TDMS Study 05203-08 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst O-NITROTOLUENE DATE: 11/16/00
EXPERIMENT: 05203 TEST: 08 TIME: 09:36:35
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62340D
PATHOLOGIST: HEATH, JAMES E. CAS: 88-72-2
------------------------------------------------------------------------------------------------------------------------------------
RATS, FINAL#1; CORE STUDY
REASONS FOR REMOVAL: 25022 Accidently Killed
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 PPM
INCLUDE 002 0 PPM
INCLUDE 003 625 PPM
INCLUDE 004 625 PPM
INCLUDE 005 1250 PPM
INCLUDE 006 1250 PPM
INCLUDE 007 2000 PPM
INCLUDE 008 2000 PPM
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst O-NITROTOLUENE DATE: 11/16/00
EXPERIMENT: 05203 TEST: 08 TIME: 09:36:35
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62340D
PATHOLOGIST: HEATH, JAMES E. CAS: 88-72-2
O-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 441 533 533 537 555 586 631 640 644 649 |
| 663 673 674 691 705 705 707 714 720 722 |
| 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 625 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 42 CENSORED DEATHS 0 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 378 428 465 471 499 529 534 555 559 567 |
| 567 569 569 589 600 603 615 615 616 616 |
| 616 621 621 632 636 636 639 641 650 656 |
| 656 658 684 684 691 707 707 713 714 726 |
| 726 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 54 CENSORED DEATHS 3 TERMINAL 3 |
| |
| UNCENSORED DEATHS |
| 384 391 432 483 483 483 502 502 512 515 |
| 519 519 523 527 531 564 567 569 576 581 |
| 581 589 597 597 597 603 615 616 616 621 |
| 628 632 636 636 637 637 652 656 656 658 |
| 658 673 676 685 685 685 691 691 691 706 |
| 714 714 714 714 |
| CENSORED DEATHS |
| 298 299 299 |
| |
==================================================================================
O-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2000 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 60 CENSORED DEATHS 0 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 359 391 391 396 404 404 414 419 419 419 |
| 421 432 439 439 463 464 471 471 471 474 |
| 479 483 483 495 495 502 509 509 509 512 |
| 512 512 512 519 523 527 531 534 534 538 |
| 540 544 544 544 544 562 567 567 569 576 |
| 581 586 589 589 603 608 632 637 655 656 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
O-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 100.0 98.3 93.3 90.0 81.7 65.0 |
| | |
| | |
|625 PPM | 100.0 100.0 100.0 100.0 98.3 93.3 88.3 73.3 46.7 30.0 |
| | |
| | |
|1250 PPM | 100.0 100.0 100.0 100.0 96.5 89.5 73.7 54.4 28.1 5.3 |
| | |
| | |
|2000 PPM | 100.0 100.0 100.0 98.3 81.7 61.7 25.0 8.3 0.0 0.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 625 PPM 1250 PPM 2000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 65.0% 30.0% 5.3% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 640.5 611.5 598.5 507.9 |
|NATURAL DEATHS (C) | (17.5) (12.7) (11.4) ( 9.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 698.0 646.8 590.1 507.9 |
|(STANDARD ERROR) | ( 8.1) (11.3) (14.0) ( 9.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 47 |
| |
| UNCENSORED DEATHS |
| 401 453 620 620 674 691 700 706 707 719 |
| 719 722 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 625 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 47 |
| |
| UNCENSORED DEATHS |
| 429 495 505 531 582 669 682 684 695 702 |
| 705 708 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 370 432 523 525 569 586 597 636 656 672 |
| 685 698 706 706 707 707 708 708 709 709 |
| 709 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
O-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2000 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 464 488 569 586 603 632 636 636 639 663 |
| 663 665 676 685 685 687 691 698 702 706 |
| 708 708 708 708 708 709 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
O-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 98.3 96.7 96.7 96.7 93.3 78.3 |
| | |
| | |
|625 PPM | 100.0 100.0 100.0 100.0 100.0 98.3 93.3 91.7 91.7 78.3 |
| | |
| | |
|1250 PPM | 100.0 100.0 100.0 100.0 98.3 96.7 93.3 88.3 85.0 65.0 |
| | |
| | |
|2000 PPM | 100.0 100.0 100.0 100.0 100.0 98.3 96.7 91.7 80.0 55.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 625 PPM 1250 PPM 2000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.3% 78.3% 65.0% 55.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.002 P=1.000 P=0.128 P=0.009 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 650.6 623.3 634.2 657.2 |
|NATURAL DEATHS (C) | (29.3) (27.9) (21.8) (12.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 712.0 706.1 695.8 696.7 |
|(STANDARD ERROR) | ( 7.5) ( 8.2) ( 9.5) ( 7.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-NITROTOLUENE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
625 PPM = 2
1250 PPM = 3
2000 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 4 2 3 1
| 4 2 33 21 2 1
| 44 3 223
| 44 2 2 21 1 1
90 + 4 4 3 3 22 1 1
| 2 2 11
| 3 3 22 11
| 444 3 3 22 1 1 1
80 + 44
| 4 4 33 2 22 1 1 1
| 22
| 44 3 3 22 11
P 70 + 33 11
E | 44 33 11
R | 22 1 1
C | 4 4 3 33 2 2
E 60 +
N | 444 22
T | 333
| 44 222
S 50 + 33
U | 33 2 2
R | 4 4 33
V | 44 22 2
I 40 +
V | 44 3 3 22
A | 2 2
L | 44
30 + 2 2
| 3 3
| 4 4 33
|
20 + 44 33
| 44
| 44 3 3
| 4 4 33
10 + 4 4
| 4 4
| 3 3
| 4 4
0 + 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 18 obs hidden.
O-NITROTOLUENE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
625 PPM = 2
1250 PPM = 3
2000 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 2 4
| 3 1 2 1 4 42
|
| 3 1 42 2 3 4 1
95 + 2 2 4 4
| 32 3 2 4 1 1
|
| 3 2 4 4 21 1
90 + 3 3 2 211
| 3 3 11
P |
E | 34 3 2 2
R 85 + 4 3 43 21 1
C | 3 3
E |
N | 3 32211
T 80 + 4 4 3322
| 44 21 1
S |
U |
R 75 + 44
V | 33
I |
V | 44
A 70 + 44
L |
|
| 44
65 + 3 3
|
|
|
60 +
|
|
| 4 4
55 + 4 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.
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