TDMS Study 05205-07 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst P-NITROTOLUENE DATE: 01/04/01
EXPERIMENT: 05205 TEST: 07 TIME: 08:04:48
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62537D
PATHOLOGIST: HEATH, JAMES E. CAS: 99-99-0
------------------------------------------------------------------------------------------------------------------------------------
Final#2/Rats
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst P-NITROTOLUENE DATE: 01/04/01
EXPERIMENT: 05205 TEST: 07 TIME: 08:04:48
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62537D
PATHOLOGIST: HEATH, JAMES E. CAS: 99-99-0
P-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 378 504 591 592 609 627 637 639 639 679 |
| 681 687 695 704 713 722 722 726 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 490 515 516 581 592 592 611 627 631 659 |
| 668 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 523 621 627 659 668 676 679 679 704 724 |
| 724 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 496 497 591 595 617 676 682 685 693 707 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM| 100.0 100.0 100.0 100.0 98.0 98.0 96.0 92.0 82.0 62.0 |
| | |
| | |
|1250 PPM| 100.0 100.0 100.0 100.0 100.0 100.0 94.0 88.0 80.0 76.0 |
| | |
| | |
|2500 PPM| 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 92.0 76.0 |
| | |
| | |
|5000 PPM| 100.0 100.0 100.0 100.0 100.0 100.0 96.0 92.0 90.0 80.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 1250 PPM 2500 PPM 5000 P|M
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.0% 76.0% 76.0% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.096N P=0.269N P=0.174N P=0.096N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 645.8 600.5 667.3 623.9 |
|NATURAL DEATHS (C) | (20.1) (19.9) (16.5) (24.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 697.4 698.2 714.2 708.0 |
|(STANDARD ERROR) | ( 9.5) ( 9.1) ( 5.4) ( 7.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 380 497 504 574 591 655 676 693 695 708 |
| 712 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 387 528 577 629 639 639 659 675 701 702 |
| 724 724 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 387 633 639 655 675 676 676 676 679 687 |
| 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 532 617 639 672 676 690 722 725 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM| 100.0 100.0 100.0 100.0 98.0 98.0 94.0 90.0 88.0 78.0 |
| | |
| | |
|1250 PPM| 100.0 100.0 100.0 100.0 98.0 98.0 96.0 94.0 86.0 74.0 |
| | |
| | |
|2500 PPM| 100.0 100.0 100.0 100.0 98.0 98.0 98.0 98.0 92.0 78.0 |
| | |
| | |
|5000 PPM| 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 94.0 82.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 1250 PPM 2500 PPM 5000 P|M
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.0% 74.0% 78.0% 82.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.507N P=0.851 P=1.000N P=0.725N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 607.7 639.4 645.8 666.8 |
|NATURAL DEATHS (C) | (32.9) (26.8) (26.9) (21.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 702.3 705.7 710.7 717.8 |
|(STANDARD ERROR) | (10.0) ( 8.8) ( 7.5) ( 5.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P-NITROTOLUENE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
1250 PPM = 2
2500 PPM = 3
5000 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 24 3
|
| 1 2 1 2 3 3
| 41 1 33
95 +
| 2 2 3 3
| 2 1 1 4 33
|
P 90 + 1 41 33
E |
R | 2 2 11 44
C | 2 211
E 85 +
N | 22 344 3
T | 21 2 1 4 3 3
|
S 80 + 2211 4 4
U |
R | 2 11 2
V | 11 2 2
I 75 +
V | 11
A | 11
L |
70 + 1 1
|
|
|
65 +
|
| 1 1
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 10 obs hidden.
P-NITROTOLUENE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
1250 PPM = 2
2500 PPM = 3
5000 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 12 4
|
| 12 1 2 4 3
| 11 2 2 4 33
P 95 +
E | 1 12 2 3 3 4
R | 1 1 2 2 3 43
C |
E 90 + 1 1 4 4
N |
T | 2 1 2 1 4 4
| 2 1 1
S 85 +
U | 2 112
R | 3 31 1 4 4
V |
I 80 + 3 2 32
V |
A | 13 1
L |
75 +
| 2 2
|
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.