TDMS Study 05203-09 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst O-NITROTOLUENE DATE: 11/16/00
EXPERIMENT: 05203 TEST: 09 TIME: 10:15:25
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62340D
PATHOLOGIST: FARNELL, D. CAS: 88-72-2
------------------------------------------------------------------------------------------------------------------------------------
MICE, FINAL#1
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst O-NITROTOLUENE DATE: 11/16/00
EXPERIMENT: 05203 TEST: 09 TIME: 10:15:25
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62340D
PATHOLOGIST: FARNELL, D. CAS: 88-72-2
O-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 52 |
| |
| UNCENSORED DEATHS |
| 263 592 596 618 637 649 710 719 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 451 460 463 469 485 526 542 545 559 572 |
| 575 592 604 630 633 641 641 655 686 688 |
| 690 690 710 717 726 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 60 CENSORED DEATHS 0 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 270 303 365 410 419 423 434 451 451 466 |
| 467 469 470 476 485 492 492 496 497 504 |
| 516 517 520 522 523 526 531 533 534 539 |
| 540 544 548 548 553 554 556 556 557 560 |
| 560 563 564 566 566 567 569 569 569 572 |
| 572 588 588 590 592 596 619 624 645 706 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
O-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 60 CENSORED DEATHS 0 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 277 295 297 302 312 326 339 345 350 354 |
| 358 365 368 368 368 368 371 372 374 375 |
| 375 375 376 380 386 391 391 391 392 392 |
| 392 393 394 394 396 401 403 403 405 406 |
| 406 408 408 408 409 409 409 412 414 414 |
| 414 414 420 422 422 427 440 449 450 462 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
O-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 98.3 98.3 98.3 98.3 98.3 95.0 90.0 86.7 |
| | |
| | |
|1250 PPM | 100.0 100.0 100.0 100.0 100.0 91.7 86.7 78.3 70.0 56.7 |
| | |
| | |
|2500 PPM | 100.0 100.0 98.3 95.0 90.0 75.0 46.7 6.7 1.7 0.0 |
| | |
| | |
|5000 PPM | 100.0 100.0 100.0 80.0 8.3 0.0 0.0 0.0 0.0 0.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 1250 PPM 2500 PPM 5000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 86.7% 56.7% 0.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 598.0 603.0 523.4 385.6 |
|NATURAL DEATHS (C) | (50.7) (17.7) ( 9.7) ( 4.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 711.5 674.4 523.4 385.6 |
|(STANDARD ERROR) | ( 8.6) (11.1) ( 9.7) ( 4.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 52 |
| |
| UNCENSORED DEATHS |
| 299 362 483 562 592 710 710 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 266 312 343 497 553 608 612 644 658 660 |
| 679 712 721 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 47 |
| |
| UNCENSORED DEATHS |
| 553 618 624 661 671 672 673 690 701 701 |
| 709 710 715 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
O-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 55 CENSORED DEATHS 0 TERMINAL 5 |
| |
| UNCENSORED DEATHS |
| 403 409 444 444 488 507 516 522 548 567 |
| 567 569 575 579 581 583 583 588 590 597 |
| 605 608 609 610 611 619 624 629 630 640 |
| 643 647 658 659 661 661 668 669 671 675 |
| 677 679 685 686 686 688 690 690 693 696 |
| 702 710 710 722 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
O-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 96.7 96.7 95.0 95.0 91.7 91.7 86.7 |
| | |
| | |
|1250 PPM | 100.0 100.0 98.3 95.0 95.0 95.0 93.3 91.7 83.3 76.7 |
| | |
| | |
|2500 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.3 93.3 78.3 |
| | |
| | |
|5000 PPM | 100.0 100.0 100.0 100.0 96.7 93.3 86.7 65.0 40.0 8.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 1250 PPM 2500 PPM 5000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 86.7% 76.7% 78.3% 8.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.236 P=0.355 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 555.4 570.6 669.1 616.3 |
|NATURAL DEATHS (C) | (57.7) (41.9) (12.9) (10.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 705.9 692.0 716.0 625.7 |
|(STANDARD ERROR) | (10.6) (12.9) ( 4.2) (10.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-NITROTOLUENE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
1250 PPM = 2
2500 PPM = 3
5000 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
106.67 +
|
|1 134 43 22 1
| 43 3 3 22 11 1
93.33 + 4 4 4 333 2 2 2 1 1 1
| 4 44 33 3 2 2 1 11
| 44 3 3 2 2 2 1 1
| 444 22 2
P 80.00 + 33 2 2 2
E | 3 33 222
R | 44 2 2
C | 33 2 22
E 66.67 + 3 3
N | 4 4 3 3 2 22
T | 44 33 22
| 33 2 2
S 53.33 +
U | 44 33
R | 33
V | 44 33
I 40.00 +
V |
A | 44 33
L |
26.67 +
| 33
| 44
| 3 3
13.33 + 44 3 3
| 33
| 4 4 4 3 33
| 44 3 3 3
0.00 + 4 3
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 28 obs hidden.
O-NITROTOLUENE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
1250 PPM = 2
2500 PPM = 3
5000 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 2 1 4 3
| 2 1 2 2 1 44 4 1 3 33
| 2 1 2 1 3 3
| 4 42 4 2 1 1 2 33 1
90 + 44 22 33
| 4 4 4 2 2 2 3 3 31 1 1
| 4 4 2 2
| 44 2 2 32
80 + 44 22
| 22 2
| 44
|
P 70 + 4 4
E | 444
R |
C | 44
E 60 +
N | 444
T |
| 4 4
S 50 +
U | 444
R | 4 4
V |
I 40 + 44
V |
A | 44
L |
30 + 44
|
| 44
|
20 +
| 444
| 44
| 4 4
10 +
| 4 4
|
|
0 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 25 obs hidden.