TDMS Study 05203-08 Pathology Tables
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:00:55
RATS, FINAL#1; 14 WEEK SSAC
Facility: Southern Research Institute
Chemical CAS #: 88-72-2
Lock Date: 12/10/98
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 PPM
Include 009 2000 PPM(STOP)
Include 010 5000 PPM(STOP)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:00:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 2000 PPM 5000 PPM
(STOP) (STOP)
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70
Scheduled Sacrifice 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10)
Hepatodiaphragmatic Nodule 1 (10%) 2 (20%)
Hepatocyte, Vacuolization Cytoplasmic 10 (100%)
Mesentery (1)
Accessory Spleen 1 (100%)
Pancreas (10) (10) (10)
Atrophy 1 (10%)
Salivary Glands (10) (10) (10)
Atrophy 10 (100%) 10 (100%)
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CARDIOVASCULAR SYSTEM
Heart (10) (10) (10)
Cardiomyopathy 5 (50%) 3 (30%) 6 (60%)
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10)
Accessory Adrenal Cortical Nodule 1 (10%) 2 (20%) 2 (20%)
Islets, Pancreatic (10) (10) (10)
Hyperplasia 8 (80%)
Pituitary Gland (10) (10) (10)
Pars Distalis, Cyst 1 (10%)
Thyroid Gland (10) (10) (10)
Ultimobranchial Cyst 1 (10%) 2 (20%)
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GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:00:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 2000 PPM 5000 PPM
(STOP) (STOP)
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10)
Atrophy 5 (50%)
Atypia Cellular 2 (20%) 10 (100%)
Preputial Gland (10) (10) (10)
Atrophy 1 (10%) 8 (80%)
Prostate (10) (10) (10)
Inflammation, Chronic 1 (10%)
Testes (10) (10) (10)
Mineralization 5 (50%)
Germinal Epithelium, Atrophy 1 (10%) 9 (90%)
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HEMATOPOIETIC SYSTEM
Lymph Node (1) (1)
Mediastinal, Hemorrhage 1 (100%)
Mediastinal, Pigmentation 1 (100%)
Renal, Hemorrhage 1 (100%)
Renal, Pigmentation 1 (100%)
Spleen (10) (10) (10)
Congestion 3 (30%) 10 (100%)
Hematopoietic Cell Proliferation 2 (20%) 10 (100%)
Pigmentation 1 (10%)
Thymus (10) (10) (10)
Hemorrhage 1 (10%)
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:00:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 2000 PPM 5000 PPM
(STOP) (STOP)
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Nose (10) (10) (10)
Olfactory Epithelium, Degeneration 4 (40%) 10 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (10) (10) (10)
Nephropathy 8 (80%)
Renal Tubule, Degeneration, Hyaline 1 (10%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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