https://ntp.niehs.nih.gov/go/6884

TDMS Study 05203-08 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 08                                                                                     TIME: 09:39:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 88-72-2         
------------------------------------------------------------------------------------------------------------------------------------
                                        RATS, FINAL#1; CONTROL + 2000 & 5000PPM STOP GROUPS                                         
               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE 001    0 PPM                                                                         
                                       INCLUDE 009    2000 PPM(STOP)                                                                
                                       INCLUDE 010    5000 PPM(STOP)                                                                
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 08                                                                                     TIME: 09:39:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 88-72-2         
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  O-NITROTOLUENE                                                                                  
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Accessory Adrenal Cortical Nodule                                                            
                                       Degeneration Fatty                                                                           
                                       Hyperplasia Diffuse                                                                          
                                       Hyperplasia Focal                                                                            
                                       Hypertrophy Focal                                                                            
Adrenal Medulla                        Hyperplasia                                                                                  
Bone Marrow                            Hyperplasia                                                                                  
Brain                                  Compression                                                                                  
Epididymis                             Atypia Cellular                                                                              
Heart                                  Cardiomyopathy                                                                               
                                       Thrombosis                                                                                   
Islets, Pancreatic                     Hyperplasia                                                                                  
                                       Pigmentation                                                                                 
Kidney                                 Cyst                                                                                         
                                       Hydronephrosis                                                                               
                                       Inflammation Chronic                                                                         
                                       Nephropathy                                                                                  
Kidney: Renal Tubule                   Pigmentation                                                                                 
Liver                                  Angiectasis                                                                                  
                                       Atrophy                                                                                      
                                       Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
                                       Degeneration Cystic                                                                          
                                       Eosinophilic Focus                                                                           
                                       Hematopoietic Cell Proliferation                                                             
                                       Hepatodiaphragmatic Nodule                                                                   
                                       Infiltration Cellular Mixed Cell                                                             
                                       Mixed Cell Focus                                                                             
                                       Necrosis Focal                                                                               
Liver: Bile Duct                       Hyperplasia                                                                                  
Liver: Centrilobular                   Necrosis                                                                                     
Liver: Hepatocyte                      Vacuolization Cytoplasmic                                                                    
Lung                                   Congestion                                                                                   
                                       Hemorrhage                                                                                   
                                       Infiltration Cellular Histiocyte                                                             
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Lymph Node, Mandibular                 Hemorrhage                                                                                   
                                       Hyperplasia Lymphoid                                                                         
                                       Pigmentation                                                                                 
Lymph Node, Mediastinal                Hemorrhage                                                                                   
                                       Pigmentation                                                                                 
Lymph Node, Mesenteric                 Ectasia                                                                                      
                                       Hemorrhage                                                                                   
                                       Hyperplasia Lymphoid                                                                         
Lymph Node: Pancreatic                 Hyperplasia                                                                                  
Mesentery: Fat                         Necrosis                                                                                     
Nose                                   Foreign Body                                                                                 
                                       Inflammation Chronic                                                                         
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 08                                                                                     TIME: 09:39:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 88-72-2         
Nose: Respiratory Epithelium           Hyperplasia                                                                                  
Pancreas                               Atrophy                                                                                      
Pancreas: Acinus                       Hyperplasia Focal                                                                            
Peritoneum: Mesothelium                Hyperplasia                                                                                  
Pituitary Gland: Pars Distalis         Angiectasis                                                                                  
                                       Cyst                                                                                         
                                       Cytoplasmic Alteration                                                                       
                                       Hyperplasia Focal                                                                            
Pituitary Gland: Pars Intermedia       Cyst                                                                                         
Preputial Gland                        Atrophy                                                                                      
                                       Inflammation Chronic                                                                         
Prostate                               Inflammation Chronic                                                                         
Prostate: Ventral                      Hyperplasia                                                                                  
Salivary Glands                        Atrophy                                                                                      
Spleen                                 Fibrosis                                                                                     
                                       Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Stomach, Forestomach                   Edema                                                                                        
Stomach, Forestomach: Epithelium       Hyperplasia                                                                                  
Stomach, Glandular                     Erosion                                                                                      
Testes: Germinal Epithelium            Atrophy                                                                                      
Testes: Interstitial Cell              Hyperplasia                                                                                  
Thymus                                 Cyst                                                                                         
Thyroid Gland                          Ultimobranchial Cyst                                                                         
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
===============================================================                                                                     
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                   O-NITROTOLUENE 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        13/60 (22%)      14/60 (23%)      9/60 (15%)                                                         | 
|POLY-3 RATE (b)    |        13/54.52         14/43.80         9/25.12                                                            | 
|POLY-3 PERCENT (g) |        23.8%            32.0%            35.8%                                                              | 
|TERMINAL (d)       |        9/39 (23%)       2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        640              419              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.009 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.156          P=0.251          P=0.225                                                            | 
|POLY 1.5           |        P=0.443          P=0.350          P=0.523                                                            | 
|POLY 6             |        P=0.024 *        P=0.141          P=0.053                                                            | 
|LOGISTIC REGRESSION|        P=0.505N         P=0.451          P=0.456                                                            | 
|COCH-ARM / FISHERS |        P=0.194N         P=0.500          P=0.240N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Fatty                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        16/60 (27%)      14/60 (23%)      12/60 (20%)                                                        | 
|POLY-3 RATE (b)    |        16/54.85         14/42.46         12/26.34                                                           | 
|POLY-3 PERCENT (g) |        29.2%            33.0%            45.6%                                                              | 
|TERMINAL (d)       |        13/39 (33%)      2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              502              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.015 *        P<0.001 **                                                         | 
|POLY 3             |        P=0.124          P=0.428          P=0.134                                                            | 
|POLY 1.5           |        P=0.387          P=0.562          P=0.423                                                            | 
|POLY 6             |        P=0.018 *        P=0.265          P=0.020 *                                                          | 
|LOGISTIC REGRESSION|        P=0.133          P=0.428          P=0.171                                                            | 
|COCH-ARM / FISHERS |        P=0.233N         P=0.417N         P=0.259N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia Diffuse                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        0/60 (0%)        2/60 (3%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          0/38.63          2/20.85                                                            | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             9.6%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              ---              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.049 *        (e)              P=0.143                                                            | 
|POLY 3             |        P=0.084          (e)              P=0.106                                                            | 
|POLY 1.5           |        P=0.065          (e)              P=0.147                                                            | 
|POLY 6             |        P=0.173          (e)              P=0.077                                                            | 
|LOGISTIC REGRESSION|        P=0.352          (e)              P=0.852                                                            | 
|COCH-ARM / FISHERS |        P=0.092          (e)              P=0.248                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/60 (10%)       4/60 (7%)        6/60 (10%)                                                         | 
|POLY-3 RATE (b)    |        6/53.85          4/39.90          6/23.27                                                            | 
|POLY-3 PERCENT (g) |        11.1%            10.0%            25.8%                                                              | 
|TERMINAL (d)       |        6/39 (15%)       0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          531              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.282          P<0.001 **                                                         | 
|POLY 3             |        P=0.159          P=0.564N         P=0.132                                                            | 
|POLY 1.5           |        P=0.277          P=0.482N         P=0.298                                                            | 
|POLY 6             |        P=0.086          P=0.585          P=0.042 *                                                          | 
|LOGISTIC REGRESSION|        P=0.304          P=0.627N         P=0.393                                                            | 
|COCH-ARM / FISHERS |        P=0.542          P=0.372N         P=0.619N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/60 (5%)        3/60 (5%)        2/60 (3%)                                                          | 
|POLY-3 RATE (b)    |        3/54.09          3/39.00          2/20.56                                                            | 
|POLY-3 PERCENT (g) |        5.6%             7.7%             9.7%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        674              658              485                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.009 **       P=0.194          P=0.076                                                            | 
|POLY 3             |        P=0.374          P=0.505          P=0.459                                                            | 
|POLY 1.5           |        P=0.530          P=0.573          P=0.626                                                            | 
|POLY 6             |        P=0.237          P=0.410          P=0.294                                                            | 
|LOGISTIC REGRESSION|        P=0.305          P=0.397          P=0.682                                                            | 
|COCH-ARM / FISHERS |        P=0.419N         P=0.660N         P=0.500N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/60 (12%)       3/60 (5%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        7/54.16          3/39.44          1/19.92                                                            | 
|POLY-3 PERCENT (g) |        12.9%            7.6%             5.0%                                                               | 
|TERMINAL (d)       |        5/39 (13%)       0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        674              499              540                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.327          P=0.544          P=0.338                                                            | 
|POLY 3             |        P=0.203N         P=0.318N         P=0.328N                                                           | 
|POLY 1.5           |        P=0.084N         P=0.243N         P=0.146N                                                           | 
|POLY 6             |        P=0.430N         P=0.438N         P=0.579N                                                           | 
|LOGISTIC REGRESSION|        P=0.350N         P=0.365N         P=0.744N                                                           | 
|COCH-ARM / FISHERS |        P=0.023N*        P=0.161N         P=0.031N*                                                          | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/60 (3%)        37/60 (62%)      33/60 (55%)                                                        | 
|POLY-3 RATE (b)    |        2/53.85          37/52.90         33/41.18                                                           | 
|POLY-3 PERCENT (g) |        3.7%             69.9%            80.1%                                                              | 
|TERMINAL (d)       |        2/39 (5%)        4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          260              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/60 (10%)       2/60 (3%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        6/55.95          2/39.16          1/19.86                                                            | 
|POLY-3 PERCENT (g) |        10.7%            5.1%             5.0%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              658              567                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.641          P=0.410N         P=0.692                                                            | 
|POLY 3             |        P=0.229N         P=0.282N         P=0.405N                                                           | 
|POLY 1.5           |        P=0.111N         P=0.212N         P=0.211N                                                           | 
|POLY 6             |        P=0.418N         P=0.391N         P=0.624                                                            | 
|LOGISTIC REGRESSION|        P=0.025N*        P=0.053N         P=0.016N*                                                          | 
|COCH-ARM / FISHERS |        P=0.040N*        P=0.136N         P=0.057N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hydrocephalus                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/60 (5%)        2/60 (3%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        3/54.87          2/38.89          1/19.71                                                            | 
|POLY-3 PERCENT (g) |        5.5%             5.1%             5.1%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              658              621                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.194          P=0.549          P=0.395                                                            | 
|POLY 3             |        P=0.599N         P=0.650N         P=0.659N                                                           | 
|POLY 1.5           |        P=0.419N         P=0.588N         P=0.513N                                                           | 
|POLY 6             |        P=0.523          P=0.611          P=0.523                                                            | 
|LOGISTIC REGRESSION|        P=0.524N         P=0.493N         P=0.455N                                                           | 
|COCH-ARM / FISHERS |        P=0.240N         P=0.500N         P=0.309N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Atypia Cellular                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        39/60 (65%)      24/60 (40%)      28/58 (48%)                                                        | 
|POLY-3 RATE (b)    |        39/57.69         24/46.73         28/38.71                                                           | 
|POLY-3 PERCENT (g) |        67.6%            51.4%            72.3%                                                              | 
|TERMINAL (d)       |        25/39 (64%)      5/11 (46%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              420              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.056          P<0.001 **                                                         | 
|POLY 3             |        P=0.435          P=0.060N         P=0.389                                                            | 
|POLY 1.5           |        P=0.325N         P=0.022N*        P=0.375N                                                           | 
|POLY 6             |        P=0.106          P=0.184N         P=0.064                                                            | 
|LOGISTIC REGRESSION|        P=0.087N         P=0.025N*        P=0.029N*                                                          | 
|COCH-ARM / FISHERS |        P=0.070N         P=0.005N**       P=0.050N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        2/60 (3%)        0/58 (0%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          2/39.12          0/18.38                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.1%             0.0%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              658              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.239          P=0.104          (e)                                                                | 
|POLY 3             |        P=0.350          P=0.175          (e)                                                                | 
|POLY 1.5           |        P=0.519          P=0.200          (e)                                                                | 
|POLY 6             |        P=0.167          P=0.146          (e)                                                                | 
|LOGISTIC REGRESSION|        P=0.604          P=0.196          (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.622N         P=0.248          (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        40/60 (67%)      39/60 (65%)      46/60 (77%)                                                        | 
|POLY-3 RATE (b)    |        40/57.01         39/50.36         46/49.91                                                           | 
|POLY-3 PERCENT (g) |        70.2%            77.5%            92.2%                                                              | 
|TERMINAL (d)       |        27/39 (69%)      10/11 (91%)      0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              275              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.250          P=0.002 **                                                         | 
|POLY 1.5           |        P=0.010 *        P=0.414          P=0.013 *                                                          | 
|POLY 6             |        P<0.001 **       P=0.094          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.003 **       P=0.244          P=0.022 *                                                          | 
|COCH-ARM / FISHERS |        P=0.121          P=0.500N         P=0.156                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        4/60 (7%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        1/53.85          4/39.86          1/20.00                                                            | 
|POLY-3 PERCENT (g) |        1.9%             10.0%            5.0%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          589              501                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.037 *        P=0.032 *        P=0.365                                                            | 
|POLY 3             |        P=0.191          P=0.104          P=0.522                                                            | 
|POLY 1.5           |        P=0.377          P=0.132          P=0.630                                                            | 
|POLY 6             |        P=0.062          P=0.074          P=0.407                                                            | 
|LOGISTIC REGRESSION|        P=0.509          P=0.148          P=0.806                                                            | 
|COCH-ARM / FISHERS |        P=0.540N         P=0.182          P=0.752N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/60 (3%)        2/60 (3%)        10/60 (17%)                                                        | 
|POLY-3 RATE (b)    |        2/54.06          2/39.49          10/27.60                                                           | 
|POLY-3 PERCENT (g) |        3.7%             5.1%             36.2%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        674              537              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.424          P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.575          P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.627          P=0.002 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.501          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.313          P=0.696N         P=0.556N                                                           | 
|COCH-ARM / FISHERS |        P=0.004 **       P=0.691N         P=0.015 *                                                          | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        0/60 (0%)        11/60 (18%)                                                        | 
|POLY-3 RATE (b)    |        1/53.85          0/38.63          11/28.01                                                           | 
|POLY-3 PERCENT (g) |        1.9%             0.0%             39.3%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          ---              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.750N         P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.565N         P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.537N         P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.601N         P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.043 *        (e)              P=0.508                                                            | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500N         P=0.002 **                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        1/60 (2%)        2/60 (3%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          1/38.85          2/20.63                                                            | 
|POLY-3 PERCENT (g) |        0.0%             2.6%             9.7%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              670              464                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.011 *        P=0.349          P=0.086                                                            | 
|POLY 3             |        P=0.072          P=0.436          P=0.105                                                            | 
|POLY 1.5           |        P=0.084          P=0.463          P=0.146                                                            | 
|POLY 6             |        P=0.085          P=0.400          P=0.077                                                            | 
|LOGISTIC REGRESSION|        P=0.183          P=0.469          P=0.449                                                            | 
|COCH-ARM / FISHERS |        P=0.161          P=0.500          P=0.248                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hydronephrosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        0/60 (0%)        3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          0/38.63          3/21.15                                                            | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             14.2%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              ---              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.004 **                                                         | 
|POLY 3             |        P=0.026 *        (e)              P=0.034 *                                                          | 
|POLY 1.5           |        P=0.019 *        (e)              P=0.056                                                            | 
|POLY 6             |        P=0.064          (e)              P=0.021 *                                                          | 
|LOGISTIC REGRESSION|        P=0.095          (e)              P=0.307                                                            | 
|COCH-ARM / FISHERS |        P=0.033 *        (e)              P=0.122                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        2/60 (3%)        4/60 (7%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          2/38.89          4/21.75                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.1%             18.4%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              658              464                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.068          P=0.002 **                                                         | 
|POLY 3             |        P=0.007 **       P=0.174          P=0.011 *                                                          | 
|POLY 1.5           |        P=0.012 *        P=0.199          P=0.022 *                                                          | 
|POLY 6             |        P=0.006 **       P=0.145          P=0.006 **                                                         | 
|LOGISTIC REGRESSION|        P=0.020 *        P=0.132          P=0.096                                                            | 
|COCH-ARM / FISHERS |        P=0.043 *        P=0.248          P=0.059                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        56/60 (93%)      60/60 (100%)     60/60 (100%)                                                       | 
|POLY-3 RATE (b)    |        56/59.40         60/60.00         60/60.00                                                           | 
|POLY-3 PERCENT (g) |        94.3%            100.0%           100.0%                                                             | 
|TERMINAL (d)       |        37/39 (95%)      11/11 (100%)     0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              260              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.032 *        P=0.077          P=0.077                                                            | 
|POLY 1.5           |        P=0.028 *        P=0.068          P=0.068                                                            | 
|POLY 6             |        P=0.043 *        P=0.098          P=0.098                                                            | 
|LOGISTIC REGRESSION|        P=0.085          P=0.093          P=0.338                                                            | 
|COCH-ARM / FISHERS |        P=0.027 *        P=0.059          P=0.059                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/60 (5%)        2/60 (3%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        3/54.07          2/38.94          1/20.03                                                            | 
|POLY-3 PERCENT (g) |        5.6%             5.1%             5.0%                                                               | 
|TERMINAL (d)       |        2/39 (5%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        673              658              485                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.155          P=0.430          P=0.404                                                            | 
|POLY 3             |        P=0.588N         P=0.643N         P=0.652N                                                           | 
|POLY 1.5           |        P=0.412N         P=0.584N         P=0.507N                                                           | 
|POLY 6             |        P=0.535          P=0.622          P=0.532                                                            | 
|LOGISTIC REGRESSION|        P=0.681          P=0.650          P=0.735N                                                           | 
|COCH-ARM / FISHERS |        P=0.240N         P=0.500N         P=0.309N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        2/60 (3%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        1/54.15          2/40.12          1/19.92                                                            | 
|POLY-3 PERCENT (g) |        1.9%             5.0%             5.0%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        649              420              540                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.355          P=0.414          P=0.336                                                            | 
|POLY 3             |        P=0.337          P=0.398          P=0.520                                                            | 
|POLY 1.5           |        P=0.454          P=0.441          P=0.629                                                            | 
|POLY 6             |        P=0.237          P=0.340          P=0.405                                                            | 
|LOGISTIC REGRESSION|        P=0.286N         P=0.691N         P=0.875                                                            | 
|COCH-ARM / FISHERS |        P=0.613N         P=0.500          P=0.752N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        0/60 (0%)        2/60 (3%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          0/38.63          2/21.06                                                            | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             9.5%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              ---              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.074          (e)              P=0.200                                                            | 
|POLY 3             |        P=0.083          (e)              P=0.106                                                            | 
|POLY 1.5           |        P=0.065          (e)              P=0.148                                                            | 
|POLY 6             |        P=0.170          (e)              P=0.077                                                            | 
|LOGISTIC REGRESSION|        P=0.384          (e)              P=0.994                                                            | 
|COCH-ARM / FISHERS |        P=0.092          (e)              P=0.248                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/60 (8%)        18/60 (30%)      6/60 (10%)                                                         | 
|POLY-3 RATE (b)    |        5/54.15          18/43.30         6/23.35                                                            | 
|POLY-3 PERCENT (g) |        9.2%             41.6%            25.7%                                                              | 
|TERMINAL (d)       |        3/39 (8%)        5/11 (46%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        673              523              391                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.004 **       P<0.001 **       P=0.089                                                            | 
|POLY 1.5           |        P=0.086          P<0.001 **       P=0.213                                                            | 
|POLY 6             |        P<0.001 **       P<0.001 **       P=0.028 *                                                          | 
|LOGISTIC REGRESSION|        P=0.131          P<0.001 **       P=0.486                                                            | 
|COCH-ARM / FISHERS |        P=0.493N         P=0.002 **       P=0.500                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Transitional Epithelium                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        2/60 (3%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        1/53.85          2/39.35          1/19.92                                                            | 
|POLY-3 PERCENT (g) |        1.9%             5.1%             5.0%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          595              540                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.094          P=0.247          P=0.314                                                            | 
|POLY 3             |        P=0.335          P=0.394          P=0.521                                                            | 
|POLY 1.5           |        P=0.454          P=0.438          P=0.630                                                            | 
|POLY 6             |        P=0.234          P=0.336          P=0.406                                                            | 
|LOGISTIC REGRESSION|        P=0.538          P=0.480          P=0.715                                                            | 
|COCH-ARM / FISHERS |        P=0.613N         P=0.500          P=0.752N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        3/60 (5%)        2/60 (3%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          3/39.98          2/20.85                                                            | 
|POLY-3 PERCENT (g) |        0.0%             7.5%             9.6%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              502              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.042 *        P=0.054          P=0.151                                                            | 
|POLY 3             |        P=0.046 *        P=0.076          P=0.106                                                            | 
|POLY 1.5           |        P=0.096          P=0.092          P=0.147                                                            | 
|POLY 6             |        P=0.021 *        P=0.058          P=0.077                                                            | 
|LOGISTIC REGRESSION|        P=0.602          P=0.209          P=0.756                                                            | 
|COCH-ARM / FISHERS |        P=0.266          P=0.122          P=0.248                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        0/60 (0%)        3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        1/53.94          0/38.63          3/21.43                                                            | 
|POLY-3 PERCENT (g) |        1.9%             0.0%             14.0%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        707              ---              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.011 *        P=0.701N         P=0.027 *                                                          | 
|POLY 3             |        P=0.114          P=0.565N         P=0.096                                                            | 
|POLY 1.5           |        P=0.105          P=0.537N         P=0.161                                                            | 
|POLY 6             |        P=0.180          P=0.602N         P=0.055                                                            | 
|LOGISTIC REGRESSION|        P=0.325          P=0.630N         P=0.615                                                            | 
|COCH-ARM / FISHERS |        P=0.153          P=0.500N         P=0.309                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        38/60 (63%)      31/60 (52%)      17/60 (28%)                                                        | 
|POLY-3 RATE (b)    |        38/54.87         31/47.22         17/30.44                                                           | 
|POLY-3 PERCENT (g) |        69.3%            65.7%            55.9%                                                              | 
|TERMINAL (d)       |        34/39 (87%)      8/11 (73%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              260              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.133N         P=0.425N         P=0.147N                                                           | 
|POLY 1.5           |        P=0.009N**       P=0.277N         P=0.010N*                                                          | 
|POLY 6             |        P=0.482          P=0.559          P=0.526                                                            | 
|LOGISTIC REGRESSION|        P=0.374N         P=0.424          P=0.592N                                                           | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.134N         P<0.001N**                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        29/60 (48%)      30/60 (50%)      34/60 (57%)                                                        | 
|POLY-3 RATE (b)    |        29/54.06         30/48.25         34/42.40                                                           | 
|POLY-3 PERCENT (g) |        53.6%            62.2%            80.2%                                                              | 
|TERMINAL (d)       |        26/39 (67%)      9/11 (82%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        705              370              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.002 **       P=0.240          P=0.003 **                                                         | 
|POLY 1.5           |        P=0.022 *        P=0.337          P=0.026 *                                                          | 
|POLY 6             |        P<0.001 **       P=0.136          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.018 *        P=0.118          P=0.027 *                                                          | 
|COCH-ARM / FISHERS |        P=0.202          P=0.500          P=0.232                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/60 (5%)        6/60 (10%)       3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        3/53.85          6/39.38          3/20.96                                                            | 
|POLY-3 PERCENT (g) |        5.6%             15.2%            14.3%                                                              | 
|TERMINAL (d)       |        3/39 (8%)        4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          569              547                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.005 **       P=0.003 **                                                         | 
|POLY 3             |        P=0.114          P=0.117          P=0.261                                                            | 
|POLY 1.5           |        P=0.284          P=0.164          P=0.418                                                            | 
|POLY 6             |        P=0.029 *        P=0.070          P=0.141                                                            | 
|LOGISTIC REGRESSION|        P=0.025 *        P=0.039 *        P=0.197                                                            | 
|COCH-ARM / FISHERS |        P=0.529N         P=0.245          P=0.660N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/60 (12%)       15/60 (25%)      13/60 (22%)                                                        | 
|POLY-3 RATE (b)    |        7/53.98          15/42.08         13/26.74                                                           | 
|POLY-3 PERCENT (g) |        13.0%            35.7%            48.6%                                                              | 
|TERMINAL (d)       |        5/39 (13%)       4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        705              569              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.007 **       P<0.001 **                                                         | 
|POLY 1.5           |        P=0.006 **       P=0.017 *        P=0.010 *                                                          | 
|POLY 6             |        P<0.001 **       P=0.002 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.004 **       P=0.002 **                                                         | 
|COCH-ARM / FISHERS |        P=0.139          P=0.049 *        P=0.110                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        2/60 (3%)        0/60 (0%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          2/39.46          0/19.33                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.1%             0.0%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              523              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.459          P=0.144          (e)                                                                | 
|POLY 3             |        P=0.360          P=0.177          (e)                                                                | 
|POLY 1.5           |        P=0.529          P=0.201          (e)                                                                | 
|POLY 6             |        P=0.172          P=0.148          (e)                                                                | 
|LOGISTIC REGRESSION|        P=0.668N         P=0.316          (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.613N         P=0.248          (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        11/60 (18%)      6/60 (10%)                                                         | 
|POLY-3 RATE (b)    |        0/53.85          11/43.80         6/22.67                                                            | 
|POLY-3 PERCENT (g) |        0.0%             25.1%            26.5%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              260              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 1.5           |        P=0.003 **       P<0.001 **       P=0.003 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.422          P=0.013 *        P=0.011 *                                                          | 
|COCH-ARM / FISHERS |        P=0.090          P<0.001 **       P=0.014 *                                                          | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/60 (3%)        2/60 (3%)        0/60 (0%)                                                          | 
|POLY-3 RATE (b)    |        2/53.85          2/39.41          0/19.33                                                            | 
|POLY-3 PERCENT (g) |        3.7%             5.1%             0.0%                                                               | 
|TERMINAL (d)       |        2/39 (5%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          499              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.623          P=0.362          P=1.000N                                                           | 
|POLY 3             |        P=0.542N         P=0.576          P=0.485N                                                           | 
|POLY 1.5           |        P=0.333N         P=0.628          P=0.373N                                                           | 
|POLY 6             |        P=0.578          P=0.501          P=0.603N                                                           | 
|LOGISTIC REGRESSION|        P=0.427N         P=0.677          (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.173N         P=0.691N         P=0.248N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/60 (8%)        10/60 (17%)      4/60 (7%)                                                          | 
|POLY-3 RATE (b)    |        5/54.30          10/41.36         4/21.85                                                            | 
|POLY-3 PERCENT (g) |        9.2%             24.2%            18.3%                                                              | 
|TERMINAL (d)       |        3/39 (8%)        3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        649              555              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.003 **       P=0.003 **                                                         | 
|POLY 3             |        P=0.085          P=0.043 *        P=0.273                                                            | 
|POLY 1.5           |        P=0.304          P=0.072          P=0.473                                                            | 
|POLY 6             |        P=0.009 **       P=0.020 *        P=0.124                                                            | 
|LOGISTIC REGRESSION|        P=0.346          P=0.071          P=0.613                                                            | 
|COCH-ARM / FISHERS |        P=0.369N         P=0.135          P=0.500N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        15/60 (25%)      33/60 (55%)                                                        | 
|POLY-3 RATE (b)    |        1/53.85          15/45.26         33/40.91                                                           | 
|POLY-3 PERCENT (g) |        1.9%             33.1%            80.7%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          370              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.002 **       P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/60 (8%)        12/60 (20%)      8/60 (13%)                                                         | 
|POLY-3 RATE (b)    |        5/53.85          12/42.23         8/24.64                                                            | 
|POLY-3 PERCENT (g) |        9.3%             28.4%            32.5%                                                              | 
|TERMINAL (d)       |        5/39 (13%)       2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          499              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.006 **       P=0.014 *        P=0.022 *                                                          | 
|POLY 1.5           |        P=0.047 *        P=0.026 *        P=0.075                                                            | 
|POLY 6             |        P<0.001 **       P=0.006 **       P=0.005 **                                                         | 
|LOGISTIC REGRESSION|        P=0.110          P=0.026 *        P=0.189                                                            | 
|COCH-ARM / FISHERS |        P=0.331          P=0.057          P=0.279                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/60 (5%)        2/60 (3%)        3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        3/54.55          2/39.14          3/21.22                                                            | 
|POLY-3 PERCENT (g) |        5.5%             5.1%             14.1%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              595              471                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.019 *        P=0.525          P=0.055                                                            | 
|POLY 3             |        P=0.278          P=0.645N         P=0.261                                                            | 
|POLY 1.5           |        P=0.372          P=0.585N         P=0.417                                                            | 
|POLY 6             |        P=0.222          P=0.620          P=0.142                                                            | 
|LOGISTIC REGRESSION|        P=0.551          P=0.507N         P=0.738N                                                           | 
|COCH-ARM / FISHERS |        P=0.581          P=0.500N         P=0.660N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        53/60 (88%)      6/60 (10%)       1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        53/58.86         6/39.55          1/20.18                                                            | 
|POLY-3 PERCENT (g) |        90.1%            15.2%            5.0%                                                               | 
|TERMINAL (d)       |        35/39 (90%)      3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              595              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002N**       P<0.001N**       P=0.361N                                                           | 
|POLY 3             |        P<0.001N**       P<0.001N**       P<0.001N**                                                         | 
|POLY 1.5           |        P<0.001N**       P<0.001N**       P<0.001N**                                                         | 
|POLY 6             |        P<0.001N**       P<0.001N**       P<0.001N**                                                         | 
|LOGISTIC REGRESSION|        P<0.001N**       P<0.001N**       P<0.001N**                                                         | 
|COCH-ARM / FISHERS |        P<0.001N**       P<0.001N**       P<0.001N**                                                         | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        9/60 (15%)       3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        1/53.86          9/41.86          3/21.34                                                            | 
|POLY-3 PERCENT (g) |        1.9%             21.5%            14.1%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        727              420              417                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P=0.026 *                                                          | 
|POLY 3             |        P=0.012 *        P=0.002 **       P=0.096                                                            | 
|POLY 1.5           |        P=0.083          P=0.004 **       P=0.161                                                            | 
|POLY 6             |        P<0.001 **       P<0.001 **       P=0.055                                                            | 
|LOGISTIC REGRESSION|        P=0.450          P=0.016 *        P=0.456                                                            | 
|COCH-ARM / FISHERS |        P=0.435          P=0.008 **       P=0.309                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/60 (7%)        1/60 (2%)        6/60 (10%)                                                         | 
|POLY-3 RATE (b)    |        4/54.62          1/39.26          6/24.22                                                            | 
|POLY-3 PERCENT (g) |        7.3%             2.6%             24.8%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        640              523              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       P=0.437N         P=0.008 **                                                         | 
|POLY 3             |        P=0.089          P=0.296N         P=0.059                                                            | 
|POLY 1.5           |        P=0.122          P=0.242N         P=0.146                                                            | 
|POLY 6             |        P=0.075          P=0.381N         P=0.018 *                                                          | 
|LOGISTIC REGRESSION|        P=0.350N         P=0.133N         P=0.196N                                                           | 
|COCH-ARM / FISHERS |        P=0.232          P=0.182N         P=0.372                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Kupffer Cell                                                                                                              | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/60 (7%)        0/60 (0%)        2/60 (3%)                                                          | 
|POLY-3 RATE (b)    |        4/54.70          0/38.63          2/20.94                                                            | 
|POLY-3 PERCENT (g) |        7.3%             0.0%             9.6%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              ---              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.381          P=0.213N         P=0.338                                                            | 
|POLY 3             |        P=0.452N         P=0.121N         P=0.550                                                            | 
|POLY 1.5           |        P=0.382N         P=0.091N         P=0.584N                                                           | 
|POLY 6             |        P=0.489N         P=0.174N         P=0.351                                                            | 
|LOGISTIC REGRESSION|        P=0.166N         P=0.056N         P=0.185N                                                           | 
|COCH-ARM / FISHERS |        P=0.307N         P=0.059N         P=0.340N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        2/60 (3%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          2/38.63          1/20.24                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.2%             4.9%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              729 (T)          316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.034 *        P=0.034 *        P=0.493                                                            | 
|POLY 3             |        P=0.149          P=0.173          P=0.338                                                            | 
|POLY 1.5           |        P=0.234          P=0.199          P=0.402                                                            | 
|POLY 6             |        P=0.088          P=0.143          P=0.281                                                            | 
|LOGISTIC REGRESSION|        P=0.455          P=0.034 *        (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.444          P=0.248          P=0.500                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/60 (5%)        3/60 (5%)        4/60 (7%)                                                          | 
|POLY-3 RATE (b)    |        3/54.48          3/39.29          4/21.81                                                            | 
|POLY-3 PERCENT (g) |        5.5%             7.6%             18.3%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              534              362                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       P=0.262          P=0.015 *                                                          | 
|POLY 3             |        P=0.123          P=0.505          P=0.135                                                            | 
|POLY 1.5           |        P=0.207          P=0.573          P=0.255                                                            | 
|POLY 6             |        P=0.075          P=0.410          P=0.061                                                            | 
|LOGISTIC REGRESSION|        P=0.355          P=0.650          P=0.641                                                            | 
|COCH-ARM / FISHERS |        P=0.427          P=0.660N         P=0.500                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        25/60 (42%)      23/60 (38%)      15/60 (25%)                                                        | 
|POLY-3 RATE (b)    |        25/56.21         23/45.45         15/28.55                                                           | 
|POLY-3 PERCENT (g) |        44.5%            50.6%            52.5%                                                              | 
|TERMINAL (d)       |        16/39 (41%)      4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              419              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.002 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.258          P=0.336          P=0.328                                                            | 
|POLY 1.5           |        P=0.386N         P=0.491          P=0.405N                                                           | 
|POLY 6             |        P=0.028 *        P=0.177          P=0.053                                                            | 
|LOGISTIC REGRESSION|        P=0.506          P=0.436          P=0.608                                                            | 
|COCH-ARM / FISHERS |        P=0.031N*        P=0.426N         P=0.040N*                                                          | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/60 (3%)        15/60 (25%)      29/60 (48%)                                                        | 
|POLY-3 RATE (b)    |        2/53.86          15/42.70         29/39.41                                                           | 
|POLY-3 PERCENT (g) |        3.7%             35.1%            73.6%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        727              420              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P=0.002 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/58 (3%)        1/58 (2%)        0/59 (0%)                                                          | 
|POLY-3 RATE (b)    |        2/51.94          1/38.10          0/19.21                                                            | 
|POLY-3 PERCENT (g) |        3.9%             2.6%             0.0%                                                               | 
|TERMINAL (d)       |        2/38 (5%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          658              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.765          P=0.651          P=1.000N                                                           | 
|POLY 3             |        P=0.392N         P=0.605N         P=0.479N                                                           | 
|POLY 1.5           |        P=0.251N         P=0.561N         P=0.367N                                                           | 
|POLY 6             |        P=0.602N         P=0.663N         P=0.600N                                                           | 
|LOGISTIC REGRESSION|        P=0.661N         P=0.700N         (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.158N         P=0.500N         P=0.244N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/58 (3%)        4/58 (7%)        3/59 (5%)                                                          | 
|POLY-3 RATE (b)    |        2/52.72          4/38.98          3/20.96                                                            | 
|POLY-3 PERCENT (g) |        3.8%             10.3%            14.3%                                                              | 
|TERMINAL (d)       |        1/38 (3%)        2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              502              453                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.008 **       P=0.095          P=0.050                                                            | 
|POLY 3             |        P=0.103          P=0.213          P=0.179                                                            | 
|POLY 1.5           |        P=0.209          P=0.262          P=0.294                                                            | 
|POLY 6             |        P=0.045 *        P=0.157          P=0.098                                                            | 
|LOGISTIC REGRESSION|        P=0.533          P=0.468          P=0.754N                                                           | 
|COCH-ARM / FISHERS |        P=0.476          P=0.340          P=0.508                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/58 (5%)        5/58 (9%)        3/59 (5%)                                                          | 
|POLY-3 RATE (b)    |        3/52.26          5/38.86          3/21.38                                                            | 
|POLY-3 PERCENT (g) |        5.7%             12.9%            14.0%                                                              | 
|TERMINAL (d)       |        2/38 (5%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        640              615              391                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002 **       P=0.043 *        P=0.044 *                                                          | 
|POLY 3             |        P=0.158          P=0.212          P=0.275                                                            | 
|POLY 1.5           |        P=0.320          P=0.268          P=0.434                                                            | 
|POLY 6             |        P=0.058          P=0.149          P=0.149                                                            | 
|LOGISTIC REGRESSION|        P=0.410          P=0.208          P=0.693N                                                           | 
|COCH-ARM / FISHERS |        P=0.540N         P=0.358          P=0.652N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/58 (16%)       5/58 (9%)        5/59 (8%)                                                          | 
|POLY-3 RATE (b)    |        9/52.29          5/39.91          5/22.30                                                            | 
|POLY-3 PERCENT (g) |        17.2%            12.5%            22.4%                                                              | 
|TERMINAL (d)       |        6/38 (16%)       1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        673              370              453                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       P=0.381          P<0.001 **                                                         | 
|POLY 3             |        P=0.519          P=0.373N         P=0.431                                                            | 
|POLY 1.5           |        P=0.415N         P=0.291N         P=0.521N                                                           | 
|POLY 6             |        P=0.335          P=0.501N         P=0.181                                                            | 
|LOGISTIC REGRESSION|        P=0.480N         P=0.266N         P=0.456                                                            | 
|COCH-ARM / FISHERS |        P=0.169N         P=0.197N         P=0.187N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/60 (3%)        4/60 (7%)        9/60 (15%)                                                         | 
|POLY-3 RATE (b)    |        2/54.21          4/40.70          9/24.48                                                            | 
|POLY-3 PERCENT (g) |        3.7%             9.8%             36.8%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        631              370              419                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.126          P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.219          P<0.001 **                                                         | 
|POLY 1.5           |        P=0.002 **       P=0.267          P=0.003 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.162          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.032 *        P=0.595          P=0.009 **                                                         | 
|COCH-ARM / FISHERS |        P=0.015 *        P=0.340          P=0.027 *                                                          | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/60 (10%)       13/60 (22%)      13/60 (22%)                                                        | 
|POLY-3 RATE (b)    |        6/54.93          13/43.19         13/28.14                                                           | 
|POLY-3 PERCENT (g) |        10.9%            30.1%            46.2%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        631              370              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.015 *        P<0.001 **                                                         | 
|POLY 1.5           |        P=0.004 **       P=0.030 *        P=0.006 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.006 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.173          P=0.102          P=0.283                                                            | 
|COCH-ARM / FISHERS |        P=0.080          P=0.066          P=0.066                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        0/60 (0%)        2/59 (3%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          0/38.63          2/20.37                                                            | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             9.8%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              ---              419                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.028 *        (e)              P=0.094                                                            | 
|POLY 3             |        P=0.084          (e)              P=0.103                                                            | 
|POLY 1.5           |        P=0.064          (e)              P=0.144                                                            | 
|POLY 6             |        P=0.173          (e)              P=0.076                                                            | 
|LOGISTIC REGRESSION|        P=0.222          (e)              P=0.551                                                            | 
|COCH-ARM / FISHERS |        P=0.090          (e)              P=0.244                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/60 (3%)        4/60 (7%)        4/59 (7%)                                                          | 
|POLY-3 RATE (b)    |        2/54.46          4/39.99          4/21.49                                                            | 
|POLY-3 PERCENT (g) |        3.7%             10.0%            18.6%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              499              502                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       P=0.103          P=0.014 *                                                          | 
|POLY 3             |        P=0.048 *        P=0.211          P=0.076                                                            | 
|POLY 1.5           |        P=0.104          P=0.261          P=0.148                                                            | 
|POLY 6             |        P=0.021 *        P=0.153          P=0.036 *                                                          | 
|LOGISTIC REGRESSION|        P=0.361          P=0.462          P=0.508                                                            | 
|COCH-ARM / FISHERS |        P=0.299          P=0.340          P=0.332                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        0/60 (0%)        2/59 (3%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          0/38.63          2/20.12                                                            | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             9.9%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              ---              540                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.010 *        (e)              P=0.036 *                                                          | 
|POLY 3             |        P=0.085          (e)              P=0.103                                                            | 
|POLY 1.5           |        P=0.064          (e)              P=0.143                                                            | 
|POLY 6             |        P=0.178          (e)              P=0.075                                                            | 
|LOGISTIC REGRESSION|        P=0.088          (e)              P=0.241                                                            | 
|COCH-ARM / FISHERS |        P=0.090          (e)              P=0.244                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/60 (5%)        0/60 (0%)        0/59 (0%)                                                          | 
|POLY-3 RATE (b)    |        3/54.18          0/38.63          0/19.00                                                            | 
|POLY-3 PERCENT (g) |        5.5%             0.0%             0.0%                                                               | 
|TERMINAL (d)       |        2/39 (5%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        640              ---              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.469N         P=0.352N         P=1.000N                                                           | 
|POLY 3             |        P=0.121N         P=0.192N         P=0.383N                                                           | 
|POLY 1.5           |        P=0.079N         P=0.158N         P=0.252N                                                           | 
|POLY 6             |        P=0.194N         P=0.250N         P=0.537N                                                           | 
|LOGISTIC REGRESSION|        P=0.220N         P=0.200N         P=0.643N                                                           | 
|COCH-ARM / FISHERS |        P=0.061N         P=0.122N         P=0.125N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/16 (0%)        0/18 (0%)        2/16 (13%)                                                         | 
|POLY-3 RATE (b)    |        0/13.11          0/10.69          2/6.39                                                             | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             31.3%                                                              | 
|TERMINAL (d)       |        0/4 (0%)         0/2 (0%)         0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              ---              581                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P<0.001 **                                                         | 
|POLY 3             |        P=0.055          (e)              P=0.105                                                            | 
|POLY 1.5           |        P=0.052          (e)              P=0.148                                                            | 
|POLY 6             |        P=0.066          (e)              P=0.071                                                            | 
|LOGISTIC REGRESSION|        P=0.028 *        (e)              P=0.081                                                            | 
|COCH-ARM / FISHERS |        P=0.083          (e)              P=0.242                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/57 (5%)        3/51 (6%)        1/50 (2%)                                                          | 
|POLY-3 RATE (b)    |        3/53.07          3/32.38          1/16.57                                                            | 
|POLY-3 PERCENT (g) |        5.7%             9.3%             6.0%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              658              567                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.151          P=0.269          P=0.560                                                            | 
|POLY 3             |        P=0.480          P=0.425          P=0.663                                                            | 
|POLY 1.5           |        P=0.531N         P=0.502          P=0.563N                                                           | 
|POLY 6             |        P=0.281          P=0.330          P=0.503                                                            | 
|LOGISTIC REGRESSION|        P=0.538N         P=0.638          P=0.218N                                                           | 
|COCH-ARM / FISHERS |        P=0.281N         P=0.606          P=0.360N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Galactocele                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/57 (4%)        0/51 (0%)        0/50 (0%)                                                          | 
|POLY-3 RATE (b)    |        2/51.98          0/32.12          0/16.04                                                            | 
|POLY-3 PERCENT (g) |        3.9%             0.0%             0.0%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        727              ---              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.705N         P=0.544N         P=1.000N                                                           | 
|POLY 3             |        P=0.254N         P=0.355N         P=0.515N                                                           | 
|POLY 1.5           |        P=0.183N         P=0.314N         P=0.407N                                                           | 
|POLY 6             |        P=0.362N         P=0.413N         P=0.622N                                                           | 
|LOGISTIC REGRESSION|        P=0.693N         P=0.534N         (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.153N         P=0.276N         P=0.281N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/57 (11%)       1/51 (2%)        4/50 (8%)                                                          | 
|POLY-3 RATE (b)    |        6/53.30          1/32.12          4/19.18                                                            | 
|POLY-3 PERCENT (g) |        11.3%            3.1%             20.9%                                                              | 
|TERMINAL (d)       |        2/39 (5%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              729 (T)          391                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.076          P=0.324N         P=0.117                                                            | 
|POLY 3             |        P=0.454          P=0.189N         P=0.293                                                            | 
|POLY 1.5           |        P=0.555          P=0.133N         P=0.498                                                            | 
|POLY 6             |        P=0.371          P=0.284N         P=0.137                                                            | 
|LOGISTIC REGRESSION|        P=0.245N         P=0.078N         P=0.103N                                                           | 
|COCH-ARM / FISHERS |        P=0.439N         P=0.076N         P=0.457N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Accessory Spleen                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/16 (19%)       0/1 (0%)         0/3 (0%)                                                           | 
|POLY-3 RATE (b)    |        3/14.77          0/1.00           0/1.72                                                             | 
|POLY-3 PERCENT (g) |        20.3%            0.0%             0.0%                                                               | 
|TERMINAL (d)       |        2/11 (18%)       0/1 (0%)         0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        586              ---              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.525N         P=0.473N         P=0.889N                                                           | 
|POLY 3             |        P=0.448N         P=0.789N         P=0.623N                                                           | 
|POLY 1.5           |        P=0.375N         P=0.792N         P=0.575N                                                           | 
|POLY 6             |        P=0.588N         P=0.784N         P=0.690N                                                           | 
|LOGISTIC REGRESSION|        P=0.318N         P=0.849N         P=0.510N                                                           | 
|COCH-ARM / FISHERS |        P=0.357N         P=0.824N         P=0.578N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/16 (19%)       0/1 (0%)         0/3 (0%)                                                           | 
|POLY-3 RATE (b)    |        3/14.29          0/1.00           0/1.72                                                             | 
|POLY-3 PERCENT (g) |        21.0%            0.0%             0.0%                                                               | 
|TERMINAL (d)       |        3/11 (27%)       0/1 (0%)         0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          ---              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.876N         P=0.718N         P=1.000N                                                           | 
|POLY 3             |        P=0.440N         P=0.786N         P=0.617N                                                           | 
|POLY 1.5           |        P=0.370N         P=0.791N         P=0.571N                                                           | 
|POLY 6             |        P=0.577N         P=0.778N         P=0.686N                                                           | 
|LOGISTIC REGRESSION|        P=0.876N         (e)              (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.357N         P=0.824N         P=0.578N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        13/16 (81%)      1/1 (100%)       0/3 (0%)                                                           | 
|POLY-3 RATE (b)    |        13/16.00         1/1.00           0/1.72                                                             | 
|POLY-3 PERCENT (g) |        81.3%            100.0%           0.0%                                                               | 
|TERMINAL (d)       |        8/11 (73%)       1/1 (100%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              729 (T)          ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.249N         P=0.231N         P=0.681N                                                           | 
|POLY 3             |        P=0.108N         P=0.796          P=0.106N                                                           | 
|POLY 1.5           |        P=0.021N*        P=0.796          P=0.033N*                                                          | 
|POLY 6             |        P=0.513N         P=0.796          P=0.336N                                                           | 
|LOGISTIC REGRESSION|        P=0.021N*        P=0.231N         P=0.028N*                                                          | 
|COCH-ARM / FISHERS |        P=0.011N*        P=0.824          P=0.021N*                                                          | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/60 (15%)       14/60 (23%)      5/60 (8%)                                                          | 
|POLY-3 RATE (b)    |        9/54.19          14/44.17         5/22.72                                                            | 
|POLY-3 PERCENT (g) |        16.6%            31.7%            22.0%                                                              | 
|TERMINAL (d)       |        6/39 (15%)       3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        691              370              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.002 **       P=0.003 **                                                         | 
|POLY 3             |        P=0.162          P=0.062          P=0.420                                                            | 
|POLY 1.5           |        P=0.505          P=0.101          P=0.533N                                                           | 
|POLY 6             |        P=0.017 *        P=0.028 *        P=0.176                                                            | 
|LOGISTIC REGRESSION|        P=0.225N         P=0.234          P=0.692                                                            | 
|COCH-ARM / FISHERS |        P=0.139N         P=0.177          P=0.197N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/60 (15%)       10/60 (17%)      2/60 (3%)                                                          | 
|POLY-3 RATE (b)    |        9/54.34          10/41.18         2/20.80                                                            | 
|POLY-3 PERCENT (g) |        16.6%            24.3%            9.6%                                                               | 
|TERMINAL (d)       |        6/39 (15%)       3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        663              419              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.014 *        P=0.013 *        P=0.141                                                            | 
|POLY 3             |        P=0.574          P=0.251          P=0.371N                                                           | 
|POLY 1.5           |        P=0.208N         P=0.350          P=0.154N                                                           | 
|POLY 6             |        P=0.167          P=0.142          P=0.558                                                            | 
|LOGISTIC REGRESSION|        P=0.328N         P=0.272          P=0.330N                                                           | 
|COCH-ARM / FISHERS |        P=0.024N*        P=0.500          P=0.027N*                                                          | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/60 (10%)       7/60 (12%)       3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        6/54.35          7/40.25          3/21.51                                                            | 
|POLY-3 PERCENT (g) |        11.0%            17.4%            14.0%                                                              | 
|TERMINAL (d)       |        4/39 (10%)       2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        631              567              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       P=0.041 *        P=0.042 *                                                          | 
|POLY 3             |        P=0.338          P=0.283          P=0.513                                                            | 
|POLY 1.5           |        P=0.525N         P=0.370          P=0.529N                                                           | 
|POLY 6             |        P=0.114          P=0.184          P=0.281                                                            | 
|LOGISTIC REGRESSION|        P=0.569N         P=0.282          P=0.403N                                                           | 
|COCH-ARM / FISHERS |        P=0.192N         P=0.500          P=0.245N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/60 (3%)        0/60 (0%)        0/60 (0%)                                                          | 
|POLY-3 RATE (b)    |        2/53.95          0/38.63          0/19.33                                                            | 
|POLY-3 PERCENT (g) |        3.7%             0.0%             0.0%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        705              ---              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.674N         P=0.515N         P=1.000N                                                           | 
|POLY 3             |        P=0.221N         P=0.319N         P=0.486N                                                           | 
|POLY 1.5           |        P=0.159N         P=0.282N         P=0.373N                                                           | 
|POLY 6             |        P=0.319N         P=0.374N         P=0.604N                                                           | 
|LOGISTIC REGRESSION|        P=0.530N         P=0.422N         P=0.975N                                                           | 
|COCH-ARM / FISHERS |        P=0.137N         P=0.248N         P=0.248N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        11/60 (18%)      11/60 (18%)      9/60 (15%)                                                         | 
|POLY-3 RATE (b)    |        11/54.55         11/41.89         9/24.84                                                            | 
|POLY-3 PERCENT (g) |        20.2%            26.3%            36.2%                                                              | 
|TERMINAL (d)       |        9/39 (23%)       3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              420              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.019 *        P<0.001 **                                                         | 
|POLY 3             |        P=0.104          P=0.323          P=0.132                                                            | 
|POLY 1.5           |        P=0.313          P=0.434          P=0.365                                                            | 
|POLY 6             |        P=0.018 *        P=0.195          P=0.027 *                                                          | 
|LOGISTIC REGRESSION|        P=0.311          P=0.422          P=0.364                                                            | 
|COCH-ARM / FISHERS |        P=0.356N         P=0.593N         P=0.404N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        6/60 (10%)       3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        1/53.85          6/39.76          3/21.04                                                            | 
|POLY-3 PERCENT (g) |        1.9%             15.1%            14.3%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          502              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.002 **       P=0.002 **                                                         | 
|POLY 3             |        P=0.026 *        P=0.022 *        P=0.095                                                            | 
|POLY 1.5           |        P=0.096          P=0.034 *        P=0.160                                                            | 
|POLY 6             |        P=0.004 **       P=0.012 *        P=0.054                                                            | 
|LOGISTIC REGRESSION|        P=0.065          P=0.018 *        P=0.284                                                            | 
|COCH-ARM / FISHERS |        P=0.366          P=0.057          P=0.309                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Peritoneum: Mesothelium                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/3 (33%)        3/47 (6%)        0/54 (0%)                                                          | 
|POLY-3 RATE (b)    |        1/3.00           3/30.85          0/16.55                                                            | 
|POLY-3 PERCENT (g) |        33.3%            9.7%             0.0%                                                               | 
|TERMINAL (d)       |        1/3 (33%)        0/10 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          684              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.232          P=0.155          P=1.000N                                                           | 
|POLY 3             |        P=0.078N         P=0.371N         P=0.045N*                                                          | 
|POLY 1.5           |        P=0.029N*        P=0.327N         P=0.016N*                                                          | 
|POLY 6             |        P=0.269N         P=0.453N         P=0.266N                                                           | 
|LOGISTIC REGRESSION|        P=0.544N         P=0.559N         (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.019N*        P=0.226N         P=0.053N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/59 (5%)        4/57 (7%)        4/59 (7%)                                                          | 
|POLY-3 RATE (b)    |        3/53.10          4/38.39          4/22.02                                                            | 
|POLY-3 PERCENT (g) |        5.7%             10.4%            18.2%                                                              | 
|TERMINAL (d)       |        3/39 (8%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          592              391                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.088          P=0.019 *                                                          | 
|POLY 3             |        P=0.104          P=0.331          P=0.141                                                            | 
|POLY 1.5           |        P=0.201          P=0.393          P=0.262                                                            | 
|POLY 6             |        P=0.049 *        P=0.252          P=0.065                                                            | 
|LOGISTIC REGRESSION|        P=0.420          P=0.315          P=0.717                                                            | 
|COCH-ARM / FISHERS |        P=0.453          P=0.481          P=0.500                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/59 (3%)        3/57 (5%)        6/59 (10%)                                                         | 
|POLY-3 RATE (b)    |        2/53.10          3/38.82          6/22.92                                                            | 
|POLY-3 PERCENT (g) |        3.8%             7.7%             26.2%                                                              | 
|TERMINAL (d)       |        2/39 (5%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          370              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.195          P<0.001 **                                                         | 
|POLY 3             |        P=0.012 *        P=0.362          P=0.013 *                                                          | 
|POLY 1.5           |        P=0.025 *        P=0.414          P=0.037 *                                                          | 
|POLY 6             |        P=0.007 **       P=0.292          P=0.004 **                                                         | 
|LOGISTIC REGRESSION|        P=0.237          P=0.623          P=0.197                                                            | 
|COCH-ARM / FISHERS |        P=0.093          P=0.484          P=0.136                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/59 (2%)        1/57 (2%)        42/59 (71%)                                                        | 
|POLY-3 RATE (b)    |        1/53.11          1/38.31          42/49.79                                                           | 
|POLY-3 PERCENT (g) |        1.9%             2.6%             84.4%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        727              275              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.628          P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.683          P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.715          P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.632          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.515N         P=0.002 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.743          P<0.001 **                                                         | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/59 (15%)       9/57 (16%)       15/59 (25%)                                                        | 
|POLY-3 RATE (b)    |        9/54.07          9/39.84          15/28.59                                                           | 
|POLY-3 PERCENT (g) |        16.7%            22.6%            52.5%                                                              | 
|TERMINAL (d)       |        5/39 (13%)       3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        555              523              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.044 *        P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.326          P<0.001 **                                                         | 
|POLY 1.5           |        P=0.008 **       P=0.426          P=0.011 *                                                          | 
|POLY 6             |        P<0.001 **       P=0.207          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.029 *        P=0.446          P=0.083                                                            | 
|COCH-ARM / FISHERS |        P=0.089          P=0.570          P=0.126                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/59 (0%)        1/57 (2%)        2/59 (3%)                                                          | 
|POLY-3 RATE (b)    |        0/53.10          1/37.70          2/20.12                                                            | 
|POLY-3 PERCENT (g) |        0.0%             2.7%             9.9%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              637              540                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       P=0.380          P=0.046 *                                                          | 
|POLY 3             |        P=0.072          P=0.433          P=0.104                                                            | 
|POLY 1.5           |        P=0.085          P=0.459          P=0.146                                                            | 
|POLY 6             |        P=0.087          P=0.398          P=0.076                                                            | 
|LOGISTIC REGRESSION|        P=0.130          P=0.531          P=0.248                                                            | 
|COCH-ARM / FISHERS |        P=0.163          P=0.491          P=0.248                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/60 (12%)       38/60 (63%)      54/59 (92%)                                                        | 
|POLY-3 RATE (b)    |        7/54.53          38/51.02         54/55.43                                                           | 
|POLY-3 PERCENT (g) |        12.8%            74.5%            97.4%                                                              | 
|TERMINAL (d)       |        2/39 (5%)        4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        663              420              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        40/60 (67%)      33/60 (55%)      14/59 (24%)                                                        | 
|POLY-3 RATE (b)    |        40/56.29         33/50.22         14/28.29                                                           | 
|POLY-3 PERCENT (g) |        71.1%            65.7%            49.5%                                                              | 
|TERMINAL (d)       |        29/39 (74%)      8/11 (73%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              419              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.043N*        P=0.342N         P=0.041N*                                                          | 
|POLY 1.5           |        P<0.001N**       P=0.239N         P<0.001N**                                                         | 
|POLY 6             |        P=0.475N         P=0.529N         P=0.520N                                                           | 
|LOGISTIC REGRESSION|        P=0.009N**       P=0.372N         P=0.130N                                                           | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.131N         P<0.001N**                                                         | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        24/60 (40%)      17/60 (28%)      8/60 (13%)                                                         | 
|POLY-3 RATE (b)    |        24/57.24         17/43.71         8/25.13                                                            | 
|POLY-3 PERCENT (g) |        41.9%            38.9%            31.8%                                                              | 
|TERMINAL (d)       |        16/39 (41%)      3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              420              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002 **       P=0.062          P=0.015 *                                                          | 
|POLY 3             |        P=0.262N         P=0.459N         P=0.290N                                                           | 
|POLY 1.5           |        P=0.038N*        P=0.294N         P=0.045N*                                                          | 
|POLY 6             |        P=0.366          P=0.481          P=0.401                                                            | 
|LOGISTIC REGRESSION|        P=0.011N*        P=0.183N         P=0.004N**                                                         | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.124N         P<0.001N**                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate: Ventral                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        18/60 (30%)      4/60 (7%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        18/54.46         4/39.09          1/20.15                                                            | 
|POLY-3 PERCENT (g) |        33.1%            10.2%            5.0%                                                               | 
|TERMINAL (d)       |        15/39 (39%)      2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        631              621              412                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.634          P=0.336N         P=0.497                                                            | 
|POLY 3             |        P<0.001N**       P=0.009N**       P=0.033N*                                                          | 
|POLY 1.5           |        P<0.001N**       P=0.003N**       P=0.002N**                                                         | 
|POLY 6             |        P=0.016N*        P=0.036N*        P=0.269N                                                           | 
|LOGISTIC REGRESSION|        P=0.063N         P=0.078N         P=0.236N                                                           | 
|COCH-ARM / FISHERS |        P<0.001N**       P<0.001N**       P<0.001N**                                                         | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        16/58 (28%)      49/59 (83%)                                                        | 
|POLY-3 RATE (b)    |        0/53.85          16/43.40         49/53.51                                                           | 
|POLY-3 PERCENT (g) |        0.0%             36.9%            91.6%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              502              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/60 (10%)       14/60 (23%)      27/60 (45%)                                                        | 
|POLY-3 RATE (b)    |        6/54.06          14/40.92         27/35.21                                                           | 
|POLY-3 PERCENT (g) |        11.1%            34.2%            76.7%                                                              | 
|TERMINAL (d)       |        5/39 (13%)       6/11 (55%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        674              531              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.006 **       P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.014 *        P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.042 *        P<0.001 **                                                         | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 41      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/60 (12%)       36/60 (60%)      35/60 (58%)                                                        | 
|POLY-3 RATE (b)    |        7/54.65          36/53.67         35/44.61                                                           | 
|POLY-3 PERCENT (g) |        12.8%            67.1%            78.5%                                                              | 
|TERMINAL (d)       |        2/39 (5%)        4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              260              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.155          P<0.001 **       P=0.107                                                            | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/60 (15%)       4/60 (7%)        7/60 (12%)                                                         | 
|POLY-3 RATE (b)    |        9/55.67          4/39.82          7/23.88                                                            | 
|POLY-3 PERCENT (g) |        16.2%            10.1%            29.3%                                                              | 
|TERMINAL (d)       |        4/39 (10%)       1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              523              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.618N         P=0.002 **                                                         | 
|POLY 3             |        P=0.281          P=0.293N         P=0.185                                                            | 
|POLY 1.5           |        P=0.446          P=0.208N         P=0.422                                                            | 
|POLY 6             |        P=0.154          P=0.429N         P=0.053                                                            | 
|LOGISTIC REGRESSION|        P=0.387N         P=0.098N         P=0.306N                                                           | 
|COCH-ARM / FISHERS |        P=0.401N         P=0.120N         P=0.395N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 42      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/59 (7%)        2/60 (3%)        0/60 (0%)                                                          | 
|POLY-3 RATE (b)    |        4/54.87          2/39.21          0/19.33                                                            | 
|POLY-3 PERCENT (g) |        7.3%             5.1%             0.0%                                                               | 
|TERMINAL (d)       |        0/38 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              567              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.341N         P=0.549N         P=0.397N                                                           | 
|POLY 3             |        P=0.250N         P=0.500N         P=0.308N                                                           | 
|POLY 1.5           |        P=0.114N         P=0.426N         P=0.169N                                                           | 
|POLY 6             |        P=0.510N         P=0.599N         P=0.490N                                                           | 
|LOGISTIC REGRESSION|        P=0.007N**       P=0.125N         P=0.002N**                                                         | 
|COCH-ARM / FISHERS |        P=0.041N*        P=0.332N         P=0.057N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/59 (3%)        1/60 (2%)        0/60 (0%)                                                          | 
|POLY-3 RATE (b)    |        2/53.49          1/38.89          0/19.33                                                            | 
|POLY-3 PERCENT (g) |        3.7%             2.6%             0.0%                                                               | 
|TERMINAL (d)       |        0/38 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        640              658              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.754N         P=0.713N         P=0.992N                                                           | 
|POLY 3             |        P=0.398N         P=0.608N         P=0.484N                                                           | 
|POLY 1.5           |        P=0.253N         P=0.560N         P=0.370N                                                           | 
|POLY 6             |        P=0.612N         P=0.670N         P=0.603N                                                           | 
|LOGISTIC REGRESSION|        P=0.230N         P=0.470N         P=0.327N                                                           | 
|COCH-ARM / FISHERS |        P=0.158N         P=0.494N         P=0.244N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 43      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/59 (10%)       4/60 (7%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        6/55.74          4/39.79          1/19.92                                                            | 
|POLY-3 PERCENT (g) |        10.8%            10.1%            5.0%                                                               | 
|TERMINAL (d)       |        0/38 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              523              540                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.580          P=0.585          P=0.614N                                                           | 
|POLY 3             |        P=0.389N         P=0.587N         P=0.403N                                                           | 
|POLY 1.5           |        P=0.171N         P=0.491N         P=0.207N                                                           | 
|POLY 6             |        P=0.546          P=0.542          P=0.624                                                            | 
|LOGISTIC REGRESSION|        P=0.010N*        P=0.131N         P<0.001N**                                                         | 
|COCH-ARM / FISHERS |        P=0.043N*        P=0.361N         P=0.054N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/59 (7%)        7/60 (12%)       3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        4/52.89          7/40.35          3/21.73                                                            | 
|POLY-3 PERCENT (g) |        7.6%             17.4%            13.8%                                                              | 
|TERMINAL (d)       |        3/38 (8%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        720              470              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       P=0.010 *        P=0.069                                                            | 
|POLY 3             |        P=0.176          P=0.132          P=0.368                                                            | 
|POLY 1.5           |        P=0.403          P=0.184          P=0.556                                                            | 
|POLY 6             |        P=0.043 *        P=0.080          P=0.199                                                            | 
|LOGISTIC REGRESSION|        P=0.591          P=0.127          P=0.511N                                                           | 
|COCH-ARM / FISHERS |        P=0.375N         P=0.274          P=0.491N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 44      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        2/60 (3%)        0/60 (0%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          2/39.99          0/19.33                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.0%             0.0%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              420              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.649          P=0.213          (e)                                                                | 
|POLY 3             |        P=0.360          P=0.179          (e)                                                                | 
|POLY 1.5           |        P=0.529          P=0.202          (e)                                                                | 
|POLY 6             |        P=0.173          P=0.150          (e)                                                                | 
|LOGISTIC REGRESSION|        P=0.281N         P=0.527          (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.613N         P=0.248          (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        13/60 (22%)      18/60 (30%)      53/60 (88%)                                                        | 
|POLY-3 RATE (b)    |        13/56.48         18/44.43         53/56.31                                                           | 
|POLY-3 PERCENT (g) |        23.0%            40.5%            94.1%                                                              | 
|TERMINAL (d)       |        5/39 (13%)       4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              499              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.002 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.045 *        P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.089          P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.016 *        P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.257          P=0.033 *                                                          | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.202          P<0.001 **                                                         | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 45      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/60 (17%)      15/60 (25%)      4/60 (7%)                                                          | 
|POLY-3 RATE (b)    |        10/57.13         15/45.16         4/22.04                                                            | 
|POLY-3 PERCENT (g) |        17.5%            33.2%            18.2%                                                              | 
|TERMINAL (d)       |        2/39 (5%)        2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              370              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.040 *        P=0.014 *        P=0.169                                                            | 
|POLY 3             |        P=0.212          P=0.053          P=0.586                                                            | 
|POLY 1.5           |        P=0.471N         P=0.094          P=0.344N                                                           | 
|POLY 6             |        P=0.018 *        P=0.022 *        P=0.289                                                            | 
|LOGISTIC REGRESSION|        P=0.004N**       P=0.576N         P=0.007N**                                                         | 
|COCH-ARM / FISHERS |        P=0.055N         P=0.184          P=0.077N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/56 (0%)        2/56 (4%)        1/56 (2%)                                                          | 
|POLY-3 RATE (b)    |        0/50.79          2/37.22          1/18.18                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.4%             5.5%                                                               | 
|TERMINAL (d)       |        0/38 (0%)        0/10 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              523              636                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.103          P=0.208          P=0.007 **                                                         | 
|POLY 3             |        P=0.144          P=0.176          P=0.333                                                            | 
|POLY 1.5           |        P=0.228          P=0.200          P=0.398                                                            | 
|POLY 6             |        P=0.089          P=0.148          P=0.277                                                            | 
|LOGISTIC REGRESSION|        P=0.593          P=0.456          P=0.296                                                            | 
|COCH-ARM / FISHERS |        P=0.444          P=0.248          P=0.500                                                            | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 46      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Ultimobranchial Cyst                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/59 (0%)        4/60 (7%)        3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        0/52.85          4/40.07          3/21.83                                                            | 
|POLY-3 PERCENT (g) |        0.0%             10.0%            13.7%                                                              | 
|TERMINAL (d)       |        0/38 (0%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              555              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       P=0.016 *        P=0.079                                                            | 
|POLY 3             |        P=0.016 *        P=0.034 *        P=0.036 *                                                          | 
|POLY 1.5           |        P=0.044 *        P=0.044 *        P=0.059                                                            | 
|POLY 6             |        P=0.005 **       P=0.023 *        P=0.022 *                                                          | 
|LOGISTIC REGRESSION|        P=0.530          P=0.081          P=0.892                                                            | 
|COCH-ARM / FISHERS |        P=0.170          P=0.061          P=0.125                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/59 (17%)      9/60 (15%)       6/60 (10%)                                                         | 
|POLY-3 RATE (b)    |        10/53.36         9/41.81          6/23.38                                                            | 
|POLY-3 PERCENT (g) |        18.7%            21.5%            25.7%                                                              | 
|TERMINAL (d)       |        8/38 (21%)       3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        649              419              362                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.062          P<0.001 **                                                         | 
|POLY 3             |        P=0.323          P=0.469          P=0.370                                                            | 
|POLY 1.5           |        P=0.515N         P=0.573          P=0.558N                                                           | 
|POLY 6             |        P=0.109          P=0.326          P=0.133                                                            | 
|LOGISTIC REGRESSION|        P=0.413N         P=0.606N         P=0.643N                                                           | 
|COCH-ARM / FISHERS |        P=0.168N         P=0.484N         P=0.200N                                                           | 
|=================================================================================================================================| 
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 47      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/59 (5%)        0/60 (0%)        0/60 (0%)                                                          | 
|POLY-3 RATE (b)    |        3/52.85          0/38.63          0/19.33                                                            | 
|POLY-3 PERCENT (g) |        5.7%             0.0%             0.0%                                                               | 
|TERMINAL (d)       |        3/38 (8%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          ---              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.543N         P=0.403N         P=1.000N                                                           | 
|POLY 3             |        P=0.115N         P=0.186N         P=0.373N                                                           | 
|POLY 1.5           |        P=0.075N         P=0.153N         P=0.242N                                                           | 
|POLY 6             |        P=0.185N         P=0.241N         P=0.531N                                                           | 
|LOGISTIC REGRESSION|        P=0.543N         (e)              (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.058N         P=0.119N         P=0.119N                                                           | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).