TDMS Study 05205-08 Pathology Tables
NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00 Route: DOSED FEED Time: 09:18:07 FINAL#1 CHRONIC STUDY FOR MICE Facility: Southern Research Institute Chemical CAS #: 99-99-0 Lock Date: 08/24/98 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00 Route: DOSED FEED Time: 09:18:07 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 1250 2500 5000 PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 2 1 5 1 Natural Death 2 2 2 Survivors Terminal Sacrifice 46 47 41 49 Natural Death 2 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (49) (48) (48) (49) Inflammation, Chronic 1 (2%) Intestine Small, Duodenum (49) (49) (49) (50) Inflammation, Chronic, Focal 1 (2%) Epithelium, Cyst 1 (2%) Intestine Small, Jejunum (49) (48) (48) (50) Inflammation, Focal 1 (2%) Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) Serosa, Cyst 1 (2%) Intestine Small, Ileum (49) (48) (48) (50) Peyer's Patch, Hyperplasia, Lymphoid 2 (4%) Liver (49) (50) (50) (50) Angiectasis 1 (2%) Atrophy, Focal 1 (2%) Basophilic Focus 2 (4%) 3 (6%) Congestion, Focal 1 (2%) Eosinophilic Focus 3 (6%) Hemorrhage, Focal 1 (2%) Hyperplasia, Focal, Lymphoid 1 (2%) 1 (2%) 1 (2%) Infarct 1 (2%) Infiltration Cellular, Mixed Cell 40 (82%) 41 (82%) 39 (78%) 39 (78%) Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%) Mixed Cell Focus 1 (2%) Tension Lipidosis 1 (2%) Artery, Inflammation, Chronic 1 (2%) Bile Duct, Cyst 1 (2%) Centrilobular, Necrosis 1 (2%) Hepatocyte, Fatty Change, Diffuse 1 (2%) Hepatocyte, Necrosis, Focal 2 (4%) 1 (2%) Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (2%) Hepatocyte, Periportal, Vacuolization Cytoplasmic 3 (6%) Portal, Inflammation, Chronic 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00 Route: DOSED FEED Time: 09:18:07 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 1250 2500 5000 PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Serosa, Inflammation, Chronic 1 (2%) Mesentery (3) (3) (4) (7) Inflammation, Chronic 2 (67%) 1 (25%) 1 (14%) Artery, Inflammation, Chronic 1 (33%) 1 (14%) Fat, Necrosis 1 (33%) 1 (33%) 1 (25%) 1 (14%) Pancreas (49) (50) (49) (50) Acinus, Atrophy, Diffuse 2 (4%) Acinus, Atrophy, Focal 1 (2%) 1 (2%) Duct, Cyst 3 (6%) 1 (2%) Stomach, Forestomach (49) (50) (50) (50) Diverticulum 5 (10%) 1 (2%) Epithelium, Hyperplasia 2 (4%) Stomach, Glandular (49) (50) (49) (50) Erosion 1 (2%) Tooth (3) (6) (7) (6) Malformation 1 (14%) Peridontal Tissue, Inflammation, Chronic 3 (100%) 6 (100%) 6 (86%) 6 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) Inflammation, Chronic 1 (100%) Heart (50) (50) (50) (50) Infiltration Cellular, Mixed Cell 4 (8%) 2 (4%) 1 (2%) 6 (12%) Inflammation, Chronic, Focal 1 (2%) Artery, Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%) Epicardium, Infiltration Cellular, Mixed Cell 2 (4%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Accessory Adrenal Cortical Nodule 1 (2%) Cyst 1 (2%) 1 (2%) Cytoplasmic Alteration, Focal 1 (2%) Hemorrhage 1 (2%) Adrenal Medulla (50) (50) (50) (50) Hyperplasia 1 (2%) Parathyroid Gland (49) (48) (44) (48) Cyst 1 (2%) Pituitary Gland (45) (49) (49) (45) Angiectasis 1 (2%) Pars Distalis, Angiectasis 1 (2%) Pars Distalis, Cyst 1 (2%) Pars Distalis, Cytoplasmic Alteration, Focal 4 (9%) 2 (4%) 3 (6%) Pars Distalis, Hyperplasia, Focal 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00 Route: DOSED FEED Time: 09:18:07 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 1250 2500 5000 PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Thyroid Gland (50) (50) (49) (50) Degeneration, Cystic, Focal 18 (36%) 27 (54%) 29 (59%) 22 (44%) Follicle, Cyst 1 (2%) 1 (2%) 1 (2%) Follicular Cell, Hyperplasia 1 (2%) 3 (6%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (2) Abdominal, Inflammation, Chronic 1 (50%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (50) (45) (49) (48) Degeneration, Cystic 1 (2%) 2 (4%) Inflammation, Chronic 1 (2%) Pigmentation 1 (2%) 4 (9%) 3 (6%) 2 (4%) Ovary (48) (50) (50) (49) Angiectasis 1 (2%) 2 (4%) Cyst 11 (23%) 13 (26%) 13 (26%) 13 (27%) Cyst, Multiple 1 (2%) Hemorrhage 1 (2%) 2 (4%) 5 (10%) Mineralization 1 (2%) Bilateral, Cyst 1 (2%) Periovarian Tissue, Cyst 1 (2%) Uterus (50) (50) (50) (50) Angiectasis 1 (2%) Cyst 1 (2%) 4 (8%) 3 (6%) Hemorrhage 2 (4%) 1 (2%) Hydrometra 19 (38%) 21 (42%) 23 (46%) 25 (50%) Inflammation, Suppurative 1 (2%) Thrombosis 1 (2%) Endometrium, Hyperplasia, Cystic 47 (94%) 45 (90%) 44 (88%) 49 (98%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Hyperplasia 1 (2%) 1 (2%) Hyperplasia, Focal, Histiocytic 1 (2%) Lymph Node (2) (5) (13) (4) Bronchial, Hyperplasia 1 (20%) 2 (15%) Bronchial, Hyperplasia, Lymphoid 3 (23%) 1 (25%) Iliac, Hyperplasia, Lymphoid 1 (50%) Inguinal, Hyperplasia, Histiocytic 1 (8%) Inguinal, Hyperplasia, Lymphoid 1 (8%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00 Route: DOSED FEED Time: 09:18:07 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 1250 2500 5000 PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Inguinal, Pigmentation 1 (25%) Mediastinal, Hyperplasia, Lymphoid 1 (25%) Pancreatic, Hyperplasia, Lymphoid 1 (20%) Renal, Hyperplasia, Lymphoid 1 (50%) 1 (20%) Lymph Node, Mandibular (50) (48) (48) (47) Hyperplasia 1 (2%) Hyperplasia, Lymphoid 1 (2%) 2 (4%) Lymph Node, Mesenteric (48) (49) (49) (50) Hyperplasia 1 (2%) 2 (4%) Hyperplasia, Histiocytic 1 (2%) 1 (2%) Hyperplasia, Lymphoid 2 (4%) 5 (10%) Spleen (49) (50) (49) (50) Congestion 1 (2%) Hematopoietic Cell Proliferation 2 (4%) 7 (14%) 11 (22%) 4 (8%) Hyperplasia, Lymphoid 5 (10%) 9 (18%) 4 (8%) 2 (4%) Thymus (48) (49) (47) (46) Angiectasis 1 (2%) 2 (4%) Cyst 1 (2%) 1 (2%) 2 (4%) Hyperplasia, Lymphoid 2 (4%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) (50) Ectasia 2 (4%) Hyperplasia 1 (2%) Skin (50) (50) (50) (50) Subcutaneous Tissue, Angiectasis, Focal 1 (2%) Subcutaneous Tissue, Cyst Epithelial Inclusion 1 (2%) Subcutaneous Tissue, Degeneration, Mucoid 1 (2%) 1 (2%) Subcutaneous Tissue, Edema 1 (2%) Subcutaneous Tissue, Inflammation, Chronic, Focal 2 (4%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Callus 1 (2%) Skeletal Muscle (1) (3) (1) Artery, Inflammation, Chronic 1 (100%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00 Route: DOSED FEED Time: 09:18:07 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 1250 2500 5000 PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Atrophy, Focal 1 (2%) Meninges, Hyperplasia, Lymphoid 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Congestion 1 (2%) Hemorrhage 1 (2%) 5 (10%) 2 (4%) 5 (10%) Hyperplasia, Histiocytic 2 (4%) Hyperplasia, Lymphoid 1 (2%) Infiltration Cellular, Mixed Cell 1 (2%) Thrombosis, Chronic 1 (2%) Alveolar Epithelium, Bronchiolization 33 (66%) 41 (82%) 49 (98%) Alveolar Epithelium, Hyperplasia 2 (4%) 1 (2%) 2 (4%) 1 (2%) Nose (50) (50) (50) (50) Hemorrhage 1 (2%) Inflammation, Suppurative 1 (2%) 1 (2%) Nasolacrimal Duct, Inflammation 1 (2%) Squamous Epithelium, Nasolacrimal Duct, Hyperplasia, Focal 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (50) (50) (50) Congestion 1 (2%) Hyperplasia, Lymphoid 1 (2%) 2 (4%) Infiltration Cellular, Mixed Cell 1 (2%) Metaplasia, Focal, Osseous 1 (2%) 1 (2%) 1 (2%) Nephropathy 11 (22%) 7 (14%) 9 (18%) 3 (6%) Renal Tubule, Accumulation, Hyaline Droplet 1 (2%) 4 (8%) Renal Tubule, Casts Protein 1 (2%) Renal Tubule, Pigmentation 1 (2%) Urinary Bladder (49) (50) (50) (50) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00 Route: DOSED FEED Time: 09:18:07 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 1250 2500 5000 PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Hyperplasia, Lymphoid 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00 Route: DOSED FEED Time: 09:18:07 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 1250 2500 5000 PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 2 2 3 6 Natural Death 2 2 2 2 Survivors Terminal Sacrifice 46 46 45 42 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (49) (48) (48) (47) Inflammation, Chronic 1 (2%) Epithelium, Hyperplasia 1 (2%) Intestine Small, Duodenum (48) (49) (49) (49) Ectasia 1 (2%) Inflammation, Chronic, Focal 1 (2%) Necrosis, Focal 1 (2%) Epithelium, Hyperplasia, Focal 1 (2%) Intestine Small, Jejunum (48) (49) (48) (49) Epithelium, Hyperplasia, Focal 1 (2%) Peyer's Patch, Hyperplasia, Lymphoid 2 (4%) Peyer's Patch, Inflammation, Chronic, Suppurative 1 (2%) Intestine Small, Ileum (48) (49) (48) (49) Epithelium, Cyst 1 (2%) Peyer's Patch, Hyperplasia, Lymphoid 3 (6%) Liver (50) (50) (50) (50) Basophilic Focus 4 (8%) 5 (10%) 1 (2%) Basophilic Focus, Multiple 1 (2%) 1 (2%) Clear Cell Focus 4 (8%) 5 (10%) 6 (12%) 9 (18%) Clear Cell Focus, Multiple 1 (2%) 1 (2%) Cyst 1 (2%) 1 (2%) Eosinophilic Focus 3 (6%) 3 (6%) 2 (4%) 6 (12%) Infiltration Cellular, Mixed Cell 30 (60%) 30 (60%) 26 (52%) 33 (66%) Inflammation, Chronic 1 (2%) Mixed Cell Focus 1 (2%) 1 (2%) 2 (4%) 3 (6%) Pigmentation, Focal 1 (2%) Thrombosis 1 (2%) Bile Duct, Hyperplasia 1 (2%) 1 (2%) Centrilobular, Necrosis 1 (2%) Hepatocyte, Fatty Change, Diffuse 1 (2%) Hepatocyte, Necrosis, Focal 4 (8%) 3 (6%) 4 (8%) 3 (6%) Hepatocyte, Syncytial Alteration, Focal 2 (4%) 13 (26%) 17 (34%) 33 (66%) Hepatocyte, Vacuolization Cytoplasmic, a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00 Route: DOSED FEED Time: 09:18:07 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 1250 2500 5000 PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Diffuse 1 (2%) Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (2%) 1 (2%) Hepatocyte, Centrilobular, Fatty Change 1 (2%) Serosa, Inflammation, Chronic 1 (2%) Mesentery (6) (7) (8) (5) Hemorrhage 1 (13%) Inflammation, Chronic 1 (17%) 1 (14%) 1 (13%) 2 (40%) Fat, Necrosis 4 (67%) 4 (57%) 4 (50%) 2 (40%) Oral Mucosa (1) Inflammation, Chronic 1 (100%) Pancreas (50) (50) (50) (50) Angiectasis 1 (2%) Inflammation, Chronic 1 (2%) Lipomatosis 1 (2%) Acinus, Atrophy, Diffuse 1 (2%) Acinus, Cytoplasmic Alteration 1 (2%) Duct, Cyst 1 (2%) 1 (2%) Stomach, Forestomach (50) (50) (50) (50) Diverticulum 1 (2%) Edema 1 (2%) Inflammation, Focal 1 (2%) 1 (2%) Ulcer 1 (2%) 1 (2%) Epithelium, Cyst 1 (2%) Epithelium, Hyperplasia 3 (6%) 5 (10%) 2 (4%) Stomach, Glandular (49) (49) (50) (50) Foreign Body 1 (2%) Inflammation, Focal 1 (2%) Pigmentation, Focal 1 (2%) Epithelium, Cytoplasmic Alteration, Focal 1 (2%) Glands, Degeneration, Cystic, Focal 1 (2%) 1 (2%) Tooth (6) (13) (8) (8) Malformation 1 (17%) 1 (8%) 2 (25%) Peridontal Tissue, Inflammation, Chronic 5 (83%) 13 (100%) 8 (100%) 6 (75%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) Infiltration Cellular, Mixed Cell 2 (4%) 1 (2%) 3 (6%) 3 (6%) Inflammation, Chronic, Focal 2 (4%) 1 (2%) Mineralization 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00 Route: DOSED FEED Time: 09:18:07 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 1250 2500 5000 PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (49) (50) (49) (50) Accessory Adrenal Cortical Nodule 2 (4%) Cyst 1 (2%) 1 (2%) Cytoplasmic Alteration, Focal 1 (2%) 5 (10%) 9 (18%) 2 (4%) Hypertrophy 1 (2%) Hypertrophy, Focal 4 (8%) 4 (8%) Infiltration Cellular, Mixed Cell 1 (2%) Capsule, Hyperplasia, Focal 1 (2%) 6 (12%) 1 (2%) 1 (2%) Adrenal Medulla (49) (50) (49) (49) Hyperplasia 1 (2%) 1 (2%) Parathyroid Gland (48) (45) (44) (50) Cyst 3 (6%) Pituitary Gland (46) (49) (49) (45) Pars Distalis, Cyst 2 (4%) 1 (2%) 1 (2%) Pars Distalis, Hyperplasia, Focal 1 (2%) Pars Intermedia, Hyperplasia, Focal 1 (2%) Thyroid Gland (50) (50) (49) (49) Degeneration, Cystic, Focal 10 (20%) 9 (18%) 13 (27%) 15 (31%) Follicle, Cyst 1 (2%) Follicular Cell, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (49) (50) Inflammation, Chronic 1 (2%) 1 (2%) Preputial Gland (50) (50) (50) (50) Degeneration, Cystic 29 (58%) 29 (58%) 32 (64%) 28 (56%) Inflammation, Chronic 3 (6%) 2 (4%) 1 (2%) Bilateral, Degeneration, Cystic 2 (4%) Seminal Vesicle (50) (50) (50) (50) Dilatation 1 (2%) 1 (2%) Inflammation, Chronic 1 (2%) Testes (50) (50) (50) (50) Cyst 1 (2%) Germinal Epithelium, Degeneration 3 (6%) 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00 Route: DOSED FEED Time: 09:18:07 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 1250 2500 5000 PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Angiectasis 1 (2%) Hyperplasia 1 (2%) 1 (2%) Hyperplasia, Focal, Histiocytic 1 (2%) Inflammation, Chronic, Focal 1 (2%) Necrosis, Focal 1 (2%) Lymph Node (5) (5) (3) (5) Bronchial, Hyperplasia 1 (20%) Bronchial, Hyperplasia, Lymphoid 1 (20%) 1 (33%) Inguinal, Hyperplasia, Lymphoid 1 (20%) Mediastinal, Hyperplasia 1 (20%) Mediastinal, Hyperplasia, Lymphoid 1 (20%) 1 (20%) Mediastinal, Infiltration Cellular, Lipocyte 1 (20%) Mediastinal, Pigmentation 1 (20%) Pancreatic, Amyloid Deposition 1 (20%) Pancreatic, Hyperplasia 1 (20%) Renal, Hyperplasia 1 (20%) Lymph Node, Mandibular (48) (50) (45) (48) Hyperplasia 1 (2%) Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%) Lymph Node, Mesenteric (50) (49) (49) (49) Hemorrhage 1 (2%) Hyperplasia 1 (2%) 1 (2%) Hyperplasia, Lymphoid 1 (2%) Inflammation, Chronic, Suppurative 1 (2%) Spleen (50) (50) (50) (50) Angiectasis 1 (2%) Congestion 1 (2%) 1 (2%) Depletion Cellular 1 (2%) 1 (2%) Fibrosis, Focal 2 (4%) Hematopoietic Cell Proliferation 9 (18%) 15 (30%) 10 (20%) 11 (22%) Hyperplasia, Lymphoid 3 (6%) 2 (4%) 1 (2%) 1 (2%) Inflammation, Focal 1 (2%) Thymus (47) (40) (44) (45) Atrophy 1 (2%) Cyst 3 (6%) 3 (8%) 1 (2%) Hyperplasia, Lymphoid 1 (2%) 1 (2%) Epithelial Cell, Hyperplasia 1 (2%) 1 (3%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (50) (50) (50) Subcutaneous Tissue, Edema 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00 Route: DOSED FEED Time: 09:18:07 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 1250 2500 5000 PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Cranium, Hyperostosis 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Atrophy, Focal 1 (2%) Hemorrhage, Focal 1 (2%) Peripheral Nerve (1) Sciatic, Degeneration 1 (100%) Spinal Cord (2) (1) Meninges, Inflammation, Focal 1 (50%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Congestion 1 (2%) 2 (4%) Embolus 1 (2%) Hemorrhage 7 (14%) 4 (8%) 1 (2%) Hyperplasia, Histiocytic 1 (2%) 1 (2%) 1 (2%) Hyperplasia, Lymphoid 1 (2%) Infiltration Cellular, Mixed Cell 2 (4%) Thrombosis 1 (2%) Alveolar Epithelium, Bronchiolization 20 (40%) 30 (60%) 48 (96%) Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 4 (8%) 6 (12%) Bronchiole, Hyperplasia 1 (2%) Mediastinum, Inflammation, Chronic 1 (2%) Nose (50) (50) (50) (50) Foreign Body 1 (2%) Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%) Nasolacrimal Duct, Cyst 1 (2%) Nasolacrimal Duct, Inflammation 1 (2%) Sinus, Foreign Body 1 (2%) 2 (4%) 2 (4%) 2 (4%) Sinus, Inflammation, Chronic, Suppurative 1 (2%) 3 (6%) 3 (6%) 2 (4%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (1) Cataract 1 (100%) Cornea, Inflammation, Chronic 1 (100%) Cornea, Necrosis, Focal 1 (100%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00 Route: DOSED FEED Time: 09:18:07 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 1250 2500 5000 PPM PPM PPM PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (49) (50) (50) Atrophy, Focal 1 (2%) Congestion 2 (4%) 2 (4%) 2 (4%) Cyst 2 (4%) 1 (2%) Cyst, Multiple 1 (2%) Inflammation, Chronic 1 (2%) Nephropathy 46 (92%) 49 (100%) 47 (94%) 43 (86%) Nephropathy, Focal 1 (2%) 1 (2%) Glomerulus, Thrombosis 1 (2%) Pelvis, Dilatation 1 (2%) Renal Tubule, Accumulation, Hyaline Droplet 1 (2%) Renal Tubule, Hyperplasia, Focal 1 (2%) 1 (2%) 2 (4%) Renal Tubule, Pigmentation 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion ------------------------------------------------------------ ---------- END OF REPORT ---------- 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