TDMS Study 05203-09 Pathology Tables
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
MICE, FINAL#1
Facility: Southern Research Institute
Chemical CAS #: 88-72-2
Lock Date: 03/08/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to days on test
Page 1
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 3| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 6| 8| 6| 9| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 2| 3| 2| 2| 0| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 8| 9| 9| 8| 6| 4| 5| 8| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 4| 4| 4| 4|
| 6| 9| 5| 8| 3| 5| 1| 1| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A A + A + + + A + + + + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + A + A + M + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + A + A + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A A + A + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | A A + A + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A A + A + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A + A + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X |
|__________________________________________________________________________|
Mesentery | + + + |
|__________________________________________________________________________|
Oral Mucosa | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Squamous Cell Papilloma | X |
|__________________________________________________________________________|
Stomach, Glandular | + A + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 3| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 6| 8| 6| 9| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 2| 3| 2| 2| 0| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 8| 9| 9| 8| 6| 4| 5| 8| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 4| 4| 4| 4|
| 6| 9| 5| 8| 3| 5| 1| 1| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + A + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Pars Distalis, Adenoma | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + I + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + I + + + + + + + + + + +|
Cystadenoma | X |
Luteoma | X |
|__________________________________________________________________________|
Oviduct | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Endometrium, Polyp Stromal | X |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 3| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 6| 8| 6| 9| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 2| 3| 2| 2| 0| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 8| 9| 9| 8| 6| 4| 5| 8| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 4| 4| 4| 4|
| 6| 9| 5| 8| 3| 5| 1| 1| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + M + + + + + + + + + + + + +|
Sarcoma | |
|__________________________________________________________________________|
Spleen | + + + + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Hemangioma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X X |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 3| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 6| 8| 6| 9| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 2| 3| 2| 2| 0| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 8| 9| 9| 8| 6| 4| 5| 8| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 4| 4| 4| 4|
| 6| 9| 5| 8| 3| 5| 1| 1| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pleura | + |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | A + + + |
Adenoma | X X |
Carcinoma | X |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2|
0 PPM | 5| 5| 5| 5| 5| 8| 8| 8| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 7| 7|
| 0| 2| 3| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + I + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X X X |
|__________________________________________________________________________|
Mesentery | + + + + + +|
|__________________________________________________________________________|
Oral Mucosa | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Squamous Cell Papilloma | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2|
0 PPM | 5| 5| 5| 5| 5| 8| 8| 8| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 7| 7|
| 0| 2| 3| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 6| 7|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Adenoma | |
Pars Distalis, Adenoma | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
Luteoma | |
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Endometrium, Polyp Stromal | |
__________________________________________|__________________________________________________________________________|
Page 7
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2|
0 PPM | 5| 5| 5| 5| 5| 8| 8| 8| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 7| 7|
| 0| 2| 3| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 6| 7|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + I + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + I I +|
Sarcoma | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Hemangioma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
__________________________________________|__________________________________________________________________________|
Page 8
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2|
0 PPM | 5| 5| 5| 5| 5| 8| 8| 8| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 7| 7|
| 0| 2| 3| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 6| 7|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pleura | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
Carcinoma | |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________|__________________________________________________________________________|
Page 9
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 PPM | 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 8| 9| 0| 7| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 56 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 56 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hepatocellular Carcinoma | | 2 |
Hepatocellular Adenoma | X | 7 |
|__________________________________________________________________________|____________|
Mesentery | + + | 11 |
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hemangioma | | 1 |
Squamous Cell Papilloma | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 PPM | 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 8| 9| 0| 7| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Glandular | + + + + + + + + + + | 58 |
|__________________________________________________________________________|____________|
Tooth | + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Capsule, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Adenoma | | 1 |
Pars Distalis, Adenoma | | 2 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 PPM | 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 8| 9| 0| 7| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Cystadenoma | | 1 |
Luteoma | X | 2 |
|__________________________________________________________________________|____________|
Oviduct | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hemangioma | X | 1 |
Endometrium, Polyp Stromal | X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Lymph Node | + | 6 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + M + + | 53 |
Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + I + + | 57 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 PPM | 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 8| 9| 0| 7| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Hemangioma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Alveolar/Bronchiolar Carcinoma | | 3 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Pleura | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + M + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + | 5 |
Adenoma | X | 4 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 PPM | 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 8| 9| 0| 7| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Lymphoma Malignant | X X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 3| 3| 4| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 1| 4| 9| 5| 0| 1| 4| 5| 6| 7| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 2| 3| 7| 3| 8| 2| 4| 8| 0| 9| 2| 1| 3| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 3| 5| 5| 4| 4| 3| 1| 0| 0| 3| 2| 0| 4| 0| 0| 0| 0| 0| 0| 1| 4| 4| 4| 4| 4|
| 9| 9| 3| 9| 8| 6| 2| 8| 1| 2| 9| 7| 0| 4| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A + A + + A + M A + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | A + A + + A + A A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | A + A + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + A + + A + A A A + + + A + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Intestine Small, Duodenum | A + A + + + + A A + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + A + + A + A A A + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | A + A + + A + A A A + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X |
Histiocytic Sarcoma | X X |
Osteosarcoma, Metastatic, Bone | X |
|__________________________________________________________________________|
Mesentery | + + + + + +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | X |
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Pancreas | A + + + + + + A A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + A + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 3| 3| 4| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 1| 4| 9| 5| 0| 1| 4| 5| 6| 7| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 2| 3| 7| 3| 8| 2| 4| 8| 0| 9| 2| 1| 3| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 3| 5| 5| 4| 4| 3| 1| 0| 0| 3| 2| 0| 4| 0| 0| 0| 0| 0| 0| 1| 4| 4| 4| 4| 4|
| 9| 9| 3| 9| 8| 6| 2| 8| 1| 2| 9| 7| 0| 4| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Glandular | A + A + + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + A M + + + + + + + + + + + + I + +|
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + A A + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + M + + M + + + + + + + M|
|__________________________________________________________________________|
Pituitary Gland | + + I + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 3| 3| 4| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 1| 4| 9| 5| 0| 1| 4| 5| 6| 7| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 2| 3| 7| 3| 8| 2| 4| 8| 0| 9| 2| 1| 3| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 3| 5| 5| 4| 4| 3| 1| 0| 0| 3| 2| 0| 4| 0| 0| 0| 0| 0| 0| 1| 4| 4| 4| 4| 4|
| 9| 9| 3| 9| 8| 6| 2| 8| 1| 2| 9| 7| 0| 4| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Ovary | A + + + + + + + A + + + + A + + + + + + + + + + +|
Carcinoma | X |
Hemangiosarcoma | X |
Histiocytic Sarcoma | X |
Tubulostromal Adenoma | |
|__________________________________________________________________________|
Uterus | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma | |
Histiocytic Sarcoma | X |
Leiomyoma | |
Endometrium, Polyp Stromal | X |
|__________________________________________________________________________|
Vagina | + |
Carcinoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | A + + + + + + + A + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | X |
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Mandibular | A + + + + + + M A M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | A + + + + + + + A + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Spleen | A + A + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + M + + + + M + + + + + + + + I + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 3| 3| 4| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 1| 4| 9| 5| 0| 1| 4| 5| 6| 7| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 2| 3| 7| 3| 8| 2| 4| 8| 0| 9| 2| 1| 3| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 3| 5| 5| 4| 4| 3| 1| 0| 0| 3| 2| 0| 4| 0| 0| 0| 0| 0| 0| 1| 4| 4| 4| 4| 4|
| 9| 9| 3| 9| 8| 6| 2| 8| 1| 2| 9| 7| 0| 4| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + I + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Malignant | X |
Subcutaneous Tissue, Carcinoma, | |
Multiple | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | X |
|__________________________________________________________________________|
Skeletal Muscle | + + + |
Carcinoma, Metastatic, Uncertain | |
Primary Site | X |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + |
|__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Carcinoma, Metastatic, Harderian | |
Gland | X |
Carcinoma, Metastatic, Uncertain | |
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 3| 3| 4| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 1| 4| 9| 5| 0| 1| 4| 5| 6| 7| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 2| 3| 7| 3| 8| 2| 4| 8| 0| 9| 2| 1| 3| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 3| 5| 5| 4| 4| 3| 1| 0| 0| 3| 2| 0| 4| 0| 0| 0| 0| 0| 0| 1| 4| 4| 4| 4| 4|
| 9| 9| 3| 9| 8| 6| 2| 8| 1| 2| 9| 7| 0| 4| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Primary Site | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | X |
Osteosarcoma, Metastatic, Bone | X |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Mediastinum, Carcinoma | X |
Mediastinum, Carcinoma, Metastatic, | |
Harderian Gland | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | A + A + + + + A A + + + + + + + + + + + + + + + +|
Carcinoma | X |
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Urinary Bladder | + + A + + + + A M A + + + M + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X X X X |
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 1| 1| 1| 1| 2| 2| 2| 2| 3| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 0| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X |
Histiocytic Sarcoma | |
Osteosarcoma, Metastatic, Bone | |
|__________________________________________________________________________|
Mesentery | + |
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 20
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 1| 1| 1| 1| 2| 2| 2| 2| 3| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 0| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + I + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 1| 1| 1| 1| 2| 2| 2| 2| 3| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 0| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +|
Carcinoma | |
Hemangiosarcoma | |
Histiocytic Sarcoma | |
Tubulostromal Adenoma | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | X |
Histiocytic Sarcoma | |
Leiomyoma | X |
Endometrium, Polyp Stromal | X |
|__________________________________________________________________________|
Vagina | |
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 1| 1| 1| 1| 2| 2| 2| 2| 3| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 0| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Malignant | |
Subcutaneous Tissue, Carcinoma, | |
Multiple | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | |
|__________________________________________________________________________|
Skeletal Muscle | |
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Carcinoma, Metastatic, Harderian | |
Gland | |
Carcinoma, Metastatic, Uncertain | |
__________________________________________|__________________________________________________________________________|
Page 23
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 1| 1| 1| 1| 2| 2| 2| 2| 3| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 0| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Primary Site | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Osteosarcoma, Metastatic, Bone | |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinum, Carcinoma | |
Mediastinum, Carcinoma, Metastatic, | |
Harderian Gland | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 3| 3| 3| 4| 4| 5| 5| 5| 5| 6| | L |
| 5| 7| 8| 6| 7| 0| 6| 7| 8| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 55 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 53 |
Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 55 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Hepatocellular Carcinoma | X | 3 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | | 5 |
Histiocytic Sarcoma | | 2 |
Osteosarcoma, Metastatic, Bone | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + | 9 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 3| 3| 3| 4| 4| 5| 5| 5| 5| 6| | L |
| 5| 7| 8| 6| 7| 0| 6| 7| 8| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Squamous Cell Papilloma | | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Tooth | + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 2 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 57 |
Pheochromocytoma Benign | | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 57 |
Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 55 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Adenoma | X | 4 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 3| 3| 3| 4| 4| 5| 5| 5| 5| 6| | L |
| 5| 7| 8| 6| 7| 0| 6| 7| 8| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + | 57 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 56 |
Carcinoma | | 1 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 1 |
Tubulostromal Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Hemangioma | X | 2 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 1 |
Leiomyoma | | 1 |
Endometrium, Polyp Stromal | | 2 |
|__________________________________________________________________________|____________|
Vagina | | 1 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Histiocytic Sarcoma | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 3| 3| 3| 4| 4| 5| 5| 5| 5| 6| | L |
| 5| 7| 8| 6| 7| 0| 6| 7| 8| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lymph Node | + | 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 55 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Basosquamous Tumor Malignant | | 1 |
Subcutaneous Tissue, Carcinoma, | | |
Multiple | | 1 |
Subcutaneous Tissue, Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Osteosarcoma | | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 3| 3| 3| 4| 4| 5| 5| 5| 5| 6| | L |
| 5| 7| 8| 6| 7| 0| 6| 7| 8| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
|__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 2 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | | 1 |
Osteosarcoma, Metastatic, Bone | | 1 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Mediastinum, Carcinoma | | 1 |
Mediastinum, Carcinoma, Metastatic, | | |
Harderian Gland | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1250 PPM | 3| 3| 3| 4| 4| 5| 5| 5| 5| 6| | L |
| 5| 7| 8| 6| 7| 0| 6| 7| 8| 0| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 56 |
Carcinoma | | 1 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 54 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | X X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 1| 2| 6| 7| 7| 7| 9| 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 8| 4| 1| 1| 2| 3| 0| 1| 1| 9| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 3| 3| 3| 3| 4| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
2500 PPM | 1| 6| 7| 8| 9| 1| 2| 6| 6| 8| 0| 7| 7| 6| 6| 6| 9| 9| 9| 9| 0| 0| 0| 0| 1|
| 3| 4| 5| 2| 5| 9| 0| 8| 3| 5| 2| 0| 3| 6| 7| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A + + A + + + A A A + + + + M + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A A A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + A A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + M + + + + A A A + + + + + + + + + + + + + +|
Carcinoma | X X |
Sarcoma | X |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A A A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + A A A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + A A A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Carcinoma, Metastatic, Intestine | |
Large, Cecum | X |
Sarcoma, Multiple | X |
Sarcoma, Metastatic, Skin | X |
Sarcoma, Metastatic, Skeletal Muscle | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + A + A + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 1| 2| 6| 7| 7| 7| 9| 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 8| 4| 1| 1| 2| 3| 0| 1| 1| 9| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 3| 3| 3| 3| 4| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
2500 PPM | 1| 6| 7| 8| 9| 1| 2| 6| 6| 8| 0| 7| 7| 6| 6| 6| 9| 9| 9| 9| 0| 0| 0| 0| 1|
| 3| 4| 5| 2| 5| 9| 0| 8| 3| 5| 2| 0| 3| 6| 7| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Sarcoma | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + M + + + + M + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + A + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A A A + + + + + + + + + + + + + +|
Sarcoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + M + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + M + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + A + M + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
Pars Intermedia, Adenoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 1| 2| 6| 7| 7| 7| 9| 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 8| 4| 1| 1| 2| 3| 0| 1| 1| 9| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 3| 3| 3| 3| 4| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
2500 PPM | 1| 6| 7| 8| 9| 1| 2| 6| 6| 8| 0| 7| 7| 6| 6| 6| 9| 9| 9| 9| 0| 0| 0| 0| 1|
| 3| 4| 5| 2| 5| 9| 0| 8| 3| 5| 2| 0| 3| 6| 7| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + I + M + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + A + + + + + + + + M + + + + M + +|
Cystadenoma | |
Luteoma | X |
Teratoma Malignant | X|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leiomyosarcoma | |
Endometrium, Carcinoma | X |
Endometrium, Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Lymph Node | + + + + + + |
Inguinal, Sarcoma, Metastatic, Skin | X |
Pancreatic, Sarcoma | X |
Renal, Sarcoma, Metastatic, Skin | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + M + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + A + A + + + + + + + + I + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + A + A + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Thymus | M M + + + + + + A I M + + + + + + + + + + + + + +|
Thymoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 1| 2| 6| 7| 7| 7| 9| 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 8| 4| 1| 1| 2| 3| 0| 1| 1| 9| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 3| 3| 3| 3| 4| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
2500 PPM | 1| 6| 7| 8| 9| 1| 2| 6| 6| 8| 0| 7| 7| 6| 6| 6| 9| 9| 9| 9| 0| 0| 0| 0| 1|
| 3| 4| 5| 2| 5| 9| 0| 8| 3| 5| 2| 0| 3| 6| 7| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | X X |
Subcutaneous Tissue, Sarcoma | X X X X |
Subcutaneous Tissue, Sarcoma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteosarcoma | X |
|__________________________________________________________________________|
Skeletal Muscle | + + + |
Sarcoma | X X |
Sarcoma, Multiple | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + |
|__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + M + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Histiocytic Sarcoma | X |
Osteosarcoma, Metastatic, Bone | X |
Sarcoma, Metastatic, Skeletal Muscle | X |
Teratoma Malignant, Metastatic, Ovary| X|
Mediastinum, Histiocytic Sarcoma | X |
Mediastinum, Sarcoma, Metastatic, | |
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 1| 2| 6| 7| 7| 7| 9| 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 8| 4| 1| 1| 2| 3| 0| 1| 1| 9| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 3| 3| 3| 3| 4| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
2500 PPM | 1| 6| 7| 8| 9| 1| 2| 6| 6| 8| 0| 7| 7| 6| 6| 6| 9| 9| 9| 9| 0| 0| 0| 0| 1|
| 3| 4| 5| 2| 5| 9| 0| 8| 3| 5| 2| 0| 3| 6| 7| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Uncertain Primary Site | X |
Mediastinum, Sarcoma, Metastatic, | |
Skeletal Muscle | X |
|__________________________________________________________________________|
Nose | + + + + + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + |
Adenoma | |
Carcinoma | X |
|__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + A + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + M + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X |
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 6| 7| 8| 9| 0| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
Sarcoma | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X X X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
|__________________________________________________________________________|
Mesentery | + + + |
Carcinoma, Metastatic, Intestine | |
Large, Cecum | |
Sarcoma, Multiple | |
Sarcoma, Metastatic, Skin | |
Sarcoma, Metastatic, Skeletal Muscle | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 6| 7| 8| 9| 0| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Sarcoma | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + M M M M + + + +|
Pars Distalis, Adenoma | X |
Pars Intermedia, Adenoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | +|
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 6| 7| 8| 9| 0| 6|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +|
Cystadenoma | X |
Luteoma | |
Teratoma Malignant | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leiomyosarcoma | |
Endometrium, Carcinoma | |
Endometrium, Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Lymph Node | + + + |
Inguinal, Sarcoma, Metastatic, Skin | |
Pancreatic, Sarcoma | |
Renal, Sarcoma, Metastatic, Skin | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thymoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 6| 7| 8| 9| 0| 6|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | |
Subcutaneous Tissue, Sarcoma | X |
Subcutaneous Tissue, Sarcoma, | |
Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteosarcoma | |
|__________________________________________________________________________|
Skeletal Muscle | |
Sarcoma | |
Sarcoma, Multiple | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Histiocytic Sarcoma | |
Osteosarcoma, Metastatic, Bone | |
Sarcoma, Metastatic, Skeletal Muscle | |
Teratoma Malignant, Metastatic, Ovary| |
Mediastinum, Histiocytic Sarcoma | |
Mediastinum, Sarcoma, Metastatic, | |
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 6| 7| 8| 9| 0| 6|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Uncertain Primary Site | |
Mediastinum, Sarcoma, Metastatic, | |
Skeletal Muscle | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + |
Adenoma | X |
Carcinoma | X X |
|__________________________________________________________________________|
Lacrimal Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 3| 3| 3| 4| 4| 4| | A |
2500 PPM | 9| 9| 9| 0| 6| 6| 6| 1| 1| 1| | L |
| 7| 8| 9| 0| 1| 2| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M + + + + + | 54 |
Carcinoma | | 4 |
Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 56 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma | X | 4 |
Hepatocellular Carcinoma, Multiple | X | 2 |
Hepatocellular Adenoma | X X | 16 |
Hepatocellular Adenoma, Multiple | X | 3 |
Histiocytic Sarcoma | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
|__________________________________________________________________________|____________|
Mesentery | | 9 |
Carcinoma, Metastatic, Intestine | | |
Large, Cecum | | 1 |
Sarcoma, Multiple | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 3| 3| 3| 4| 4| 4| | A |
2500 PPM | 9| 9| 9| 0| 6| 6| 6| 1| 1| 1| | L |
| 7| 8| 9| 0| 1| 2| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Sarcoma, Metastatic, Skin | | 1 |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 58 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Squamous Cell Papilloma | | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 57 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + | 57 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 3| 3| 3| 4| 4| 4| | A |
2500 PPM | 9| 9| 9| 0| 6| 6| 6| 1| 1| 1| | L |
| 7| 8| 9| 0| 1| 2| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | | 3 |
Pars Intermedia, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + I + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 56 |
Cystadenoma | X | 2 |
Luteoma | | 1 |
Teratoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Leiomyosarcoma | X | 1 |
Endometrium, Carcinoma | | 1 |
Endometrium, Polyp Stromal | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | + | 10 |
Inguinal, Sarcoma, Metastatic, Skin | | 1 |
Pancreatic, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 3| 3| 3| 4| 4| 4| | A |
2500 PPM | 9| 9| 9| 0| 6| 6| 6| 1| 1| 1| | L |
| 7| 8| 9| 0| 1| 2| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Sarcoma, Metastatic, Skin | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + I M + + + + + | 55 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 55 |
Thymoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Hemangiosarcoma | | 2 |
Subcutaneous Tissue, Sarcoma | | 5 |
Subcutaneous Tissue, Sarcoma, | | |
Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Femur, Osteosarcoma | | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Sarcoma | | 2 |
Sarcoma, Multiple | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 3| 3| 3| 4| 4| 4| | A |
2500 PPM | 9| 9| 9| 0| 6| 6| 6| 1| 1| 1| | L |
| 7| 8| 9| 0| 1| 2| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
|__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Alveolar/Bronchiolar Adenoma | X | 4 |
Histiocytic Sarcoma | | 1 |
Osteosarcoma, Metastatic, Bone | | 1 |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
Teratoma Malignant, Metastatic, Ovary| | 1 |
Mediastinum, Histiocytic Sarcoma | | 1 |
Mediastinum, Sarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Mediastinum, Sarcoma, Metastatic, | | |
Skeletal Muscle | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | | 4 |
Adenoma | | 1 |
Carcinoma | | 3 |
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 3| 3| 3| 4| 4| 4| | A |
2500 PPM | 9| 9| 9| 0| 6| 6| 6| 1| 1| 1| | L |
| 7| 8| 9| 0| 1| 2| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + M + + + | 57 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 0| 0| 4| 4| 8| 0| 1| 2| 4| 6| 6| 6| 7| 7| 8| 8| 8| 8| 9| 9| 0| 0| 0| 1| 1|
| 3| 9| 4| 4| 8| 7| 6| 2| 8| 7| 7| 9| 5| 9| 1| 3| 3| 8| 0| 7| 5| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 3| 6| 4| 5| 2| 3| 6| 4| 6| 2| 5| 6| 3| 7| 2| 2| 3| 2| 2| 5| 7| 3| 2| 4| 8|
| 1| 7| 1| 0| 6| 6| 1| 4| 4| 9| 5| 5| 0| 4| 3| 8| 4| 5| 7| 2| 1| 9| 1| 3| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + A A A + + + M + A A A + + + + A + A + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + A + A A + + + + + A + A + + A|
Hemangiosarcoma, Metastatic, | |
Mesentery | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + A + A + + + + + + A + A + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + A A + + A + A + A A + + + + + A A A + + A|
Carcinoma | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + A + A + A A + + + + + A A A + + A|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A A + + + + A + A A + + + + + A A A + + A|
Carcinoma | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + A A + + + + A + A A + + + + + A A A + + A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangioma | |
Hemangiosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X X X|
Hepatocellular Adenoma, Multiple | X |
Hepatocholangiocarcinoma | |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X X X X X|
Hemangiosarcoma, Multiple | X X X |
Sarcoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, | |
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 0| 0| 4| 4| 8| 0| 1| 2| 4| 6| 6| 6| 7| 7| 8| 8| 8| 8| 9| 9| 0| 0| 0| 1| 1|
| 3| 9| 4| 4| 8| 7| 6| 2| 8| 7| 7| 9| 5| 9| 1| 3| 3| 8| 0| 7| 5| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 3| 6| 4| 5| 2| 3| 6| 4| 6| 2| 5| 6| 3| 7| 2| 2| 3| 2| 2| 5| 7| 3| 2| 4| 8|
| 1| 7| 1| 0| 6| 6| 1| 4| 4| 9| 5| 5| 0| 4| 3| 8| 4| 5| 7| 2| 1| 9| 1| 3| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mesentery | X |
Sarcoma, Metastatic, Mesentery | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + M + + + + + M + M + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + A A + + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + M + + + + + + + + M + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + M + + + + + + + + M + + + + M|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + M + + + M + + M + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
Abdominal, Hemangiosarcoma | |
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 0| 0| 4| 4| 8| 0| 1| 2| 4| 6| 6| 6| 7| 7| 8| 8| 8| 8| 9| 9| 0| 0| 0| 1| 1|
| 3| 9| 4| 4| 8| 7| 6| 2| 8| 7| 7| 9| 5| 9| 1| 3| 3| 8| 0| 7| 5| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 3| 6| 4| 5| 2| 3| 6| 4| 6| 2| 5| 6| 3| 7| 2| 2| 3| 2| 2| 5| 7| 3| 2| 4| 8|
| 1| 7| 1| 0| 6| 6| 1| 4| 4| 9| 5| 5| 0| 4| 3| 8| 4| 5| 7| 2| 1| 9| 1| 3| 0|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
Abdominal, Hemangiosarcoma, Multiple | X |
Thoracic, Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + M + + + + + + + + + +|
Luteoma | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Cervix, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Sarcoma, Metastatic, Skin | |
Mediastinal, Sarcoma, Metastatic, | |
Uncertain Primary Site | X |
Renal, Hemangiosarcoma, Metastatic, | |
Mesentery | X |
Renal, Sarcoma, Metastatic, Skin | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + M M + + M + + M + M + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Mesentery | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + M I + + + A + + M M + + M + I I M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 0| 0| 4| 4| 8| 0| 1| 2| 4| 6| 6| 6| 7| 7| 8| 8| 8| 8| 9| 9| 0| 0| 0| 1| 1|
| 3| 9| 4| 4| 8| 7| 6| 2| 8| 7| 7| 9| 5| 9| 1| 3| 3| 8| 0| 7| 5| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 3| 6| 4| 5| 2| 3| 6| 4| 6| 2| 5| 6| 3| 7| 2| 2| 3| 2| 2| 5| 7| 3| 2| 4| 8|
| 1| 7| 1| 0| 6| 6| 1| 4| 4| 9| 5| 5| 0| 4| 3| 8| 4| 5| 7| 2| 1| 9| 1| 3| 0|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Subcutaneous Tissue, Hemangiosarcoma | X X X |
Subcutaneous Tissue, Hemangiosarcoma,| |
Multiple | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + |
Hemangiosarcoma | X X X |
Hemangiosarcoma, Multiple | X |
Sarcoma | |
Sarcoma, Multiple | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + |
|__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Carcinoma, Metastatic, Harderian | |
Gland | |
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 0| 0| 4| 4| 8| 0| 1| 2| 4| 6| 6| 6| 7| 7| 8| 8| 8| 8| 9| 9| 0| 0| 0| 1| 1|
| 3| 9| 4| 4| 8| 7| 6| 2| 8| 7| 7| 9| 5| 9| 1| 3| 3| 8| 0| 7| 5| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 3| 6| 4| 5| 2| 3| 6| 4| 6| 2| 5| 6| 3| 7| 2| 2| 3| 2| 2| 5| 7| 3| 2| 4| 8|
| 1| 7| 1| 0| 6| 6| 1| 4| 4| 9| 5| 5| 0| 4| 3| 8| 4| 5| 7| 2| 1| 9| 1| 3| 0|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemangiosarcoma, Metastatic, Skin | |
Hemangiosarcoma, Metastatic, | |
Uncertain Primary Site | |
Hemangiosarcoma, Metastatic, | |
Skeletal Muscle | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Sarcoma, Metastatic, Mesentery | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + M + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + M + + M + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + |
Adenoma | |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + A + + + + + + I + + + + + + +|
Hemangiosarcoma | |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 1| 2| 2| 3| 4| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|
| 9| 4| 9| 0| 0| 3| 7| 8| 9| 1| 1| 8| 9| 1| 5| 7| 9| 5| 6| 6| 8| 0| 0| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 6| 5| 5| 3| 2| 7| 3| 5| 2| 4| 5| 3| 5| 3| 4| 6| 5| 4| 7| 7| 4| 6| 7| 6| 4|
| 9| 7| 3| 3| 4| 8| 8| 6| 2| 8| 8| 5| 1| 2| 7| 8| 4| 9| 0| 2| 5| 3| 9| 6| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + A + + + + + + + + + + + + + + + + M|
|__________________________________________________________________________|
Gallbladder | + A A A A A A A A + A A A A A A + A M A + + + + M|
|__________________________________________________________________________|
Intestine Large, Colon | + + A A A A + A + + + + + + A A + A + A + + + + A|
Hemangiosarcoma, Metastatic, | |
Mesentery | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + A + + A + A + + + + + + + A + A + A + + + + A|
|__________________________________________________________________________|
Intestine Large, Cecum | + A A A A A A A A + A A A A + A + A + A + + + + A|
Carcinoma | X X |
|__________________________________________________________________________|
Intestine Small, Duodenum | + A A A A A A A A + + A A + A A + A + A + + + + A|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A A A A A A A A + + A A + A A + A + A + + + + A|
Carcinoma | X |
|__________________________________________________________________________|
Intestine Small, Ileum | + A A A A A A A A + + A A + A + A A + A + + + + A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangioma | |
Hemangiosarcoma, Metastatic, Skin | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X X X X |
Hepatocellular Adenoma | X X|
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X |
Hepatocholangiocarcinoma | X |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X X X X X X X X X|
Hemangiosarcoma, Multiple | X X X |
Sarcoma | |
|__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + M + + + + +|
Hemangiosarcoma, Metastatic, | |
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 1| 2| 2| 3| 4| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|
| 9| 4| 9| 0| 0| 3| 7| 8| 9| 1| 1| 8| 9| 1| 5| 7| 9| 5| 6| 6| 8| 0| 0| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 6| 5| 5| 3| 2| 7| 3| 5| 2| 4| 5| 3| 5| 3| 4| 6| 5| 4| 7| 7| 4| 6| 7| 6| 4|
| 9| 7| 3| 3| 4| 8| 8| 6| 2| 8| 8| 5| 1| 2| 7| 8| 4| 9| 0| 2| 5| 3| 9| 6| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mesentery | |
Sarcoma, Metastatic, Mesentery | |
|__________________________________________________________________________|
Salivary Glands | + + M M + + M M + + + + M + + M + + + + + + + + M|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +|
Squamous Cell Papilloma | X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + A A + + + A + + + + A|
|__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + M + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + A + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M + M + + + M + + + + + + + + M + + + + + + + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + I + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + A + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + + |
Abdominal, Hemangiosarcoma | X |
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 1| 2| 2| 3| 4| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|
| 9| 4| 9| 0| 0| 3| 7| 8| 9| 1| 1| 8| 9| 1| 5| 7| 9| 5| 6| 6| 8| 0| 0| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 6| 5| 5| 3| 2| 7| 3| 5| 2| 4| 5| 3| 5| 3| 4| 6| 5| 4| 7| 7| 4| 6| 7| 6| 4|
| 9| 7| 3| 3| 4| 8| 8| 6| 2| 8| 8| 5| 1| 2| 7| 8| 4| 9| 0| 2| 5| 3| 9| 6| 0|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
Abdominal, Hemangiosarcoma, Multiple | |
Thoracic, Sarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + I M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + M + + + + + + + + + + + + A + + + M + + + + +|
Luteoma | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hemangiosarcoma | X X |
Cervix, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Sarcoma, Metastatic, Skin | |
Mediastinal, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
Renal, Hemangiosarcoma, Metastatic, | |
Mesentery | |
Renal, Sarcoma, Metastatic, Skin | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + M M + + + + M + + M + + + + + + + + A|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + A + + + + +|
Sarcoma, Metastatic, Mesentery | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + M + + + A + + + + +|
|__________________________________________________________________________|
Thymus | + + + + M + M M + + + + + + + M + M + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 1| 2| 2| 3| 4| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|
| 9| 4| 9| 0| 0| 3| 7| 8| 9| 1| 1| 8| 9| 1| 5| 7| 9| 5| 6| 6| 8| 0| 0| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 6| 5| 5| 3| 2| 7| 3| 5| 2| 4| 5| 3| 5| 3| 4| 6| 5| 4| 7| 7| 4| 6| 7| 6| 4|
| 9| 7| 3| 3| 4| 8| 8| 6| 2| 8| 8| 5| 1| 2| 7| 8| 4| 9| 0| 2| 5| 3| 9| 6| 0|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X |
Subcutaneous Tissue, Hemangiosarcoma | X X X X X X X X |
Subcutaneous Tissue, Hemangiosarcoma,| |
Multiple | X X X |
Subcutaneous Tissue, Sarcoma | X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + |
Hemangiosarcoma | X X X X X X X X X |
Hemangiosarcoma, Multiple | X |
Sarcoma | |
Sarcoma, Multiple | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + M M + + + + + + + + + + + + + + + + M|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Carcinoma, Metastatic, Harderian | |
Gland | |
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 1| 2| 2| 3| 4| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|
| 9| 4| 9| 0| 0| 3| 7| 8| 9| 1| 1| 8| 9| 1| 5| 7| 9| 5| 6| 6| 8| 0| 0| 3| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5000 PPM | 6| 5| 5| 3| 2| 7| 3| 5| 2| 4| 5| 3| 5| 3| 4| 6| 5| 4| 7| 7| 4| 6| 7| 6| 4|
| 9| 7| 3| 3| 4| 8| 8| 6| 2| 8| 8| 5| 1| 2| 7| 8| 4| 9| 0| 2| 5| 3| 9| 6| 0|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemangiosarcoma, Metastatic, Skin | X |
Hemangiosarcoma, Metastatic, | |
Uncertain Primary Site | X |
Hemangiosarcoma, Metastatic, | |
Skeletal Muscle | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Sarcoma, Metastatic, Mesentery | X |
|__________________________________________________________________________|
Nose | + + + + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + M + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + M + + + A + + + + +|
Hemangiosarcoma | X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________|__________________________________________________________________________|
Page 56
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| | |
| 2| 0| 0| 2| 5| 9| 9| 9| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 4| 5| 6| 6| 3| 4| 7| 7| 7| 7| | L |
| 2| 9| 0| 2| 7| 6| 3| 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Gallbladder | A + + A + + + + + + | 31 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | A + + A + + + + + + | 41 |
Hemangiosarcoma, Metastatic, | | |
Mesentery | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + A + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + A + + + + + + | 32 |
Carcinoma | X | 3 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + A + + + + + + | 34 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + A + + + + + + | 34 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + A + + + + + + | 34 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Cholangioma | X | 1 |
Hemangiosarcoma, Metastatic, Skin | | 1 |
Hepatocellular Carcinoma | X X | 9 |
Hepatocellular Carcinoma, Multiple | X X X | 7 |
Hepatocellular Adenoma | | 9 |
Hepatocellular Adenoma, Multiple | X X X X X X X | 20 |
Hepatocholangiocarcinoma | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 34 |
Hemangiosarcoma | X X X X X | 25 |
Hemangiosarcoma, Multiple | X | 7 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| | |
| 2| 0| 0| 2| 5| 9| 9| 9| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 4| 5| 6| 6| 3| 4| 7| 7| 7| 7| | L |
| 2| 9| 0| 2| 7| 6| 3| 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 57 |
Hemangiosarcoma, Metastatic, | | |
Mesentery | | 1 |
Sarcoma, Metastatic, Mesentery | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Squamous Cell Papilloma | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 52 |
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 56 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + | 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| | |
| 2| 0| 0| 2| 5| 9| 9| 9| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 4| 5| 6| 6| 3| 4| 7| 7| 7| 7| | L |
| 2| 9| 0| 2| 7| 6| 3| 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Pituitary Gland | + + + + + + + + + + | 53 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 53 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 3 |
Abdominal, Hemangiosarcoma | | 1 |
Abdominal, Hemangiosarcoma, Multiple | | 1 |
Thoracic, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 58 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 56 |
Luteoma | X | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Hemangiosarcoma | | 2 |
Cervix, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Lymph Node | + + | 11 |
Iliac, Sarcoma, Metastatic, Skin | X | 1 |
Mediastinal, Sarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Renal, Hemangiosarcoma, Metastatic, | | |
Mesentery | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| | |
| 2| 0| 0| 2| 5| 9| 9| 9| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 4| 5| 6| 6| 3| 4| 7| 7| 7| 7| | L |
| 2| 9| 0| 2| 7| 6| 3| 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Sarcoma, Metastatic, Skin | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Sarcoma, Metastatic, Mesentery | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Thymus | + + + I + + + + + + | 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Basal Cell Carcinoma | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | X X X X X | 16 |
Subcutaneous Tissue, Hemangiosarcoma,| | |
Multiple | | 3 |
Subcutaneous Tissue, Sarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 18 |
Hemangiosarcoma | X X | 14 |
Hemangiosarcoma, Multiple | | 2 |
Sarcoma | X | 1 |
Sarcoma, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| | |
| 2| 0| 0| 2| 5| 9| 9| 9| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 4| 5| 6| 6| 3| 4| 7| 7| 7| 7| | L |
| 2| 9| 0| 2| 7| 6| 3| 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 57 |
Alveolar/Bronchiolar Adenoma | | 4 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 2 |
Carcinoma, Metastatic, Harderian | | |
Gland | X | 1 |
Hemangiosarcoma, Metastatic, Skin | | 1 |
Hemangiosarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Hemangiosarcoma, Metastatic, | | |
Skeletal Muscle | | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
Sarcoma, Metastatic, Mesentery | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
Adenoma | X | 2 |
Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| | |
| 2| 0| 0| 2| 5| 9| 9| 9| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 4| 5| 6| 6| 3| 4| 7| 7| 7| 7| | L |
| 2| 9| 0| 2| 7| 6| 3| 5| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 54 |
Hemangiosarcoma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 9| 9| 1| 3| 4| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 2| 6| 8| 7| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 5| 1| 1| 3| 4| 2| 5| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4|
| 4| 3| 9| 8| 1| 3| 3| 4| 1| 3| 4| 8| 9| 5| 6| 1| 2| 7| 9| 2| 4| 7| 0| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + A M M A A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + A + A A A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + A + A A A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + A + A A A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + A A + A A A + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + A A A + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Carcinoma | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + A A + A A A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatoblastoma | X |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | X X X |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X |
|__________________________________________________________________________|
Mesentery | + + + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + A + A + A + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 9| 9| 1| 3| 4| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 2| 6| 8| 7| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 5| 1| 1| 3| 4| 2| 5| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4|
| 4| 3| 9| 8| 1| 3| 3| 4| 1| 3| 4| 8| 9| 5| 6| 1| 2| 7| 9| 2| 4| 7| 0| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Tooth | + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Capsule, Adenoma | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + M|
|__________________________________________________________________________|
Pituitary Gland | I + + + M + + + + + M + M + + + + M + + + + + + +|
Pars Distalis, Adenoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + + |
Thoracic, Sarcoma | X |
Thoracic, Sarcoma, Multiple | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 9| 9| 1| 3| 4| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 2| 6| 8| 7| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 5| 1| 1| 3| 4| 2| 5| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4|
| 4| 3| 9| 8| 1| 3| 3| 4| 1| 3| 4| 8| 9| 5| 6| 1| 2| 7| 9| 2| 4| 7| 0| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant | |
|__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Sarcoma, Metastatic, | |
Tissue NOS | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | X X |
|__________________________________________________________________________|
Thymus | + + + M M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M + M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 9| 9| 1| 3| 4| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 2| 6| 8| 7| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 5| 1| 1| 3| 4| 2| 5| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4|
| 4| 3| 9| 8| 1| 3| 3| 4| 1| 3| 4| 8| 9| 5| 6| 1| 2| 7| 9| 2| 4| 7| 0| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X|
Alveolar/Bronchiolar Carcinoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
External Ear, Neural Crest Tumor, | |
Malignant | X |
|__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 9| 9| 1| 3| 4| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 2| 6| 8| 7| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 5| 1| 1| 3| 4| 2| 5| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4|
| 4| 3| 9| 8| 1| 3| 3| 4| 1| 3| 4| 8| 9| 5| 6| 1| 2| 7| 9| 2| 4| 7| 0| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Kidney | + + + A + A + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 4| 4| 5| 5| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
| 6| 9| 2| 7| 5| 6| 7| 0| 1| 2| 3| 4| 7| 0| 5| 6| 8| 3| 5| 6| 8| 9| 1| 2| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Carcinoma | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatoblastoma | |
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X X|
Hepatocellular Adenoma, Multiple | X X |
|__________________________________________________________________________|
Mesentery | + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 4| 4| 5| 5| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
| 6| 9| 2| 7| 5| 6| 7| 0| 1| 2| 3| 4| 7| 0| 5| 6| 8| 3| 5| 6| 8| 9| 1| 2| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Capsule, Adenoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M M + + + + + + + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Adenoma | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
Thoracic, Sarcoma | |
Thoracic, Sarcoma, Multiple | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 69
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 4| 4| 5| 5| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
| 6| 9| 2| 7| 5| 6| 7| 0| 1| 2| 3| 4| 7| 0| 5| 6| 8| 3| 5| 6| 8| 9| 1| 2| 7|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant | X |
|__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Sarcoma, Metastatic, | |
Tissue NOS | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + I + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 70
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 4| 4| 5| 5| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
| 6| 9| 2| 7| 5| 6| 7| 0| 1| 2| 3| 4| 7| 0| 5| 6| 8| 3| 5| 6| 8| 9| 1| 2| 7|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
External Ear, Neural Crest Tumor, | |
Malignant | |
|__________________________________________________________________________|
Harderian Gland | + + + |
Adenoma | X X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 4| 4| 5| 5| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|
| 6| 9| 2| 7| 5| 6| 7| 0| 1| 2| 3| 4| 7| 0| 5| 6| 8| 3| 5| 6| 8| 9| 1| 2| 7|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 4| 5| 5| 5| 6| 0| 3| 5| 5| 5| | L |
| 8| 5| 6| 8| 0| 2| 0| 0| 1| 9| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Gallbladder | + + + I + + + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 56 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 55 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 56 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 55 |
Hemangiosarcoma | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
Adenocarcinoma | | 1 |
Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 55 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 1 |
Hepatoblastoma | | 1 |
Hepatocellular Carcinoma | X | 9 |
Hepatocellular Carcinoma, Multiple | | 3 |
Hepatocellular Adenoma | X X X | 15 |
Hepatocellular Adenoma, Multiple | | 3 |
|__________________________________________________________________________|____________|
Mesentery | + + | 12 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 73
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 4| 5| 5| 5| 6| 0| 3| 5| 5| 5| | L |
| 8| 5| 6| 8| 0| 2| 0| 0| 1| 9| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Tooth | + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Adenoma | | 1 |
Capsule, Adenoma | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 55 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + + | 53 |
Pars Distalis, Adenoma | | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 74
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 4| 5| 5| 5| 6| 0| 3| 5| 5| 5| | L |
| 8| 5| 6| 8| 0| 2| 0| 0| 1| 9| | |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM - cont | | |
| | |
Thoracic, Sarcoma | | 1 |
Thoracic, Sarcoma, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Mast Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | | 3 |
Mediastinal, Sarcoma, Metastatic, | | |
Tissue NOS | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hemangioma | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 75
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 4| 5| 5| 5| 6| 0| 3| 5| 5| 5| | L |
| 8| 5| 6| 8| 0| 2| 0| 0| 1| 9| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemangiosarcoma | | 2 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | X X X | 9 |
Alveolar/Bronchiolar Carcinoma | | 3 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 2 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 76
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 4| 5| 5| 5| 6| 0| 3| 5| 5| 5| | L |
| 8| 5| 6| 8| 0| 2| 0| 0| 1| 9| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Nose | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
External Ear, Neural Crest Tumor, | | |
Malignant | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + | 5 |
Adenoma | X | 4 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 6| 6| 6| 8| 2| 4| 4| 5| 7| 7| 9| 0| 3| 3| 4| 4| 5| 8| 8| 9| 9| 1| 1| 2|
| 1| 0| 3| 9| 5| 6| 2| 5| 9| 2| 5| 2| 4| 0| 3| 1| 1| 5| 6| 8| 0| 0| 0| 7| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 1| 1| 0| 1| 0| 0| 0|
1250 PPM | 1| 0| 2| 8| 8| 9| 6| 7| 6| 7| 9| 0| 8| 6| 7| 7| 9| 6| 1| 0| 9| 1| 7| 8| 8|
| 9| 3| 0| 7| 0| 0| 3| 7| 6| 6| 8| 1| 6| 9| 0| 1| 1| 8| 0| 5| 7| 4| 3| 9| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A A A A + + + A A A M + + + A M A A A A + A + + A|
|__________________________________________________________________________|
Intestine Large, Colon | + + + A + A + M + A A + + M + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + M + + M A + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + A + A A + + A + + + + A A + A A + + + + A A|
Carcinoma | X X X X X X X X |
|__________________________________________________________________________|
Intestine Small, Duodenum | + A A A + A + A A + A + + + A A + A A + + A + + A|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A A A + A A A + A A + + A A A A A A + + A + + A|
|__________________________________________________________________________|
Intestine Small, Ileum | + A A A + A + A A A A + + A A A A A A + + A + A A|
Carcinoma | |
|__________________________________________________________________________|
Liver | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hemangiosarcoma, Multiple | X |
Hepatoblastoma | |
Hepatocellular Carcinoma | X X X X X|
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X|
|__________________________________________________________________________|
Mesentery | + + + + + |
Carcinoma, Metastatic, Intestine | |
Large, Cecum | X |
Hemangiosarcoma | X X X |
|__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 6| 6| 6| 8| 2| 4| 4| 5| 7| 7| 9| 0| 3| 3| 4| 4| 5| 8| 8| 9| 9| 1| 1| 2|
| 1| 0| 3| 9| 5| 6| 2| 5| 9| 2| 5| 2| 4| 0| 3| 1| 1| 5| 6| 8| 0| 0| 0| 7| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 1| 1| 0| 1| 0| 0| 0|
1250 PPM | 1| 0| 2| 8| 8| 9| 6| 7| 6| 7| 9| 0| 8| 6| 7| 7| 9| 6| 1| 0| 9| 1| 7| 8| 8|
| 9| 3| 0| 7| 0| 0| 3| 7| 6| 6| 8| 1| 6| 9| 0| 1| 1| 8| 0| 5| 7| 4| 3| 9| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + A + + + + + + + A + + + + + A A|
|__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + I + + M + M + M + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 79
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 6| 6| 6| 8| 2| 4| 4| 5| 7| 7| 9| 0| 3| 3| 4| 4| 5| 8| 8| 9| 9| 1| 1| 2|
| 1| 0| 3| 9| 5| 6| 2| 5| 9| 2| 5| 2| 4| 0| 3| 1| 1| 5| 6| 8| 0| 0| 0| 7| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 1| 1| 0| 1| 0| 0| 0|
1250 PPM | 1| 0| 2| 8| 8| 9| 6| 7| 6| 7| 9| 0| 8| 6| 7| 7| 9| 6| 1| 0| 9| 1| 7| 8| 8|
| 9| 3| 0| 7| 0| 0| 3| 7| 6| 6| 8| 1| 6| 9| 0| 1| 1| 8| 0| 5| 7| 4| 3| 9| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Preputial Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + I + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
|__________________________________________________________________________|
Lymph Node | + + +|
Pancreatic, Histiocytic Sarcoma | X|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + M + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + A + + + M + + + + + M + + + + + + + + + + +|
Carcinoma, Metastatic, Intestine | |
Large, Cecum | X |
Histiocytic Sarcoma | X|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Histiocytic Sarcoma | X|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + M + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 80
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 6| 6| 6| 8| 2| 4| 4| 5| 7| 7| 9| 0| 3| 3| 4| 4| 5| 8| 8| 9| 9| 1| 1| 2|
| 1| 0| 3| 9| 5| 6| 2| 5| 9| 2| 5| 2| 4| 0| 3| 1| 1| 5| 6| 8| 0| 0| 0| 7| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 1| 1| 0| 1| 0| 0| 0|
1250 PPM | 1| 0| 2| 8| 8| 9| 6| 7| 6| 7| 9| 0| 8| 6| 7| 7| 9| 6| 1| 0| 9| 1| 7| 8| 8|
| 9| 3| 0| 7| 0| 0| 3| 7| 6| 6| 8| 1| 6| 9| 0| 1| 1| 8| 0| 5| 7| 4| 3| 9| 4|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Sebaceous Gland, Carcinoma | |
Subcutaneous Tissue, Hemangioma | |
Subcutaneous Tissue, Hemangiosarcoma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteoma | |
|__________________________________________________________________________|
Skeletal Muscle | + + + + |
Hemangiosarcoma | X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Intestine | |
Large, Cecum | X |
Hemangiosarcoma, Metastatic, | |
Uncertain Primary Site | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
__________________________________________|__________________________________________________________________________|
Page 81
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 5| 6| 6| 6| 8| 2| 4| 4| 5| 7| 7| 9| 0| 3| 3| 4| 4| 5| 8| 8| 9| 9| 1| 1| 2|
| 1| 0| 3| 9| 5| 6| 2| 5| 9| 2| 5| 2| 4| 0| 3| 1| 1| 5| 6| 8| 0| 0| 0| 7| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 1| 1| 0| 1| 0| 0| 0|
1250 PPM | 1| 0| 2| 8| 8| 9| 6| 7| 6| 7| 9| 0| 8| 6| 7| 7| 9| 6| 1| 0| 9| 1| 7| 8| 8|
| 9| 3| 0| 7| 0| 0| 3| 7| 6| 6| 8| 1| 6| 9| 0| 1| 1| 8| 0| 5| 7| 4| 3| 9| 4|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
|__________________________________________________________________________|
Harderian Gland | + |
Adenoma | |
Carcinoma | X |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
|__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
__________________________________________|__________________________________________________________________________|
Page 82
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1250 PPM | 6| 6| 7| 8| 8| 8| 9| 0| 0| 0| 0| 1| 1| 1| 1| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9|
| 7| 4| 2| 1| 3| 5| 4| 2| 7| 8| 9| 2| 3| 7| 8| 1| 2| 5| 5| 8| 9| 2| 2| 3| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X X X |
|__________________________________________________________________________|
Intestine Small, Duodenum | A + + M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | A + + M + + + + + + + + + + + + + + M + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | X X |
Hepatoblastoma | X |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | X X X |
Hepatocellular Adenoma | X X X X X X|
Hepatocellular Adenoma, Multiple | X X X X X X |
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Mesentery | + + + + + |
Carcinoma, Metastatic, Intestine | |
Large, Cecum | |
Hemangiosarcoma | X X X X |
|__________________________________________________________________________|
Oral Mucosa | |
Pharyngeal, Squamous Cell Carcinoma | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1250 PPM | 6| 6| 7| 8| 8| 8| 9| 0| 0| 0| 0| 1| 1| 1| 1| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9|
| 7| 4| 2| 1| 3| 5| 4| 2| 7| 8| 9| 2| 3| 7| 8| 1| 2| 5| 5| 8| 9| 2| 2| 3| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + M + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + M M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1250 PPM | 6| 6| 7| 8| 8| 8| 9| 0| 0| 0| 0| 1| 1| 1| 1| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9|
| 7| 4| 2| 1| 3| 5| 4| 2| 7| 8| 9| 2| 3| 7| 8| 1| 2| 5| 5| 8| 9| 2| 2| 3| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
|__________________________________________________________________________|
Lymph Node | + |
Pancreatic, Histiocytic Sarcoma | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Intestine | |
Large, Cecum | |
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Thymus | + + + + + + M + + I + + + + + + + + I + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1250 PPM | 6| 6| 7| 8| 8| 8| 9| 0| 0| 0| 0| 1| 1| 1| 1| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9|
| 7| 4| 2| 1| 3| 5| 4| 2| 7| 8| 9| 2| 3| 7| 8| 1| 2| 5| 5| 8| 9| 2| 2| 3| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Sebaceous Gland, Carcinoma | X |
Subcutaneous Tissue, Hemangioma | X |
Subcutaneous Tissue, Hemangiosarcoma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteoma | X|
|__________________________________________________________________________|
Skeletal Muscle | + + |
Hemangiosarcoma | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Intestine | |
Large, Cecum | |
Hemangiosarcoma, Metastatic, | |
Uncertain Primary Site | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
__________________________________________|__________________________________________________________________________|
Page 86
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1250 PPM | 6| 6| 7| 8| 8| 8| 9| 0| 0| 0| 0| 1| 1| 1| 1| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9|
| 7| 4| 2| 1| 3| 5| 4| 2| 7| 8| 9| 2| 3| 7| 8| 1| 2| 5| 5| 8| 9| 2| 2| 3| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
|__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X |
Carcinoma | |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________|__________________________________________________________________________|
Page 87
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 0| 0| 0| 1| 1| 1| | A |
1250 PPM | 9| 0| 1| 1| 7| 8| 9| 0| 0| 1| | L |
| 9| 4| 5| 6| 4| 8| 6| 0| 6| 1| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 49 |
Carcinoma | | 12 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 45 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 43 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 40 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Hemangiosarcoma | | 1 |
Hemangiosarcoma, Multiple | | 3 |
Hepatoblastoma | | 1 |
Hepatocellular Carcinoma | | 9 |
Hepatocellular Carcinoma, Multiple | X X X | 7 |
Hepatocellular Adenoma | X X | 12 |
Hepatocellular Adenoma, Multiple | | 6 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + | 12 |
Carcinoma, Metastatic, Intestine | | |
Large, Cecum | | 1 |
Hemangiosarcoma | X | 8 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 88
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 0| 0| 0| 1| 1| 1| | A |
1250 PPM | 9| 0| 1| 1| 7| 8| 9| 0| 0| 1| | L |
| 9| 4| 5| 6| 4| 8| 6| 0| 6| 1| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Pharyngeal, Squamous Cell Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 54 |
|__________________________________________________________________________|____________|
Tooth | + + + | 9 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + M + + | 54 |
|__________________________________________________________________________|____________|
Pituitary Gland | + M + M M + + + + + | 50 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + I + + + + + + + | 59 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 89
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 0| 0| 0| 1| 1| 1| | A |
1250 PPM | 9| 0| 1| 1| 7| 8| 9| 0| 0| 1| | L |
| 9| 4| 5| 6| 4| 8| 6| 0| 6| 1| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | | 4 |
Pancreatic, Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 55 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M | 55 |
Carcinoma, Metastatic, Intestine | | |
Large, Cecum | | 1 |
Histiocytic Sarcoma | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 90
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 0| 0| 0| 1| 1| 1| | A |
1250 PPM | 9| 0| 1| 1| 7| 8| 9| 0| 0| 1| | L |
| 9| 4| 5| 6| 4| 8| 6| 0| 6| 1| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 3 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Thymus | I + + M + + + + + + | 52 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Sebaceous Gland, Carcinoma | | 1 |
Subcutaneous Tissue, Hemangioma | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Cranium, Osteoma | | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 6 |
Hemangiosarcoma | | 6 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | X | 6 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 91
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 0| 0| 0| 1| 1| 1| | A |
1250 PPM | 9| 0| 1| 1| 7| 8| 9| 0| 0| 1| | L |
| 9| 4| 5| 6| 4| 8| 6| 0| 6| 1| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Carcinoma | | 1 |
Carcinoma, Metastatic, Intestine | | |
Large, Cecum | | 1 |
Hemangiosarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 2 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | | 3 |
Adenoma | | 1 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 92
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 7| 0| 6| 1| 1| 2| 3| 5| 5| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| 0| 1| 1| 2| 2| 2|
| 0| 3| 5| 0| 9| 3| 4| 1| 1| 6| 7| 9| 0| 6| 5| 2| 2| 6| 7| 4| 6| 7| 0| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 2| 7| 7| 5| 4| 7| 6| 6| 4| 4| 8| 4| 5| 4| 3| 6| 3| 7| 6| 3| 2| 5| 6| 3|
| 7| 4| 7| 1| 1| 9| 5| 0| 9| 1| 0| 0| 4| 4| 8| 8| 3| 6| 6| 4| 4| 7| 3| 1| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A + A A + + + + + + A A + + A + + + + + A A A + A|
|__________________________________________________________________________|
Intestine Large, Colon | A + + + A + + + + + A A + + A + + + + + A + + + A|
Muscularis, Serosa, Hemangiosarcoma | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + A A + + A + + + + + A + + + A|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + A A A + + + + A A + + A + + A + + A A A + A|
Carcinoma | X X X |
|__________________________________________________________________________|
Intestine Small, Duodenum | A + + A + + + + + + A A + + A + + + + + A + A + A|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + A A A A + + + + A A + + A + + + + + A A A + A|
|__________________________________________________________________________|
Intestine Small, Ileum | A + + A A A + + + + A A + + A + + + + + A A A + A|
|__________________________________________________________________________|
Liver | A + + + + + + + + + + A + + + + + + + + A + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Metastatic, | |
Skeletal Muscle | X |
Hepatocellular Carcinoma | |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Intestine | |
Large, Cecum | X |
Hemangiosarcoma | X X X X X X X X X X X X X |
Hemangiosarcoma, Multiple | X X X|
Hemangiosarcoma, Metastatic, | |
Skeletal Muscle | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 93
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 7| 0| 6| 1| 1| 2| 3| 5| 5| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| 0| 1| 1| 2| 2| 2|
| 0| 3| 5| 0| 9| 3| 4| 1| 1| 6| 7| 9| 0| 6| 5| 2| 2| 6| 7| 4| 6| 7| 0| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 2| 7| 7| 5| 4| 7| 6| 6| 4| 4| 8| 4| 5| 4| 3| 6| 3| 7| 6| 3| 2| 5| 6| 3|
| 7| 4| 7| 1| 1| 9| 5| 0| 9| 1| 0| 0| 4| 4| 8| 8| 3| 6| 6| 4| 4| 7| 3| 1| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinus, Hemangiosarcoma | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + A + + + + + A + A + A|
|__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + I + + + + A + + + + + + + + M + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | M + + + I + + + + M + + + I + + + + + + + + M + M|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
Pelvic, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + + |
__________________________________________|__________________________________________________________________________|
Page 94
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 7| 0| 6| 1| 1| 2| 3| 5| 5| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| 0| 1| 1| 2| 2| 2|
| 0| 3| 5| 0| 9| 3| 4| 1| 1| 6| 7| 9| 0| 6| 5| 2| 2| 6| 7| 4| 6| 7| 0| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 2| 7| 7| 5| 4| 7| 6| 6| 4| 4| 8| 4| 5| 4| 3| 6| 3| 7| 6| 3| 2| 5| 6| 3|
| 7| 4| 7| 1| 1| 9| 5| 0| 9| 1| 0| 0| 4| 4| 8| 8| 3| 6| 6| 4| 4| 7| 3| 1| 2|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hemangiosarcoma | X |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + +|
Mediastinal, Hemangiosarcoma, | |
Metastatic, Mesentery | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + M + + + M + A + + + M|
Hemangioma | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M M + + + +|
Carcinoma, Metastatic, Intestine | |
Large, Cecum | X X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + A + + A + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + I + + M + + I M + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 95
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 7| 0| 6| 1| 1| 2| 3| 5| 5| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| 0| 1| 1| 2| 2| 2|
| 0| 3| 5| 0| 9| 3| 4| 1| 1| 6| 7| 9| 0| 6| 5| 2| 2| 6| 7| 4| 6| 7| 0| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 2| 7| 7| 5| 4| 7| 6| 6| 4| 4| 8| 4| 5| 4| 3| 6| 3| 7| 6| 3| 2| 5| 6| 3|
| 7| 4| 7| 1| 1| 9| 5| 0| 9| 1| 0| 0| 4| 4| 8| 8| 3| 6| 6| 4| 4| 7| 3| 1| 2|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + |
Hemangiosarcoma | X X X X X X X |
Hemangiosarcoma, Multiple | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + |
|__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | |
Hemangiosarcoma, Metastatic, | |
Mesentery | |
Hemangiosarcoma, Metastatic, Skin | |
Hemangiosarcoma, Metastatic, | |
Uncertain Primary Site | X |
Hemangiosarcoma, Metastatic, | |
Skeletal Muscle | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 96
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 7| 0| 6| 1| 1| 2| 3| 5| 5| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| 0| 1| 1| 2| 2| 2|
| 0| 3| 5| 0| 9| 3| 4| 1| 1| 6| 7| 9| 0| 6| 5| 2| 2| 6| 7| 4| 6| 7| 0| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 2| 7| 7| 5| 4| 7| 6| 6| 4| 4| 8| 4| 5| 4| 3| 6| 3| 7| 6| 3| 2| 5| 6| 3|
| 7| 4| 7| 1| 1| 9| 5| 0| 9| 1| 0| 0| 4| 4| 8| 8| 3| 6| 6| 4| 4| 7| 3| 1| 2|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Pleura | + |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + A + + + + + A + + + +|
Hemangiosarcoma, Metastatic, | |
Mesentery | X |
|__________________________________________________________________________|
Urethra | + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hemangiosarcoma | |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 97
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 1| 3| 4| 9| 0| 4| 8| 8| 3| 4| 6| 6| 7| 0| 0| 3| 4| 6| 6| 7| 9| 9| 9| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 2| 2| 4| 4| 5| 5| 5| 7| 6| 3| 2| 2| 3| 3| 5| 6| 2| 3| 4| 7| 3| 6| 6| 2|
| 5| 2| 6| 5| 3| 9| 8| 6| 0| 8| 1| 5| 8| 5| 7| 0| 5| 9| 0| 7| 8| 3| 2| 7| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A A + A A + A M + A + + M A A A A + M + A + A A|
|__________________________________________________________________________|
Intestine Large, Colon | + + A A + + + + + + A + + + + + A + + + + + + + +|
Muscularis, Serosa, Hemangiosarcoma | |
|__________________________________________________________________________|
Intestine Large, Rectum | + A A A + + + + + + A + + + + + A + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A A A A A + + M + + + + + + A A + + A + + + A A|
Carcinoma | X X X X |
|__________________________________________________________________________|
Intestine Small, Duodenum | + A A + A A + + + + A + + + + + A + + A + + + A A|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A A A A + + + + A + + + + A A + + A + + + A A|
|__________________________________________________________________________|
Intestine Small, Ileum | + A A A A A + + + + A + + + + A A + + A + + + A A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Metastatic, | |
Skeletal Muscle | |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | |
Hepatocellular Adenoma, Multiple | X |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Intestine | |
Large, Cecum | |
Hemangiosarcoma | X X X X X X X X X X X X X|
Hemangiosarcoma, Multiple | X |
Hemangiosarcoma, Metastatic, | |
Skeletal Muscle | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 98
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 1| 3| 4| 9| 0| 4| 8| 8| 3| 4| 6| 6| 7| 0| 0| 3| 4| 6| 6| 7| 9| 9| 9| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 2| 2| 4| 4| 5| 5| 5| 7| 6| 3| 2| 2| 3| 3| 5| 6| 2| 3| 4| 7| 3| 6| 6| 2|
| 5| 2| 6| 5| 3| 9| 8| 6| 0| 8| 1| 5| 8| 5| 7| 0| 5| 9| 0| 7| 8| 3| 2| 7| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinus, Hemangiosarcoma | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + A + + + + + + + +|
|__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
Pelvic, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
__________________________________________|__________________________________________________________________________|
Page 99
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 1| 3| 4| 9| 0| 4| 8| 8| 3| 4| 6| 6| 7| 0| 0| 3| 4| 6| 6| 7| 9| 9| 9| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 2| 2| 4| 4| 5| 5| 5| 7| 6| 3| 2| 2| 3| 3| 5| 6| 2| 3| 4| 7| 3| 6| 6| 2|
| 5| 2| 6| 5| 3| 9| 8| 6| 0| 8| 1| 5| 8| 5| 7| 0| 5| 9| 0| 7| 8| 3| 2| 7| 3|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hemangiosarcoma | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hemangiosarcoma | X X |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Hemangiosarcoma, | |
Metastatic, Mesentery | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + M + + M + + + + + + + + + + M + + + + +|
Hemangioma | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M M + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Intestine | |
Large, Cecum | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + I + + + M + + I + + + + I + + + + M + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 100
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 1| 3| 4| 9| 0| 4| 8| 8| 3| 4| 6| 6| 7| 0| 0| 3| 4| 6| 6| 7| 9| 9| 9| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 2| 2| 4| 4| 5| 5| 5| 7| 6| 3| 2| 2| 3| 3| 5| 6| 2| 3| 4| 7| 3| 6| 6| 2|
| 5| 2| 6| 5| 3| 9| 8| 6| 0| 8| 1| 5| 8| 5| 7| 0| 5| 9| 0| 7| 8| 3| 2| 7| 3|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Hemangiosarcoma | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X X X X X X X X|
Hemangiosarcoma, Multiple | X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X X |
Hemangiosarcoma, Metastatic, | |
Mesentery | X X |
Hemangiosarcoma, Metastatic, Skin | X X |
Hemangiosarcoma, Metastatic, | |
Uncertain Primary Site | |
Hemangiosarcoma, Metastatic, | |
Skeletal Muscle | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 101
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 1| 3| 4| 9| 0| 4| 8| 8| 3| 4| 6| 6| 7| 0| 0| 3| 4| 6| 6| 7| 9| 9| 9| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 2| 2| 4| 4| 5| 5| 5| 7| 6| 3| 2| 2| 3| 3| 5| 6| 2| 3| 4| 7| 3| 6| 6| 2|
| 5| 2| 6| 5| 3| 9| 8| 6| 0| 8| 1| 5| 8| 5| 7| 0| 5| 9| 0| 7| 8| 3| 2| 7| 3|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Pleura | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
|__________________________________________________________________________|
Harderian Gland | + |
Adenoma | |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, | |
Mesentery | |
|__________________________________________________________________________|
Urethra | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 102
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 6| 6| 6| 7| | |
DAY ON TEST | 7| 8| 8| 9| 9| 9| 1| 2| 4| 0| | |
| 2| 8| 8| 0| 2| 6| 9| 4| 5| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 7| 4| 5| 3| 7| 2| 7| 7| 6| 4| | L |
| 3| 6| 2| 9| 2| 1| 9| 4| 6| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Gallbladder | + + A + + A + + + A | 31 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + A + + + A | 46 |
Muscularis, Serosa, Hemangiosarcoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + A + + + A | 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + A + + + + | 36 |
Carcinoma | X X | 9 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + A + + + A | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + A + + + A | 35 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + A + + + A | 35 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 57 |
Hemangiosarcoma | X | 1 |
Hemangiosarcoma, Metastatic, | | |
Skeletal Muscle | | 1 |
Hepatocellular Carcinoma | X X | 4 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | | 1 |
Hepatocellular Adenoma, Multiple | X | 2 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 42 |
Carcinoma, Metastatic, Intestine | | |
Large, Cecum | | 1 |
Hemangiosarcoma | X X X X | 30 |
Hemangiosarcoma, Multiple | X X X X | 8 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 103
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 6| 6| 6| 7| | |
DAY ON TEST | 7| 8| 8| 9| 9| 9| 1| 2| 4| 0| | |
| 2| 8| 8| 0| 2| 6| 9| 4| 5| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 7| 4| 5| 3| 7| 2| 7| 7| 6| 4| | L |
| 3| 6| 2| 9| 2| 1| 9| 4| 6| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Hemangiosarcoma, Metastatic, | | |
Skeletal Muscle | X | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Acinus, Hemangiosarcoma | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + I + + + + | 58 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 53 |
|__________________________________________________________________________|____________|
Tooth | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 56 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + | 57 |
|__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + M I M | 50 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 104
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 6| 6| 6| 7| | |
DAY ON TEST | 7| 8| 8| 9| 9| 9| 1| 2| 4| 0| | |
| 2| 8| 8| 0| 2| 6| 9| 4| 5| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 7| 4| 5| 3| 7| 2| 7| 7| 6| 4| | L |
| 3| 6| 2| 9| 2| 1| 9| 4| 6| 2| | |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Pelvic, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
Hemangiosarcoma | | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Prostate | + + + + I + + + + M | 57 |
Hemangiosarcoma | X | 4 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Lymph Node | | 7 |
Mediastinal, Hemangiosarcoma, | | |
Metastatic, Mesentery | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + | 50 |
Hemangioma | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 56 |
Carcinoma, Metastatic, Intestine | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 105
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 6| 6| 6| 7| | |
DAY ON TEST | 7| 8| 8| 9| 9| 9| 1| 2| 4| 0| | |
| 2| 8| 8| 0| 2| 6| 9| 4| 5| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 7| 4| 5| 3| 7| 2| 7| 7| 6| 4| | L |
| 3| 6| 2| 9| 2| 1| 9| 4| 6| 2| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Large, Cecum | | 3 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
|__________________________________________________________________________|____________|
Thymus | I + + M + + + M + + | 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | X X X X X | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 35 |
Hemangiosarcoma | X X X X X X X | 25 |
Hemangiosarcoma, Multiple | X X X | 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 106
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 6| 6| 6| 7| | |
DAY ON TEST | 7| 8| 8| 9| 9| 9| 1| 2| 4| 0| | |
| 2| 8| 8| 0| 2| 6| 9| 4| 5| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 7| 4| 5| 3| 7| 2| 7| 7| 6| 4| | L |
| 3| 6| 2| 9| 2| 1| 9| 4| 6| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | X | 4 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Hemangiosarcoma, Metastatic, | | |
Mesentery | X | 3 |
Hemangiosarcoma, Metastatic, Skin | X | 3 |
Hemangiosarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Hemangiosarcoma, Metastatic, | | |
Skeletal Muscle | | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Pleura | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
Adenoma | X | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
Hemangiosarcoma, Metastatic, | | |
Mesentery | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 107
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 6| 6| 6| 7| | |
DAY ON TEST | 7| 8| 8| 9| 9| 9| 1| 2| 4| 0| | |
| 2| 8| 8| 0| 2| 6| 9| 4| 5| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 7| 4| 5| 3| 7| 2| 7| 7| 6| 4| | L |
| 3| 6| 2| 9| 2| 1| 9| 4| 6| 2| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Urethra | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Hemangiosarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 108
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 9| 9| 0| 1| 2| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8|
| 7| 5| 7| 2| 2| 6| 9| 5| 0| 4| 8| 5| 8| 8| 8| 8| 1| 2| 4| 5| 5| 5| 6| 0| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1| 2| 1| 2| 1|
5000 PPM | 9| 0| 0| 1| 3| 1| 2| 3| 2| 3| 2| 9| 9| 0| 1| 3| 8| 1| 0| 8| 9| 2| 8| 2| 8|
| 0| 1| 7| 3| 5| 7| 7| 3| 3| 1| 4| 3| 9| 5| 8| 2| 3| 1| 3| 8| 4| 2| 6| 0| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + A + + + + M A A M + + + + M + + A + + + A A M|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A A + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + A A + + + + + A + + A + + + + A +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + A A + + + + A A A + + + + + A + + A + + + A + A|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + A A A + + + + + A + + A + + + A A A|
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + M A A A + + + + + A + + A + + + A + A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X X X X|
Hemangiosarcoma, Multiple | X X X X X X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
|__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 109
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 9| 9| 0| 1| 2| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8|
| 7| 5| 7| 2| 2| 6| 9| 5| 0| 4| 8| 5| 8| 8| 8| 8| 1| 2| 4| 5| 5| 5| 6| 0| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1| 2| 1| 2| 1|
5000 PPM | 9| 0| 0| 1| 3| 1| 2| 3| 2| 3| 2| 9| 9| 0| 1| 3| 8| 1| 0| 8| 9| 2| 8| 2| 8|
| 0| 1| 7| 3| 5| 7| 7| 3| 3| 1| 4| 3| 9| 5| 8| 2| 3| 1| 3| 8| 4| 2| 6| 0| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Hemangiosarcoma | X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + M + + + + + + + + I|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + I + + I + M + + M + + I + + + I + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + I + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + + |
Hemangiosarcoma | X |
Pelvic, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, | |
Mesentery | |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 110
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 9| 9| 0| 1| 2| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8|
| 7| 5| 7| 2| 2| 6| 9| 5| 0| 4| 8| 5| 8| 8| 8| 8| 1| 2| 4| 5| 5| 5| 6| 0| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1| 2| 1| 2| 1|
5000 PPM | 9| 0| 0| 1| 3| 1| 2| 3| 2| 3| 2| 9| 9| 0| 1| 3| 8| 1| 0| 8| 9| 2| 8| 2| 8|
| 0| 1| 7| 3| 5| 7| 7| 3| 3| 1| 4| 3| 9| 5| 8| 2| 3| 1| 3| 8| 4| 2| 6| 0| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | |
Inguinal, Hemangiosarcoma, | |
Metastatic, Skeletal Muscle | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + M + + + M + M + M + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + M + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + I + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | X X X X |
Subcutaneous Tissue, Hemangiosarcoma,| |
Multiple | X X X X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + |
Hemangiosarcoma | X X X X X X X X X X |
Hemangiosarcoma, Multiple | X X X X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 111
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 9| 9| 0| 1| 2| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8|
| 7| 5| 7| 2| 2| 6| 9| 5| 0| 4| 8| 5| 8| 8| 8| 8| 1| 2| 4| 5| 5| 5| 6| 0| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1| 2| 1| 2| 1|
5000 PPM | 9| 0| 0| 1| 3| 1| 2| 3| 2| 3| 2| 9| 9| 0| 1| 3| 8| 1| 0| 8| 9| 2| 8| 2| 8|
| 0| 1| 7| 3| 5| 7| 7| 3| 3| 1| 4| 3| 9| 5| 8| 2| 3| 1| 3| 8| 4| 2| 6| 0| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, | |
Mesentery | X |
Hemangiosarcoma, Metastatic, Skin | X X X|
Hemangiosarcoma, Metastatic, | |
Uncertain Primary Site | |
Hemangiosarcoma, Metastatic, | |
Skeletal Muscle | X X X |
Mediastinum, Hemangiosarcoma | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hemangiosarcoma | X |
|__________________________________________________________________________|
Urethra | + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 112
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 1| 1| 2| 2| 2| 3| 4| 4| 6| 1| 3| 3| 5| 6| 6| 8| 8| 8| 9| 9| 9| 2| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 1| 1| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| 1| 1|
5000 PPM | 0| 2| 3| 9| 9| 1| 0| 8| 0| 8| 1| 8| 1| 3| 0| 2| 8| 2| 2| 9| 1| 3| 3| 8| 9|
| 2| 1| 7| 6| 8| 4| 4| 1| 0| 2| 5| 4| 2| 0| 8| 6| 9| 5| 9| 7| 9| 4| 9| 7| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A + + + + I A A A M + + A + + A + A + + + A A +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + A + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A A + A + + A + + A + A + + + + A +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + A + A A + A + + + + + A + A + + + + A +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + A + + A + A + + A + + A + A + + + A A +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + A + A + + A + + A + + A + A + + + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X X X X X X X X |
Hemangiosarcoma, Multiple | X X X X X X|
|__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + A + + + + + + + + + + +|
Hemangiosarcoma | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
|__________________________________________________________________________|
Stomach, Glandular | + A + + + A + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 113
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 1| 1| 2| 2| 2| 3| 4| 4| 6| 1| 3| 3| 5| 6| 6| 8| 8| 8| 9| 9| 9| 2| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 1| 1| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| 1| 1|
5000 PPM | 0| 2| 3| 9| 9| 1| 0| 8| 0| 8| 1| 8| 1| 3| 0| 2| 8| 2| 2| 9| 1| 3| 3| 8| 9|
| 2| 1| 7| 6| 8| 4| 4| 1| 0| 2| 5| 4| 2| 0| 8| 6| 9| 5| 9| 7| 9| 4| 9| 7| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + I + + M + + + + M + I + + + + + + M I +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
Hemangiosarcoma | |
Pelvic, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, | |
Mesentery | X |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 114
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 1| 1| 2| 2| 2| 3| 4| 4| 6| 1| 3| 3| 5| 6| 6| 8| 8| 8| 9| 9| 9| 2| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 1| 1| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| 1| 1|
5000 PPM | 0| 2| 3| 9| 9| 1| 0| 8| 0| 8| 1| 8| 1| 3| 0| 2| 8| 2| 2| 9| 1| 3| 3| 8| 9|
| 2| 1| 7| 6| 8| 4| 4| 1| 0| 2| 5| 4| 2| 0| 8| 6| 9| 5| 9| 7| 9| 4| 9| 7| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
Inguinal, Hemangiosarcoma, | |
Metastatic, Skeletal Muscle | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M M + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | X X X X X X |
Subcutaneous Tissue, Hemangiosarcoma,| |
Multiple | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X X X X |
Hemangiosarcoma, Multiple | X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 115
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 1| 1| 2| 2| 2| 3| 4| 4| 6| 1| 3| 3| 5| 6| 6| 8| 8| 8| 9| 9| 9| 2| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 1| 1| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| 1| 1|
5000 PPM | 0| 2| 3| 9| 9| 1| 0| 8| 0| 8| 1| 8| 1| 3| 0| 2| 8| 2| 2| 9| 1| 3| 3| 8| 9|
| 2| 1| 7| 6| 8| 4| 4| 1| 0| 2| 5| 4| 2| 0| 8| 6| 9| 5| 9| 7| 9| 4| 9| 7| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, | |
Mesentery | |
Hemangiosarcoma, Metastatic, Skin | X |
Hemangiosarcoma, Metastatic, | |
Uncertain Primary Site | X |
Hemangiosarcoma, Metastatic, | |
Skeletal Muscle | X X X X |
Mediastinum, Hemangiosarcoma | X X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hemangiosarcoma | |
|__________________________________________________________________________|
Urethra | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 116
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 1| 2| 2| 2| 2| 4| 4| 5| 6| | |
| 4| 4| 0| 2| 2| 7| 0| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| | A |
5000 PPM | 1| 2| 9| 0| 4| 3| 0| 9| 1| 3| | L |
| 6| 8| 1| 9| 0| 6| 6| 2| 0| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + M + A + A M | 35 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A | 54 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A | 54 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + A A | 44 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + | 42 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + A | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A A A A | 39 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hepatocellular Carcinoma | | 2 |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 38 |
Hemangiosarcoma | X X X X X X | 24 |
Hemangiosarcoma, Multiple | X X | 14 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Hemangiosarcoma | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Squamous Cell Papilloma | X | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 117
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 1| 2| 2| 2| 2| 4| 4| 5| 6| | |
| 4| 4| 0| 2| 2| 7| 0| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| | A |
5000 PPM | 1| 2| 9| 0| 4| 3| 0| 9| 1| 3| | L |
| 6| 8| 1| 9| 0| 6| 6| 2| 0| 8| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Hemangiosarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 56 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M M + | 46 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 3 |
Hemangiosarcoma | | 1 |
Pelvic, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 118
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 1| 2| 2| 2| 2| 4| 4| 5| 6| | |
| 4| 4| 0| 2| 2| 7| 0| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| | A |
5000 PPM | 1| 2| 9| 0| 4| 3| 0| 9| 1| 3| | L |
| 6| 8| 1| 9| 0| 6| 6| 2| 0| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Hemangiosarcoma, Metastatic, | | |
Mesentery | | 1 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Lymph Node | | 1 |
Inguinal, Hemangiosarcoma, | | |
Metastatic, Skeletal Muscle | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M | 54 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M M | 53 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + M M I | 54 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Hemangiosarcoma | X X | 12 |
Subcutaneous Tissue, Hemangiosarcoma,| | |
Multiple | X | 8 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 119
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 1| 2| 2| 2| 2| 4| 4| 5| 6| | |
| 4| 4| 0| 2| 2| 7| 0| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| | A |
5000 PPM | 1| 2| 9| 0| 4| 3| 0| 9| 1| 3| | L |
| 6| 8| 1| 9| 0| 6| 6| 2| 0| 8| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + | 47 |
Hemangiosarcoma | X X | 19 |
Hemangiosarcoma, Multiple | X X X X X X X | 26 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 12 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemangiosarcoma, Metastatic, | | |
Mesentery | | 1 |
Hemangiosarcoma, Metastatic, Skin | | 4 |
Hemangiosarcoma, Metastatic, | | |
Uncertain Primary Site | X | 2 |
Hemangiosarcoma, Metastatic, | | |
Skeletal Muscle | X | 8 |
Mediastinum, Hemangiosarcoma | X | 4 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 120
NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00
Route: DOSED FEED Time: 10:17:16
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 1| 1| 2| 2| 2| 2| 4| 4| 5| 6| | |
| 4| 4| 0| 2| 2| 7| 0| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| | A |
5000 PPM | 1| 2| 9| 0| 4| 3| 0| 9| 1| 3| | L |
| 6| 8| 1| 9| 0| 6| 6| 2| 0| 8| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Capsule, Hemangiosarcoma | | 1 |
|__________________________________________________________________________|____________|
Urethra | + | 2 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 121
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---------- END OF REPORT ----------
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