TDMS Study 05203-08 Pathology Tables
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:23:03
RATS, FINAL#1; CORE STUDY
Facility: Southern Research Institute
Chemical CAS #: 88-72-2
Lock Date: 12/10/98
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 002 0 PPM
Include 004 625 PPM
Include 006 1250 PPM
Include 008 2000 PPM
Include 001 0 PPM
Include 003 625 PPM
Include 005 1250 PPM
Include 007 2000 PPM
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:23:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Moribund Sacrifice 10 11 19 22
Natural Death 3 2 2 5
Survivors
Terminal Sacrifice 45 46 39 33
Moribund Sacrifice 1 1
Natural Death 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (58) (59) (60) (59)
Crypt, Diverticulum 1 (2%)
Intestine Large, Rectum (60) (60) (60) (58)
Fibrosis 1 (2%)
Intestine Large, Cecum (58) (59) (60) (59)
Edema 1 (2%) 1 (2%)
Liver (60) (59) (60) (60)
Angiectasis 2 (3%) 3 (5%) 4 (7%) 4 (7%)
Basophilic Focus 51 (85%) 56 (95%) 60 (100%) 54 (90%)
Clear Cell Focus 16 (27%) 30 (51%) 28 (47%) 33 (55%)
Degeneration, Cystic 1 (2%) 2 (3%)
Eosinophilic Focus 5 (8%) 12 (20%) 25 (42%) 32 (53%)
Hematopoietic Cell Proliferation 2 (3%) 1 (2%) 3 (5%)
Hemorrhage 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 9 (15%) 13 (22%) 10 (17%) 7 (12%)
Infiltration Cellular, Mixed Cell 15 (25%) 11 (19%) 6 (10%) 12 (20%)
Mixed Cell Focus 6 (10%) 9 (15%) 11 (18%) 28 (47%)
Necrosis, Focal 1 (2%) 3 (5%) 5 (8%)
Regeneration, Diffuse 1 (2%)
Regeneration, Focal 1 (2%) 2 (3%)
Bile Duct, Hyperplasia 7 (12%) 2 (3%)
Centrilobular, Necrosis 3 (5%) 2 (3%) 2 (3%)
Hepatocyte, Vacuolization Cytoplasmic 4 (7%) 2 (3%) 1 (2%)
Kupffer Cell, Pigmentation 3 (5%)
Mesentery (9) (1) (3) (3)
Accessory Spleen 2 (22%) 1 (33%) 1 (33%)
Fat, Necrosis 7 (78%) 1 (100%) 2 (67%)
Pancreas (60) (59) (60) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:23:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Atrophy 13 (22%) 10 (17%) 7 (12%) 4 (7%)
Acinus, Hyperplasia, Focal 1 (2%) 1 (2%) 2 (3%) 2 (3%)
Salivary Glands (60) (60) (60) (60)
Atrophy 2 (3%) 3 (5%) 9 (15%) 48 (80%)
Stomach, Forestomach (59) (59) (60) (60)
Erosion 1 (2%) 1 (2%)
Perforation 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia 5 (8%) 3 (5%) 1 (2%)
Stomach, Glandular (60) (59) (60) (60)
Erosion 1 (2%) 1 (2%) 1 (2%) 3 (5%)
Ulcer 2 (3%) 1 (2%) 1 (2%)
Tooth (2)
Inflammation, Chronic 1 (50%)
Malformation 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Cardiomyopathy 22 (37%) 16 (27%) 13 (22%) 13 (22%)
Thrombosis 1 (2%)
Myocardium, Fibrosis 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (59)
Accessory Adrenal Cortical Nodule 8 (13%) 10 (17%) 8 (13%) 10 (17%)
Degeneration, Fatty 13 (22%) 11 (18%) 17 (28%) 11 (19%)
Hyperplasia, Diffuse 3 (5%) 1 (2%) 1 (2%)
Hyperplasia, Focal 9 (15%) 6 (10%) 14 (23%) 15 (25%)
Hypertrophy, Focal 6 (10%) 7 (12%) 6 (10%) 7 (12%)
Necrosis 1 (2%)
Adrenal Medulla (60) (60) (60) (58)
Hyperplasia 8 (13%) 2 (3%) 3 (5%) 3 (5%)
Pituitary Gland (59) (60) (60) (60)
Pars Distalis, Angiectasis 6 (10%) 5 (8%) 4 (7%) 4 (7%)
Pars Distalis, Cyst 22 (37%) 20 (33%) 22 (37%) 24 (40%)
Pars Distalis, Hyperplasia, Focal 12 (20%) 6 (10%) 12 (20%) 9 (15%)
Pars Intermedia, Angiectasis 2 (3%) 1 (2%)
Pars Intermedia, Cyst 3 (5%) 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (60) (60) (60) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:23:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Ultimobranchial Cyst 1 (2%) 1 (2%) 1 (2%)
C-Cell, Hyperplasia 22 (37%) 24 (40%) 22 (37%) 9 (15%)
Follicle, Cyst 2 (3%) 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (59) (57) (54) (53)
Atrophy 1 (2%) 3 (5%) 6 (11%) 25 (47%)
Cyst 2 (3%) 4 (7%) 4 (7%) 2 (4%)
Hyperplasia 5 (8%) 1 (2%) 4 (7%) 1 (2%)
Inflammation, Chronic 4 (7%) 4 (7%) 6 (11%) 5 (9%)
Ovary (60) (59) (60) (60)
Angiectasis 2 (3%)
Cyst 9 (15%) 8 (14%) 11 (18%) 6 (10%)
Uterus (60) (59) (60) (60)
Angiectasis 1 (2%)
Cyst 1 (2%)
Hydrometra 7 (12%) 6 (10%) 1 (2%) 3 (5%)
Hyperplasia, Cystic 8 (13%) 6 (10%) 9 (15%) 8 (13%)
Inflammation, Chronic 2 (3%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Hyperplasia 2 (3%) 7 (12%) 15 (25%) 24 (40%)
Infiltration Cellular, Histiocyte 2 (3%) 1 (2%) 1 (2%)
Myelofibrosis 1 (2%) 2 (3%)
Lymph Node (8) (4) (4) (4)
Mediastinal, Hemorrhage 1 (13%) 1 (25%) 1 (25%) 3 (75%)
Mediastinal, Pigmentation 6 (75%) 1 (25%) 1 (25%) 3 (75%)
Renal, Hemorrhage 1 (25%)
Renal, Pigmentation 1 (25%)
Lymph Node, Mandibular (60) (60) (59) (59)
Ectasia 1 (2%) 3 (5%) 4 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:23:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage 4 (7%) 4 (7%) 1 (2%) 4 (7%)
Hyperplasia, Lymphoid 3 (5%) 5 (8%) 6 (10%) 15 (25%)
Pigmentation 31 (52%) 33 (55%) 30 (51%) 30 (51%)
Lymph Node, Mesenteric (59) (58) (59) (59)
Hemorrhage 5 (8%) 3 (5%) 4 (7%) 5 (8%)
Hyperplasia, Lymphoid 1 (2%)
Pigmentation 4 (7%) 1 (2%) 3 (5%)
Spleen (60) (59) (60) (59)
Congestion 1 (2%)
Fibrosis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 22 (37%) 38 (64%) 48 (80%) 48 (81%)
Necrosis 2 (3%)
Pigmentation 36 (60%) 44 (75%) 43 (72%) 46 (78%)
Lymphoid Follicle, Atrophy 1 (2%) 1 (2%)
Thymus (57) (55) (58) (58)
Cyst 1 (2%) 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (60) (59) (60)
Dilatation 40 (67%) 30 (50%) 29 (49%) 24 (40%)
Galactocele 1 (2%)
Hyperplasia 14 (23%) 36 (60%) 30 (51%) 19 (32%)
Skin (59) (60) (60) (60)
Angiectasis 1 (2%)
Ulcer 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Cranium, Osteopetrosis 2 (3%) 6 (10%) 6 (10%) 10 (17%)
Femur, Osteopetrosis 8 (13%) 9 (15%) 13 (22%) 16 (27%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 6 (10%) 10 (17%) 5 (8%) 3 (5%)
Hydrocephalus 2 (3%) 4 (7%) 3 (5%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:23:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Hemorrhage 2 (3%) 2 (3%) 2 (3%) 1 (2%)
Infiltration Cellular, Histiocyte 52 (87%) 54 (90%) 53 (88%) 55 (92%)
Alveolar Epithelium, Hyperplasia 6 (10%) 14 (23%) 16 (27%) 9 (15%)
Alveolar Epithelium, Hyperplasia, Atypical 1 (2%)
Nose (60) (60) (60) (60)
Foreign Body 2 (3%) 7 (12%)
Inflammation, Chronic 2 (3%) 1 (2%) 2 (3%) 8 (13%)
Respiratory Epithelium, Hyperplasia 2 (3%) 3 (5%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (3) (2) (1)
Cataract 1 (33%) 2 (67%) 1 (50%) 1 (100%)
Hemorrhage 1 (33%)
Inflammation, Chronic 1 (33%) 1 (33%)
Retina, Degeneration 2 (67%) 2 (67%) 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (59) (60) (60)
Cyst 1 (2%) 1 (2%)
Hydronephrosis 1 (2%)
Infarct 2 (3%) 1 (2%)
Inflammation, Chronic 2 (3%) 1 (2%) 1 (2%) 1 (2%)
Nephropathy 53 (88%) 45 (76%) 48 (80%) 52 (87%)
Renal Tubule, Cytoplasmic Alteration 1 (2%) 1 (2%)
Renal Tubule, Degeneration, Hyaline 9 (15%) 10 (17%) 4 (7%) 11 (18%)
Renal Tubule, Necrosis 2 (3%)
Renal Tubule, Pigmentation 9 (15%) 10 (17%) 7 (12%) 17 (28%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Urinary Bladder (60) (59) (60) (60)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:23:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 60 60 60
Early Deaths
Moribund Sacrifice 18 35 48 53
Natural Death 3 7 6 7
Accidently Killed 3
Survivors
Terminal Sacrifice 38 18 3
Natural Death 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (60) (60) (60) (58)
Edema 1 (2%)
Liver (60) (60) (60) (60)
Angiectasis 1 (2%) 2 (3%) 2 (3%)
Atrophy 1 (2%) 1 (2%) 1 (2%) 4 (7%)
Basophilic Focus 38 (63%) 22 (37%) 21 (35%) 25 (42%)
Clear Cell Focus 29 (48%) 29 (48%) 34 (57%) 31 (52%)
Cyst 1 (2%)
Degeneration, Cystic 3 (5%) 3 (5%) 1 (2%) 2 (3%)
Eosinophilic Focus 7 (12%) 18 (30%) 29 (48%) 24 (40%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 6 (10%) 2 (3%) 2 (3%)
Hemorrhage 2 (3%) 2 (3%) 2 (3%)
Hepatodiaphragmatic Nodule 5 (8%) 8 (13%) 8 (13%) 5 (8%)
Infiltration Cellular, Mixed Cell 1 (2%) 5 (8%) 11 (18%) 20 (33%)
Mixed Cell Focus 5 (8%) 7 (12%) 12 (20%) 6 (10%)
Necrosis, Focal 3 (5%) 4 (7%) 6 (10%) 6 (10%)
Bile Duct, Hyperplasia 53 (88%) 37 (62%) 7 (12%)
Centrilobular, Necrosis 1 (2%) 3 (5%) 8 (13%) 5 (8%)
Hepatocyte, Vacuolization Cytoplasmic 4 (7%) 2 (3%) 1 (2%) 1 (2%)
Kupffer Cell, Pigmentation 4 (7%) 1 (2%) 3 (5%)
Mesentery (16) (6) (5) (4)
Accessory Spleen 3 (19%) 3 (75%)
Congestion 3 (19%)
Hemorrhage 1 (17%)
Fat, Necrosis 13 (81%) 3 (50%) 5 (100%) 1 (25%)
Oral Mucosa (1) (1)
Hyperplasia 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:23:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (60) (60) (60) (60)
Atrophy 11 (18%) 14 (23%) 7 (12%) 4 (7%)
Acinus, Hyperplasia, Focal 1 (2%) 2 (3%) 3 (5%) 4 (7%)
Salivary Glands (60) (60) (59) (60)
Atrophy 2 (3%) 18 (31%) 43 (72%)
Stomach, Forestomach (59) (60) (60) (60)
Edema 4 (7%) 2 (3%) 1 (2%)
Ulcer 2 (3%) 2 (3%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia 6 (10%) 2 (3%) 1 (2%) 2 (3%)
Stomach, Glandular (59) (60) (60) (60)
Edema 1 (2%)
Erosion 4 (7%) 2 (3%) 7 (12%) 7 (12%)
Infiltration Cellular, Lymphoid 1 (2%)
Ulcer 1 (2%) 2 (3%) 3 (5%)
Tongue (1) (1)
Epithelium, Hyperplasia 1 (100%)
Tooth (1)
Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Cardiomyopathy 40 (67%) 43 (72%) 43 (72%) 37 (62%)
Thrombosis 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Accessory Adrenal Cortical Nodule 13 (22%) 12 (20%) 13 (22%) 10 (17%)
Degeneration, Fatty 16 (27%) 10 (17%) 11 (18%) 4 (7%)
Hyperplasia, Diffuse 1 (2%) 3 (5%)
Hyperplasia, Focal 6 (10%) 2 (3%) 6 (10%) 3 (5%)
Hypertrophy, Focal 3 (5%) 2 (3%) 2 (3%)
Adrenal Medulla (60) (60) (60) (59)
Hyperplasia 7 (12%) 4 (7%) 2 (3%)
Islets, Pancreatic (60) (60) (60) (60)
Hyperplasia 2 (3%) 2 (3%)
Pigmentation 1 (2%) 2 (3%)
Parathyroid Gland (58) (55) (59) (58)
Hyperplasia 1 (2%)
Pituitary Gland (59) (60) (58) (59)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:23:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Angiectasis 3 (5%) 7 (12%) 2 (3%)
Pars Distalis, Cyst 2 (3%) 6 (10%) 3 (5%) 4 (7%)
Pars Distalis, Cytoplasmic Alteration 1 (2%) 1 (2%) 4 (7%)
Pars Distalis, Hyperplasia, Focal 10 (17%) 13 (22%) 13 (22%) 10 (17%)
Pars Intermedia, Cyst 1 (2%) 1 (2%)
Thyroid Gland (59) (60) (60) (60)
Ultimobranchial Cyst 1 (2%) 2 (3%) 3 (5%)
C-Cell, Hyperplasia 10 (17%) 11 (18%) 9 (15%) 7 (12%)
Follicle, Cyst 3 (5%) 2 (3%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (3) (21) (33) (46)
Mesothelium, Hyperplasia 1 (33%) 1 (5%) 4 (12%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (60) (59) (60)
Atypia Cellular 39 (65%) 32 (53%) 27 (46%) 21 (35%)
Fibrosis 2 (3%)
Inflammation, Chronic 1 (2%)
Preputial Gland (60) (59) (58) (56)
Atrophy 7 (12%) 9 (15%) 35 (60%) 41 (73%)
Cyst 1 (2%) 4 (7%) 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic 40 (67%) 43 (73%) 36 (62%) 27 (48%)
Prostate (60) (59) (60) (60)
Inflammation, Chronic 24 (40%) 14 (24%) 18 (30%) 9 (15%)
Ventral, Hyperplasia 18 (30%) 3 (5%) 9 (15%) 1 (2%)
Testes (60) (60) (60) (60)
Angiectasis 2 (3%)
Germinal Epithelium, Atrophy 13 (22%) 21 (35%) 12 (20%) 19 (32%)
Interstitial Cell, Hyperplasia 10 (17%) 14 (23%) 13 (22%) 31 (52%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Hyperplasia 2 (3%) 25 (42%) 43 (72%) 45 (75%)
Lymph Node (16) (14) (4) (9)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:23:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Iliac, Hyperplasia, Lymphoid 1 (11%)
Mediastinal, Atrophy 1 (11%)
Mediastinal, Hemorrhage 2 (13%) 3 (21%) 1 (25%) 2 (22%)
Mediastinal, Pigmentation 6 (38%) 9 (64%) 3 (75%) 8 (89%)
Pancreatic, Pigmentation 1 (6%) 1 (7%)
Renal, Ectasia 1 (25%)
Renal, Pigmentation 1 (6%) 1 (25%)
Lymph Node, Mandibular (58) (59) (58) (59)
Atrophy 1 (2%)
Ectasia 2 (3%)
Hemorrhage 2 (3%) 2 (3%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 3 (5%) 4 (7%) 3 (5%) 2 (3%)
Pigmentation 9 (16%) 2 (3%) 6 (10%) 12 (20%)
Lymph Node, Mesenteric (60) (60) (59) (58)
Atrophy 1 (2%) 2 (3%) 1 (2%)
Hemorrhage 2 (3%) 6 (10%) 3 (5%) 2 (3%)
Pigmentation 3 (5%) 3 (5%)
Spleen (60) (60) (60) (60)
Fibrosis 6 (10%) 6 (10%) 9 (15%) 7 (12%)
Hematopoietic Cell Proliferation 7 (12%) 33 (55%) 38 (63%) 47 (78%)
Hemorrhage 2 (3%)
Pigmentation 9 (15%) 8 (13%) 13 (22%) 16 (27%)
Capsule, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (57) (47) (46) (43)
Dilatation 3 (5%) 10 (21%) 1 (2%) 1 (2%)
Galactocele 2 (4%)
Hyperplasia 6 (11%) 2 (4%) 2 (4%) 2 (5%)
Skin (60) (60) (60) (60)
Cyst 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Cranium, Osteopetrosis 1 (2%) 2 (3%)
Skeletal Muscle (1) (5) (3)
Atrophy 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:23:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Hemorrhage 1 (20%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 6 (10%) 3 (5%) 2 (3%) 1 (2%)
Developmental Malformation 1 (2%)
Gliosis 1 (2%)
Hemorrhage 1 (2%)
Hydrocephalus 3 (5%) 1 (2%) 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Congestion 1 (2%)
Hemorrhage 3 (5%) 1 (2%)
Infiltration Cellular, Histiocyte 25 (42%) 42 (70%) 40 (67%) 22 (37%)
Metaplasia, Osseous 1 (2%) 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (3%) 8 (13%) 3 (5%) 7 (12%)
Nose (60) (60) (60) (60)
Foreign Body 9 (15%) 13 (22%) 10 (17%) 11 (18%)
Inflammation, Chronic 9 (15%) 9 (15%) 8 (13%) 9 (15%)
Inflammation, Suppurative 2 (3%)
Respiratory Epithelium, Hyperplasia 6 (10%) 5 (8%) 7 (12%) 8 (13%)
Respiratory Epithelium, Metaplasia, Squamous 2 (3%) 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (2) (1)
Atrophy 1 (50%)
Cataract 1 (100%) 1 (50%) 1 (100%)
Inflammation, Chronic 1 (50%)
Retina, Degeneration 1 (50%) 1 (100%) 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Cyst 1 (2%) 3 (5%) 2 (3%)
Infarct 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05203-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 09:23:03
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 1250 PPM 2000 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%)
Nephropathy 56 (93%) 59 (98%) 56 (93%) 56 (93%)
Renal Tubule, Degeneration, Hyaline 3 (5%) 3 (5%) 1 (2%)
Renal Tubule, Dilatation 1 (2%) 3 (5%) 2 (3%)
Renal Tubule, Necrosis 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 5 (8%) 12 (20%) 14 (23%) 9 (15%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
Urinary Bladder (60) (60) (60) (59)
Fibrosis 1 (2%) 2 (3%)
Inflammation, Chronic 2 (3%)
Transitional Epithelium, Hyperplasia 2 (3%) 2 (3%) 3 (5%)
Transitional Epithelium, Inflammation,
Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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