TDMS Study 05205-07 Pathology Tables
NTP Experiment-Test: 05205-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 01/04/01
Route: DOSED FEED Time: 07:51:49
Final#2/Rats
Facility: Southern Research Institute
Chemical CAS #: 99-99-0
Lock Date: 08/24/98
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05205-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 01/04/01
Route: DOSED FEED Time: 07:51:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 4 1 1 2
Moribund Sacrifice 7 12 10 7
Survivors
Terminal Sacrifice 39 37 39 41
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (49) (50) (50)
Edema 1 (2%)
Intestine Small, Ileum (48) (47) (50) (48)
Ulcer 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%) 2 (4%)
Basophilic Focus 44 (88%) 41 (82%) 49 (98%) 46 (92%)
Clear Cell Focus 12 (24%) 11 (22%) 18 (36%) 10 (20%)
Cyst 1 (2%)
Eosinophilic Focus 1 (2%) 2 (4%) 7 (14%) 9 (18%)
Fatty Change 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 3 (6%) 7 (14%) 14 (28%) 12 (24%)
Infiltration Cellular, Mixed Cell 41 (82%) 33 (66%) 43 (86%) 49 (98%)
Mixed Cell Focus 4 (8%) 3 (6%) 5 (10%) 3 (6%)
Necrosis, Focal 1 (2%) 1 (2%) 1 (2%)
Regeneration 1 (2%)
Bile Duct, Hyperplasia 3 (6%) 1 (2%)
Centrilobular, Necrosis 2 (4%)
Hepatocyte, Vacuolization Cytoplasmic 2 (4%) 1 (2%)
Kupffer Cell, Pigmentation 2 (4%) 3 (6%)
Mesentery (5) (1) (3)
Fat, Necrosis 5 (100%) 1 (100%) 3 (100%)
Pancreas (50) (50) (50) (50)
Atrophy 3 (6%) 1 (2%) 8 (16%) 4 (8%)
Acinus, Hyperplasia, Focal 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%) 2 (4%)
Stomach, Forestomach (50) (50) (50) (50)
Edema 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05205-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 01/04/01
Route: DOSED FEED Time: 07:51:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Erosion 1 (2%)
Ulcer 2 (4%)
Epithelium, Hyperplasia 3 (6%) 2 (4%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Erosion 2 (4%)
Tooth (1)
Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 13 (26%) 10 (20%) 11 (22%) 8 (16%)
Inflammation, Chronic 3 (6%)
Endocardium, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 10 (20%) 6 (12%) 9 (18%) 5 (10%)
Degeneration, Fatty 11 (22%) 19 (38%) 9 (18%) 10 (20%)
Hyperplasia, Focal 5 (10%) 8 (16%) 3 (6%) 3 (6%)
Hypertrophy 2 (4%)
Hypertrophy, Focal 4 (8%) 14 (28%) 7 (14%) 2 (4%)
Necrosis 1 (2%) 1 (2%) 1 (2%)