TDMS Study 05205-07 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst P-NITROTOLUENE DATE: 01/04/01
EXPERIMENT: 05205 TEST: 07 TIME: 08:27:02
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62537D
PATHOLOGIST: HEATH, JAMES E. CAS: 99-99-0
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Final#2/Rats
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst P-NITROTOLUENE DATE: 01/04/01
EXPERIMENT: 05205 TEST: 07 TIME: 08:27:02
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62537D
PATHOLOGIST: HEATH, JAMES E. CAS: 99-99-0
Rats(FISCHER 344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED. IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
---------------
Adrenal Cortex
Adrenal Medulla
Brain
Clitoral/Preputial Gland
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Ovary
Pancreas
Pituitary Gland
Prostate
Salivary Glands
Testes
Thymus
Thyroid Gland
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst P-NITROTOLUENE DATE: 01/04/01
EXPERIMENT: 05205 TEST: 07 TIME: 08:27:02
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62537D
PATHOLOGIST: HEATH, JAMES E. CAS: 99-99-0
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF P-NITROTOLUENE
===============================================================
Male Rats
------------
Organ Morphology
----- ----------
Islets, Pancreatic Carcinoma or Adenoma
Skin Fibroma
Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma
Testes Adenoma
Thyroid Gland: C-Cell Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
===============================================================
Female Rats
------------
Organ Morphology
----- ----------
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
===============================================================
Date: 01/04/01 EXPERIMENT: 05205 TEST: 07 Page 1
Statistical Analysis of Primary Tumors in Rats(FISCHER 344) - P-NITROTOLUENE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 1250 2500 5000 |0 1250 2500 5000 |
| | PPM PPM PPM PPM |PPM PPM PPM PPM |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 2/50 (4%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/44.85 0/44.95 1/47.38 2/46.70 |0/45.91 0/46.28 0/47.00 0/48.05 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 2.1% 4.3% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/38 (0%) 1/38 (3%) 1/40 (3%) |0/39 (0%) 0/37 (0%) 0/39 (0%) 0/41 (0%) |
|FIRST INCIDENCE | --- --- 729 (T) 685 |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.088 (e) P=0.541 P=0.279 |(e) (e) (e) (e) |
|POLY 3 | P=0.075 (e) P=0.511 P=0.246 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.073 (e) P=0.507 P=0.242 |(e) (e) (e) (e) |
|POLY 6 | P=0.078 (e) P=0.516 P=0.252 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.073 (e) P=0.541 P=0.240 |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.070 (e) P=0.500 P=0.247 |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 1250 2500 5000 |0 1250 2500 5000 |
| | PPM PPM PPM PPM |PPM PPM PPM PPM |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/49 (6%) 2/50 (4%) 4/50 (8%) |2/49 (4%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 3/45.04 3/43.95 2/47.38 4/46.62 |2/44.91 1/46.28 0/47.00 1/48.05 |
|POLY-3 PERCENT (g) | 6.7% 6.8% 4.2% 8.6% |4.5%