TDMS Study 05203-08 Pathology Tables
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 09:00:55 RATS, FINAL#1; 14 WEEK SSAC Facility: Southern Research Institute Chemical CAS #: 88-72-2 Lock Date: 12/10/98 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: All Treatment Groups: Include 001 0 PPM Include 009 2000 PPM(STOP) Include 010 5000 PPM(STOP) a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 09:00:55 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 2000 PPM 5000 PPM (STOP) (STOP) ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 70 70 70 Scheduled Sacrifice 10 10 10 Early Deaths Survivors Animals Examined Microscopically 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) Hepatodiaphragmatic Nodule 1 (10%) 2 (20%) Hepatocyte, Vacuolization Cytoplasmic 10 (100%) Mesentery (1) Accessory Spleen 1 (100%) Pancreas (10) (10) (10) Atrophy 1 (10%) Salivary Glands (10) (10) (10) Atrophy 10 (100%) 10 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) (10) Cardiomyopathy 5 (50%) 3 (30%) 6 (60%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) Accessory Adrenal Cortical Nodule 1 (10%) 2 (20%) 2 (20%) Islets, Pancreatic (10) (10) (10) Hyperplasia 8 (80%) Pituitary Gland (10) (10) (10) Pars Distalis, Cyst 1 (10%) Thyroid Gland (10) (10) (10) Ultimobranchial Cyst 1 (10%) 2 (20%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 09:00:55 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 2000 PPM 5000 PPM (STOP) (STOP) ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (10) (10) (10) Atrophy 5 (50%) Atypia Cellular 2 (20%) 10 (100%) Preputial Gland (10) (10) (10) Atrophy 1 (10%) 8 (80%) Prostate (10) (10) (10) Inflammation, Chronic 1 (10%) Testes (10) (10) (10) Mineralization 5 (50%) Germinal Epithelium, Atrophy 1 (10%) 9 (90%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (1) (1) Mediastinal, Hemorrhage 1 (100%) Mediastinal, Pigmentation 1 (100%) Renal, Hemorrhage 1 (100%) Renal, Pigmentation 1 (100%) Spleen (10) (10) (10) Congestion 3 (30%) 10 (100%) Hematopoietic Cell Proliferation 2 (20%) 10 (100%) Pigmentation 1 (10%) Thymus (10) (10) (10) Hemorrhage 1 (10%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 09:00:55 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 2000 PPM 5000 PPM (STOP) (STOP) ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Nose (10) (10) (10) Olfactory Epithelium, Degeneration 4 (40%) 10 (100%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) Nephropathy 8 (80%) Renal Tubule, Degeneration, Hyaline 1 (10%) 10 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 ------------------------------------------------------------ ---------- END OF REPORT ---------- 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