TDMS Study 05205-08 Pathology Tables
NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00
Route: DOSED FEED Time: 09:18:07
FINAL#1 CHRONIC STUDY FOR MICE
Facility: Southern Research Institute
Chemical CAS #: 99-99-0
Lock Date: 08/24/98
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00
Route: DOSED FEED Time: 09:18:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 2 1 5 1
Natural Death 2 2 2
Survivors
Terminal Sacrifice 46 47 41 49
Natural Death 2
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (49) (48) (48) (49)
Inflammation, Chronic 1 (2%)
Intestine Small, Duodenum (49) (49) (49) (50)
Inflammation, Chronic, Focal 1 (2%)
Epithelium, Cyst 1 (2%)
Intestine Small, Jejunum (49) (48) (48) (50)
Inflammation, Focal 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Serosa, Cyst 1 (2%)
Intestine Small, Ileum (49) (48) (48) (50)
Peyer's Patch, Hyperplasia, Lymphoid 2 (4%)
Liver (49) (50) (50) (50)
Angiectasis 1 (2%)
Atrophy, Focal 1 (2%)
Basophilic Focus 2 (4%) 3 (6%)
Congestion, Focal 1 (2%)
Eosinophilic Focus 3 (6%)
Hemorrhage, Focal 1 (2%)
Hyperplasia, Focal, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Mixed Cell 40 (82%) 41 (82%) 39 (78%) 39 (78%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Mixed Cell Focus 1 (2%)
Tension Lipidosis 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Bile Duct, Cyst 1 (2%)
Centrilobular, Necrosis 1 (2%)
Hepatocyte, Fatty Change, Diffuse 1 (2%)
Hepatocyte, Necrosis, Focal 2 (4%) 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (2%)
Hepatocyte, Periportal, Vacuolization
Cytoplasmic 3 (6%)
Portal, Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00
Route: DOSED FEED Time: 09:18:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Serosa, Inflammation, Chronic 1 (2%)
Mesentery (3) (3) (4) (7)
Inflammation, Chronic 2 (67%) 1 (25%) 1 (14%)
Artery, Inflammation, Chronic 1 (33%) 1 (14%)
Fat, Necrosis 1 (33%) 1 (33%) 1 (25%) 1 (14%)
Pancreas (49) (50) (49) (50)
Acinus, Atrophy, Diffuse 2 (4%)
Acinus, Atrophy, Focal 1 (2%) 1 (2%)
Duct, Cyst 3 (6%) 1 (2%)
Stomach, Forestomach (49) (50) (50) (50)
Diverticulum 5 (10%) 1 (2%)
Epithelium, Hyperplasia 2 (4%)
Stomach, Glandular (49) (50) (49) (50)
Erosion 1 (2%)
Tooth (3) (6) (7) (6)
Malformation 1 (14%)
Peridontal Tissue, Inflammation, Chronic 3 (100%) 6 (100%) 6 (86%) 6 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Inflammation, Chronic 1 (100%)
Heart (50) (50) (50) (50)
Infiltration Cellular, Mixed Cell 4 (8%) 2 (4%) 1 (2%) 6 (12%)
Inflammation, Chronic, Focal 1 (2%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Epicardium, Infiltration Cellular, Mixed Cell 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Cyst 1 (2%) 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%)
Hemorrhage 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (49) (48) (44) (48)
Cyst 1 (2%)
Pituitary Gland (45) (49) (49) (45)
Angiectasis 1 (2%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Cytoplasmic Alteration, Focal 4 (9%) 2 (4%) 3 (6%)
Pars Distalis, Hyperplasia, Focal 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00
Route: DOSED FEED Time: 09:18:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thyroid Gland (50) (50) (49) (50)
Degeneration, Cystic, Focal 18 (36%) 27 (54%) 29 (59%) 22 (44%)
Follicle, Cyst 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 1 (2%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2)
Abdominal, Inflammation, Chronic 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (45) (49) (48)
Degeneration, Cystic 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Pigmentation 1 (2%) 4 (9%) 3 (6%) 2 (4%)
Ovary (48) (50) (50) (49)
Angiectasis 1 (2%) 2 (4%)
Cyst 11 (23%) 13 (26%) 13 (26%) 13 (27%)
Cyst, Multiple 1 (2%)
Hemorrhage 1 (2%) 2 (4%) 5 (10%)
Mineralization 1 (2%)
Bilateral, Cyst 1 (2%)
Periovarian Tissue, Cyst 1 (2%)
Uterus (50) (50) (50) (50)
Angiectasis 1 (2%)
Cyst 1 (2%) 4 (8%) 3 (6%)
Hemorrhage 2 (4%) 1 (2%)
Hydrometra 19 (38%) 21 (42%) 23 (46%) 25 (50%)
Inflammation, Suppurative 1 (2%)
Thrombosis 1 (2%)
Endometrium, Hyperplasia, Cystic 47 (94%) 45 (90%) 44 (88%) 49 (98%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%)
Hyperplasia, Focal, Histiocytic 1 (2%)
Lymph Node (2) (5) (13) (4)
Bronchial, Hyperplasia 1 (20%) 2 (15%)
Bronchial, Hyperplasia, Lymphoid 3 (23%) 1 (25%)
Iliac, Hyperplasia, Lymphoid 1 (50%)
Inguinal, Hyperplasia, Histiocytic 1 (8%)
Inguinal, Hyperplasia, Lymphoid 1 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00
Route: DOSED FEED Time: 09:18:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Inguinal, Pigmentation 1 (25%)
Mediastinal, Hyperplasia, Lymphoid 1 (25%)
Pancreatic, Hyperplasia, Lymphoid 1 (20%)
Renal, Hyperplasia, Lymphoid 1 (50%) 1 (20%)
Lymph Node, Mandibular (50) (48) (48) (47)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Lymph Node, Mesenteric (48) (49) (49) (50)
Hyperplasia 1 (2%) 2 (4%)
Hyperplasia, Histiocytic 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 5 (10%)
Spleen (49) (50) (49) (50)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 7 (14%) 11 (22%) 4 (8%)
Hyperplasia, Lymphoid 5 (10%) 9 (18%) 4 (8%) 2 (4%)
Thymus (48) (49) (47) (46)
Angiectasis 1 (2%) 2 (4%)
Cyst 1 (2%) 1 (2%) 2 (4%)
Hyperplasia, Lymphoid 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Ectasia 2 (4%)
Hyperplasia 1 (2%)
Skin (50) (50) (50) (50)
Subcutaneous Tissue, Angiectasis, Focal 1 (2%)
Subcutaneous Tissue, Cyst Epithelial
Inclusion 1 (2%)
Subcutaneous Tissue, Degeneration, Mucoid 1 (2%) 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic,
Focal 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Callus 1 (2%)
Skeletal Muscle (1) (3) (1)
Artery, Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00
Route: DOSED FEED Time: 09:18:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Atrophy, Focal 1 (2%)
Meninges, Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 1 (2%)
Hemorrhage 1 (2%) 5 (10%) 2 (4%) 5 (10%)
Hyperplasia, Histiocytic 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Thrombosis, Chronic 1 (2%)
Alveolar Epithelium, Bronchiolization 33 (66%) 41 (82%) 49 (98%)
Alveolar Epithelium, Hyperplasia 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Nose (50) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation 1 (2%)
Squamous Epithelium, Nasolacrimal Duct,
Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Congestion 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Infiltration Cellular, Mixed Cell 1 (2%)
Metaplasia, Focal, Osseous 1 (2%) 1 (2%) 1 (2%)
Nephropathy 11 (22%) 7 (14%) 9 (18%) 3 (6%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (2%) 4 (8%)
Renal Tubule, Casts Protein 1 (2%)
Renal Tubule, Pigmentation 1 (2%)
Urinary Bladder (49) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00
Route: DOSED FEED Time: 09:18:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Hyperplasia, Lymphoid 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00
Route: DOSED FEED Time: 09:18:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 2 2 3 6
Natural Death 2 2 2 2
Survivors
Terminal Sacrifice 46 46 45 42
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (49) (48) (48) (47)
Inflammation, Chronic 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Duodenum (48) (49) (49) (49)
Ectasia 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Necrosis, Focal 1 (2%)
Epithelium, Hyperplasia, Focal 1 (2%)
Intestine Small, Jejunum (48) (49) (48) (49)
Epithelium, Hyperplasia, Focal 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 2 (4%)
Peyer's Patch, Inflammation, Chronic,
Suppurative 1 (2%)
Intestine Small, Ileum (48) (49) (48) (49)
Epithelium, Cyst 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 3 (6%)
Liver (50) (50) (50) (50)
Basophilic Focus 4 (8%) 5 (10%) 1 (2%)
Basophilic Focus, Multiple 1 (2%) 1 (2%)
Clear Cell Focus 4 (8%) 5 (10%) 6 (12%) 9 (18%)
Clear Cell Focus, Multiple 1 (2%) 1 (2%)
Cyst 1 (2%) 1 (2%)
Eosinophilic Focus 3 (6%) 3 (6%) 2 (4%) 6 (12%)
Infiltration Cellular, Mixed Cell 30 (60%) 30 (60%) 26 (52%) 33 (66%)
Inflammation, Chronic 1 (2%)
Mixed Cell Focus 1 (2%) 1 (2%) 2 (4%) 3 (6%)
Pigmentation, Focal 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 1 (2%) 1 (2%)
Centrilobular, Necrosis 1 (2%)
Hepatocyte, Fatty Change, Diffuse 1 (2%)
Hepatocyte, Necrosis, Focal 4 (8%) 3 (6%) 4 (8%) 3 (6%)
Hepatocyte, Syncytial Alteration, Focal 2 (4%) 13 (26%) 17 (34%) 33 (66%)
Hepatocyte, Vacuolization Cytoplasmic,
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00
Route: DOSED FEED Time: 09:18:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Diffuse 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (2%) 1 (2%)
Hepatocyte, Centrilobular, Fatty Change 1 (2%)
Serosa, Inflammation, Chronic 1 (2%)
Mesentery (6) (7) (8) (5)
Hemorrhage 1 (13%)
Inflammation, Chronic 1 (17%) 1 (14%) 1 (13%) 2 (40%)
Fat, Necrosis 4 (67%) 4 (57%) 4 (50%) 2 (40%)
Oral Mucosa (1)
Inflammation, Chronic 1 (100%)
Pancreas (50) (50) (50) (50)
Angiectasis 1 (2%)
Inflammation, Chronic 1 (2%)
Lipomatosis 1 (2%)
Acinus, Atrophy, Diffuse 1 (2%)
Acinus, Cytoplasmic Alteration 1 (2%)
Duct, Cyst 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Diverticulum 1 (2%)
Edema 1 (2%)
Inflammation, Focal 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%)
Epithelium, Cyst 1 (2%)
Epithelium, Hyperplasia 3 (6%) 5 (10%) 2 (4%)
Stomach, Glandular (49) (49) (50) (50)
Foreign Body 1 (2%)
Inflammation, Focal 1 (2%)
Pigmentation, Focal 1 (2%)
Epithelium, Cytoplasmic Alteration, Focal 1 (2%)
Glands, Degeneration, Cystic, Focal 1 (2%) 1 (2%)
Tooth (6) (13) (8) (8)
Malformation 1 (17%) 1 (8%) 2 (25%)
Peridontal Tissue, Inflammation, Chronic 5 (83%) 13 (100%) 8 (100%) 6 (75%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Infiltration Cellular, Mixed Cell 2 (4%) 1 (2%) 3 (6%) 3 (6%)
Inflammation, Chronic, Focal 2 (4%) 1 (2%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00
Route: DOSED FEED Time: 09:18:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (49) (50)
Accessory Adrenal Cortical Nodule 2 (4%)
Cyst 1 (2%) 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%) 5 (10%) 9 (18%) 2 (4%)
Hypertrophy 1 (2%)
Hypertrophy, Focal 4 (8%) 4 (8%)
Infiltration Cellular, Mixed Cell 1 (2%)
Capsule, Hyperplasia, Focal 1 (2%) 6 (12%) 1 (2%) 1 (2%)
Adrenal Medulla (49) (50) (49) (49)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (48) (45) (44) (50)
Cyst 3 (6%)
Pituitary Gland (46) (49) (49) (45)
Pars Distalis, Cyst 2 (4%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 1 (2%)
Pars Intermedia, Hyperplasia, Focal 1 (2%)
Thyroid Gland (50) (50) (49) (49)
Degeneration, Cystic, Focal 10 (20%) 9 (18%) 13 (27%) 15 (31%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (49) (50)
Inflammation, Chronic 1 (2%) 1 (2%)
Preputial Gland (50) (50) (50) (50)
Degeneration, Cystic 29 (58%) 29 (58%) 32 (64%) 28 (56%)
Inflammation, Chronic 3 (6%) 2 (4%) 1 (2%)
Bilateral, Degeneration, Cystic 2 (4%)
Seminal Vesicle (50) (50) (50) (50)
Dilatation 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Testes (50) (50) (50) (50)
Cyst 1 (2%)
Germinal Epithelium, Degeneration 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00
Route: DOSED FEED Time: 09:18:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Angiectasis 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Hyperplasia, Focal, Histiocytic 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Necrosis, Focal 1 (2%)
Lymph Node (5) (5) (3) (5)
Bronchial, Hyperplasia 1 (20%)
Bronchial, Hyperplasia, Lymphoid 1 (20%) 1 (33%)
Inguinal, Hyperplasia, Lymphoid 1 (20%)
Mediastinal, Hyperplasia 1 (20%)
Mediastinal, Hyperplasia, Lymphoid 1 (20%) 1 (20%)
Mediastinal, Infiltration Cellular, Lipocyte 1 (20%)
Mediastinal, Pigmentation 1 (20%)
Pancreatic, Amyloid Deposition 1 (20%)
Pancreatic, Hyperplasia 1 (20%)
Renal, Hyperplasia 1 (20%)
Lymph Node, Mandibular (48) (50) (45) (48)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Lymph Node, Mesenteric (50) (49) (49) (49)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic, Suppurative 1 (2%)
Spleen (50) (50) (50) (50)
Angiectasis 1 (2%)
Congestion 1 (2%) 1 (2%)
Depletion Cellular 1 (2%) 1 (2%)
Fibrosis, Focal 2 (4%)
Hematopoietic Cell Proliferation 9 (18%) 15 (30%) 10 (20%) 11 (22%)
Hyperplasia, Lymphoid 3 (6%) 2 (4%) 1 (2%) 1 (2%)
Inflammation, Focal 1 (2%)
Thymus (47) (40) (44) (45)
Atrophy 1 (2%)
Cyst 3 (6%) 3 (8%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%) 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00
Route: DOSED FEED Time: 09:18:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Cranium, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Atrophy, Focal 1 (2%)
Hemorrhage, Focal 1 (2%)
Peripheral Nerve (1)
Sciatic, Degeneration 1 (100%)
Spinal Cord (2) (1)
Meninges, Inflammation, Focal 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 1 (2%) 2 (4%)
Embolus 1 (2%)
Hemorrhage 7 (14%) 4 (8%) 1 (2%)
Hyperplasia, Histiocytic 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Mixed Cell 2 (4%)
Thrombosis 1 (2%)
Alveolar Epithelium, Bronchiolization 20 (40%) 30 (60%) 48 (96%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 4 (8%) 6 (12%)
Bronchiole, Hyperplasia 1 (2%)
Mediastinum, Inflammation, Chronic 1 (2%)
Nose (50) (50) (50) (50)
Foreign Body 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Nasolacrimal Duct, Cyst 1 (2%)
Nasolacrimal Duct, Inflammation 1 (2%)
Sinus, Foreign Body 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Sinus, Inflammation, Chronic, Suppurative 1 (2%) 3 (6%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Cataract 1 (100%)
Cornea, Inflammation, Chronic 1 (100%)
Cornea, Necrosis, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05205-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROTOLUENE Date: 02/08/00
Route: DOSED FEED Time: 09:18:07
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 1250 2500 5000
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50) (50)
Atrophy, Focal 1 (2%)
Congestion 2 (4%) 2 (4%) 2 (4%)
Cyst 2 (4%) 1 (2%)
Cyst, Multiple 1 (2%)
Inflammation, Chronic 1 (2%)
Nephropathy 46 (92%) 49 (100%) 47 (94%) 43 (86%)
Nephropathy, Focal 1 (2%) 1 (2%)
Glomerulus, Thrombosis 1 (2%)
Pelvis, Dilatation 1 (2%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (2%)
Renal Tubule, Hyperplasia, Focal 1 (2%) 1 (2%) 2 (4%)
Renal Tubule, Pigmentation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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