TDMS Study 05203-09 Pathology Tables
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
MICE, FINAL#1
Facility: Southern Research Institute
Chemical CAS #: 88-72-2
Lock Date: 03/08/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3|
| 1| 1| 1| 1| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
Cyst | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Congestion, Focal | |
Eosinophilic Focus | X |
Hyperplasia, Focal, Lymphoid | |
Infiltration Cellular, Mixed Cell | 1 1 1 2 1 1 1 2 1 2 1 1 1 1 1 1 2 2 2 1 3 1 1|
Necrosis | 2 2 1 |
Tension Lipidosis | |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 2 |
Hepatocyte, Centrilobular, Fatty | |
Change | |
|__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | |
Fat, Necrosis | 3 3 1 |
|__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3|
| 1| 1| 1| 1| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | |
Duct, Cyst | 3|
Duct, Inflammation, Chronic, Focal | 2 2|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Focal | |
Ulcer | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
|__________________________________________________________________________|
Tooth | + + |
Peridontal Tissue, Inflammation, | |
Chronic | 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3|
| 1| 1| 1| 1| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cytoplasmic | |
Alteration, Focal | |
Pars Distalis, Hyperplasia, Focal | 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 1 2 2 3 2 |
Inflammation, Chronic, Focal | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + I|
Degeneration, Cystic | 3 3 3 2 2 |
Inflammation, Chronic | 3 |
Pigmentation | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + I + + + + + + + +|
Angiectasis | 3 |
Cyst | 3 X 3 3 |
Cyst, Multiple | |
Hemorrhage | 2 |
|__________________________________________________________________________|
Oviduct | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Hydrometra | 2 3 3 3 3 3 4 3 3 2 3 2 3 |
Inflammation, Suppurative | 3 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3 3 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3|
| 1| 1| 1| 1| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic, Focal | |
Myelofibrosis, Focal | 3 |
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + I + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Mast Cell | 3 |
Hyperplasia | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 3 2 2 |
Hyperplasia, Lymphoid | 3 2 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Cyst | 2 |
Hyperplasia, Lymphoid | 3 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Cyst | |
Subcutaneous Tissue, Hemorrhage, | |
Focal | |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3|
| 1| 1| 1| 1| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Hyperostosis, Focal | |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pleura | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 |
Congestion | 2 1 |
Cyst | 1 2 |
Nephropathy | 1 1 |
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3|
| 1| 1| 1| 1| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | |
Renal Tubule, Casts Protein | 2 1 2 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 3| 3|
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 2| 2| 2| 2| 9| 5| 2| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + I + + + + + + + + + + + + + A + + + + A + A + +|
Cyst | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + A + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + A + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + A + A + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + A + A + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + A + A + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + A + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X |
Congestion, Focal | 2 |
Eosinophilic Focus | X |
Hyperplasia, Focal, Lymphoid | 2 |
Infiltration Cellular, Mixed Cell | 1 1 1 1 1 2 1 1 1 1 1 2 1 2 1 1 1|
Necrosis | |
Tension Lipidosis | X |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | |
Hepatocyte, Centrilobular, Fatty | |
Change | 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic | 3 |
Fat, Necrosis | 3 1 |
|__________________________________________________________________________|
Oral Mucosa | |
__________________________________________|__________________________________________________________________________|
Page 8
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 3| 3|
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 2| 2| 2| 2| 9| 5| 2| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 3 |
Duct, Cyst | 3 |
Duct, Inflammation, Chronic, Focal | |
|__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Inflammation, Focal | 3 |
Ulcer | 2 |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +|
Erosion | |
|__________________________________________________________________________|
Tooth | + + + + |
Peridontal Tissue, Inflammation, | |
Chronic | 1 2 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + A + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + M + + + + + + + + + +|
Cyst | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 9
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 3| 3|
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 2| 2| 2| 2| 9| 5| 2| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 |
Pars Distalis, Hyperplasia, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 1 2 1 2 2 1 3 3 |
Inflammation, Chronic, Focal | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 2 |
Inflammation, Chronic | 3 |
Pigmentation | 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Cyst | 3 2 2 3 3 |
Cyst, Multiple | 2 |
Hemorrhage | |
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 2 |
Hydrometra | 3 2 3 3 4 3 4 3 3 3 |
Inflammation, Suppurative | 3 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 10
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 3| 3|
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 2| 2| 2| 2| 9| 5| 2| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic, Focal | 3 |
Myelofibrosis, Focal | |
|__________________________________________________________________________|
Lymph Node | + + + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + I + + + + + + + + + M M + + +|
Hyperplasia, Lymphoid | 3 2 3 3 |
Hyperplasia, Mast Cell | |
Hyperplasia | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + M + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 3 |
Hyperplasia, Lymphoid | 2 3 2 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Atrophy | 4 |
Cyst | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Cyst | |
Subcutaneous Tissue, Hemorrhage, | |
Focal | |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 11
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 3| 3|
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 2| 2| 2| 2| 9| 5| 2| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Hyperostosis, Focal | 3 |
|__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pleura | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + A |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +|
Atrophy, Focal | |
Congestion | |
Cyst | |
Nephropathy | 1 1 2 1 1 1 |
__________________________________________|__________________________________________________________________________|
Page 12
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 3| 3|
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 2| 2| 2| 2| 9| 5| 2| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Casts Protein | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 13
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| | |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| | |
| 5| 5| 5| 5| 3| 3| 3| 3| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + A + | 54 |
Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + | 56 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + | 57 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + | 56 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + | 56 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + | 56 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + | 57 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 1 |
Clear Cell Focus | | 1 |
Congestion, Focal | | 1 2.0|
Eosinophilic Focus | | 2 |
Hyperplasia, Focal, Lymphoid | 2 | 2 2.0|
Infiltration Cellular, Mixed Cell | 1 1 1 1 1 | 45 1.2|
Necrosis | | 3 1.7|
Tension Lipidosis | | 1 |
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | | 1 2.0|
Hepatocyte, Centrilobular, Fatty | | |
Change | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + | 11 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| | |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| | |
| 5| 5| 5| 5| 3| 3| 3| 3| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | 3 | 6 2.3|
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy, Focal | | 1 3.0|
Duct, Cyst | | 2 3.0|
Duct, Inflammation, Chronic, Focal | | 2 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Diverticulum | | 1 2.0|
Inflammation, Focal | | 1 3.0|
Ulcer | | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A + | 58 |
Erosion | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Tooth | + + | 8 |
Peridontal Tissue, Inflammation, | | |
Chronic | 3 2 | 8 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Accessory Adrenal Cortical Nodule | | 2 1.5|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| | |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| | |
| 5| 5| 5| 5| 3| 3| 3| 3| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + A + | 58 |
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic, Focal | 1 | 14 1.9|
Inflammation, Chronic, Focal | 2 1 | 2 1.5|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 58 |
Degeneration, Cystic | 3 3 3 | 11 2.7|
Inflammation, Chronic | 3 | 3 3.0|
Pigmentation | 2 2 | 3 2.3|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Angiectasis | | 3 2.7|
Cyst | 3 3 | 11 2.8|
Cyst, Multiple | | 1 2.0|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| | |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| | |
| 5| 5| 5| 5| 3| 3| 3| 3| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Oviduct | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Cyst | | 1 2.0|
Hydrometra | 3 | 24 3.0|
Inflammation, Suppurative | | 2 3.0|
Endometrium, Hyperplasia, Cystic | 3 3 2 3 3 3 3 3 | 54 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic, Focal | | 1 3.0|
Myelofibrosis, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + | 6 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + I | 53 |
Hyperplasia, Lymphoid | 2 | 6 2.5|
Hyperplasia, Mast Cell | | 1 3.0|
Hyperplasia | | 2 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 4 3 2 | 11 2.5|
Hyperplasia, Lymphoid | 2 | 8 2.3|
|__________________________________________________________________________|____________|
Thymus | + I + + M + + + + M | 57 |
Angiectasis | | 1 2.0|
Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| | |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| | |
| 5| 5| 5| 5| 3| 3| 3| 3| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Cyst | | 1 2.0|
Hyperplasia, Lymphoid | | 5 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Ectasia | | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Cyst | 4 | 1 4.0|
Subcutaneous Tissue, Hemorrhage, | | |
Focal | 4 | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Maxilla, Hyperostosis, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Atrophy, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Hemorrhage | 2 | 2 2.0|
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| | |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| | |
| 5| 5| 5| 5| 3| 3| 3| 3| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Pleura | + | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | | 5 |
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Atrophy, Focal | | 2 2.0|
Congestion | | 2 1.5|
Cyst | | 2 1.5|
Nephropathy | 1 | 9 1.1|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 1 3.0|
Renal Tubule, Casts Protein | 2 | 6 1.8|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 2| 3| 3| 1| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 1| 1| 3| 1| 2| 2| 4| 2| 2| 5| 2| 5| 5| 5| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A + + A + + + M + + + + + + + + + + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + A + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | A + + A + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + + + A + + + + + + + + + + + + + + + + +|
Peyer's Patch, Inflammation, Chronic,| |
Focal, Suppurative | |
|__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + A + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X |
Congestion, Focal | 2 2 |
Cyst | 3 |
Eosinophilic Focus | X |
Hyperplasia, Focal, Lymphoid | 2 2 |
Infiltration Cellular, Mixed Cell | 1 1 2 1 1 1 1 1 1 1 1 1 2 1 2 1 1 |
Tension Lipidosis | X |
Bile Duct, Cyst | |
Hepatocyte, Fatty Change, Diffuse | 3 |
Hepatocyte, Fatty Change | 4 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Diffuse | |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 2 |
|__________________________________________________________________________|
Mesentery | + + + + |
__________________________________________|__________________________________________________________________________|
Page 20
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 2| 3| 3| 1| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 1| 1| 3| 1| 2| 2| 4| 2| 2| 5| 2| 5| 5| 5| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Fat, Necrosis | 2 3 2 |
|__________________________________________________________________________|
Pancreas | A + + + + + + A + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | 4 |
Duct, Cyst | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Focal | 2 2 |
Ulcer | 1 |
Epithelium, Hyperplasia | 1 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 |
|__________________________________________________________________________|
Tooth | + + |
Peridontal Tissue, Inflammation, | |
Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | A + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
|__________________________________________________________________________|
Adrenal Medulla | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + A + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 3 |
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 2| 3| 3| 1| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 1| 1| 3| 1| 2| 2| 4| 2| 2| 5| 2| 5| 5| 5| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Parathyroid Gland | + + + M M + + + + + + + + + + + + + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 1 |
Pars Distalis, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 3 2 1 1 2 2 1 2|
Inflammation, Chronic, Focal | 2 |
Follicle, Cyst | 3 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Inflammation, Chronic | |
Pigmentation | 2 2 |
|__________________________________________________________________________|
Ovary | A + + A + + + + + + + + + + + + + + + M + + + + +|
Angiectasis | |
Cyst | 2 4 2 2 3 2 3 3 2 |
Cyst, Multiple | 3 |
Hemorrhage | |
Periovarian Tissue, Cyst | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Congestion | 3 |
Cyst | 2 |
Hemorrhage | 3 |
__________________________________________|__________________________________________________________________________|
Page 22
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 2| 3| 3| 1| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 1| 1| 3| 1| 2| 2| 4| 2| 2| 5| 2| 5| 5| 5| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Hydrometra | 4 3 3 2 3 3 4 3|
Inflammation, Suppurative | 3 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 3 3 3|
|__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 |
|__________________________________________________________________________|
Lymph Node | + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | A + + + + + + M + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia | 3 |
|__________________________________________________________________________|
Spleen | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 3 2 3 |
Hyperplasia, Lymphoid | 3 3 2 2 |
|__________________________________________________________________________|
Thymus | M + + + + I + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
__________________________________________|__________________________________________________________________________|
Page 23
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 2| 3| 3| 1| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 1| 1| 3| 1| 2| 2| 4| 2| 2| 5| 2| 5| 5| 5| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Hyperplasia, Focal, Histiocytic | |
Hyperplasia, Lymphoid | 2|
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | A + + + + + + A + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 |
Nephropathy | 1 1 3 1 1 1 1 1 |
Bilateral, Atrophy, Focal | |
Bilateral, Fibrosis, Focal | |
Bilateral, Inflammation, Chronic, | |
Focal | |
Pelvis, Dilatation | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | |
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 2| 3| 3| 1| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 1| 1| 3| 1| 2| 2| 4| 2| 2| 5| 2| 5| 5| 5| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Renal Tubule, Casts Protein | 2 2 2 2 2 |
Renal Tubule, Pigmentation | 2 |
|__________________________________________________________________________|
Urinary Bladder | M + + M + + + A + + + + + + + + + + + + + + + + M|
__________________________________________|__________________________________________________________________________
Page 25
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3|
| 3| 3| 3| 9| 3| 5| 0| 5| 5| 5| 8| 5| 5| 6| 1| 2| 2| 2| 2| 2| 5| 5| 3| 7| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + A + + A + + + + + + + + + + +|
Cyst | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + A + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + A + + A + + + + + + + + + + +|
Peyer's Patch, Inflammation, Chronic,| |
Focal, Suppurative | 3 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + A + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X |
Congestion, Focal | |
Cyst | |
Eosinophilic Focus | X |
Hyperplasia, Focal, Lymphoid | 4 2 |
Infiltration Cellular, Mixed Cell | 1 1 1 1 1 1 1 1 1 1 1 3 2 1|
Tension Lipidosis | |
Bile Duct, Cyst | 3 |
Hepatocyte, Fatty Change, Diffuse | 3 |
Hepatocyte, Fatty Change | |
Hepatocyte, Vacuolization | |
Cytoplasmic, Diffuse | 2|
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | |
|__________________________________________________________________________|
Mesentery | + + + +|
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3|
| 3| 3| 3| 9| 3| 5| 0| 5| 5| 5| 8| 5| 5| 6| 1| 2| 2| 2| 2| 2| 5| 5| 3| 7| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Fat, Necrosis | 2 2|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | 4 |
Duct, Cyst | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +|
Edema | 3 |
Inflammation, Focal | |
Ulcer | |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +|
Ulcer | |
|__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + M + + + + + + + + + + I + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +|
Atrophy, Diffuse | |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3|
| 3| 3| 3| 9| 3| 5| 0| 5| 5| 5| 8| 5| 5| 6| 1| 2| 2| 2| 2| 2| 5| 5| 3| 7| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 2 1|
Pars Distalis, Hyperplasia, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Degeneration, Cystic, Focal | 1 2 2 2 2 1 |
Inflammation, Chronic, Focal | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | I + + M + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 |
Inflammation, Chronic | |
Pigmentation | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + A + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | X 2 2 2 2 3 |
Cyst, Multiple | 3 |
Hemorrhage | 3 |
Periovarian Tissue, Cyst | 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + A + + + + + + + + + + +|
Angiectasis, Focal | |
Congestion | |
Cyst | |
Hemorrhage | |
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3|
| 3| 3| 3| 9| 3| 5| 0| 5| 5| 5| 8| 5| 5| 6| 1| 2| 2| 2| 2| 2| 5| 5| 3| 7| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Hydrometra | 3 3 3 3 3 3 3 3 3 3 3 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3|
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +|
Myelofibrosis | 3 |
|__________________________________________________________________________|
Lymph Node | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + A + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 2 2 3 2 2 3 |
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + I + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + |
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3|
| 3| 3| 3| 9| 3| 5| 0| 5| 5| 5| 8| 5| 5| 6| 1| 2| 2| 2| 2| 2| 5| 5| 3| 7| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Hemorrhage | 2 |
Hyperplasia, Focal, Histiocytic | 4 |
Hyperplasia, Lymphoid | |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + A + + + + + + + + + + +|
Congestion | 2 2 |
Hyperplasia, Lymphoid | 2 2 |
Nephropathy | 1 1 2 3 1 |
Bilateral, Atrophy, Focal | 3 |
Bilateral, Fibrosis, Focal | 3 |
Bilateral, Inflammation, Chronic, | |
Focal | 3 |
Pelvis, Dilatation | 3 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 4 2 |
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7|
DAY ON TEST | 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3|
| 3| 3| 3| 9| 3| 5| 0| 5| 5| 5| 8| 5| 5| 6| 1| 2| 2| 2| 2| 2| 5| 5| 3| 7| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Renal Tubule, Casts Protein | 1 2 2 |
Renal Tubule, Pigmentation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 31
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 7| 3| 7| | |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 1| 3| | |
| 2| 2| 3| 2| 2| 5| 5| 5| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Gallbladder | + M A + + + + + + + | 53 |
Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + | 55 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + | 55 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + | 53 |
Peyer's Patch, Inflammation, Chronic,| | |
Focal, Suppurative | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 6 |
Congestion, Focal | | 2 2.0|
Cyst | | 1 3.0|
Eosinophilic Focus | X | 3 |
Hyperplasia, Focal, Lymphoid | 2 | 5 2.4|
Infiltration Cellular, Mixed Cell | 2 1 1 1 1 1 2 | 38 1.2|
Tension Lipidosis | | 1 |
Bile Duct, Cyst | | 1 3.0|
Hepatocyte, Fatty Change, Diffuse | | 2 3.0|
Hepatocyte, Fatty Change | | 1 4.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | 3 | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 7| 3| 7| | |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 1| 3| | |
| 2| 2| 3| 2| 2| 5| 5| 5| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 1 | 2 1.5|
|__________________________________________________________________________|____________|
Mesentery | + | 9 |
Fat, Necrosis | | 5 2.2|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 57 |
Acinus, Atrophy, Diffuse | | 2 4.0|
Duct, Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Edema | | 1 3.0|
Inflammation, Focal | | 2 2.0|
Ulcer | | 1 1.0|
Epithelium, Hyperplasia | | 4 1.8|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + | 57 |
Ulcer | | 1 1.0|
|__________________________________________________________________________|____________|
Tooth | + | 4 |
Peridontal Tissue, Inflammation, | | |
Chronic | 3 | 4 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Aorta, Mineralization | | 1 3.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Infiltration Cellular, Mixed Cell | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 7| 3| 7| | |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 1| 3| | |
| 2| 2| 3| 2| 2| 5| 5| 5| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Cytoplasmic Alteration, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 57 |
Atrophy, Diffuse | | 1 3.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + + + + | 55 |
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + I + + + + + + + | 58 |
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 4 1.3|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic, Focal | 2 1 | 16 1.7|
Inflammation, Chronic, Focal | | 1 2.0|
Follicle, Cyst | | 1 3.0|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + | 57 |
Degeneration, Cystic | 3 | 4 2.8|
Inflammation, Chronic | 3 2 | 2 2.5|
Pigmentation | | 2 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 7| 3| 7| | |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 1| 3| | |
| 2| 2| 3| 2| 2| 5| 5| 5| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Ovary | + + + + + + + + + + | 56 |
Angiectasis | 3 | 2 3.0|
Cyst | 3 | 16 2.5|
Cyst, Multiple | | 2 3.0|
Hemorrhage | 3 | 2 3.0|
Periovarian Tissue, Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Angiectasis, Focal | 3 | 1 3.0|
Congestion | | 1 3.0|
Cyst | | 1 2.0|
Hemorrhage | | 1 3.0|
Hydrometra | 3 3 3 3 4 | 24 3.1|
Inflammation, Suppurative | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 3 3 3 3 4 3 3 | 51 2.9|
|__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
Myelofibrosis | | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + | 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 55 |
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + A + + + + + + + | 57 |
Hematopoietic Cell Proliferation | 2 2 2 3 | 19 2.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 7| 3| 7| | |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 1| 3| | |
| 2| 2| 3| 2| 2| 5| 5| 5| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia, Lymphoid | | 5 2.4|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 2.5|
Hemorrhage | | 1 2.0|
Hyperplasia, Focal, Histiocytic | 3 | 2 3.5|
Hyperplasia, Lymphoid | | 1 2.0|
Metaplasia, Osseous | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 7| 3| 7| | |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 1| 3| | |
| 2| 2| 3| 2| 2| 5| 5| 5| 2| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + A + + + + + + + | 56 |
Congestion | 3 | 3 2.3|
Hyperplasia, Lymphoid | 2 | 4 2.0|
Nephropathy | 1 | 14 1.4|
Bilateral, Atrophy, Focal | | 1 3.0|
Bilateral, Fibrosis, Focal | | 1 3.0|
Bilateral, Inflammation, Chronic, | | |
Focal | | 1 3.0|
Pelvis, Dilatation | | 1 3.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 3 | 3 3.0|
Renal Tubule, Casts Protein | | 8 1.9|
Renal Tubule, Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + | 54 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 1| 3| 3| 3| 9| 3| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 0|
| 5| 5| 1| 8| 5| 1| 1| 0| 1| 0| 2| 2| 5| 2| 4| 2| 2| 2| 2| 2| 3| 1| 3| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + A A + + + + M + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Large, Cecum | M + A A + + + + + + + + + + + + + + + + + M + + A|
Edema | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + + + + + + + + + + + + + + + + + + + + A|
Peyer's Patch, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + A A + + + + + + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Liver | + + A + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | |
Congestion, Focal | 2 |
Eosinophilic Focus | X X X |
Hyperplasia, Focal, Lymphoid | 2 |
Infiltration Cellular, Mixed Cell | 1 1 1 2 1 2 1 1 2 2 1 1 1 1 3 1 |
Mixed Cell Focus | 2 |
Necrosis | 2 1 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 1 |
Hepatocyte, Centrilobular, Fatty | |
Change | 3 |
Hepatocyte, Centrilobular, Necrosis | 3 |
|__________________________________________________________________________|
Mesentery | + + + |
Hemorrhage | |
Artery, Inflammation, Chronic | |
Fat, Necrosis | 1 1 |
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 1| 3| 3| 3| 9| 3| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 0|
| 5| 5| 1| 8| 5| 1| 1| 0| 1| 0| 2| 2| 5| 2| 4| 2| 2| 2| 2| 2| 3| 1| 3| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 1 |
Ulcer | |
Epithelium, Hyperplasia | 2 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + A|
Ulcer | 2 |
Glands, Degeneration, Cystic, Focal | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + A + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Cyst | 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + A + + + + + + + + + + + + + + + + + + + M M +|
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 2|
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 1| 3| 3| 3| 9| 3| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 0|
| 5| 5| 1| 8| 5| 1| 1| 0| 1| 0| 2| 2| 5| 2| 4| 2| 2| 2| 2| 2| 3| 1| 3| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Distalis, Hyperplasia, Focal | 3 3 |
|__________________________________________________________________________|
Thyroid Gland | I + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 2 3 1 2 1 1|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
Abdominal, Cyst | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
|__________________________________________________________________________|
Ovary | + + A + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X 3 |
Cyst, Multiple | |
Hyperplasia, Tubular | |
Mineralization | |
Interstitial Cell, Hyperplasia | |
Periovarian Tissue, Inflammation, | |
Chronic | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Cyst | 3 |
Hemorrhage | |
Hydrometra | 3 3 3 3 3 4 4 3 3 3|
Hyperplasia, Focal, Histiocytic | |
Inflammation, Suppurative | 4 |
Pigmentation, Focal | |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 2 3 3 3 2 2 3 3 2 4 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 1| 3| 3| 3| 9| 3| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 0|
| 5| 5| 1| 8| 5| 1| 1| 0| 1| 0| 2| 2| 5| 2| 4| 2| 2| 2| 2| 2| 3| 1| 3| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Hemorrhage | 3 |
Iliac, Hyperplasia, Lymphoid | 2 |
Iliac, Hyperplasia | 3 |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hemorrhage | 3 |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | |
Hyperplasia | 2 |
|__________________________________________________________________________|
Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hematopoietic Cell Proliferation | 3 2 3 3 3 4 2 2 2 |
Hyperplasia, Lymphoid | |
Pigmentation, Focal | |
|__________________________________________________________________________|
Thymus | + + A M + + + + + + + + + + + + + + + + + + + + I|
Angiectasis | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 1| 3| 3| 3| 9| 3| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 0|
| 5| 5| 1| 8| 5| 1| 1| 0| 1| 0| 2| 2| 5| 2| 4| 2| 2| 2| 2| 2| 3| 1| 3| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Subcutaneous Tissue, Angiectasis, | |
Focal | 2 |
Subcutaneous Tissue, Edema | 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Callus | |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Compression, Focal | |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Edema, Focal | 3 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Nose | + + A + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Glands, Dilatation, Focal | 2 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 1| 3| 3| 3| 9| 3| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 0|
| 5| 5| 1| 8| 5| 1| 1| 0| 1| 0| 2| 2| 5| 2| 4| 2| 2| 2| 2| 2| 3| 1| 3| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + A + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | 2 |
Hydronephrosis | |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Mixed Cell | |
Nephropathy | 1 3 1 1 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 1 3|
Renal Tubule, Casts Protein | |
Renal Tubule, Necrosis | 2 |
Renal Tubule, Pigmentation | 2 |
Renal Tubule, Vacuolization | |
Cytoplasmic | |
|__________________________________________________________________________|
Urinary Bladder | + + M + M + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia,| |
Focal | |
__________________________________________|__________________________________________________________________________
Page 43
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 9| 2| 2| 2| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + A + + + + + + A + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Edema | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X |
Congestion, Focal | |
Eosinophilic Focus | X |
Hyperplasia, Focal, Lymphoid | 2 |
Infiltration Cellular, Mixed Cell | 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 |
Mixed Cell Focus | |
Necrosis | |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | |
Hepatocyte, Centrilobular, Fatty | |
Change | 3 |
Hepatocyte, Centrilobular, Necrosis | |
|__________________________________________________________________________|
Mesentery | + + + |
Hemorrhage | |
Artery, Inflammation, Chronic | 1 |
Fat, Necrosis | 2 |
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 9| 2| 2| 2| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +|
Acinus, Atrophy, Diffuse | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation, Focal | |
Ulcer | |
Epithelium, Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +|
Ulcer | |
Glands, Degeneration, Cystic, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + M + + + + + + + +|
Infiltration Cellular, Mixed Cell | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | M M + + + + + + + + + + + + + + M M + + + + + + +|
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 9| 2| 2| 2| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Distalis, Hyperplasia, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Degeneration, Cystic, Focal | 1 2 1 1 2 1|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + + |
Abdominal, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + I + M + + + + + + + M + + + + + + + +|
Degeneration, Cystic | 3 2 3 |
|__________________________________________________________________________|
Ovary | + + + + + + M + + + + + + + + + + + + + + + M + +|
Angiectasis | |
Cyst | 2 2 3 3 3 2 3 |
Cyst, Multiple | 3 |
Hyperplasia, Tubular | 3 |
Mineralization | |
Interstitial Cell, Hyperplasia | 3 |
Periovarian Tissue, Inflammation, | |
Chronic | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Atrophy | 3 |
Cyst | 3 2 |
Hemorrhage | 3 |
Hydrometra | 3 3 3 3 2 3 3 3 3|
Hyperplasia, Focal, Histiocytic | 3 |
Inflammation, Suppurative | |
Pigmentation, Focal | 3 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 2 3 3 3 3 2 3 3 3 2 3 3 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 9| 2| 2| 2| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 3 |
Hyperplasia | |
|__________________________________________________________________________|
Lymph Node | + + |
Iliac, Hemorrhage | |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia | |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hemorrhage | |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + I + M + + + + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + I + + + + + + + A + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 3 3 2 2 2 2 2|
Hyperplasia, Lymphoid | 2 2 |
Pigmentation, Focal | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 9| 2| 2| 2| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Subcutaneous Tissue, Angiectasis, | |
Focal | |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Callus | 2 |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + M + + + + + + + +|
Atrophy, Focal | 4 |
Compression, Focal | 2 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + M + + + + + + + +|
Congestion | |
Edema, Focal | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Glands, Dilatation, Focal | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 9| 2| 2| 2| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +|
Congestion | 2 2 |
Cyst | 2 |
Hydronephrosis | 3 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Mixed Cell | 2 |
Nephropathy | 3 4 1 1 1|
Renal Tubule, Accumulation, Hyaline | |
Droplet | |
Renal Tubule, Casts Protein | 2 2 2 2 |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 2 2 |
Renal Tubule, Vacuolization | |
Cytoplasmic | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +|
Transitional Epithelium, Hyperplasia,| |
Focal | 2 |
__________________________________________|__________________________________________________________________________
Page 49
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 7| 7| | |
| 2| 2| 3| 2| 2| 5| 5| 5| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 54 |
Edema | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 56 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Basophilic Focus | | 2 |
Clear Cell Focus | | 2 |
Congestion, Focal | | 1 2.0|
Eosinophilic Focus | X X | 6 |
Hyperplasia, Focal, Lymphoid | | 2 2.0|
Infiltration Cellular, Mixed Cell | 1 1 1 2 1 1 | 37 1.2|
Mixed Cell Focus | | 1 2.0|
Necrosis | | 2 1.5|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 | 2 1.5|
Hepatocyte, Centrilobular, Fatty | | |
Change | | 2 3.0|
Hepatocyte, Centrilobular, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 7| 7| | |
| 2| 2| 3| 2| 2| 5| 5| 5| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + + + | 9 |
Hemorrhage | 2 | 1 2.0|
Artery, Inflammation, Chronic | | 1 1.0|
Fat, Necrosis | 1 | 4 1.3|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Acinus, Atrophy, Diffuse | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + M + | 58 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Inflammation, Focal | | 1 1.0|
Ulcer | 1 | 1 1.0|
Epithelium, Hyperplasia | 2 | 6 1.8|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 57 |
Ulcer | 2 | 2 2.0|
Glands, Degeneration, Cystic, Focal | | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 3.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Infiltration Cellular, Mixed Cell | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + M + | 58 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Cyst | | 2 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + M + | 58 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 7| 7| | |
| 2| 2| 3| 2| 2| 5| 5| 5| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 53 |
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 3 2.0|
Pars Distalis, Hyperplasia, Focal | | 2 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 58 |
Degeneration, Cystic, Focal | 1 2 1 | 16 1.5|
Hyperplasia, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 3 |
Abdominal, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 57 |
Degeneration, Cystic | 3 3 | 5 2.8|
|__________________________________________________________________________|____________|
Ovary | + M + + + + + + + + | 56 |
Angiectasis | 2 | 1 2.0|
Cyst | 2 2 2 | 12 2.5|
Cyst, Multiple | | 1 3.0|
Hyperplasia, Tubular | | 1 3.0|
Mineralization | 2 | 1 2.0|
Interstitial Cell, Hyperplasia | 3 | 2 3.0|
Periovarian Tissue, Inflammation, | | |
Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 7| 7| | |
| 2| 2| 3| 2| 2| 5| 5| 5| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Uterus | + + + + + + + + + + | 60 |
Angiectasis | 2 | 2 2.5|
Atrophy | | 1 3.0|
Cyst | | 3 2.7|
Hemorrhage | | 1 3.0|
Hydrometra | 3 3 3 | 22 3.0|
Hyperplasia, Focal, Histiocytic | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Pigmentation, Focal | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 3 4 2 3 3 3 3 3 2 | 53 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hemorrhage, Focal | | 1 3.0|
Hyperplasia | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 10 |
Iliac, Hemorrhage | | 1 3.0|
Iliac, Hyperplasia, Lymphoid | 3 | 2 2.5|
Iliac, Hyperplasia | | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Hemorrhage | | 1 3.0|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Hyperplasia | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + | 55 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | 3 3 | 2 3.0|
Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 7| 7| | |
| 2| 2| 3| 2| 2| 5| 5| 5| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Spleen | + + + + + + + + + + | 58 |
Congestion | 3 | 2 2.5|
Hematopoietic Cell Proliferation | 2 3 2 3 2 | 21 2.5|
Hyperplasia, Lymphoid | 2 2 | 4 2.0|
Pigmentation, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 55 |
Angiectasis | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Ectasia | | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Angiectasis, | | |
Focal | | 1 2.0|
Subcutaneous Tissue, Edema | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Callus | | 1 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Atrophy, Focal | | 1 4.0|
Compression, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 7| 7| | |
| 2| 2| 3| 2| 2| 5| 5| 5| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Congestion | | 1 2.0|
Edema, Focal | | 1 3.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | | 2 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Mucosa, Glands, Dilatation, Focal | | 3 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
Congestion | 2 | 3 2.0|
Cyst | | 2 2.0|
Hydronephrosis | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Nephropathy | 2 | 10 1.8|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 2 2.0|
Renal Tubule, Casts Protein | 2 2 2 | 7 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 7| 7| | |
| 2| 2| 3| 2| 2| 5| 5| 5| 2| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Renal Tubule, Necrosis | | 1 2.0|
Renal Tubule, Pigmentation | | 3 2.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
Transitional Epithelium, Hyperplasia,| | |
Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 6| 5| 7| 6| 6| 6| 4| 7| 6| 5| 6|
DAY ON TEST | 0| 5| 8| 4| 8| 8| 9| 8| 6| 7| 0| 7| 3| 8| 6| 0| 2| 4| 0| 9| 4| 0| 1| 2| 8|
| 9| 9| 1| 0| 8| 8| 0| 3| 7| 5| 3| 1| 0| 3| 8| 7| 5| 7| 8| 6| 4| 2| 0| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Gallbladder | + A A A + A + + + A + A A + A A + A A M + A + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + A + + A + + A + + A A + A + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + A + + A A + A + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + A + A + + + A + A A + A A + A A A + A + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + A + A + + + + + A + + A + A A + A A A + A + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + A + A + + + A + + A + A A + A A A + A + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A + A + A + + + A + + A + A A + A A A + A + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X X|
Hyperplasia, Focal, Lymphoid | 3 |
Infiltration Cellular, Mixed Cell | 2 3 3 2 2 3 2 3 1 2 3 3 2 3 3 3 2 3 3|
Inflammation, Focal | 3 |
Mixed Cell Focus | |
Necrosis | 2 2 3 2 3 3 4 |
Hepatocyte, Necrosis, Focal | 1 |
Hepatocyte, Tension Lipidosis | X |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 2 1|
Hepatocyte, Periportal, Depletion | |
Glycogen | 3 |
Oval Cell, Hyperplasia | 3 2 1 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 57
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 6| 5| 7| 6| 6| 6| 4| 7| 6| 5| 6|
DAY ON TEST | 0| 5| 8| 4| 8| 8| 9| 8| 6| 7| 0| 7| 3| 8| 6| 0| 2| 4| 0| 9| 4| 0| 1| 2| 8|
| 9| 9| 1| 0| 8| 8| 0| 3| 7| 5| 3| 1| 0| 3| 8| 7| 5| 7| 8| 6| 4| 2| 0| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | 4 |
Acinus, Atrophy, Focal | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + M M M + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + A + + + A + + + + +|
Inflammation, Focal | 1 |
Ulcer | 3 |
|__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + M + + + + +|
Angiectasis | |
Inflammation, Chronic, Focal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + M M + + + + +|
Cyst | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 58
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 6| 5| 7| 6| 6| 6| 4| 7| 6| 5| 6|
DAY ON TEST | 0| 5| 8| 4| 8| 8| 9| 8| 6| 7| 0| 7| 3| 8| 6| 0| 2| 4| 0| 9| 4| 0| 1| 2| 8|
| 9| 9| 1| 0| 8| 8| 0| 3| 7| 5| 3| 1| 0| 3| 8| 7| 5| 7| 8| 6| 4| 2| 0| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + M +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M M + + + + +|
Degeneration, Cystic, Focal | 2 2 1 2 2|
Follicle, Cyst | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + I + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Pigmentation | 2 |
|__________________________________________________________________________|
Ovary | + + M + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 |
Hemorrhage | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hemorrhage | 3 |
Hydrometra | 3 3 3|
Inflammation, Suppurative | 3 4 |
Endometrium, Hyperplasia, Cystic | 3 2 2 2 3 3 2 3 3 4 2 2 3 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Hematopoietic Cell | |
Proliferation | |
Inguinal, Hyperplasia | 4 |
Mediastinal, Hematopoietic Cell | |
Proliferation | 2 |
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 6| 5| 7| 6| 6| 6| 4| 7| 6| 5| 6|
DAY ON TEST | 0| 5| 8| 4| 8| 8| 9| 8| 6| 7| 0| 7| 3| 8| 6| 0| 2| 4| 0| 9| 4| 0| 1| 2| 8|
| 9| 9| 1| 0| 8| 8| 0| 3| 7| 5| 3| 1| 0| 3| 8| 7| 5| 7| 8| 6| 4| 2| 0| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Mediastinal, Hemorrhage | 2 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | 3 |
Renal, Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + M M + + + M M A + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3|
Hyperplasia | 1 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Hematopoietic Cell Proliferation | 4 4 4 3 4 3 3 4 4 3 4 4 4 3 3 3 4 3 4 4 4 4 4 4|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Thymus | + + M M M + + + + + + + + + + M + M M M + + + + +|
Angiectasis | |
Atrophy | 3 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 3 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
Hyperostosis | 3 3 |
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 6| 5| 7| 6| 6| 6| 4| 7| 6| 5| 6|
DAY ON TEST | 0| 5| 8| 4| 8| 8| 9| 8| 6| 7| 0| 7| 3| 8| 6| 0| 2| 4| 0| 9| 4| 0| 1| 2| 8|
| 9| 9| 1| 0| 8| 8| 0| 3| 7| 5| 3| 1| 0| 3| 8| 7| 5| 7| 8| 6| 4| 2| 0| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Femur, Callus | |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + M + M + + + + +|
Congestion | |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Mixed Cell | 1 3 |
Artery, Mediastinum, Inflammation, | |
Chronic | |
Bronchus, Glands, Cyst | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hemorrhage | 3 |
Mucosa, Glands, Dilatation, Focal | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + M M + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | 2 |
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 6| 5| 7| 6| 6| 6| 4| 7| 6| 5| 6|
DAY ON TEST | 0| 5| 8| 4| 8| 8| 9| 8| 6| 7| 0| 7| 3| 8| 6| 0| 2| 4| 0| 9| 4| 0| 1| 2| 8|
| 9| 9| 1| 0| 8| 8| 0| 3| 7| 5| 3| 1| 0| 3| 8| 7| 5| 7| 8| 6| 4| 2| 0| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Inflammation, Suppurative | 3 |
Mineralization, Focal | |
Nephropathy | 1 1 1 2 3 2 |
Pigmentation | 3 |
Artery, Inflammation, Chronic | 2 |
Pelvis, Dilatation | |
Pelvis, Hemorrhage | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 3 2 3 |
Renal Tubule, Casts Protein | 2 2 2 2 2 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Pigmentation | 2 3 3 3 3 3 2 2 3 3 3 3 2 4 3|
|__________________________________________________________________________|
Urinary Bladder | + + + + I A + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 62
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 6| 5| 6| 6| 5| 6| 6| 6| 7| 7| 5| 7| 6| 5| 5| 6| 4| 6| 6| 6|
DAY ON TEST | 2| 7| 6| 8| 4| 6| 9| 2| 7| 6| 5| 2| 6| 1| 1| 1| 2| 9| 4| 6| 9| 0| 7| 1| 8|
| 9| 5| 1| 5| 4| 9| 7| 9| 9| 7| 8| 4| 1| 0| 0| 6| 2| 0| 8| 9| 3| 9| 7| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + M A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A + A + A A A + M A A A + + A A + + + + + A + M|
|__________________________________________________________________________|
Intestine Large, Colon | + A + A + + A A + A A + + + + + A + + + + + A + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + A A + A A + + + + + A + + + + + A + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + A + A A A + A A A A + + + A + A + + + A + +|
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + A + A + A A A + A A A + + + + A + A + + + A + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + A + A A A + A A A + + + + A + + + + + A + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A + A + A A A A A A A + + + + A + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X X X X X X X X X X |
Hyperplasia, Focal, Lymphoid | |
Infiltration Cellular, Mixed Cell | 3 2 3 3 2 2 1 3 2 3 2 2 3 3 1 3 2|
Inflammation, Focal | |
Mixed Cell Focus | X X X |
Necrosis | 1 2 1 3 1 1 |
Hepatocyte, Necrosis, Focal | 2 2 1 |
Hepatocyte, Tension Lipidosis | |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 1 2 1 2 |
Hepatocyte, Periportal, Depletion | |
Glycogen | |
Oval Cell, Hyperplasia | |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 6| 5| 6| 6| 5| 6| 6| 6| 7| 7| 5| 7| 6| 5| 5| 6| 4| 6| 6| 6|
DAY ON TEST | 2| 7| 6| 8| 4| 6| 9| 2| 7| 6| 5| 2| 6| 1| 1| 1| 2| 9| 4| 6| 9| 0| 7| 1| 8|
| 9| 5| 1| 5| 4| 9| 7| 9| 9| 7| 8| 4| 1| 0| 0| 6| 2| 0| 8| 9| 3| 9| 7| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + A A + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | |
|__________________________________________________________________________|
Salivary Glands | + + + + + M M M + M M + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + A A + + + + + + + + + + + A + +|
Inflammation, Focal | 2 |
Ulcer | |
|__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + M + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
|__________________________________________________________________________|
Adrenal Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A A A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + M M M M + + + M + + + + + + + + +|
Cyst | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 6| 5| 6| 6| 5| 6| 6| 6| 7| 7| 5| 7| 6| 5| 5| 6| 4| 6| 6| 6|
DAY ON TEST | 2| 7| 6| 8| 4| 6| 9| 2| 7| 6| 5| 2| 6| 1| 1| 1| 2| 9| 4| 6| 9| 0| 7| 1| 8|
| 9| 5| 1| 5| 4| 9| 7| 9| 9| 7| 8| 4| 1| 0| 0| 6| 2| 0| 8| 9| 3| 9| 7| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pituitary Gland | + + + + + + M + + M M + I + + + + + + + + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + M M + + + + M + + + + + + + + +|
Degeneration, Cystic, Focal | 2 2 1 2 2 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Pigmentation | |
|__________________________________________________________________________|
Ovary | + + + + + + + M + + + + + + + + + + + + + + A + +|
Cyst | 3 2 2 3 |
Hemorrhage | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | |
Hydrometra | 3 3 3 4|
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 3 3 1 3 3 3 3 3 2 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hematopoietic Cell | |
Proliferation | |
Inguinal, Hyperplasia | |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 6| 5| 6| 6| 5| 6| 6| 6| 7| 7| 5| 7| 6| 5| 5| 6| 4| 6| 6| 6|
DAY ON TEST | 2| 7| 6| 8| 4| 6| 9| 2| 7| 6| 5| 2| 6| 1| 1| 1| 2| 9| 4| 6| 9| 0| 7| 1| 8|
| 9| 5| 1| 5| 4| 9| 7| 9| 9| 7| 8| 4| 1| 0| 0| 6| 2| 0| 8| 9| 3| 9| 7| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 3 |
Mediastinal, Hyperplasia | |
Renal, Hyperplasia | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M M + + M M + + + + + + + + + + + M + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + A M + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia | 3 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + M + +|
Depletion Cellular | 2 |
Hematopoietic Cell Proliferation | 3 4 4 4 3 4 3 4 3 2 4 3 3 3 4 3 4 3 4 4 4|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Thymus | + + + M + + I + + A M + + + + I I + + + + + M + +|
Angiectasis | 2 |
Atrophy | |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 3 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperostosis | |
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 6| 5| 6| 6| 5| 6| 6| 6| 7| 7| 5| 7| 6| 5| 5| 6| 4| 6| 6| 6|
DAY ON TEST | 2| 7| 6| 8| 4| 6| 9| 2| 7| 6| 5| 2| 6| 1| 1| 1| 2| 9| 4| 6| 9| 0| 7| 1| 8|
| 9| 5| 1| 5| 4| 9| 7| 9| 9| 7| 8| 4| 1| 0| 0| 6| 2| 0| 8| 9| 3| 9| 7| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Femur, Callus | 3 |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + M M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + |
|__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + M + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Mixed Cell | 3 3 2 3 2 |
Artery, Mediastinum, Inflammation, | |
Chronic | 3 |
Bronchus, Glands, Cyst | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + M M + + + + + + + + + + + + + +|
Hemorrhage | |
Mucosa, Glands, Dilatation, Focal | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + M M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Cyst | |
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 6| 5| 6| 6| 5| 6| 6| 6| 7| 7| 5| 7| 6| 5| 5| 6| 4| 6| 6| 6|
DAY ON TEST | 2| 7| 6| 8| 4| 6| 9| 2| 7| 6| 5| 2| 6| 1| 1| 1| 2| 9| 4| 6| 9| 0| 7| 1| 8|
| 9| 5| 1| 5| 4| 9| 7| 9| 9| 7| 8| 4| 1| 0| 0| 6| 2| 0| 8| 9| 3| 9| 7| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Inflammation, Suppurative | |
Mineralization, Focal | 3 |
Nephropathy | 1 3 2 2 1|
Pigmentation | |
Artery, Inflammation, Chronic | |
Pelvis, Dilatation | 3 |
Pelvis, Hemorrhage | 3 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 2 2 2 3 2 |
Renal Tubule, Casts Protein | 2 |
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | 2 3 3 3 3 3 3 3 3 3 4 3 3 3 3 3|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + A + + + + + + + + + + + + M + +|
__________________________________________|__________________________________________________________________________
Page 68
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| | |
DAY ON TEST | 0| 8| 2| 7| 2| 2| 2| 4| 9| 1| | |
| 5| 6| 9| 9| 9| 9| 9| 3| 0| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Gallbladder | + A + A + + + A + + | 31 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + A + A + + + A + A | 41 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + A + + | 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A A + A + + + A + A | 32 |
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A A + A + + + A + A | 34 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A + A + + + A + A | 34 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + A + + + A + A | 34 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 3 2.3|
Basophilic Focus | | 6 |
Clear Cell Focus | X X | 4 |
Eosinophilic Focus | X X X X | 28 |
Hyperplasia, Focal, Lymphoid | | 1 3.0|
Infiltration Cellular, Mixed Cell | 2 2 1 2 1 2 2 | 43 2.3|
Inflammation, Focal | | 1 3.0|
Mixed Cell Focus | | 3 |
Necrosis | | 13 2.2|
Hepatocyte, Necrosis, Focal | 2 1 | 6 1.5|
Hepatocyte, Tension Lipidosis | | 1 |
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 1 1 2 | 9 1.4|
Hepatocyte, Periportal, Depletion | | |
Glycogen | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| | |
DAY ON TEST | 0| 8| 2| 7| 2| 2| 2| 4| 9| 1| | |
| 5| 6| 9| 9| 9| 9| 9| 3| 0| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Oval Cell, Hyperplasia | | 4 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 34 |
Inflammation, Chronic | | 2 2.0|
|__________________________________________________________________________|____________|
Pancreas | + M + + + + + + + + | 57 |
Acinus, Atrophy, Diffuse | | 1 4.0|
Acinus, Atrophy, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + + + | 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + + | 59 |
Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + | 52 |
Inflammation, Focal | | 2 1.5|
Ulcer | | 1 3.0|
|__________________________________________________________________________|____________|
Tooth | | 2 |
Peridontal Tissue, Inflammation, | | |
Chronic | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 58 |
Angiectasis | 2 | 1 2.0|
Inflammation, Chronic, Focal | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| | |
DAY ON TEST | 0| 8| 2| 7| 2| 2| 2| 4| 9| 1| | |
| 5| 6| 9| 9| 9| 9| 9| 3| 0| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + + + + + + + | 56 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + | 50 |
Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M | 53 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + | 53 |
Degeneration, Cystic, Focal | 1 2 | 13 1.7|
Follicle, Cyst | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 58 |
Degeneration, Cystic | | 2 3.0|
Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Ovary | + M + + + + + + + + | 56 |
Cyst | 2 2 3 | 11 2.6|
Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + A + + + + + + + + | 59 |
Angiectasis | | 1 2.0|
Hemorrhage | | 1 3.0|
Hydrometra | 3 3 3 3 3 3 3 3 | 15 3.1|
Inflammation, Suppurative | | 2 3.5|
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 | 37 2.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| | |
DAY ON TEST | 0| 8| 2| 7| 2| 2| 2| 4| 9| 1| | |
| 5| 6| 9| 9| 9| 9| 9| 3| 0| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia | | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + | 11 |
Iliac, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Inguinal, Hyperplasia | | 1 4.0|
Mediastinal, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Mediastinal, Hemorrhage | | 3 2.7|
Mediastinal, Hyperplasia, Lymphoid | | 2 3.0|
Mediastinal, Hyperplasia | | 1 3.0|
Renal, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + | 48 |
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + A + + + + + + + + | 57 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia | 3 | 4 2.5|
|__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + | 57 |
Depletion Cellular | | 1 2.0|
Hematopoietic Cell Proliferation | 4 3 4 3 3 3 4 3 3 | 54 3.5|
Hyperplasia, Lymphoid | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Thymus | I + + M + + + + + + | 44 |
Angiectasis | | 1 2.0|
Atrophy | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| | |
DAY ON TEST | 0| 8| 2| 7| 2| 2| 2| 4| 9| 1| | |
| 5| 6| 9| 9| 9| 9| 9| 3| 0| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Edema | | 4 2.8|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | | 1 3.0|
Hyperostosis | | 2 3.0|
Femur, Callus | | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 18 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 57 |
Congestion | | 1 2.0|
Hemorrhage | | 2 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Mixed Cell | 2 3 | 9 2.4|
Artery, Mediastinum, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| | |
DAY ON TEST | 0| 8| 2| 7| 2| 2| 2| 4| 9| 1| | |
| 5| 6| 9| 9| 9| 9| 9| 3| 0| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Bronchus, Glands, Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 57 |
Hemorrhage | | 1 3.0|
Mucosa, Glands, Dilatation, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + M + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + A + + + + + + + + | 59 |
Congestion | | 1 1.0|
Cyst | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Mineralization, Focal | | 1 3.0|
Nephropathy | | 11 1.7|
Pigmentation | | 1 3.0|
Artery, Inflammation, Chronic | | 1 2.0|
Pelvis, Dilatation | | 1 3.0|
Pelvis, Hemorrhage | | 1 3.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 10 2.3|
Renal Tubule, Casts Protein | | 6 2.0|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Pigmentation | 3 3 3 3 | 35 2.9|
|__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + | 54 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7|
DAY ON TEST | 2| 3| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 2| 2| 3| 1| 9| 3| 2| 2| 1| 6| 3|
| 9| 1| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 0| 0| 9| 9| 0| 8| 6| 0| 9| 9| 0| 3| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + A + + + + A + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + A + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + A + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + A + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A A + + + A + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + A + +|
Epithelium, Degeneration, Cystic, | |
Focal | 1 |
Epithelium, Hyperplasia, Focal, | |
Adenomatous | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A A + + + A + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Clear Cell Focus | X X |
Congestion, Focal | |
Eosinophilic Focus | |
Infiltration Cellular, Mixed Cell | 1 1 1 2 1 1 1 2 1 1 1 1 1 2 1 2 1 1|
Mixed Cell Focus | |
Necrosis | 1 |
Hepatocyte, Fatty Change, Diffuse | 3 2 |
Hepatocyte, Necrosis, Focal | 3 |
Hepatocyte, Syncytial Alteration, | |
Focal | 1 1 1 1 1 1 1 1 |
Hepatocyte, Tension Lipidosis | |
Hepatocyte, Vacuolization | |
Cytoplasmic, Diffuse | 3 1 3 3 2 3 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 1 2 2 1 |
__________________________________________|__________________________________________________________________________|
Page 75
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7|
DAY ON TEST | 2| 3| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 2| 2| 3| 1| 9| 3| 2| 2| 1| 6| 3|
| 9| 1| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 0| 0| 9| 9| 0| 8| 6| 0| 9| 9| 0| 3| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Hepatocyte, Centrilobular, Fatty | |
Change | |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic | 2 2 2 |
Artery, Inflammation, Chronic | 1 |
Fat, Necrosis | 2 1 2 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 3 |
Duct, Cyst | 4 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Cyst | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + |
Malformation | 2 |
Peridontal Tissue, Inflammation, | |
Chronic | 3 3 3 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 1 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7|
DAY ON TEST | 2| 3| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 2| 2| 3| 1| 9| 3| 2| 2| 1| 6| 3|
| 9| 1| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 0| 0| 9| 9| 0| 8| 6| 0| 9| 9| 0| 3| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + M M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + M + + + + M + + + + + + + + + + + + + + I +|
Pars Distalis, Cyst | 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 3 3 3 1 3 3 2 3 3 3|
Inflammation, Chronic | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Hemorrhage | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Lymphoid | 3 |
__________________________________________|__________________________________________________________________________|
Page 77
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7|
DAY ON TEST | 2| 3| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 2| 2| 3| 1| 9| 3| 2| 2| 1| 6| 3|
| 9| 1| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 0| 0| 9| 9| 0| 8| 6| 0| 9| 9| 0| 3| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Hematopoietic Cell Proliferation | 2 2 3 2 |
Hyperplasia, Lymphoid | |
Pigmentation, Focal | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + I|
Cyst | 2 |
Hyperplasia, Lymphoid | 3 |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M + M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Chronic, Focal | |
Artery, Subcutaneous Tissue, | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7|
DAY ON TEST | 2| 3| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 2| 2| 3| 1| 9| 3| 2| 2| 1| 6| 3|
| 9| 1| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 0| 0| 9| 9| 0| 8| 6| 0| 9| 9| 0| 3| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Alveolar Epithelium, Hyperplasia | |
Bronchus, Glands, Cyst | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sinus, Foreign Body | |
Sinus, Inflammation, Chronic, | |
Suppurative | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Harderian Gland | + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +|
Congestion | 2 |
Cyst | |
Hyperplasia, Lymphoid | 2 |
Nephropathy | 1 2 1 2 1 1 1 2 1 2 1 1 2 2 1 1 1 1 1 1 2 1|
Artery, Inflammation, Chronic | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | |
Renal Tubule, Pigmentation | |
Renal Tubule, Vacuolization | |
Cytoplasmic | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 79
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 4| 2| 2| 2| 3| 3| 2| 3|
| 0| 9| 0| 9| 1| 7| 9| 0| 9| 0| 0| 9| 0| 0| 9| 0| 0| 9| 9| 9| 9| 0| 0| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + M + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Epithelium, Degeneration, Cystic, | |
Focal | |
Epithelium, Hyperplasia, Focal, | |
Adenomatous | 3 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | X |
Congestion, Focal | 2 |
Eosinophilic Focus | X X X |
Infiltration Cellular, Mixed Cell | 1 2 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1|
Mixed Cell Focus | X X|
Necrosis | |
Hepatocyte, Fatty Change, Diffuse | |
Hepatocyte, Necrosis, Focal | 1 |
Hepatocyte, Syncytial Alteration, | |
Focal | 1 1 1 1 1 1 1 1 |
Hepatocyte, Tension Lipidosis | |
Hepatocyte, Vacuolization | |
Cytoplasmic, Diffuse | 2 3 3 2 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | |
__________________________________________|__________________________________________________________________________|
Page 80
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 4| 2| 2| 2| 3| 3| 2| 3|
| 0| 9| 0| 9| 1| 7| 9| 0| 9| 0| 0| 9| 0| 0| 9| 0| 0| 9| 9| 9| 9| 0| 0| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Hepatocyte, Centrilobular, Fatty | |
Change | |
|__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | |
Artery, Inflammation, Chronic | 2 |
Fat, Necrosis | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Acinus, Atrophy, Focal | |
Duct, Cyst | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Cyst | 1 |
Epithelium, Hyperplasia | 2 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + +|
Malformation | 3 2 1 |
Peridontal Tissue, Inflammation, | |
Chronic | 3 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 1 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 81
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 4| 2| 2| 2| 3| 3| 2| 3|
| 0| 9| 0| 9| 1| 7| 9| 0| 9| 0| 0| 9| 0| 0| 9| 0| 0| 9| 9| 9| 9| 0| 0| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + M + + + M + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 3 3 3 3 3 3 3 3 |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Hemorrhage | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________|__________________________________________________________________________|
Page 82
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 4| 2| 2| 2| 3| 3| 2| 3|
| 0| 9| 0| 9| 1| 7| 9| 0| 9| 0| 0| 9| 0| 0| 9| 0| 0| 9| 9| 9| 9| 0| 0| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Hematopoietic Cell Proliferation | 3 2 1 3 3 |
Hyperplasia, Lymphoid | 2 3 |
Pigmentation, Focal | |
|__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 |
Hyperplasia, Lymphoid | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Chronic, Focal | 2 |
Artery, Subcutaneous Tissue, | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | + |
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 4| 2| 2| 2| 3| 3| 2| 3|
| 0| 9| 0| 9| 1| 7| 9| 0| 9| 0| 0| 9| 0| 0| 9| 0| 0| 9| 9| 9| 9| 0| 0| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | |
Bronchus, Glands, Cyst | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sinus, Foreign Body | 3 |
Sinus, Inflammation, Chronic, | |
Suppurative | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +|
Congestion | 1 2 2|
Cyst | 2 2 |
Hyperplasia, Lymphoid | |
Nephropathy | 1 1 2 1 1 4 2 1 1 1 1 2 1 1 2 2 2 1 1 1 1 1 1 1|
Artery, Inflammation, Chronic | 2 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 4 |
Renal Tubule, Pigmentation | 1 |
Renal Tubule, Vacuolization | |
Cytoplasmic | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 84
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 9| 1| 3| 3| 2| 3| 3| 3| | |
| 1| 9| 2| 9| 0| 0| 9| 0| 1| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Gallbladder | + + + A + + + I + + | 54 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + | 56 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + M + + + | 55 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + | 56 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + | 55 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + | 56 |
Epithelium, Degeneration, Cystic, | | |
Focal | | 1 1.0|
Epithelium, Hyperplasia, Focal, | | |
Adenomatous | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + | 55 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Clear Cell Focus | | 3 |
Congestion, Focal | 2 | 2 2.0|
Eosinophilic Focus | | 3 |
Infiltration Cellular, Mixed Cell | 1 1 2 1 1 2 1 1 1 | 46 1.2|
Mixed Cell Focus | | 2 |
Necrosis | | 1 1.0|
Hepatocyte, Fatty Change, Diffuse | | 2 2.5|
Hepatocyte, Necrosis, Focal | | 2 2.0|
Hepatocyte, Syncytial Alteration, | | |
Focal | | 16 1.0|
Hepatocyte, Tension Lipidosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 9| 1| 3| 3| 2| 3| 3| 3| | |
| 1| 9| 2| 9| 0| 0| 9| 0| 1| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | | 10 2.5|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | | 4 1.5|
Hepatocyte, Centrilobular, Fatty | | |
Change | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + | 12 |
Inflammation, Chronic | | 3 2.0|
Artery, Inflammation, Chronic | 3 | 3 2.0|
Fat, Necrosis | 2 1 | 6 1.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Acinus, Atrophy, Focal | | 1 3.0|
Duct, Cyst | | 1 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Epithelium, Cyst | | 1 1.0|
Epithelium, Hyperplasia | | 2 1.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + | 57 |
|__________________________________________________________________________|____________|
Tooth | + + + + + | 14 |
Malformation | 2 | 5 2.0|
Peridontal Tissue, Inflammation, | | |
Chronic | 3 2 3 2 | 10 2.9|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 9| 1| 3| 3| 2| 3| 3| 3| | |
| 1| 9| 2| 9| 0| 0| 9| 0| 1| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Cytoplasmic Alteration, Focal | 2 | 7 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 55 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + | 53 |
Pars Distalis, Cyst | | 2 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + A + + + + + + | 59 |
Degeneration, Cystic, Focal | 1 1 | 10 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 3 3 3 3 | 28 2.9|
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | | 2 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 9| 1| 3| 3| 2| 3| 3| 3| | |
| 1| 9| 2| 9| 0| 0| 9| 0| 1| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Mediastinal, Hemorrhage | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Hemorrhage | | 1 1.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Depletion Cellular | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 2 2 2 | 13 2.3|
Hyperplasia, Lymphoid | | 2 2.5|
Pigmentation, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
Cyst | 2 | 4 1.8|
Hyperplasia, Lymphoid | | 1 3.0|
Epithelial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Ulcer, Chronic, Focal | | 1 2.0|
Artery, Subcutaneous Tissue, | | |
Inflammation, Chronic | 3 | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 9| 1| 3| 3| 2| 3| 3| 3| | |
| 1| 9| 2| 9| 0| 0| 9| 0| 1| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
Bronchus, Glands, Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Sinus, Foreign Body | | 1 3.0|
Sinus, Inflammation, Chronic, | | |
Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 9| 1| 3| 3| 2| 3| 3| 3| | |
| 1| 9| 2| 9| 0| 0| 9| 0| 1| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
Congestion | 1 | 5 1.6|
Cyst | | 2 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Nephropathy | 1 1 1 1 1 2 1 2 1 1 | 56 1.3|
Artery, Inflammation, Chronic | 3 | 2 2.5|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 1 4.0|
Renal Tubule, Pigmentation | | 1 1.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 6| 6| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 2| 3| 5| 2| 5| 3| 3| 4| 2| 1| 3| 3| 7| 4| 3| 3| 8| 2| 3| 2| 2| 2|
| 0| 0| 2| 9| 0| 9| 8| 5| 0| 3| 1| 9| 0| 1| 0| 2| 5| 0| 0| 5| 9| 0| 9| 6| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + A A A + A M + + + + A A + + + + + + A +|
Fibrosis | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + M + A + + + + A M + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + M A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + A A + A A + + + + A + + + + + + + A +|
Epithelium, Degeneration, Mucoid | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A A A + A A + + + + + A + + + M + + A +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + A A A A A + + + + A A + + + + + + A +|
Inflammation, Focal | |
Ulcer | |
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
Peyer's Patch, Inflammation, Chronic | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A A A A A A + + + M A A + + + M + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Basophilic Focus | X X X |
Clear Cell Focus | X X |
Congestion, Focal | |
Eosinophilic Focus | X X X X X |
Fibrosis, Focal | |
Infiltration Cellular, Mixed Cell | 1 2 1 2 2 2 1 1 1 2 1 2 1 1 1|
Inflammation, Chronic, Focal | |
Inflammation, Focal, Suppurative | |
Mineralization, Focal | |
Necrosis | 2 1 2 1 2 2 1 3 |
Hepatocyte, Syncytial Alteration, | |
Focal | 1 1 2 1 1 1 1 1 1 1 1|
Hepatocyte, Vacuolization | |
__________________________________________|__________________________________________________________________________|
Page 91
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 6| 6| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 2| 3| 5| 2| 5| 3| 3| 4| 2| 1| 3| 3| 7| 4| 3| 3| 8| 2| 3| 2| 2| 2|
| 0| 0| 2| 9| 0| 9| 8| 5| 0| 3| 1| 9| 0| 1| 0| 2| 5| 0| 0| 5| 9| 0| 9| 6| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Cytoplasmic, Diffuse | 2 2 2 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 1 1 2 2 |
Hepatocyte, Centrilobular, Depletion | |
Glycogen | 2 |
Hepatocyte, Centrilobular, Fatty | |
Change | 2 2 |
|__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic | 2 |
Artery, Inflammation, Chronic | |
Fat, Necrosis | |
|__________________________________________________________________________|
Oral Mucosa | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Acinus, Atrophy, Focal | |
Duct, Cyst | |
Duct, Inflammation, Chronic, Focal | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | |
Ulcer | 1 |
Epithelium, Hyperplasia | 2 1 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + A A + + + + + + + A A + + + + + + A +|
Inflammation, Chronic, Focal | 2 |
Inflammation, Focal | |
|__________________________________________________________________________|
Tooth | + + + + + + |
Peridontal Tissue, Inflammation, | |
Chronic | 2 3 3 3 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 92
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 6| 6| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 2| 3| 5| 2| 5| 3| 3| 4| 2| 1| 3| 3| 7| 4| 3| 3| 8| 2| 3| 2| 2| 2|
| 0| 0| 2| 9| 0| 9| 8| 5| 0| 3| 1| 9| 0| 1| 0| 2| 5| 0| 0| 5| 9| 0| 9| 6| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Cyst | 1 1 |
Cytoplasmic Alteration, Focal | 2|
Hypertrophy, Focal | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Amyloid Deposition | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + I + + + M + + + + + M + + + + +|
Pars Distalis, Cyst | 2 |
Rathke's Cleft, Cyst | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 1 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 3 3 3 3 3 3 3 3 3 3 |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + I + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 93
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 6| 6| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 2| 3| 5| 2| 5| 3| 3| 4| 2| 1| 3| 3| 7| 4| 3| 3| 8| 2| 3| 2| 2| 2|
| 0| 0| 2| 9| 0| 9| 8| 5| 0| 3| 1| 9| 0| 1| 0| 2| 5| 0| 0| 5| 9| 0| 9| 6| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
Hemorrhage, Focal | 3 2 |
Hyperplasia | 3 |
Thrombosis | |
|__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia | |
Mediastinal, Pigmentation | |
Pancreatic, Hemorrhage | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + M M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + M + + + + + + + M + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Depletion Cellular | 4 3 |
Hematopoietic Cell Proliferation | 4 3 3 4 4 3 2 3 3 3 3 |
Hyperplasia, Lymphoid | 3 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + M M + + + + + I + + + + + + + + M +|
Atrophy | 3 3 |
Cyst | 2 |
__________________________________________|__________________________________________________________________________|
Page 94
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 6| 6| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 2| 3| 5| 2| 5| 3| 3| 4| 2| 1| 3| 3| 7| 4| 3| 3| 8| 2| 3| 2| 2| 2|
| 0| 0| 2| 9| 0| 9| 8| 5| 0| 3| 1| 9| 0| 1| 0| 2| 5| 0| 0| 5| 9| 0| 9| 6| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 3 2 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | 3 |
|__________________________________________________________________________|
Skeletal Muscle | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Histiocytic | 2 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Chronic, Focal | 2 |
Alveolar Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Glands, Dilatation, Focal | 1|
Nasolacrimal Duct, Inflammation | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________|__________________________________________________________________________|
Page 95
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 6| 6| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 2| 3| 5| 2| 5| 3| 3| 4| 2| 1| 3| 3| 7| 4| 3| 3| 8| 2| 3| 2| 2| 2|
| 0| 0| 2| 9| 0| 9| 8| 5| 0| 3| 1| 9| 0| 1| 0| 2| 5| 0| 0| 5| 9| 0| 9| 6| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Harderian Gland | |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Atrophy, Focal | 2 |
Atrophy | |
Congestion | 2 2 |
Cyst | 2 2 1 2 |
Fibrosis, Focal | |
Hyperplasia, Lymphoid | |
Infarct | |
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic | |
Inflammation, Focal, Suppurative | |
Inflammation, Suppurative | |
Nephropathy | 2 2 2 1 1 2 2 2 2 1 2 4 1 2 1 1 2 1 2 1 2 2 2|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 3 3 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 96
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 4| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 6| 3| 1| 2| 4| 3| 3| 2| 3| 3| 9| 7| 3| 3| 9| 2| 6| 3| 8| 3| 2| 2| 2| 8|
| 4| 9| 1| 7| 6| 1| 0| 0| 9| 0| 1| 0| 5| 0| 1| 2| 9| 0| 0| 8| 1| 9| 9| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A + + + A + + + + + + M + + + + A + A + + M + A|
Fibrosis | 3 |
|__________________________________________________________________________|
Intestine Large, Colon | + A + + A + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + A A + + + + + + + + + + + + + + + + + + + A|
Epithelium, Degeneration, Mucoid | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + A + + A + + + + + + + A + + + + A + + + + + + A|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + A A + + + + + + A + + + + A + + + + + + A|
Inflammation, Focal | |
Ulcer | |
Peyer's Patch, Hyperplasia, Lymphoid | |
Peyer's Patch, Inflammation, Chronic | |
|__________________________________________________________________________|
Intestine Small, Ileum | + A + A A A + + + + + + A + + + + A + + + + + + A|
|__________________________________________________________________________|
Liver | + A + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Basophilic Focus | X X |
Clear Cell Focus | |
Congestion, Focal | 2 |
Eosinophilic Focus | X X X X X X X |
Fibrosis, Focal | 3 |
Infiltration Cellular, Mixed Cell | 1 3 3 3 1 2 2 1 1 1 2 1 1 1 3 1 2 2|
Inflammation, Chronic, Focal | 3 |
Inflammation, Focal, Suppurative | 2 |
Mineralization, Focal | 2 |
Necrosis | 3 3 1 2 3 2|
Hepatocyte, Syncytial Alteration, | |
Focal | 2 1 1 1 1 1 1 1 |
Hepatocyte, Vacuolization | |
__________________________________________|__________________________________________________________________________|
Page 97
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 4| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 6| 3| 1| 2| 4| 3| 3| 2| 3| 3| 9| 7| 3| 3| 9| 2| 6| 3| 8| 3| 2| 2| 2| 8|
| 4| 9| 1| 7| 6| 1| 0| 0| 9| 0| 1| 0| 5| 0| 1| 2| 9| 0| 0| 8| 1| 9| 9| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Cytoplasmic, Diffuse | 2 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 2 |
Hepatocyte, Centrilobular, Depletion | |
Glycogen | |
Hepatocyte, Centrilobular, Fatty | |
Change | |
|__________________________________________________________________________|
Mesentery | + + + + + + + |
Inflammation, Chronic | 2 |
Artery, Inflammation, Chronic | 2 |
Fat, Necrosis | 2 |
|__________________________________________________________________________|
Oral Mucosa | + |
|__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Acinus, Atrophy, Focal | 3 |
Duct, Cyst | 4 |
Duct, Inflammation, Chronic, Focal | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 2 |
Ulcer | |
Epithelium, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Inflammation, Focal | 2 |
|__________________________________________________________________________|
Tooth | + +|
Peridontal Tissue, Inflammation, | |
Chronic | 3 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
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NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 4| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 6| 3| 1| 2| 4| 3| 3| 2| 3| 3| 9| 7| 3| 3| 9| 2| 6| 3| 8| 3| 2| 2| 2| 8|
| 4| 9| 1| 7| 6| 1| 0| 0| 9| 0| 1| 0| 5| 0| 1| 2| 9| 0| 0| 8| 1| 9| 9| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | |
Cytoplasmic Alteration, Focal | 1 |
Hypertrophy, Focal | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + M + + + + + + + M + +|
Amyloid Deposition | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + M + M M + + + + +|
Pars Distalis, Cyst | |
Rathke's Cleft, Cyst | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 1 1 1 1 2 1 1|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 3 3 4 3 3 3 3 |
Inflammation, Chronic | 3 2 4 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 99
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 4| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 6| 3| 1| 2| 4| 3| 3| 2| 3| 3| 9| 7| 3| 3| 9| 2| 6| 3| 8| 3| 2| 2| 2| 8|
| 4| 9| 1| 7| 6| 1| 0| 0| 9| 0| 1| 0| 5| 0| 1| 2| 9| 0| 0| 8| 1| 9| 9| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Inflammation, Chronic | |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Hemorrhage, Focal | |
Hyperplasia | 2 3 |
Thrombosis | |
|__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia | 3 |
Mediastinal, Pigmentation | 2 |
Pancreatic, Hemorrhage | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 3 2 |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Depletion Cellular | 3 4 4 4 |
Hematopoietic Cell Proliferation | 3 3 2 3 4 3 3|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + I + + + + + + + + I + +|
Atrophy | 4 |
Cyst | 2 |
__________________________________________|__________________________________________________________________________|
Page 100
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 4| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 6| 3| 1| 2| 4| 3| 3| 2| 3| 3| 9| 7| 3| 3| 9| 2| 6| 3| 8| 3| 2| 2| 2| 8|
| 4| 9| 1| 7| 6| 1| 0| 0| 9| 0| 1| 0| 5| 0| 1| 2| 9| 0| 0| 8| 1| 9| 9| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | |
|__________________________________________________________________________|
Skeletal Muscle | + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Histiocytic | 2 |
Infiltration Cellular, Mixed Cell | 3 3 |
Inflammation, Chronic, Focal | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Glands, Dilatation, Focal | |
Nasolacrimal Duct, Inflammation | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________|__________________________________________________________________________|
Page 101
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 4| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 0| 6| 3| 1| 2| 4| 3| 3| 2| 3| 3| 9| 7| 3| 3| 9| 2| 6| 3| 8| 3| 2| 2| 2| 8|
| 4| 9| 1| 7| 6| 1| 0| 0| 9| 0| 1| 0| 5| 0| 1| 2| 9| 0| 0| 8| 1| 9| 9| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Harderian Gland | + + |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Atrophy, Focal | |
Atrophy | 4 |
Congestion | 1 |
Cyst | |
Fibrosis, Focal | 4 |
Hyperplasia, Lymphoid | 2 1 |
Infarct | 3 |
Inflammation, Chronic, Focal | |
Inflammation, Chronic | 4 |
Inflammation, Focal, Suppurative | 3 |
Inflammation, Suppurative | 3 |
Nephropathy | 1 1 3 4 1 2 2 1 1 1 2 2 1 1 2 2 1 1 2 2 2|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Dilatation | |
Renal Tubule, Necrosis | 3 |
Renal Tubule, Pigmentation | 3 4 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 102
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 3| 2| 2| 9| 3| 3| 2| 2| 5| 6| | |
| 1| 9| 9| 0| 0| 0| 9| 9| 1| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + A A | 42 |
Fibrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 49 |
Epithelium, Degeneration, Mucoid | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + A | 45 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + A | 43 |
Inflammation, Focal | 4 | 1 4.0|
Ulcer | 4 | 1 4.0|
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
Peyer's Patch, Inflammation, Chronic | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + A | 40 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Amyloid Deposition | | 1 4.0|
Basophilic Focus | X | 6 |
Clear Cell Focus | | 2 |
Congestion, Focal | | 1 2.0|
Eosinophilic Focus | X X | 14 |
Fibrosis, Focal | | 1 3.0|
Infiltration Cellular, Mixed Cell | 2 2 2 1 1 1 1 | 40 1.6|
Inflammation, Chronic, Focal | | 1 3.0|
Inflammation, Focal, Suppurative | | 1 2.0|
Mineralization, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 3| 2| 2| 9| 3| 3| 2| 2| 5| 6| | |
| 1| 9| 9| 0| 0| 0| 9| 9| 1| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Necrosis | 2 | 15 2.0|
Hepatocyte, Syncytial Alteration, | | |
Focal | 1 1 1 1 1 1 1 | 26 1.1|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | | 4 2.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | | 5 1.6|
Hepatocyte, Centrilobular, Depletion | | |
Glycogen | | 1 2.0|
Hepatocyte, Centrilobular, Fatty | | |
Change | | 2 2.0|
|__________________________________________________________________________|____________|
Mesentery | + | 12 |
Inflammation, Chronic | | 2 2.0|
Artery, Inflammation, Chronic | | 1 2.0|
Fat, Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Amyloid Deposition | | 1 2.0|
Acinus, Atrophy, Focal | | 1 3.0|
Duct, Cyst | | 1 4.0|
Duct, Inflammation, Chronic, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Focal | | 1 2.0|
Ulcer | | 1 1.0|
Epithelium, Hyperplasia | | 5 1.8|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 54 |
Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 3| 2| 2| 9| 3| 3| 2| 2| 5| 6| | |
| 1| 9| 9| 0| 0| 0| 9| 9| 1| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + | 9 |
Peridontal Tissue, Inflammation, | | |
Chronic | 3 | 9 2.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Infiltration Cellular, Mixed Cell | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Cyst | | 2 1.0|
Cytoplasmic Alteration, Focal | | 2 1.5|
Hypertrophy, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + M | 54 |
Amyloid Deposition | | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + M + M + + + + | 50 |
Pars Distalis, Cyst | | 1 2.0|
Rathke's Cleft, Cyst | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + I + + + + + | 59 |
Degeneration, Cystic, Focal | | 11 1.2|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 3| 2| 2| 9| 3| 3| 2| 2| 5| 6| | |
| 1| 9| 9| 0| 0| 0| 9| 9| 1| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | 3 3 3 3 | 27 3.0|
Inflammation, Chronic | 3 | 5 3.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | | 1 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Depletion Cellular | | 1 2.0|
Hemorrhage, Focal | | 2 2.5|
Hyperplasia | | 3 2.7|
Thrombosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + | 4 |
Mediastinal, Hemorrhage | | 1 2.0|
Mediastinal, Hyperplasia | | 1 3.0|
Mediastinal, Pigmentation | | 1 2.0|
Pancreatic, Hemorrhage | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M | 55 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + | 55 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage | | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 3| 2| 2| 9| 3| 3| 2| 2| 5| 6| | |
| 1| 9| 9| 0| 0| 0| 9| 9| 1| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 3.0|
Depletion Cellular | 4 | 7 3.7|
Hematopoietic Cell Proliferation | 3 3 3 3 3 3 | 24 3.1|
Hyperplasia, Lymphoid | | 3 2.3|
|__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + | 52 |
Atrophy | | 3 3.3|
Cyst | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Edema | | 3 2.7|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fracture | | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 6 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 3| 2| 2| 9| 3| 3| 2| 2| 5| 6| | |
| 1| 9| 9| 0| 0| 0| 9| 9| 1| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + | 60 |
Congestion | 3 | 1 3.0|
Hyperplasia, Histiocytic | | 2 2.0|
Infiltration Cellular, Mixed Cell | 2 | 4 2.5|
Inflammation, Chronic, Focal | 2 | 3 2.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Mucosa, Glands, Dilatation, Focal | | 1 1.0|
Nasolacrimal Duct, Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
Atrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Amyloid Deposition | | 1 4.0|
Atrophy, Focal | 3 | 2 2.5|
Atrophy | | 1 4.0|
Congestion | | 3 1.7|
Cyst | | 4 1.8|
Fibrosis, Focal | 3 | 2 3.5|
Hyperplasia, Lymphoid | 2 | 3 1.7|
Infarct | | 1 3.0|
Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 3| 2| 2| 9| 3| 3| 2| 2| 5| 6| | |
| 1| 9| 9| 0| 0| 0| 9| 9| 1| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Inflammation, Chronic | | 1 4.0|
Inflammation, Focal, Suppurative | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Nephropathy | 3 2 2 1 2 1 2 2 1 | 53 1.7|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 2 3.0|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Necrosis | | 1 3.0|
Renal Tubule, Pigmentation | | 6 2.8|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 7| 5| 4| 5|
DAY ON TEST | 9| 3| 7| 0| 5| 3| 1| 5| 6| 6| 5| 2| 6| 1| 5| 9| 6| 9| 9| 6| 6| 0| 3| 7| 3|
| 6| 1| 2| 3| 6| 3| 7| 6| 4| 6| 4| 3| 9| 6| 7| 6| 0| 2| 0| 7| 6| 6| 9| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A A A + + A A + A + A A A A M + A + + A + A A + +|
|__________________________________________________________________________|
Intestine Large, Colon | A + + + + A + + + + A A + A + + + + + A + A + + A|
|__________________________________________________________________________|
Intestine Large, Rectum | A A + + + A + + + + A A + A + + + + + A + A + + A|
|__________________________________________________________________________|
Intestine Large, Cecum | A A A + + A A + + + + A + A + A + + + A + + A + A|
|__________________________________________________________________________|
Intestine Small, Duodenum | A A A + + A + + + + A A + A + + + + + A + A A + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + A + + A A + + + A A + A + + + + + A + A A + A|
|__________________________________________________________________________|
Intestine Small, Ileum | A A A + + A A + + + A A + A + + + + + A + A A + A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + A + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Eosinophilic Focus | X |
Fibrosis, Focal | |
Infiltration Cellular, Mixed Cell | 2 3 2 3 3 2 3 2 3|
Inflammation, Chronic, Focal | |
Necrosis | 2 1 2 2 3 3 2 2 2 1 3 2 1|
Hepatocyte, Syncytial Alteration, | |
Focal | 1 1 2 2 1 2 2 1 1 2 1 2 1 2 1 1 1|
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | |
Hepatocyte, Centrilobular, Fatty | |
Change | 3 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 |
Inflammation, Chronic | 3 3 |
Fat, Necrosis | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 110
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 7| 5| 4| 5|
DAY ON TEST | 9| 3| 7| 0| 5| 3| 1| 5| 6| 6| 5| 2| 6| 1| 5| 9| 6| 9| 9| 6| 6| 0| 3| 7| 3|
| 6| 1| 2| 3| 6| 3| 7| 6| 4| 6| 4| 3| 9| 6| 7| 6| 0| 2| 0| 7| 6| 6| 9| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Acinus, Atrophy, Focal | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | I + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 2 2 |
Necrosis, Focal | 2 |
Ulcer | 2 2 |
Epithelium, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + A + A + + + + + A + + + + +|
Erosion | 2 1 |
Pigmentation, Focal | 1 |
|__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 1 1 |
Inflammation, Chronic, Focal | 3 2 |
Mineralization | 2 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + M + +|
Fibrosis | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + M + + + + + + + + M + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 111
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 7| 5| 4| 5|
DAY ON TEST | 9| 3| 7| 0| 5| 3| 1| 5| 6| 6| 5| 2| 6| 1| 5| 9| 6| 9| 9| 6| 6| 0| 3| 7| 3|
| 6| 1| 2| 3| 6| 3| 7| 6| 4| 6| 4| 3| 9| 6| 7| 6| 0| 2| 0| 7| 6| 6| 9| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + M M + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Chronic | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 3 3 3 4 3 |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + M + + + + + + + + M + + +|
Inflammation, Chronic | 4 3 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Dilatation | |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 3 |
Hyperplasia | |
Erythroid Cell, Depletion Cellular | |
|__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________|__________________________________________________________________________|
Page 112
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 7| 5| 4| 5|
DAY ON TEST | 9| 3| 7| 0| 5| 3| 1| 5| 6| 6| 5| 2| 6| 1| 5| 9| 6| 9| 9| 6| 6| 0| 3| 7| 3|
| 6| 1| 2| 3| 6| 3| 7| 6| 4| 6| 4| 3| 9| 6| 7| 6| 0| 2| 0| 7| 6| 6| 9| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Iliac, Hematopoietic Cell | |
Proliferation | |
Iliac, Hyperplasia | |
Mediastinal, Hemorrhage | 3 3 3 |
Mediastinal, Hyperplasia | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + M + A + + + + + + + + + + M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 |
Hematopoietic Cell Proliferation | 4 4 4 4 4 3 4 3 4 4 3 4 4 4 4 3 4 4 3 3 4|
|__________________________________________________________________________|
Thymus | + + + + + I + + + + + + M M + + I + M + + + + + +|
Atrophy | 3 |
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Subcutaneous Tissue, | |
Inflammation, Suppurative | |
Subcutaneous Tissue, Edema | 2 3 3 2 3 2 3 3|
Subcutaneous Tissue, Hemorrhage, | |
Focal | |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
Subcutaneous Tissue, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 113
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 7| 5| 4| 5|
DAY ON TEST | 9| 3| 7| 0| 5| 3| 1| 5| 6| 6| 5| 2| 6| 1| 5| 9| 6| 9| 9| 6| 6| 0| 3| 7| 3|
| 6| 1| 2| 3| 6| 3| 7| 6| 4| 6| 4| 3| 9| 6| 7| 6| 0| 2| 0| 7| 6| 6| 9| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Hemorrhage, Focal | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | |
Hemorrhage | |
Infiltration Cellular, | |
Polymorphonuclear | |
Infiltration Cellular, Mixed Cell | 3 3 1 1 2 2|
Alveolar Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pleura | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
Inflammation, Chronic | 4 |
Cornea, Necrosis, Focal | 4 |
|__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 114
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 7| 5| 4| 5|
DAY ON TEST | 9| 3| 7| 0| 5| 3| 1| 5| 6| 6| 5| 2| 6| 1| 5| 9| 6| 9| 9| 6| 6| 0| 3| 7| 3|
| 6| 1| 2| 3| 6| 3| 7| 6| 4| 6| 4| 3| 9| 6| 7| 6| 0| 2| 0| 7| 6| 6| 9| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Atrophy | 4 |
Cyst | |
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 1 |
Metaplasia, Focal, Osseous | |
Nephropathy | 1 1 2 2 1 1 1 1 2 1 1 1 1 1|
Papilla, Necrosis | |
Pelvis, Dilatation | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 1 |
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | 2 3 2 2 2 2 3 3 3 3 1 3 2 2|
Renal Tubule, Vacuolization | |
Cytoplasmic | |
|__________________________________________________________________________|
Urethra | |
Inflammation, Focal | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation, Chronic | 3 |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 115
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 5| 4| 5| 5| 4| 5| 5| 6| 5| 5| 4| 5|
DAY ON TEST | 8| 6| 8| 2| 6| 1| 8| 2| 7| 2| 4| 7| 4| 4| 5| 2| 6| 9| 0| 6| 4| 6| 5| 5| 4|
| 8| 6| 5| 3| 0| 9| 8| 0| 6| 6| 8| 0| 4| 0| 1| 2| 9| 2| 4| 3| 5| 9| 3| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + M A + A + A A + + A A + A + + + + + A + A + + M|
|__________________________________________________________________________|
Intestine Large, Colon | + + A + + A + + + + + A + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + A + + A + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A A A A A + A + + + + + A + + + + + A + A + + M|
|__________________________________________________________________________|
Intestine Small, Duodenum | + A A + + + + A + + + A + A + + + + + A + A + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A A A A A + A + + + A + A + + + + + A + A + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A A A A A + A + + + A + A + + + + + A + A + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + A + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Basophilic Focus | X X X |
Eosinophilic Focus | |
Fibrosis, Focal | 1 |
Infiltration Cellular, Mixed Cell | 3 2 3 2 1 1 2 2 3 3 1 |
Inflammation, Chronic, Focal | |
Necrosis | 2 2 2 1 1 1 2 2 3 2 2 3 |
Hepatocyte, Syncytial Alteration, | |
Focal | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 1 |
Hepatocyte, Centrilobular, Fatty | |
Change | 2 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Inflammation, Chronic | |
Fat, Necrosis | 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 116
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 5| 4| 5| 5| 4| 5| 5| 6| 5| 5| 4| 5|
DAY ON TEST | 8| 6| 8| 2| 6| 1| 8| 2| 7| 2| 4| 7| 4| 4| 5| 2| 6| 9| 0| 6| 4| 6| 5| 5| 4|
| 8| 6| 5| 3| 0| 9| 8| 0| 6| 6| 8| 0| 4| 0| 1| 2| 9| 2| 4| 3| 5| 9| 3| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Acinus, Atrophy, Focal | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 1 |
Necrosis, Focal | |
Ulcer | |
Epithelium, Hyperplasia | 2 2 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + A + + + + A + + + + + + + + + + + A + + + + +|
Erosion | |
Pigmentation, Focal | |
|__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Chronic, Focal | 2 |
Mineralization | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + M + + +|
Cyst | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 117
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 5| 4| 5| 5| 4| 5| 5| 6| 5| 5| 4| 5|
DAY ON TEST | 8| 6| 8| 2| 6| 1| 8| 2| 7| 2| 4| 7| 4| 4| 5| 2| 6| 9| 0| 6| 4| 6| 5| 5| 4|
| 8| 6| 5| 3| 0| 9| 8| 0| 6| 6| 8| 0| 4| 0| 1| 2| 9| 2| 4| 3| 5| 9| 3| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pituitary Gland | + + + + + I + M I + + M + + + + + + + + I + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Chronic | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Degeneration, Cystic | 3 3 3 3 3 2 3 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 4 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Dilatation | 3 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hyperplasia | 2 |
Erythroid Cell, Depletion Cellular | 3 |
|__________________________________________________________________________|
Lymph Node | + |
__________________________________________|__________________________________________________________________________|
Page 118
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 5| 4| 5| 5| 4| 5| 5| 6| 5| 5| 4| 5|
DAY ON TEST | 8| 6| 8| 2| 6| 1| 8| 2| 7| 2| 4| 7| 4| 4| 5| 2| 6| 9| 0| 6| 4| 6| 5| 5| 4|
| 8| 6| 5| 3| 0| 9| 8| 0| 6| 6| 8| 0| 4| 0| 1| 2| 9| 2| 4| 3| 5| 9| 3| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Iliac, Hematopoietic Cell | |
Proliferation | 3 |
Iliac, Hyperplasia | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + M M + + + + + + + + + + M + + + + + + + + + + M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + M + + + + + M + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 4 |
Hematopoietic Cell Proliferation | 4 3 2 3 3 4 4 4 4 4 2 4 4 4 3 3 4 4 3 3|
|__________________________________________________________________________|
Thymus | + M + + + + + + I + + M M + + M + M I + + + I + +|
Atrophy | 1 |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Subcutaneous Tissue, | |
Inflammation, Suppurative | |
Subcutaneous Tissue, Edema | 3 2 3 2 2 |
Subcutaneous Tissue, Hemorrhage, | |
Focal | 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 3 |
Subcutaneous Tissue, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 119
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 5| 4| 5| 5| 4| 5| 5| 6| 5| 5| 4| 5|
DAY ON TEST | 8| 6| 8| 2| 6| 1| 8| 2| 7| 2| 4| 7| 4| 4| 5| 2| 6| 9| 0| 6| 4| 6| 5| 5| 4|
| 8| 6| 5| 3| 0| 9| 8| 0| 6| 6| 8| 0| 4| 0| 1| 2| 9| 2| 4| 3| 5| 9| 3| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | 2 |
Hemorrhage | |
Infiltration Cellular, | |
Polymorphonuclear | 2 |
Infiltration Cellular, Mixed Cell | 3 2 |
Alveolar Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pleura | + |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Inflammation, Chronic | |
Cornea, Necrosis, Focal | |
|__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 120
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 5| 4| 5| 5| 4| 5| 5| 6| 5| 5| 4| 5|
DAY ON TEST | 8| 6| 8| 2| 6| 1| 8| 2| 7| 2| 4| 7| 4| 4| 5| 2| 6| 9| 0| 6| 4| 6| 5| 5| 4|
| 8| 6| 5| 3| 0| 9| 8| 0| 6| 6| 8| 0| 4| 0| 1| 2| 9| 2| 4| 3| 5| 9| 3| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Atrophy | |
Cyst | |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Metaplasia, Focal, Osseous | 1 |
Nephropathy | 2 3 1 1 1 1 1 2 2 2 1 1 1 1 |
Papilla, Necrosis | |
Pelvis, Dilatation | 2 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 3 2 |
Renal Tubule, Dilatation | 3 2 2 |
Renal Tubule, Pigmentation | 2 1 2 2 3 3 2 3 2 2 3 3 |
Renal Tubule, Vacuolization | |
Cytoplasmic | |
|__________________________________________________________________________|
Urethra | + |
Inflammation, Focal | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 121
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 6| 4| 4| 3| 5| 6| 4| | |
DAY ON TEST | 1| 9| 7| 2| 3| 9| 6| 6| 1| 6| | |
| 0| 2| 2| 4| 4| 7| 5| 7| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Gallbladder | A + + + + + A + + A | 31 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + A | 46 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + A | 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A + A + + + + + + A | 36 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + A + + + + + + A | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + A + + + A + + A | 35 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + A + + + + + + A | 35 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + A | 57 |
Angiectasis | | 2 1.5|
Basophilic Focus | X | 4 |
Eosinophilic Focus | | 1 |
Fibrosis, Focal | | 1 1.0|
Infiltration Cellular, Mixed Cell | 3 2 2 2 | 24 2.3|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Necrosis | 2 1 | 27 1.9|
Hepatocyte, Syncytial Alteration, | | |
Focal | 1 1 1 2 1 1 1 | 43 1.2|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 1 | 2 1.0|
Hepatocyte, Centrilobular, Fatty | | |
Change | 3 | 5 2.8|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 42 |
Inflammation, Chronic, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 122
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 6| 4| 4| 3| 5| 6| 4| | |
DAY ON TEST | 1| 9| 7| 2| 3| 9| 6| 6| 1| 6| | |
| 0| 2| 2| 4| 4| 7| 5| 7| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation, Chronic | | 2 3.0|
Fat, Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A | 59 |
Acinus, Atrophy, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + A | 58 |
Inflammation, Focal | | 3 1.7|
Necrosis, Focal | | 1 2.0|
Ulcer | 2 | 3 2.0|
Epithelium, Hyperplasia | 2 | 6 1.8|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 53 |
Erosion | | 2 1.5|
Pigmentation, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Tooth | + | 2 |
Peridontal Tissue, Inflammation, | | |
Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Infiltration Cellular, Mixed Cell | | 3 1.3|
Inflammation, Chronic, Focal | 2 | 4 2.3|
Mineralization | 2 | 2 2.0|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + A | 58 |
Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 123
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 6| 4| 4| 3| 5| 6| 4| | |
DAY ON TEST | 1| 9| 7| 2| 3| 9| 6| 6| 1| 6| | |
| 0| 2| 2| 4| 4| 7| 5| 7| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + I + + + + A | 56 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A | 59 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + M M + + + + + + | 50 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic, Focal | | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
Inflammation, Chronic | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | 3 | 16 3.0|
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Prostate | + I + + + + + + + + | 57 |
Inflammation, Chronic | 4 4 | 7 3.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 124
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 6| 4| 4| 3| 5| 6| 4| | |
DAY ON TEST | 1| 9| 7| 2| 3| 9| 6| 6| 1| 6| | |
| 0| 2| 2| 4| 4| 7| 5| 7| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hemorrhage, Focal | | 1 3.0|
Hyperplasia | 3 | 2 2.5|
Erythroid Cell, Depletion Cellular | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + | 7 |
Iliac, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Iliac, Hyperplasia | 3 | 1 3.0|
Mediastinal, Hemorrhage | | 3 3.0|
Mediastinal, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M M + + + | 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 56 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + A | 58 |
Depletion Cellular | | 2 3.5|
Hematopoietic Cell Proliferation | 4 3 3 3 3 4 3 4 | 49 3.6|
|__________________________________________________________________________|____________|
Thymus | + + I M + + + + + + | 45 |
Atrophy | 3 | 3 2.3|
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 125
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 6| 4| 4| 3| 5| 6| 4| | |
DAY ON TEST | 1| 9| 7| 2| 3| 9| 6| 6| 1| 6| | |
| 0| 2| 2| 4| 4| 7| 5| 7| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Prepuce, Subcutaneous Tissue, | | |
Inflammation, Suppurative | 4 | 1 4.0|
Subcutaneous Tissue, Edema | 3 | 14 2.6|
Subcutaneous Tissue, Hemorrhage, | | |
Focal | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | | 1 3.0|
Subcutaneous Tissue, Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + | 35 |
Hemorrhage, Focal | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Cyst | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 126
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 6| 4| 4| 3| 5| 6| 4| | |
DAY ON TEST | 1| 9| 7| 2| 3| 9| 6| 6| 1| 6| | |
| 0| 2| 2| 4| 4| 7| 5| 7| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Infiltration Cellular, Mixed Cell | 2 | 9 2.1|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Pleura | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
Inflammation, Chronic | | 1 4.0|
Cornea, Necrosis, Focal | | 1 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
Atrophy | | 1 4.0|
Cyst | 2 | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | 3 3 | 3 2.3|
Metaplasia, Focal, Osseous | | 1 1.0|
Nephropathy | 1 1 2 1 2 1 | 34 1.3|
Papilla, Necrosis | 3 | 1 3.0|
Pelvis, Dilatation | 2 | 2 2.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 2 | 5 2.0|
Renal Tubule, Dilatation | 3 | 4 2.5|
Renal Tubule, Pigmentation | 2 2 2 3 3 2 | 32 2.3|
Renal Tubule, Vacuolization | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 127
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 6| 4| 4| 3| 5| 6| 4| | |
DAY ON TEST | 1| 9| 7| 2| 3| 9| 6| 6| 1| 6| | |
| 0| 2| 2| 4| 4| 7| 5| 7| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Cytoplasmic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Calculus Micro Observation Only | 3 | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 128
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 3| 3| 3| 4| 3| 3| 4| 3| 4| 2| 4| 4| 3| 3| 4| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 7| 0| 8| 7| 1| 7| 0| 7| 2| 4| 6| 7| 1| 9| 0| 9| 6| 9| 9| 9| 7| 9| 6|
| 4| 6| 1| 3| 6| 6| 4| 5| 8| 7| 0| 9| 5| 5| 4| 2| 9| 2| 8| 4| 5| 1| 4| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A A + + M A A + A + + + + + + + + + + A + + A I +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + A + A + + + + + + + + + + A A + A + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | A + + + A A A + A + + + + + + + + + + A A + A + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A A A + A + + + + + + + + + + A A + A + +|
|__________________________________________________________________________|
Intestine Small, Ileum | A + + + A A A + A + + A + + + + + + + + A + A + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Eosinophilic Focus | |
Infiltration Cellular, Mixed Cell | 2 2 1 1 2 1 2 2 2 3 1 2 |
Necrosis | 2 1 1 1 1 2 2 1 1 |
Artery, Angiectasis | 2 |
Artery, Inflammation, Chronic | 3 |
Hepatocyte, Syncytial Alteration, | |
Focal | 1 2 1 1 2 2 2 2 1 2 1 1 1 2 2|
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 1 |
Hepatocyte, Periportal, Atrophy | |
Hepatocyte, Centrilobular, Depletion | |
Glycogen | 3 |
Hepatocyte, Centrilobular, Fatty | |
Change | 2 |
Hepatocyte, Midzonal, Fatty Change | |
Oval Cell, Hyperplasia | 1|
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 129
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 3| 3| 3| 4| 3| 3| 4| 3| 4| 2| 4| 4| 3| 3| 4| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 7| 0| 8| 7| 1| 7| 0| 7| 2| 4| 6| 7| 1| 9| 0| 9| 6| 9| 9| 9| 7| 9| 6|
| 4| 6| 1| 3| 6| 6| 4| 5| 8| 7| 0| 9| 5| 5| 4| 2| 9| 2| 8| 4| 5| 1| 4| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | |
Ulcer | |
Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Chronic, Focal | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + I + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + I I + + + + M + + + + + + M M + + I + +|
Pars Distalis, Hyperplasia, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + +|
__________________________________________|__________________________________________________________________________|
Page 130
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 3| 3| 3| 4| 3| 3| 4| 3| 4| 2| 4| 4| 3| 3| 4| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 7| 0| 8| 7| 1| 7| 0| 7| 2| 4| 6| 7| 1| 9| 0| 9| 6| 9| 9| 9| 7| 9| 6|
| 4| 6| 1| 3| 6| 6| 4| 5| 8| 7| 0| 9| 5| 5| 4| 2| 9| 2| 8| 4| 5| 1| 4| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
Pelvic, Inflammation, Chronic, Focal | 2|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + M + + +|
Inflammation, Chronic | 3 3 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 3 4 3 3 3 3 3 3 4 3 4 3 4 4 3 4 4 4 3 4 4 3 3|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + M + + + + + + + + + +|
Atrophy | 3 3 2 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 131
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 3| 3| 3| 4| 3| 3| 4| 3| 4| 2| 4| 4| 3| 3| 4| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 7| 0| 8| 7| 1| 7| 0| 7| 2| 4| 6| 7| 1| 9| 0| 9| 6| 9| 9| 9| 7| 9| 6|
| 4| 6| 1| 3| 6| 6| 4| 5| 8| 7| 0| 9| 5| 5| 4| 2| 9| 2| 8| 4| 5| 1| 4| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 2 2 2 2 2 2 2 |
Subcutaneous Tissue, Hemorrhage, | |
Focal | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 2 2 |
Hyperplasia, Histiocytic | 1 |
Infiltration Cellular, Mixed Cell | 3 3 |
Alveolar Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 132
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 3| 3| 3| 4| 3| 3| 4| 3| 4| 2| 4| 4| 3| 3| 4| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 7| 0| 8| 7| 1| 7| 0| 7| 2| 4| 6| 7| 1| 9| 0| 9| 6| 9| 9| 9| 7| 9| 6|
| 4| 6| 1| 3| 6| 6| 4| 5| 8| 7| 0| 9| 5| 5| 4| 2| 9| 2| 8| 4| 5| 1| 4| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Nephropathy | 1 1 1 1 1 2 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 1 |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 2 3 3 2 2 2 2 2 1 3 2 2 2 1 2|
|__________________________________________________________________________|
Urethra | + +|
Inflammation, Focal | 2 3|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 133
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 4| 2| 4| 4| 4| 3| 4| 3| 3| 4| 4| 3| 3| 4| 3| 3| 3| 3| 3| 4| 4| 3| 4| 4| 4|
DAY ON TEST | 4| 9| 0| 2| 5| 7| 0| 0| 9| 0| 1| 2| 6| 0| 8| 9| 7| 5| 5| 0| 0| 3| 1| 0| 0|
| 0| 7| 6| 2| 0| 2| 3| 2| 2| 1| 4| 6| 8| 9| 0| 1| 5| 0| 8| 8| 6| 9| 4| 8| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A A + + A + + + + M + + + + A A + A M + + + + A A|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + A + + + + + + A|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + + A + + + + A + + + + A + + A + + + + + A A|
|__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + + + A A + + + + + A + A + + + + + A +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + A A + + + + A A + A + + + + + A A|
|__________________________________________________________________________|
Intestine Small, Ileum | A + + + A + + + A A + + + + + A + A + + + M + A A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Eosinophilic Focus | |
Infiltration Cellular, Mixed Cell | 1 3 3 1 3 2 1 1 1 1 2 |
Necrosis | 2 2 2 1 2 1 1 3 1 1 1 2 1 1 1 2 1|
Artery, Angiectasis | |
Artery, Inflammation, Chronic | |
Hepatocyte, Syncytial Alteration, | |
Focal | 1 1 2 2 2 2 2 1 1 2 1 1 2 1 1 1|
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | |
Hepatocyte, Periportal, Atrophy | |
Hepatocyte, Centrilobular, Depletion | |
Glycogen | 3 3 |
Hepatocyte, Centrilobular, Fatty | |
Change | |
Hepatocyte, Midzonal, Fatty Change | 2 |
Oval Cell, Hyperplasia | |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 134
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 4| 2| 4| 4| 4| 3| 4| 3| 3| 4| 4| 3| 3| 4| 3| 3| 3| 3| 3| 4| 4| 3| 4| 4| 4|
DAY ON TEST | 4| 9| 0| 2| 5| 7| 0| 0| 9| 0| 1| 2| 6| 0| 8| 9| 7| 5| 5| 0| 0| 3| 1| 0| 0|
| 0| 7| 6| 2| 0| 2| 3| 2| 2| 1| 4| 6| 8| 9| 0| 1| 5| 0| 8| 8| 6| 9| 4| 8| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + A|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 1 |
Ulcer | 1 |
Epithelium, Hyperplasia | 1 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + A + + + + + + + + +|
Inflammation, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic, Focal | 2 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + M + + + I + + + + + + + + + I + I + + + M|
Pars Distalis, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
__________________________________________|__________________________________________________________________________|
Page 135
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 4| 2| 4| 4| 4| 3| 4| 3| 3| 4| 4| 3| 3| 4| 3| 3| 3| 3| 3| 4| 4| 3| 4| 4| 4|
DAY ON TEST | 4| 9| 0| 2| 5| 7| 0| 0| 9| 0| 1| 2| 6| 0| 8| 9| 7| 5| 5| 0| 0| 3| 1| 0| 0|
| 0| 7| 6| 2| 0| 2| 3| 2| 2| 1| 4| 6| 8| 9| 0| 1| 5| 0| 8| 8| 6| 9| 4| 8| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
Pelvic, Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Chronic | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + M + + +|
Inflammation, Chronic | 3 3|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Suppurative | 4 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + M + + + + + + + + + + + + + + + + + M|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 4 4 3 3 3 3 4 4 4 4 3 3 3 4 4 3 4 3 4 3 3 3 3|
|__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + I + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 136
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 4| 2| 4| 4| 4| 3| 4| 3| 3| 4| 4| 3| 3| 4| 3| 3| 3| 3| 3| 4| 4| 3| 4| 4| 4|
DAY ON TEST | 4| 9| 0| 2| 5| 7| 0| 0| 9| 0| 1| 2| 6| 0| 8| 9| 7| 5| 5| 0| 0| 3| 1| 0| 0|
| 0| 7| 6| 2| 0| 2| 3| 2| 2| 1| 4| 6| 8| 9| 0| 1| 5| 0| 8| 8| 6| 9| 4| 8| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 2 2 2 2 2 2 2 2 3 3 3 2 |
Subcutaneous Tissue, Hemorrhage, | |
Focal | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3|
Hemorrhage | 3 4 |
Hyperplasia, Histiocytic | |
Infiltration Cellular, Mixed Cell | |
Alveolar Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 137
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
_____________________________________________________________________________________________________________________
| 4| 2| 4| 4| 4| 3| 4| 3| 3| 4| 4| 3| 3| 4| 3| 3| 3| 3| 3| 4| 4| 3| 4| 4| 4|
DAY ON TEST | 4| 9| 0| 2| 5| 7| 0| 0| 9| 0| 1| 2| 6| 0| 8| 9| 7| 5| 5| 0| 0| 3| 1| 0| 0|
| 0| 7| 6| 2| 0| 2| 3| 2| 2| 1| 4| 6| 8| 9| 0| 1| 5| 0| 8| 8| 6| 9| 4| 8| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 1 1 1 1 1 1 3 1 1 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 1 |
Renal Tubule, Necrosis | 3 3 |
Renal Tubule, Pigmentation | 2 3 3 2 2 2 1 1 3 3 3 3 2 3|
|__________________________________________________________________________|
Urethra | |
Inflammation, Focal | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 138
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 4| 3| 4| 3| 4| 4| 4| | |
DAY ON TEST | 5| 6| 4| 0| 1| 2| 9| 6| 1| 2| | |
| 4| 8| 5| 9| 2| 7| 1| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Gallbladder | A M M + + + + M A M | 35 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | A A + + + + + A + + | 54 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + A + + | 54 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A A + + + + + A + + | 44 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A A A + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A A + + + + A A + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A A A + + + + A + + | 39 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Eosinophilic Focus | X | 1 |
Infiltration Cellular, Mixed Cell | 2 1 1 2 2 3 | 29 1.8|
Necrosis | 1 2 1 3 | 30 1.5|
Artery, Angiectasis | | 1 2.0|
Artery, Inflammation, Chronic | | 1 3.0|
Hepatocyte, Syncytial Alteration, | | |
Focal | 1 1 1 1 2 1 1 1 | 39 1.4|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | | 1 1.0|
Hepatocyte, Periportal, Atrophy | 2 | 1 2.0|
Hepatocyte, Centrilobular, Depletion | | |
Glycogen | | 3 3.0|
Hepatocyte, Centrilobular, Fatty | | |
Change | | 1 2.0|
Hepatocyte, Midzonal, Fatty Change | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 139
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 4| 3| 4| 3| 4| 4| 4| | |
DAY ON TEST | 5| 6| 4| 0| 1| 2| 9| 6| 1| 2| | |
| 4| 8| 5| 9| 2| 7| 1| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Oval Cell, Hyperplasia | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 38 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Focal | | 1 1.0|
Ulcer | | 1 1.0|
Epithelium, Hyperplasia | | 3 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + | 55 |
Inflammation, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Chronic, Focal | | 1 2.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + | 56 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 140
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 4| 3| 4| 3| 4| 4| 4| | |
DAY ON TEST | 5| 6| 4| 0| 1| 2| 9| 6| 1| 2| | |
| 4| 8| 5| 9| 2| 7| 1| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pituitary Gland | + M I + + + + + M + | 46 |
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + I + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 3 |
Pelvic, Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | | 1 3.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 58 |
Inflammation, Chronic | | 4 3.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Congestion | 3 | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Lymph Node | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 141
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 4| 3| 4| 3| 4| 4| 4| | |
DAY ON TEST | 5| 6| 4| 0| 1| 2| 9| 6| 1| 2| | |
| 4| 8| 5| 9| 2| 7| 1| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + + + + M + + | 54 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + M + + | 53 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 2 4 3 3 4 3 3 4 4 4 | 60 3.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + M I + + | 54 |
Atrophy | 3 | 6 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Edema | 2 3 2 | 22 2.2|
Subcutaneous Tissue, Hemorrhage, | | |
Focal | | 2 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + | 47 |
Hemorrhage, Focal | | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 12 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 142
NTP Experiment-Test: 05203-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:07:14
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 4| 3| 4| 3| 4| 4| 4| | |
DAY ON TEST | 5| 6| 4| 0| 1| 2| 9| 6| 1| 2| | |
| 4| 8| 5| 9| 2| 7| 1| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Spinal Cord | + | 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Hemorrhage | | 5 2.4|
Hyperplasia, Histiocytic | | 1 1.0|
Infiltration Cellular, Mixed Cell | 3 | 3 3.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 1.0|
Nephropathy | 1 1 | 18 1.2|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 3 1.3|
Renal Tubule, Necrosis | | 2 3.0|
Renal Tubule, Pigmentation | 2 1 3 2 2 2 | 35 2.2|
|__________________________________________________________________________|____________|
Urethra | | 2 |
Inflammation, Focal | | 2 2.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 143
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---------- END OF REPORT ----------
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