TDMS Study 05205-08 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst P-NITROTOLUENE DATE: 02/08/00
EXPERIMENT: 05205 TEST: 08 TIME: 09:36:03
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62537D
PATHOLOGIST: FARNELL, D. CAS: 99-99-0
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1 CHRONIC STUDY FOR MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst P-NITROTOLUENE DATE: 02/08/00
EXPERIMENT: 05205 TEST: 08 TIME: 09:36:03
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62537D
PATHOLOGIST: FARNELL, D. CAS: 99-99-0
P-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 4 CENSORED DEATHS 0 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 453 665 717 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 4 CENSORED DEATHS 0 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 280 689 711 715 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 597 597 625 689 693 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 505 585 597 625 681 689 714 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM| 100.0 100.0 100.0 100.0 100.0 98.0 98.0 98.0 96.0 92.0 |
| | |
| | |
|1250 PPM| 100.0 100.0 100.0 98.0 98.0 98.0 98.0 98.0 98.0 92.0 |
| | |
| | |
|2500 PPM| 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 94.0 90.0 |
| | |
| | |
|5000 PPM| 100.0 100.0 100.0 100.0 100.0 100.0 98.0 94.0 92.0 84.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 1250 PPM 2500 PPM 5000 P|M
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 92.0% 92.0% 90.0% 84.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.187 P=1.000 P=0.974 P=0.341 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 639.0 598.8 640.2 639.6 |
|NATURAL DEATHS (C) | (63.3) ( 106) (21.4) (26.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 721.8 718.6 720.1 714.7 |
|(STANDARD ERROR) | ( 5.6) ( 9.0) ( 4.3) ( 6.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 4 CENSORED DEATHS 0 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 629 654 682 707 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 47 |
| |
| UNCENSORED DEATHS |
| 487 664 680 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 456 534 625 669 682 714 716 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 49 |
| |
| UNCENSORED DEATHS |
| 276 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM| 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 92.0 |
| | |
| | |
|1250 PPM| 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 96.0 94.0 |
| | |
| | |
|2500 PPM| 100.0 100.0 100.0 100.0 100.0 98.0 96.0 96.0 94.0 86.0 |
| | |
| | |
|5000 PPM| 100.0 100.0 100.0 98.0 98.0 98.0 98.0 98.0 98.0 98.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 1250 PPM 2500 PPM 5000 P|M
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 92.0% 94.0% 86.0% 98.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.452N P=1.000N P=0.509 P=0.366N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 668.0 610.3 628.0 276.0 |
|NATURAL DEATHS (C) | (16.9) (61.8) (37.2) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 724.1 721.9 714.9 719.9 |
|(STANDARD ERROR) | ( 2.6) ( 5.1) ( 7.0) ( 9.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P-NITROTOLUENE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
1250 PPM = 2
2500 PPM = 3
5000 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 4 3
|
|
|
98 + 2 1 4 4 1 2
|
|
|
P 96 + 4 3 3 1 2 21
E |
R |
C |
E 94 + 4 3 3 22
N |
T |
|
S 92 + 4 4 1 1
U |
R |
V |
I 90 + 43 3
V |
A |
L |
88 + 4 4
|
|
|
86 + 44
|
|
|
84 + 4 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
P-NITROTOLUENE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
1250 PPM = 2
2500 PPM = 3
5000 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 2 1
|
|
|
98 + 4 3 2 3 1 1 2 4
|
P |
E |
R 96 + 3 3 1 2 1
C |
E |
N |
T 94 + 3 3 1 1 2
|
S |
U |
R 92 + 3 3 1 1
V |
I |
V |
A 90 + 3 3
L |
|
|
88 + 33
|
|
|
86 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
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