TDMS Study 05203-08 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst O-NITROTOLUENE DATE: 11/16/00
EXPERIMENT: 05203 TEST: 08 TIME: 09:37:57
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62340D
PATHOLOGIST: HEATH, JAMES E. CAS: 88-72-2
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RATS, FINAL#1; CONTROL + 2000 & 5000PPM STOP GROUPS
REASONS FOR REMOVAL: 25022 Accidently Killed
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 PPM
INCLUDE 009 2000 PPM(STOP)
INCLUDE 010 5000 PPM(STOP)
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst O-NITROTOLUENE DATE: 11/16/00
EXPERIMENT: 05203 TEST: 08 TIME: 09:37:57
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62340D
PATHOLOGIST: HEATH, JAMES E. CAS: 88-72-2
Rats(FISCHER 344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED. IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
---------------
Adrenal Medulla
Brain
Clitoral/Preputial Gland
Heart
Islets, Pancreatic
Liver
Lung
Pancreas
Parathyroid Gland
Pituitary Gland
Prostate
Salivary Glands
Spleen
Testes
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst O-NITROTOLUENE DATE: 11/16/00
EXPERIMENT: 05203 TEST: 08 TIME: 09:37:57
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62340D
PATHOLOGIST: HEATH, JAMES E. CAS: 88-72-2
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF O-NITROTOLUENE
===============================================================
Male Rats
------------
Organ Morphology
----- ----------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Bone Osteosarcoma
Clitoral/Preputial Gland Carcinoma or Adenoma
Intestine Large: Colon/Rectum Polyp Adenomatous
Liver Cholangiocarcinoma
Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Mammary Gland Fibroadenoma
Mesentery Fibrosarcoma
Pancreas Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Skin Fibroma
Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma
Fibrosarcoma
Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma
Keratoacanthoma
Lipoma
Schwannoma Malignant
Squamous Cell Papilloma
Testes Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
All Organs Hemangioma
Hemangiosarcoma or Hemangioma
Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Mesothelioma: Benign, Malignant, NOS
Mesothelioma: Malignant
Osteosarcoma
Osteosarcoma or Osteoma
Benign Tumors
Malignant Tumors
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Date: 11/16/00 EXPERIMENT: 05203 TEST: 08 Page 1
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - O-NITROTOLUENE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 2000 PPM 5000 PPM |
| | (STOP) (STOP) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 4/60 (7%) 2/60 (3%) |
|POLY-3 RATE (b) | 2/53.85 4/39.45 2/20.31 |
|POLY-3 PERCENT (g) | 3.7% 10.1% 9.9% |
|TERMINAL (d) | 2/39 (5%) 2/11 (18%) 0/0 (0%) |
|FIRST INCIDENCE | 729 (T) 569 567 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.043 * P=0.011 * |
|POLY 3 | P=0.187 P=0.210 P=0.352 |
|POLY 1.5 | P=0.347 P=0.260 P=0.495 |
|POLY 6 | P=0.080 P=0.152 P=0.228 |
|LOGISTIC REGRESSION| P=0.115 P=0.171 P=0.251 |
|COCH-ARM / FISHERS | P=0.558N P=0.340 P=0.691N |
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 2000 PPM 5000 PPM |
| | (STOP) (STOP) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 0/60 (0%) |
|POLY-3 RATE (b) | 2/53.85 1/38.63 0/19.33 |
|POLY-3 PERCENT (g) | 3.7% 2.6% 0.0% |
|TERMINAL (d) | 2/39 (5%) 1/11 (9%) 0/0 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.720 P=0.590 P=1.000N |
|POLY 3 | P=0.401N P=0.612N P=0.485N |
|POLY 1.5 | P=0.256N P=0.565N P=0.373N |
|POLY 6 | P=0.614N P=0.674N P=0.603N |
|LOGISTIC REGRESSION| P=0.720 P=0.590 (e) |
|COCH-ARM / FISHERS | P=0.161N P=0.500N P=0.248N |
|=================================================================================================================================|
Date: 11/16/00 EXPERIMENT: 05203 TEST: 08 Page 2
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - O-NITROTOLUENE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 PPM 2000 PPM 5000 PPM |
| | (STOP) (STOP) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES |