TDMS Study 05205-07 Pathology Tables
NTP Experiment-Test: 05205-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 01/04/01 Route: DOSED FEED Time: 07:51:49 Final#2/Rats Facility: Southern Research Institute Chemical CAS #: 99-99-0 Lock Date: 08/24/98 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05205-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 01/04/01 Route: DOSED FEED Time: 07:51:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 1250 2500 5000 PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Natural Death 4 1 1 2 Moribund Sacrifice 7 12 10 7 Survivors Terminal Sacrifice 39 37 39 41 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Cecum (50) (49) (50) (50) Edema 1 (2%) Intestine Small, Ileum (48) (47) (50) (48) Ulcer 1 (2%) Liver (50) (50) (50) (50) Angiectasis 1 (2%) 1 (2%) 2 (4%) Basophilic Focus 44 (88%) 41 (82%) 49 (98%) 46 (92%) Clear Cell Focus 12 (24%) 11 (22%) 18 (36%) 10 (20%) Cyst 1 (2%) Eosinophilic Focus 1 (2%) 2 (4%) 7 (14%) 9 (18%) Fatty Change 1 (2%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) Hepatodiaphragmatic Nodule 3 (6%) 7 (14%) 14 (28%) 12 (24%) Infiltration Cellular, Mixed Cell 41 (82%) 33 (66%) 43 (86%) 49 (98%) Mixed Cell Focus 4 (8%) 3 (6%) 5 (10%) 3 (6%) Necrosis, Focal 1 (2%) 1 (2%) 1 (2%) Regeneration 1 (2%) Bile Duct, Hyperplasia 3 (6%) 1 (2%) Centrilobular, Necrosis 2 (4%) Hepatocyte, Vacuolization Cytoplasmic 2 (4%) 1 (2%) Kupffer Cell, Pigmentation 2 (4%) 3 (6%) Mesentery (5) (1) (3) Fat, Necrosis 5 (100%) 1 (100%) 3 (100%) Pancreas (50) (50) (50) (50) Atrophy 3 (6%) 1 (2%) 8 (16%) 4 (8%) Acinus, Hyperplasia, Focal 1 (2%) 1 (2%) Salivary Glands (50) (50) (50) (50) Atrophy 1 (2%) 2 (4%) Stomach, Forestomach (50) (50) (50) (50) Edema 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05205-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 01/04/01 Route: DOSED FEED Time: 07:51:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 1250 2500 5000 PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Erosion 1 (2%) Ulcer 2 (4%) Epithelium, Hyperplasia 3 (6%) 2 (4%) 1 (2%) Stomach, Glandular (50) (50) (50) (50) Erosion 2 (4%) Tooth (1) Malformation 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) Cardiomyopathy 13 (26%) 10 (20%) 11 (22%) 8 (16%) Inflammation, Chronic 3 (6%) Endocardium, Fibrosis 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Accessory Adrenal Cortical Nodule 10 (20%) 6 (12%) 9 (18%) 5 (10%) Degeneration, Fatty 11 (22%) 19 (38%) 9 (18%) 10 (20%) Hyperplasia, Focal 5 (10%) 8 (16%) 3 (6%) 3 (6%) Hypertrophy 2 (4%) Hypertrophy, Focal 4 (8%) 14 (28%) 7 (14%) 2 (4%) Necrosis 1 (2%) 1 (2%) 1 (2%)