TDMS Study 05203-09 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Southern Research Inst O-NITROTOLUENE DATE: 11/16/00
EXPERIMENT: 05203 TEST: 09 TIME: 10:00:52
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP: C62340D
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: SOUTHERN RESEARCH INSTITUTE O-NITROTOLUENE DATE: 11/16/00
EXPERIMENT: 05203 TEST: 09 TIME: 10:32:50
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP: 62340D
CONT: N01-ES-55393 CAS: 88-72-2
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
CHRONIC DOSED FEED STUDY OF O-NITROTOLUENE
==================================================================================================================================
0 PPM 1250 PPM 2500 PPM 5000 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
4 5.1 24.0 4.7 23.4 0.92 250 4.5 22.6 0.88 493 4.2 21.4 0.82 979
8 4.1 27.7 4.0 27.1 0.98 184 3.9 26.2 0.95 367 3.6 25.1 0.88 722
12 4.6 30.6 4.4 29.0 0.96 191 4.3 28.3 0.93 376 4.2 26.7 0.91 794
16 4.7 34.2 4.6 32.3 0.98 179 4.5 30.9 0.96 367 4.0 28.3 0.85 700
20 4.5 37.3 4.4 35.9 0.98 154 4.2 33.8 0.93 314 3.8 29.7 0.84 636
24 4.9 38.7 4.9 36.4 1.00 168 4.7 34.3 0.96 341 4.0 30.0 0.82 664
28 5.1 40.5 5.1 38.4 1.00 165 4.8 35.6 0.94 337 4.2 30.8 0.82 674
32 5.0 41.9 5.3 39.9 1.06 165 5.1 36.8 1.02 344 4.2 31.1 0.84 673
36 4.9 43.6 4.9 41.0 1.00 148 4.8 37.7 0.98 318 4.0 31.7 0.82 632
40 5.2 44.7 5.2 42.1 1.00 153 5.1 38.3 0.98 333 4.3 31.9 0.83 669
44 5.2 44.8 5.1 42.7 0.98 149 5.0 39.0 0.96 319 4.2 32.2 0.81 646
48 5.0 45.8 5.2 43.2 1.04 152 5.4 39.4 1.08 341 4.6 32.8 0.92 701
56 5.3 47.1 5.3 44.4 1.00 150 5.4 40.2 1.02 335 3.8 32.4 0.72 594
60 5.3 47.0 5.3 44.0 1.00 150 5.4 40.1 1.02 336
64 5.3 46.7 5.5 43.4 1.04 159 5.1 40.4 0.96 318
68 5.4 47.7 5.4 45.0 1.00 151 5.3 40.7 0.98 326
72 5.5 47.3 5.5 44.6 1.00 154 5.3 41.0 0.96 325
76 5.8 47.6 5.7 44.2 0.98 160 5.2 39.5 0.90 326
80 5.6 48.0 5.9 44.8 1.05 166 5.0 38.9 0.89 322
84 5.7 46.3 5.9 43.4 1.04 170 5.6 37.3 0.98 378
88 5.4 46.5 5.7 43.6 1.06 163
92 5.0 46.5 5.2 42.1 1.04 154
96 5.3 46.6 5.2 43.1 0.98 151
100 5.1 46.8 5.1 43.7 1.00 146 7.1 29.4 1.39 606
104 5.4 46.5 5.4 42.6 1.00 159
1 TO 13 WEEKS
----------------
MEAN 4.6 27.4 4.4 26.5 0.95 208 4.2 25.7 0.92 412 4.0 24.4 0.87 832
SD(D) 0.5 0.4 0.03 36 0.3 0.04 70 0.3 0.05 132
CV(E) 10.8 8.1 2.9 17.4 7.4 3.9 17.0 8.4 5.2 15.9
14 TO 52 WEEKS
----------------
MEAN 4.9 41.3 5.0 39.1 1.00 159 4.8 36.2 0.98 335 4.1 30.9 0.84 666
SD(D) 0.2 0.3 0.03 10 0.3 0.05 17 0.2 0.03 25
CV(E) 4.9 5.7 2.8 6.5 6.9 4.6 4.9 5.7 4.0 3.8
> 52 WEEKS
----------------
MEAN 5.4 47.0 5.5 43.8 1.01 156 5.5 38.6 1.01 364 3.8 32.4 0.72 594
SD(D) 0.2 0.3 0.03 7 0.6 0.15 93
CV(E) 4.0 4.8 2.6 4.5 11.6 14.8 25.5
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
CHRONIC DOSED FEED STUDY OF O-NITROTOLUENE
==================================================================================================================================
0 PPM 1250 PPM 2500 PPM 5000 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
4 3.7 20.6 3.8 21.1 1.03 226 3.7 20.4 1.00 449 3.3 19.4 0.89 857
8 3.4 22.4 3.8 23.2 1.12 202 3.6 23.3 1.06 388 3.2 22.1 0.94 731
12 3.8 25.7 3.9 25.5 1.03 193 3.9 25.1 1.03 386 3.5 23.2 0.92 761
16 4.0 27.8 4.1 27.4 1.03 188 4.0 26.8 1.00 374 3.7 24.3 0.93 758
20 3.7 29.4 3.8 29.3 1.03 162 3.9 29.0 1.05 336 3.5 25.4 0.95 697
24 4.3 31.8 4.5 32.2 1.05 177 4.2 30.1 0.98 353 3.9 26.4 0.91 733
28 4.3 33.2 3.9 33.6 0.91 145 4.1 32.0 0.95 323 3.8 27.1 0.88 704
32 4.6 35.4 4.5 35.8 0.98 159 4.7 33.6 1.02 348 4.1 28.0 0.89 727
36 4.2 37.3 4.1 36.7 0.98 141 4.4 35.0 1.05 313 3.8 29.0 0.90 647
40 4.5 38.1 4.6 37.7 1.02 152 4.4 35.9 0.98 306 3.9 29.5 0.87 666
44 4.4 38.1 4.2 38.6 0.95 135 4.3 37.0 0.98 288 3.8 30.5 0.86 616
48 4.3 39.3 4.4 38.8 1.02 143 4.3 37.5 1.00 290 3.8 30.4 0.88 628
52 4.7 40.4 5.0 40.7 1.06 154 4.8 38.1 1.02 315 4.6 30.6 0.98 747
56 4.2 41.8 4.4 42.6 1.05 130 4.2 38.8 1.00 269 3.7 31.5 0.88 592
60 5.0 42.4 4.9 42.5 0.98 143 4.8 39.3 0.96 304 4.2 31.6 0.84 673
64 4.6 43.7 4.8 43.5 1.04 138 4.4 39.9 0.96 277 4.1 32.2 0.89 644
68 4.3 45.2 4.8 44.4 1.12 136 4.5 41.3 1.05 274 4.4 33.4 1.02 662
72 4.6 44.5 4.8 44.4 1.04 135 4.5 41.2 0.98 270 4.3 33.3 0.93 643
76 4.5 44.8 4.7 43.9 1.04 134 4.4 40.8 0.98 268 4.4 33.8 0.98 653
80 4.2 44.8 4.5 44.2 1.07 127 4.4 40.9 1.05 268 4.1 33.6 0.98 613
84 4.8 43.8 4.7 42.2 0.98 139 4.5 38.7 0.94 293 4.5 32.8 0.94 687
88 5.2 44.7 5.3 43.1 1.02 153 5.1 39.3 0.98 325 5.0 33.4 0.96 745
92 4.3 45.1 4.6 43.9 1.07 130 4.5 39.9 1.05 283 4.8 33.0 1.12 722
96 4.0 45.0 4.5 45.3 1.13 123 4.1 39.7 1.03 260 5.4 32.7 1.35 832
100 4.4 46.2 4.8 47.4 1.09 126 4.9 41.3 1.11 296 6.0 32.3 1.36 934
104 5.1 46.6 5.2 46.9 1.02 139 5.5 41.2 1.08 334
1 TO 13 WEEKS
----------------
MEAN 3.6 22.9 3.8 23.3 1.06 207 3.7 22.9 1.03 408 3.4 21.6 0.92 783
SD(D) 0.2 0.1 0.05 17 0.1 0.03 36 0.2 0.02 66
CV(E) 5.5 2.4 5.0 8.3 3.6 2.9 8.8 4.6 2.7 8.4
14 TO 52 WEEKS
----------------
MEAN 4.3 35.1 4.3 35.1 1.00 156 4.3 33.5 1.00 325 3.9 28.1 0.91 692
SD(D) 0.3 0.4 0.05 16 0.3 0.03 28 0.3 0.04 51
CV(E) 6.6 8.4 4.7 10.6 6.5 3.3 8.7 7.2 4.0 7.3
> 52 WEEKS
----------------
MEAN 4.5 44.5 4.8 44.2 1.05 135 4.6 40.2 1.01 286 4.6 32.8 1.02 700
SD(D) 0.4 0.3 0.05 8 0.4 0.05 23 0.6 0.17 98
CV(E) 8.1 5.4 4.3 5.9 8.4 5.2 8.1 13.9 16.9 13.9
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
CHRONIC DOSED FEED STUDY OF O-NITROTOLUENE
=========================================================================================================
0 PPM 1250 PPM 2500 PPM 5000 PPM
---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
==========================================================================================================
B 20.9 60 20.8 60 20.9 60 20.8 60
1 20.9 60 20.8 60 20.9 60 20.8 60
4 5.1 9799 24.0 60 4.7 9781 23.4 60 4.5 9774 22.6 60 4.2 9705 21.4 60
8 4.1 9334 27.7 60 4.0 9613 27.1 60 3.9 9624 26.2 60 3.6 9637 25.1 60
12 4.6 9613 30.6 60 4.4 9659 29.0 60 4.3 9661 28.3 60 4.2 9520 26.7 60
16 4.7 9926 34.2 60 4.6 9864 32.3 60 4.5 9698 30.9 60 4.0 9711 28.3 60
20 4.5 9597 37.3 60 4.4 9703 35.9 60 4.2 9501 33.8 60 3.8 9416 29.7 60
24 4.9 10000 38.7 60 4.9 9832 36.4 60 4.7 9660 34.3 60 4.0 9793 30.0 60
28 5.1 9652 40.5 60 5.1 9676 38.4 60 4.8 9653 35.6 60 4.2 9649 30.8 60
32 5.0 9997 41.9 60 5.3 9904 39.9 60 5.1 9791 36.8 60 4.2 9767 31.1 60
36 4.9 9973 43.6 60 4.9 9854 41.0 60 4.8 9766 37.7 60 4.0 9738 31.7 60
40 5.2 9625 44.7 59 5.2 9749 42.1 60 5.1 9540 38.3 59 4.3 9649 31.9 60
44 5.2 9623 44.8 59 5.1 9787 42.7 60 5.0 9402 39.0 59 4.2 9132 32.2 57
48 5.0 9795 45.8 59 5.2 9912 43.2 60 5.4 9435 39.4 58 4.6 8731 32.8 54
52 46.6 59 43.8 60 39.4 58 32.7 49
56 5.3 9764 47.1 59 5.3 9753 44.4 60 5.4 9294 40.2 57 3.8 5390 32.4 35
60 5.3 9852 47.0 59 5.3 9890 44.0 60 5.4 9138 40.1 56 3.7 1296 33.0 8
64 5.3 9767 46.7 59 5.5 9753 43.4 60 5.1 8511 40.4 53 3.3 484 33.3 3
68 5.4 9884 47.7 59 5.4 9285 45.0 56 5.3 7733 40.7 48
72 5.5 9757 47.3 59 5.5 9080 44.6 55 5.3 6649 41.0 41
76 5.8 9742 47.6 59 5.7 8843 44.2 54 5.2 5385 39.5 34
80 5.6 9806 48.0 59 5.9 8432 44.8 52 5.0 3332 38.9 24
84 5.7 9999 46.3 59 5.9 8239 43.4 49 5.6 1448 37.3 9
88 5.4 9449 46.5 57 5.7 7541 43.6 47 5.5 656 37.1 4
92 5.0 8922 46.5 55 5.2 6877 42.1 45 4.8 324 31.4 2
96 5.3 6125 46.6 54 5.2 4713 43.1 42 5.9 114 31.2 1
100 5.1 8910 46.8 54 5.1 6239 43.7 38 7.1 167 29.4 1
104 5.4 8583 46.5 52 5.4 5553 42.6 36
MEAN BODY WGT FOR WEEKS
1 TO 13 25.8 25.1 24.5 23.5
14 TO 52 41.8 39.6 36.5 31.1
> 52 47.0 43.8 37.3 32.9
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
CHRONIC DOSED FEED STUDY OF O-NITROTOLUENE
=========================================================================================================
0 PPM 1250 PPM 2500 PPM 5000 PPM
---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
==========================================================================================================
B 16.9 60 16.7 60 16.8 60 16.7 60
1 16.9 60 16.7 60 16.8 60 16.7 60
4 3.7 9754 20.6 60 3.8 9759 21.1 60 3.7 9715 20.4 60 3.3 9626 19.4 60
8 3.4 7314 22.4 60 3.8 7051 23.2 60 3.6 5824 23.3 60 3.2 6879 22.1 60
12 3.8 9648 25.7 60 3.9 9299 25.5 60 3.9 9566 25.1 60 3.5 9280 23.2 60
16 4.0 10045 27.8 60 4.1 9997 27.4 60 4.0 9904 26.8 60 3.7 9844 24.3 60
20 3.7 9350 29.4 60 3.8 9542 29.3 60 3.9 9384 29.0 60 3.5 9835 25.4 60
24 4.3 9900 31.8 60 4.5 9852 32.2 60 4.2 9762 30.1 60 3.9 9715 26.4 60
28 4.3 9662 33.2 60 3.9 9665 33.6 60 4.1 9654 32.0 60 3.8 9660 27.1 60
32 4.6 9595 35.4 60 4.5 10062 35.8 60 4.7 9933 33.6 60 4.1 9876 28.0 60
36 4.2 10027 37.3 60 4.1 9996 36.7 60 4.4 9846 35.0 60 3.8 9810 29.0 60
40 4.5 9728 38.1 60 4.6 9547 37.7 59 4.4 9643 35.9 60 3.9 9635 29.5 60
44 4.4 9331 38.1 59 4.2 9624 38.6 59 4.3 9822 37.0 60 3.8 9852 30.5 60
48 4.3 9849 39.3 59 4.4 9564 38.8 58 4.3 9736 37.5 60 3.8 9658 30.4 60
52 4.7 2606 40.4 59 5.0 2544 40.7 57 4.8 2687 38.1 60 4.6 2676 30.6 60
56 4.2 9712 41.8 58 4.4 9424 42.6 57 4.2 9900 38.8 60 3.7 9870 31.5 60
60 5.0 9756 42.4 58 4.9 9474 42.5 57 4.8 9918 39.3 60 4.2 9471 31.6 58
64 4.6 9711 43.7 58 4.8 9414 43.5 57 4.4 9831 39.9 60 4.1 9286 32.2 57
68 4.3 9696 45.2 58 4.8 9435 44.4 57 4.5 9877 41.3 60 4.4 9202 33.4 56
72 4.6 9414 44.5 57 4.8 9221 44.4 56 4.5 9840 41.2 60 4.3 9000 33.3 55
76 4.5 9562 44.8 57 4.7 9344 43.9 56 4.4 9906 40.8 60 4.4 8484 33.8 52
80 4.2 9426 44.8 57 4.5 8832 44.2 55 4.4 9581 40.9 59 4.1 8260 33.6 51
84 4.8 8843 43.8 56 4.7 9162 42.2 55 4.5 9926 38.7 59 4.5 7317 32.8 43
88 5.2 9095 44.7 55 5.3 8792 43.1 54 5.1 9653 39.3 59 5.0 5786 33.4 35
92 4.3 9119 45.1 55 4.6 8649 43.9 53 4.5 9267 39.9 57 4.8 4910 33.0 30
96 4.0 6209 45.0 55 4.5 5649 45.3 50 4.1 6304 39.7 56 5.4 2506 32.7 23
100 4.4 9171 46.2 55 4.8 8202 47.4 49 4.9 8705 41.3 52 6.0 1695 32.3 10
104 5.1 8807 46.6 53 5.2 7677 46.9 46 5.5 7761 41.2 47 6.6 709 32.3 6
MEAN BODY WGT FOR WEEKS
1 TO 13 21.4 21.6 21.4 20.4
14 TO 52 35.1 35.1 33.5 28.1
> 52 44.5 44.2 40.2 32.7
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.