TDMS Study 05205-07 Pathology Tables
NTP Experiment-Test: 05205-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROTOLUENE Date: 01/15/01
Route: DOSED FEED Time: 10:40:52
FINAL#2/RATS
Facility: Southern Research Institute
Chemical CAS #: 99-99-0
Lock Date: 08/24/98
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05205-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROTOLUENE Date: 01/15/01
Route: DOSED FEED Time: 10:40:52
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FISCHER 344 RATS FEMALE 0 1250 2500 5000
PPM PPM PPM PPM
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DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 4 1 1 2
Moribund Sacrifice 7 12 10 7
Survivors
Terminal Sacrifice 39 37 39 41
Animals Examined Microscopically 50 50 50 50
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ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (49) (50)
Intestine Large, Cecum (50) (49) (50) (50)
Liver (50) (50) (50) (50)
Hepatocellular Adenoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Oral Mucosa (1) (1) (1)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%) 1 (100%)
Pancreas (50) (50) (50) (50)
Acinus, Adenoma 1 (2%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Stomach, Glandular (50) (50) (50) (50)
Tongue (3) (1) (1)
Squamous Cell Carcinoma 1 (33%) 1 (100%) 1 (100%)
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CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Endocardium, Schwannoma Malignant 1 (2%)
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ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adrenal Medulla (49) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Benign 2 (4%) 1 (2%) 1 (2%)
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NTP Experiment-Test: 05205-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROTOLUENE Date: 01/15/01
Route: DOSED FEED Time: 10:40:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Adenoma 15 (30%) 23 (46%) 17 (34%) 11 (22%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Pars Intermedia, Carcinoma 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 6 (12%) 2 (4%) 9 (18%) 2 (4%)
C-Cell, Carcinoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (50) (50) (50) (49)
Adenoma 7 (14%) 8 (16%) 13 (26%) 6 (12%)
Adenoma, Multiple 2 (4%)
Carcinoma 2 (4%) 4 (8%) 6 (12%) 1 (2%)
Carcinoma, Multiple 1 (2%)
Ovary (50) (50) (50) (50)
Granulosa Cell Tumor Malignant 1 (2%)
Histiocytic Sarcoma 1 (2%)
Uterus (50) (50) (50) (50)
Carcinoma 1 (2%)
Fibroma 1 (2%)
Hemangioma 1 (2%)
Leiomyoma 1 (2%)
Polyp Stromal 6 (12%) 4 (8%) 10 (20%) 8 (16%)
Polyp Stromal, Multiple 1 (2%)
Schwannoma Malignant 1 (2%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (4) (8) (3) (11)
Lymph Node, Mandibular (50) (50) (48) (50)
Lymph Node, Mesenteric (49) (50) (50) (50)
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NTP Experiment-Test: 05205-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P-NITROTOLUENE Date: 01/15/01
Route: DOSED FEED Time: 10:40:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Spleen (50) (50) (50) (50)
Thymus (48) (48) (45) (50)
Histiocytic Sarcoma 1 (2%)
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INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Carcinoma 1 (2%)
Fibroadenoma 14 (28%) 15 (30%) 17 (34%) 5 (10%)
Fibroadenoma, Multiple 2 (4%) 3 (6%)
Skin (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma NOS 1 (2%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%) 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Glioma Malignant 1 (2%)
Oligodendroglioma Malignant 1 (2%)
Spinal Cord (1) (2)
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