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TDMS Study 05203-08 Pathology Tables

NTP Experiment-Test: 05203-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00
Route: DOSED FEED                                                                                                 Time: 09:00:55

                                                  RATS, FINAL#1; 14 WEEK SSAC




       Facility:  Southern Research Institute

       Chemical CAS #:  88-72-2

       Lock Date:  12/10/98

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 PPM
                               Include 009    2000 PPM(STOP)
                               Include 010    5000 PPM(STOP)
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05203-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:00:55    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        2000 PPM     5000 PPM                                               
                                                                (STOP)       (STOP)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          70           70           70                                                  
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)                                                
      Hepatodiaphragmatic Nodule                                    1 (10%)      2 (20%)                                            
      Hepatocyte, Vacuolization Cytoplasmic                                     10 (100%)                                           
   Mesentery                                                                    (1)                                                 
      Accessory Spleen                                                           1 (100%)                                           
   Pancreas                                           (10)         (10)         (10)                                                
      Atrophy                                                                    1 (10%)                                            
   Salivary Glands                                    (10)         (10)         (10)                                                
      Atrophy                                                      10 (100%)    10 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (10)                                                
      Cardiomyopathy                                   5 (50%)      3 (30%)      6 (60%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)                                                
      Accessory Adrenal Cortical Nodule                1 (10%)      2 (20%)      2 (20%)                                            
   Islets, Pancreatic                                 (10)         (10)         (10)                                                
      Hyperplasia                                                                8 (80%)                                            
   Pituitary Gland                                    (10)         (10)         (10)                                                
      Pars Distalis, Cyst                                           1 (10%)                                                         
   Thyroid Gland                                      (10)         (10)         (10)                                                
      Ultimobranchial Cyst                             1 (10%)                   2 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 05203-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:00:55    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        2000 PPM     5000 PPM                                               
                                                                (STOP)       (STOP)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)         (10)                                                
      Atrophy                                                                    5 (50%)                                            
      Atypia Cellular                                               2 (20%)     10 (100%)                                           
   Preputial Gland                                    (10)         (10)         (10)                                                
      Atrophy                                                       1 (10%)      8 (80%)                                            
   Prostate                                           (10)         (10)         (10)                                                
      Inflammation, Chronic                                                      1 (10%)                                            
   Testes                                             (10)         (10)         (10)                                                
      Mineralization                                                             5 (50%)                                            
      Germinal Epithelium, Atrophy                                  1 (10%)      9 (90%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                      (1)          (1)                                                 
      Mediastinal, Hemorrhage                                       1 (100%)                                                        
      Mediastinal, Pigmentation                                     1 (100%)                                                        
      Renal, Hemorrhage                                                          1 (100%)                                           
      Renal, Pigmentation                                                        1 (100%)                                           
   Spleen                                             (10)         (10)         (10)                                                
      Congestion                                                    3 (30%)     10 (100%)                                           
      Hematopoietic Cell Proliferation                              2 (20%)     10 (100%)                                           
      Pigmentation                                                               1 (10%)                                            
   Thymus                                             (10)         (10)         (10)                                                
      Hemorrhage                                                    1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 05203-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 09:00:55    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        2000 PPM     5000 PPM                                               
                                                                (STOP)       (STOP)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Nose                                               (10)         (10)         (10)                                                
      Olfactory Epithelium, Degeneration                            4 (40%)     10 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)                                                
      Nephropathy                                                   8 (80%)                                                         
      Renal Tubule, Degeneration, Hyaline              1 (10%)                  10 (100%)                                           
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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