TDMS Study 05201-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest FURFURYL ALCOHOL DATE: 03/25/97
EXPERIMENT: 05201 TEST: 06 TIME: 21:43:46
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-15315 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56224C
PATHOLOGIST: MILLER, RODNEY CAS: 0098-00-0000
------------------------------------------------------------------------------------------------------------------------------------
CHRONIC STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest FURFURYL ALCOHOL DATE: 03/25/97
EXPERIMENT: 05201 TEST: 06 TIME: 21:43:46
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-15315 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56224C
PATHOLOGIST: MILLER, RODNEY CAS: 0098-00-0000
FURFURYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 385 465 484 497 537 547 567 567 597 651 |
| 661 687 692 697 712 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 270 287 433 497 574 577 582 590 598 601 |
| 632 665 693 715 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 8.0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 287 317 400 455 471 471 488 497 502 532 |
| 548 576 582 630 651 665 665 666 669 712 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FURFURYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 32.0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 382 413 582 582 590 637 646 707 707 709 |
| 716 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FURFURYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.0 94.0 90.0 82.0 78.0 68.0 |
| | |
| | |
|2.0 PPM | 100.0 100.0 98.0 96.0 96.0 94.0 92.0 80.0 76.0 72.0 |
| | |
| | |
|8.0 PPM | 100.0 100.0 100.0 96.0 94.0 88.0 80.0 74.0 66.0 60.0 |
| | |
| | |
|32.0 PPM | 100.0 100.0 100.0 100.0 96.0 96.0 96.0 90.0 86.0 76.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 2.0 PPM 8.0 PPM 32.0 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.0% 72.0% 60.0% 76.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.351N P=0.838N P=0.410 P=0.431N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 591.7 551.0 539.2 616.3 |
|NATURAL DEATHS (C) | (25.4) (36.4) (26.8) (33.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 687.8 682.0 655.5 705.0 |
|(STANDARD ERROR) | (12.3) (15.3) (17.2) (10.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
FURFURYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 352 448 547 547 566 573 595 596 604 609 |
| 651 651 689 693 712 715 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.0 PPM |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 15 CENSORED DEATHS 1 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 261 441 448 457 497 525 600 601 646 649 |
| 684 687 721 721 730 |
| CENSORED DEATHS |
| 681 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 8.0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 1 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 411 413 469 582 604 617 621 632 637 637 |
| 665 665 666 684 693 693 698 |
| CENSORED DEATHS |
| 639 |
| |
==================================================================================
FURFURYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 32.0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 574 579 582 600 609 663 665 689 693 713 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FURFURYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 98.0 96.0 96.0 82.0 76.0 68.0 |
| | |
| | |
|2.0 PPM | 100.0 100.0 98.0 98.0 98.0 91.8 87.8 83.7 79.6 69.1 |
| | |
| | |
|8.0 PPM | 100.0 100.0 100.0 100.0 96.0 94.0 94.0 90.0 75.9 65.6 |
| | |
| | |
|32.0 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 92.0 86.0 80.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 2.0 PPM 8.0 PPM 32.0 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.0% 69.1% 65.6% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.145N P=1.000N P=1.000 P=0.212N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 596.8 577.9 611.0 636.7 |
|NATURAL DEATHS (C) | (24.1) (35.0) (22.5) (16.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 690.1 685.1 690.3 714.5 |
|(STANDARD ERROR) | (11.9) (14.7) (11.2) ( 6.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
FURFURYL ALCOHOL
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
2.0 PPM = 2
8.0 PPM = 3
32.0 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
|
| 2 2 3 1 4 1
| 2 3 34 2 1 1 4
95 +
| 3 2 3 11
| 3 3 1 1 2 4 4
|
P 90 + 1 1 22 4 4
E |
R | 3 3 1 1 22 4 4
C | 33 2 2 4 4
E 85 +
N | 33 1 21
T | 3 3 1 1 44
|
S 80 + 3 3 2 2 1 1 44
U |
R | 3 3 2 1 1 44
V | 33 2 2 4 4
I 75 +
V | 3 3 11 2
A | 3 3 1 12 2
L |
70 + 3 3 11
|
| 1 1
| 33
65 +
|
| 3 3
|
60 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.
FURFURYL ALCOHOL
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
2.0 PPM = 2
8.0 PPM = 3
32.0 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3 4
|
| 2 1 21 44
| 3 21 3 1 44
95 +
| 2 23 3 4
P | 1 1 3 43
E | 2 2
R 90 + 2 2 11 3 3 4
C |
E | 2 1 12
N | 11 3 3 4 4
T 85 +
| 11 2
S | 4 4
U |
R 80 + 1 3 1 3 2 4 4
V |
I | 22
V | 1 33 1
A 75 + 2 2
L | 3 3
| 1 1
| 33 2 2
70 + 11
| 2
| 33 1 1
| 3 3
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.