1 | 3 1.7| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 | Inflammation, Suppurative | 1 | 1 1.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 4 1 | 4 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node | + | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + M + + M + M M + M M M M M M + + + + M M +| 27 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + M M + M + + M + M M M M M + M + + + + M +| 28 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + M M M + + + + + + + + I + + M +| 40 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3| | | 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 2 2 3 | 7 2.1| __________________________________________________________________________|____________| Thymus | + + + M + + + + + + M + + M M M M + + + + + + M +| 35 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M + M M M M M M M M M M M| 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 2 3.0| Mineralization | | 1 2.0| Prepuce, Inflammation, Chronic Active| 2 4 | 3 3.3| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | | 1 | Meninges, Infiltration Cellular, | | | Mononuclear Cell | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 2 1.5| Inflammation, Suppurative | 1 | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Histiocyte | 4 2 4 3 | 4 3.3| Alveolar Epithelium, Hyperplasia | 1 1 1 2| 5 1.4| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 1 1 | 7 1.4| Olfactory Epithelium, Atrophy | 1 1 | 3 1.0| Olfactory Epithelium, Degeneration, | | | Hyaline | 1 | 2 1.5| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 | 5 1.0| Respiratory Epithelium, Necrosis | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Metaplasia, Squamous | | 2 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3| | | 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cataract | 2 | 2 2.0| Inflammation, Chronic Active | 1 2 | 2 1.5| Cornea, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Harderian Gland | + + + | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 1.0| Hydronephrosis | 2 | 2 2.0| Inflammation, Chronic Active | 3 2 | 2 2.5| Metaplasia, Osseous | 1 1| 3 1.3| Nephropathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 3 1 1 1 1 1 1 2 2| 49 1.2| Renal Tubule, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 4 | 3 3.3| Transitional Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 2| 7| 7| 7| 6| 5| 7| 7| 2| 6| 7| 7| 7| DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 8| 3| 0| 3| 3| 8| 3| 3| 3| 6| 9| 3| 3| 7| 3| 3| 3| 3| | 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 3| 3| 7| 3| 3| 3| 5| 8| 3| 3| 0| 2| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + M + + + M + + + + + M + + + + + M + A + + + +| Degeneration, Hyaline | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| Peyer's Patch, Hyperplasia | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Clear Cell Focus | X X | Degeneration, Cystic | 2 | Degeneration, Fatty | 2 | Eosinophilic Focus | X X X X X X X X X | Hematopoietic Cell Proliferation | | Necrosis | 3 1 | Vacuolization Cytoplasmic | 2 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + M + + + +| Atrophy | 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + A + + + +| Inflammation, Chronic | 4 | Duct, Hyperplasia | 4 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +| Diverticulum | X | Hyperkeratosis | | Inflammation, Suppurative | | Epithelium, Hyperplasia | 3 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Inflammation | 2 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + A + + + +| Hyperplasia | 2 | Hypertrophy | 1 1 1 2 2 1 1 1 2 1 1 1 1 2 1 1 1 1 | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 2| 7| 7| 7| 6| 5| 7| 7| 2| 6| 7| 7| 7| DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 8| 3| 0| 3| 3| 8| 3| 3| 3| 6| 9| 3| 3| 7| 3| 3| 3| 3| | 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 3| 3| 7| 3| 3| 3| 5| 8| 3| 3| 0| 2| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Capsule, Hyperplasia | 4| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +| Hyperplasia | 1 1 1 1| __________________________________________________________________________| Parathyroid Gland | + M M + M + + + M M + M + I M M + M + + A + M M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| Pars Distalis, Hyperplasia | 1 1 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| Follicular Cell, Hyperplasia | 1 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | __________________________________________________________________________| Penis | + | Inflammation | 4 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| Cyst | 3 2 2| __________________________________________________________________________| Prostate | M + + + + + + + + + + + + + + + + + + + A + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 3 2 | Mineralization | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + M + + + + M + + + + M + M M M A + M M M| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + M + + + + M A + M + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + M + + + +| Angiectasis | 2 | Hematopoietic Cell Proliferation | 2 | Hyperplasia | 2| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + M + M + M + + M M + + + + + + A + + + +| Hematopoietic Cell Proliferation | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + M + + + +| Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2| Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + + + + + + I + + M + + + M M + M M M M A + M + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 2| 7| 7| 7| 6| 5| 7| 7| 2| 6| 7| 7| 7| DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 8| 3| 0| 3| 3| 8| 3| 3| 3| 6| 9| 3| 3| 7| 3| 3| 3| 3| | 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 3| 3| 7| 3| 3| 3| 5| 8| 3| 3| 0| 2| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M + M M M M M M M M +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Prepuce, Inflammation, Chronic Active| 4 2 | Subcutaneous Tissue, Inflammation, | | Chronic Active | 4 | Subcutaneous Tissue, Inflammation, | | Focal, Granulomatous | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | | Hyperostosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + A + + + +| Hyperplasia | 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Infiltration Cellular, Histiocyte | 2 | Alveolar Epithelium, Hyperplasia | 1 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + A + + + +| Inflammation, Suppurative | 2 1 1| Glands, Hyperplasia | 1 1 1 1 | Glands, Metaplasia, Squamous | 1 1 1 1 | Lateral Wall, Metaplasia, Squamous | 1 1 1 1 1 | Olfactory Epithelium, Atrophy | 3 1 1 1 1 1 1 1 | Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 | Olfactory Epithelium, Metaplasia | 1 1 1 1 1 1 | Respiratory Epithelium, Degeneration,| | Hyaline | 2 1 1 1 1 1 1 1 1 | Respiratory Epithelium, Metaplasia, | | Squamous | | Respiratory Epithelium, Regeneration | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + A + + + +| _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 2| 7| 7| 7| 6| 5| 7| 7| 2| 6| 7| 7| 7| DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 8| 3| 0| 3| 3| 8| 3| 3| 3| 6| 9| 3| 3| 7| 3| 3| 3| 3| | 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 3| 3| 7| 3| 3| 3| 5| 8| 3| 3| 0| 2| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Cataract | 1 | Cornea, Inflammation, Chronic Active | 3 | Retina, Atrophy | 3 | __________________________________________________________________________| Harderian Gland | + + + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +| Cyst | | Hydronephrosis | 1 | Metaplasia, Osseous | 1 1 | Nephropathy | 1 2 1 2 1 1 1 1 2 3 2 1 1 2 2 2 2 2 3 1 1 1 2| Renal Tubule, Hyperplasia | 1 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + M + + + + + + + + + + + + + A + + + +| Inflammation, Chronic Active | | Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3| | | 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + M + M + + + + + + A + + + + + + +| 42 | Degeneration, Hyaline | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + M A + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | Peyer's Patch, Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + A + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X | 5 | Clear Cell Focus | X | 3 | Degeneration, Cystic | | 1 2.0| Degeneration, Fatty | | 1 2.0| Eosinophilic Focus | X X X X X X X X X| 18 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Necrosis | 2 2 | 4 2.0| Vacuolization Cytoplasmic | | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + | 4 | Fat, Necrosis | 4 2 | 4 2.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 1 1 | 3 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic | | 1 4.0| Duct, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Diverticulum | | 1 | Hyperkeratosis | 2 | 1 2.0| Inflammation, Suppurative | 2 | 1 2.0| Epithelium, Hyperplasia | 1 4 3 | 5 2.4| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | __________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | Inflammation | | 1 2.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 47 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3| | | 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | | 1 2.0| Hypertrophy | 1 3 1 1 1 1 1 1 2 1 1 1 1 1 2 1 2 1 2| 37 1.3| Capsule, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 1 2 | 7 1.1| __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + M M + + + + + M + + + + + + + M| 32 | __________________________________________________________________________|____________| Pituitary Gland | + I + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Hyperplasia | 1 | 4 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Follicular Cell, Hyperplasia | 2 2 1 1 1 1| 9 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Penis | + | 2 | Inflammation | | 1 4.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | | 3 2.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Suppurative | 1 | 1 1.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 3 2.0| Mineralization | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 3 | 2 2.5| __________________________________________________________________________|____________| Lymph Node | + + | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M M M M M + M + M M M M M + M M M M + + M + + + M| 22 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + + M + + M M M + + M + M + M M + M M M| 33 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + M + + + +| 46 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 48 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3| | | 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Angiectasis | | 1 2.0| Hematopoietic Cell Proliferation | | 1 2.0| Hyperplasia | 2| 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + M M M + + + + + + + + + + + + M + + M +| 39 | Hematopoietic Cell Proliferation | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 2 2 | 12 2.0| Hyperplasia, Lymphoid | 4 | 2 3.0| __________________________________________________________________________|____________| Thymus | + M + + M + + + + M + + M M + + M + M + + + + M +| 31 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 1 2.0| Prepuce, Inflammation, Chronic Active| | 2 3.0| Subcutaneous Tissue, Inflammation, | | | Chronic Active | 3 | 2 3.5| Subcutaneous Tissue, Inflammation, | | | Focal, Granulomatous | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 1 | 1 1.0| Hyperostosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 1 | 1 1.0| Infiltration Cellular, Histiocyte | 4 4 2 | 4 3.0| Alveolar Epithelium, Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 2 1 1 1 1 1 1 1 | 11 1.2| Glands, Hyperplasia | 1 1 1 1 1 1 | 10 1.0| Glands, Metaplasia, Squamous | 1 1 | 6 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 49 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3| | | 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Lateral Wall, Metaplasia, Squamous | 1 1 1 1 | 9 1.0| Olfactory Epithelium, Atrophy | 1 2 1 1 1 1 1 | 15 1.2| Olfactory Epithelium, Degeneration, | | | Hyaline | 1 | 3 1.7| Olfactory Epithelium, Metaplasia | 1 2 1 1 1 1 | 12 1.1| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 1 1 1 1 1 2 1| 18 1.1| Respiratory Epithelium, Metaplasia, | | | Squamous | 1 1 | 2 1.0| Respiratory Epithelium, Regeneration | 1 | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | Cataract | | 1 1.0| Cornea, Inflammation, Chronic Active | | 1 3.0| Retina, Atrophy | | 1 3.0| __________________________________________________________________________|____________| Harderian Gland | | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 2 3 1 | 3 2.0| Hydronephrosis | 1 | 2 1.0| Metaplasia, Osseous | 1 2 | 4 1.3| Nephropathy | 1 1 3 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 2 1 1 1| 48 1.4| Renal Tubule, Hyperplasia | | 3 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 | Inflammation, Chronic Active | 4 | 1 4.0| Transitional Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 50 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 4| 7| 4| 4| 7| 4| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 5| 7| 5| 7| 7| 7| 4| 7| DAY ON TEST | 0| 3| 5| 9| 3| 8| 6| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 4| 1| 3| 3| 3| 3| 7| 3| | 0| 3| 5| 7| 3| 8| 9| 3| 0| 3| 3| 3| 3| 2| 3| 7| 3| 8| 2| 2| 3| 3| 3| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | A + + + + + A + + + + + + + + + + + M A + + + M +| Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + A + + + A +| __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + A + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + A + + + + + + + + + + + + A + + + A +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + A + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | X X | Eosinophilic Focus | X X X X X X| Hematopoietic Cell Proliferation | 2 | Inflammation, Chronic | | Necrosis | 1 2 | Bile Duct, Cyst | 3 | Centrilobular, Degeneration | 2 | Centrilobular, Necrosis | 2 | __________________________________________________________________________| Mesentery | + + + + | Fat, Necrosis | 2 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + M + + + + +| Atrophy | 1 1 | Hypertrophy | 1 | Duct, Cyst | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 2 | Epithelium, Hyperplasia | 3 | __________________________________________________________________________| Stomach, Glandular | A + + + + + + + + + + + + + + + + + + A + + + + +| Inflammation, Suppurative | 1 | Necrosis | | __________________________________________________________________________| Tooth | + | Inflammation | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 2 1 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 1 1| Hypertrophy | 1 3 1 1 1 2 1 1 1 2 1 1| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +| _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 4| 7| 4| 4| 7| 4| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 5| 7| 5| 7| 7| 7| 4| 7| DAY ON TEST | 0| 3| 5| 9| 3| 8| 6| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 4| 1| 3| 3| 3| 3| 7| 3| | 0| 3| 5| 7| 3| 8| 9| 3| 0| 3| 3| 3| 3| 2| 3| 7| 3| 8| 2| 2| 3| 3| 3| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Hyperplasia | 1 1 2 1 2 1 | __________________________________________________________________________| Parathyroid Gland | + + M + M M + + + + + M M + + + + M + M + + + M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | | Pars Intermedia, Hyperplasia | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 2 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 | Mineralization | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Inflammation | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M| Inflammation, Suppurative | 1 | __________________________________________________________________________| Seminal Vesicle | A + + + + + A + + + + + + + + + + + + A + + + + +| Inflammation | 1 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Atrophy | 1 4 1 | Degeneration | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Bronchial | M + M + M M M + M + + + M + + M + + + + M + + + M| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node, Mandibular | M M + M M + M M + M + + + M M + + M + + + M + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + A + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 | __________________________________________________________________________| Lymph Node, Mediastinal | M + M M M + + + + + + + + + + + M M M M + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 3 | __________________________________________________________________________| Thymus | M + + M + + M + + + + M M + M + + M + M + + + + +| Epithelial Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M + M M M M M + M| _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 4| 7| 4| 4| 7| 4| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 5| 7| 5| 7| 7| 7| 4| 7| DAY ON TEST | 0| 3| 5| 9| 3| 8| 6| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 4| 1| 3| 3| 3| 3| 7| 3| | 0| 3| 5| 7| 3| 8| 9| 3| 0| 3| 3| 3| 3| 2| 3| 7| 3| 8| 2| 2| 3| 3| 3| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | Prepuce, Inflammation, Chronic Active| 4 | Subcutaneous Tissue, Inflammation, | | Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 3 | Hyperostosis | | __________________________________________________________________________| Skeletal Muscle | +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 | Inflammation, Suppurative | 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 | Hemorrhage | | Infiltration Cellular, Histiocyte | 4 3 2 | Inflammation, Chronic, Focal | | Alveolar Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 2 1 2 1 1 1 1 2 1 1 1 1| Glands, Hyperplasia | 1 1 1 1 2 2 2 1 2 1 2 1 1 2 2 2 1 2 2 3 2 3 2 2| Glands, Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 | Lateral Wall, Metaplasia, Squamous | 4 1 1 2 1 | Lateral Wall, Necrosis | 2 1 | Olfactory Epithelium, Atrophy | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 1 2 2 3 2 3 2 2| Olfactory Epithelium, Degeneration, | | Hyaline | 1 1 2 1 1 2 1 1 2| Olfactory Epithelium, Metaplasia | 2 2 1 2 2 3 2 2 2 2 2 2 2 2 2 2 2 1 2 2 3 2 3 2 2| Respiratory Epithelium, Degeneration,| | Hyaline | 1 1 1 2 1 2 1 2 1 1 1 1 1 1 1 1 2 1 2 1 1 | Respiratory Epithelium, Metaplasia, | | Squamous | 1 1 1 | Respiratory Epithelium, Regeneration | 1 1 1 1 1 1 1| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 _____________________________________________________________________________________________________________________ | 4| 7| 4| 4| 7| 4| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 5| 7| 5| 7| 7| 7| 4| 7| DAY ON TEST | 0| 3| 5| 9| 3| 8| 6| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 4| 1| 3| 3| 3| 3| 7| 3| | 0| 3| 5| 7| 3| 8| 9| 3| 0| 3| 3| 3| 3| 2| 3| 7| 3| 8| 2| 2| 3| 3| 3| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Cataract | 1 1 | Cornea, Dysplasia | 1 | Cornea, Hyperplasia | 1 | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | | Inflammation, Chronic Active | 2 | Mineralization | | Nephropathy | 1 1 2 2 2 1 1 1 2 1 2 2 2 2 1 1 1 2 1| Papilla, Necrosis | | Renal Tubule, Degeneration | | Renal Tubule, Hypertrophy | 1 | __________________________________________________________________________| Urinary Bladder | A + + + + + I + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 3 | Mineralization | | Necrosis | | _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 5| | DAY ON TEST | 6| 6| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 8| | | 5| 5| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 4| 4| 1| 4| 4| 4| 4| 6| 4| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + A + + M + + + + + + + + + + M +| 42 | Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + M + + + A + + + + + + M + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Clear Cell Focus | X | 3 | Eosinophilic Focus | X X X X X X | 12 | Hematopoietic Cell Proliferation | | 1 2.0| Inflammation, Chronic | 3 | 1 3.0| Necrosis | 2 2 4 1 | 6 2.0| Bile Duct, Cyst | | 1 3.0| Centrilobular, Degeneration | | 1 2.0| Centrilobular, Necrosis | | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + | 7 | Fat, Necrosis | 3 2 2 | 6 2.2| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Atrophy | 1 1 | 4 1.0| Hypertrophy | 1 | 2 1.0| Duct, Cyst | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 2.0| Epithelium, Hyperplasia | 2 | 2 2.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 | Inflammation, Suppurative | 2 | 2 1.5| Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Tooth | | 1 | Inflammation | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 5| | DAY ON TEST | 6| 6| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 8| | | 5| 5| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 4| 4| 1| 4| 4| 4| 4| 6| 4| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 | 5 1.4| Hypertrophy | 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 | 31 1.2| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Hyperplasia | 1 1 1 1 | 10 1.2| __________________________________________________________________________|____________| Parathyroid Gland | + M + + M M + M + M M + M + + + + + + + + M + M +| 32 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + A M + + + + + + + + + + + + + +| 48 | Pars Distalis, Hyperplasia | 1 | 1 1.0| Pars Intermedia, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Follicular Cell, Hyperplasia | 1 1 1 | 6 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 | 2 2.5| Mineralization | 1 | 1 1.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Cyst | 4 | 2 3.5| Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Inflammation, Suppurative | | 1 1.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + A + + + + + + + + + + + + + + +| 46 | Inflammation | | 1 1.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Angiectasis | 4 | 1 4.0| Atrophy | 2 1| 5 1.8| Degeneration | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + + M M + M M M M + + + + + M M M + M M M| 27 | Hyperplasia | 4 | 2 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | M M M + M + M M M M M M + + + + M M + M M M M + +| 23 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + M + M + + + + + + + M + + + + + + +| 46 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 5| | DAY ON TEST | 6| 6| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 8| | | 5| 5| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 4| 4| 1| 4| 4| 4| 4| 6| 4| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Angiectasis | | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + A + + + M + M + M + + + + + + +| 38 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2| 11 2.1| __________________________________________________________________________|____________| Thymus | + + + + + + M + + A + + + M M + M + + + + + + + M| 36 | Epithelial Cell, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 2 | __________________________________________________________________________|____________| Skin | + + + M + + + + + A + + + + + + + + + + + + + + +| 48 | Cyst Epithelial Inclusion | X | 1 | Prepuce, Inflammation, Chronic Active| 4 4| 3 4.0| Subcutaneous Tissue, Inflammation, | | | Chronic Active | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 1 | 2 2.0| Hyperostosis | 2 | 1 2.0| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Hyperplasia | | 2 1.0| Inflammation, Suppurative | | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | | 1 2.0| Hemorrhage | 2 | 1 2.0| Infiltration Cellular, Histiocyte | 2 4 | 5 3.0| Inflammation, Chronic, Focal | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia | 3 | 2 2.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 1 1 1 1 1 2 1 2 1 2 2 2 2 | 27 1.3| Glands, Hyperplasia | 2 2 2 1 1 3 3 2 3 1 1 3 1 1 2 2 2 1 1 2 1 2 2 2| 48 1.8| Glands, Metaplasia, Squamous | 1 1 1 1 1 1 2 1 1 1 1 1 2 2 1 1 1 1 1 1 | 35 1.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 57 NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 5| | DAY ON TEST | 6| 6| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 8| | | 5| 5| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 4| 4| 1| 4| 4| 4| 4| 6| 4| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Lateral Wall, Metaplasia, Squamous | 1 1 3 2 1 | 10 1.7| Lateral Wall, Necrosis | 1 | 3 1.3| Olfactory Epithelium, Atrophy | 2 2 2 2 2 3 3 3 3 2 2 4 2 2 2 2 2 2 2 2 2 2 2 2| 49 2.2| Olfactory Epithelium, Degeneration, | | | Hyaline | 1 1 1 2 2 1 2 1 1 1 1 1| 21 1.3| Olfactory Epithelium, Metaplasia | 2 2 2 2 2 3 3 3 3 2 2 4 2 2 2 2 2 2 2 2 2 2 2 2| 49 2.1| Respiratory Epithelium, Degeneration,| | | Hyaline | 1 1 1 1 1 1 1 1 2 2 1 2 2 2 2 1 2 1 1 1 2| 42 1.3| Respiratory Epithelium, Metaplasia, | | | Squamous | 2 1 1 1 1 1 1 | 10 1.1| Respiratory Epithelium, Regeneration | 1 1 1 1 1 1 | 13 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Cataract | 2 | 3 1.3| Cornea, Dysplasia | | 1 1.0| Cornea, Hyperplasia | 2 | 2 1.5| __________________________________________________________________________|____________| Harderian Gland | + + + + | 5 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hydronephrosis | 1| 1 1.0| In