TDMS Study 05210-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: I. I. T. Research Inst ETHYLBENZENE DATE: 04/24/96
EXPERIMENT: 05210 TEST: 04 TIME: 10:49:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-75193 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56393
PATHOLOGIST: TOMLINSON, MIK CAS: 100-41-4
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: I. I. T. Research Inst ETHYLBENZENE DATE: 04/24/96
EXPERIMENT: 05210 TEST: 04 TIME: 10:49:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-75193 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56393
PATHOLOGIST: TOMLINSON, MIK CAS: 100-41-4
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: I. I. T. Research Inst ETHYLBENZENE DATE: 04/24/96
EXPERIMENT: 05210 TEST: 04 TIME: 10:49:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-75193 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56393
PATHOLOGIST: TOMLINSON, MIK CAS: 100-41-4
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF ETHYLBENZENE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Islets, Pancreatic Carcinoma or Adenoma
Liver Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
All Organs Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 75 PPM 250 750 | CONTROL 75 PPM 250 750 |
| | PPM PPM | PPM PPM |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/47 (0%) 0/46 (0%) 0/48 (0%) 0/48 (0%) | 0/47 (0%) 1/50 (2%) 2/50 (4%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 2.6% 4.6% 0.0% |
|TERMINAL (d) | 0/28 (0%) 0/36 (0%) 0/32 (0%) 0/30 (0%) | 0/35 (0%) 1/38 (3%) 1/40 (3%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 730 (T) 659 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.508N P=0.516 P=0.273 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.453N P=0.516 P=0.317 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.512N P=0.516 P=0.251 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.511N |
|FISHER EXACT | (e) (e) (e) | P=0.515 P=0.263 (e) |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | 3.6% 8.0% 6.3% 0.0% | 0.0% 0.0% 2.5% 8.1% |
|TERMINAL (d) | 1/28 (4%) 2/36 (6%) 2/32 (6%) 0/30 (0%) | 0/35 (0%) 0/38 (0%) 1/40 (3%) 3/37 (8%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 709 729 (T) --- | --- --- 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.192N P=0.398 P=0.547 P=0.486N | P=0.021 * (e) P=0.527 P=0.131 |
|INCIDENTAL TUMOR | P=0.153N P=0.348 P=0.547 P=0.486N | P=0.021 * (e) P=0.527 P=0.131 |
|LOGISTIC REGRESSION | P=0.182N P=0.375 P=0.547 P=0.486N | P=0.021 * (e) P=0.527 P=0.131 |
|COCHRAN-ARMITAGE | P=0.183N | P=0.021 * |
|FISHER EXACT | P=0.309 P=0.500 P=0.500N | (e) P=0.500 P=0.121 |
|=================================================================================================================================|
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 75 PPM 250 750 | CONTROL 75 PPM 250 750 |
| | PPM PPM | PPM PPM |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | 3.6% 8.0% 6.3% 0.0% | 2.4% 0.0% 2.5% 8.1% |
|TERMINAL (d) | 1/28 (4%) 2/36 (6%) 2/32 (6%) 0/30 (0%) | 0/35 (0%) 0/38 (0%) 1/40 (3%) 3/37 (8%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 709 729 (T) --- | 639 --- 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.192N P=0.398 P=0.547 P=0.486N | P=0.083 P=0.486N P=0.730N P=0.330 |
|INCIDENTAL TUMOR | P=0.153N P=0.348 P=0.547 P=0.486N | P=0.059 P=0.531N P=0.527 P=0.248 |
|LOGISTIC REGRESSION | P=0.182N P=0.375 P=0.547 P=0.486N | P=0.081 P=0.516N P=0.761 P=0.310 |
|COCHRAN-ARMITAGE | P=0.183N | P=0.080 |
|FISHER EXACT | P=0.309 P=0.500 P=0.500N | P=0.500N P=0.753N P=0.309 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 0/48 (0%) 2/48 (4%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 6.1% | 0.0% 0.0% 2.5% 0.0% |
|TERMINAL (d) | 0/28 (0%) 0/36 (0%) 0/32 (0%) 1/30 (3%) | 0/35 (0%) 0/38 (0%) 1/40 (3%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 669 | --- --- 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.038 * (e) (e) P=0.261 | P=0.786N (e) P=0.527 (e) |
|INCIDENTAL TUMOR | P=0.071 (e) (e) P=0.335 | P=0.786N (e) P=0.527 (e) |
|LOGISTIC REGRESSION | P=0.040 * (e) (e) P=0.247 | P=0.786N (e) P=0.527 (e) |
|COCHRAN-ARMITAGE | P=0.040 * | P=0.790N |
|FISHER EXACT | (e) (e) P=0.242 | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 75 PPM 250 750 | CONTROL 75 PPM 250 750 |
| | PPM PPM | PPM PPM |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/50 (24%) 16/50 (32%) 17/50 (34%) 18/50 (36%) | 6/50 (12%) 9/50 (18%) 12/50 (24%) 16/50 (32%) |
|ADJUSTED (b) | 37.6% 39.1% 46.7% 55.8% | 17.1% 22.1% 27.5% 41.8% |
|TERMINAL (d) | 9/28 (32%) 12/36 (33%) 13/32 (41%) 16/30 (53%) | 6/35 (17%) 7/38 (18%) 9/40 (23%) 15/37 (41%) |
|FIRST INCIDENCE (DAYS) | 522 360 579 618 | 730 (T) 562 659 614 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.142 P=0.503 P=0.324 P=0.186 | P=0.013 * P=0.345 P=0.165 P=0.018 * |
|INCIDENTAL TUMOR | P=0.164 P=0.335 P=0.345 P=0.175 | P=0.013 * P=0.322 P=0.179 P=0.014 * |
|LOGISTIC REGRESSION | P=0.182 P=0.322 P=0.329 P=0.189 | P=0.014 * P=0.311 P=0.128 P=0.022 * |
|COCHRAN-ARMITAGE | P=0.178 | P=0.011 * |
|FISHER EXACT | P=0.252 P=0.189 P=0.138 | P=0.288 P=0.096 P=0.014 * |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/50 (34%) 9/50 (18%) 13/50 (26%) 10/50 (20%) | 7/50 (14%) 4/50 (8%) 3/50 (6%) 12/50 (24%) |
|ADJUSTED (b) | 41.1% 21.5% 28.5% 23.8% | 17.3% 9.7% 7.5% 28.3% |
|TERMINAL (d) | 5/28 (18%) 5/36 (14%) 3/32 (9%) 1/30 (3%) | 3/35 (9%) 2/38 (5%) 3/40 (8%) 7/37 (19%) |
|FIRST INCIDENCE (DAYS) | 289 514 480 430 | 565 602 730 (T) 612 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.228N P=0.032N* P=0.170N P=0.083N | P=0.029 * P=0.238N P=0.127N P=0.205 |
|INCIDENTAL TUMOR | P=0.151N P=0.138N P=0.267N P=0.076N | P=0.031 * P=0.296N P=0.152N P=0.215 |
|LOGISTIC REGRESSION | P=0.196N P=0.064N P=0.321N P=0.091N | P=0.022 * P=0.259N P=0.150N P=0.162 |
|COCHRAN-ARMITAGE | P=0.200N | P=0.022 * |
|FISHER EXACT | P=0.055N P=0.257N P=0.088N | P=0.262N P=0.159N P=0.154 |
|=================================================================================================================================|
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 75 PPM 250 750 | CONTROL 75 PPM 250 750 |
| | PPM PPM | PPM PPM |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/50 (34%) 10/50 (20%) 13/50 (26%) 10/50 (20%) | 7/50 (14%) 4/50 (8%) 3/50 (6%) 12/50 (24%) |
|ADJUSTED (b) | 41.1% 24.1% 28.5% 23.8% | 17.3% 9.7% 7.5% 28.3% |
|TERMINAL (d) | 5/28 (18%) 6/36 (17%) 3/32 (9%) 1/30 (3%) | 3/35 (9%) 2/38 (5%) 3/40 (8%) 7/37 (19%) |
|FIRST INCIDENCE (DAYS) | 289 514 480 430 | 565 602 730 (T) 612 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.202N P=0.049N* P=0.170N P=0.083N | P=0.029 * P=0.238N P=0.127N P=0.205 |
|INCIDENTAL TUMOR | P=0.128N P=0.197N P=0.267N P=0.076N | P=0.031 * P=0.296N P=0.152N P=0.215 |
|LOGISTIC REGRESSION | P=0.167N P=0.101N P=0.321N P=0.091N | P=0.022 * P=0.259N P=0.150N P=0.162 |
|COCHRAN-ARMITAGE | P=0.173N | P=0.022 * |
|FISHER EXACT | P=0.088N P=0.257N P=0.088N | P=0.262N P=0.159N P=0.154 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 27/50 (54%) 24/50 (48%) 30/50 (60%) 27/50 (54%) | 13/50 (26%) 12/50 (24%) 15/50 (30%) 25/50 (50%) |
|ADJUSTED (b) | 63.7% 54.9% 64.6% 66.7% | 32.8% 28.2% 34.5% 57.9% |
|TERMINAL (d) | 13/28 (46%) 17/36 (47%) 16/32 (50%) 17/30 (57%) | 9/35 (26%) 8/38 (21%) 12/40 (30%) 19/37 (51%) |
|FIRST INCIDENCE (DAYS) | 289 360 480 430 | 565 562 659 612 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.413 P=0.127N P=0.505N P=0.433N | P=0.004 ** P=0.426N P=0.562 P=0.029 * |
|INCIDENTAL TUMOR | P=0.469 P=0.419N P=0.475 P=0.545N | P=0.003 ** P=0.508N P=0.537 P=0.020 * |
|LOGISTIC REGRESSION | P=0.465 P=0.321N P=0.389 P=0.521N | P=0.002 ** P=0.478N P=0.471 P=0.015 * |
|COCHRAN-ARMITAGE | P=0.447 | P=0.002 ** |
|FISHER EXACT | P=0.345N P=0.343 P=0.579N | P=0.500N P=0.412 P=0.011 * |
|=================================================================================================================================|
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 75 PPM 250 750 | CONTROL 75 PPM 250 750 |
| | PPM PPM | PPM PPM |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 27/50 (54%) 24/50 (48%) 30/50 (60%) 27/50 (54%) | 13/50 (26%) 12/50 (24%) 15/50 (30%) 25/50 (50%) |
|ADJUSTED (b) | 63.7% 54.9% 64.6% 66.7% | 32.8% 28.2% 34.5% 57.9% |
|TERMINAL (d) | 13/28 (46%) 17/36 (47%) 16/32 (50%) 17/30 (57%) | 9/35 (26%) 8/38 (21%) 12/40 (30%) 19/37 (51%) |
|FIRST INCIDENCE (DAYS) | 289 360 480 430 | 565 562 659 612 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.413 P=0.127N P=0.505N P=0.433N | P=0.004 ** P=0.426N P=0.562 P=0.029 * |
|INCIDENTAL TUMOR | P=0.469 P=0.419N P=0.475 P=0.545N | P=0.003 ** P=0.508N P=0.537 P=0.020 * |
|LOGISTIC REGRESSION | P=0.465 P=0.321N P=0.389 P=0.521N | P=0.002 ** P=0.478N P=0.471 P=0.015 * |
|COCHRAN-ARMITAGE | P=0.447 | P=0.002 ** |
|FISHER EXACT | P=0.345N P=0.343 P=0.579N | P=0.500N P=0.412 P=0.011 * |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 9/50 (18%) 10/50 (20%) 16/50 (32%) | 4/50 (8%) 4/50 (8%) 5/49 (10%) 8/50 (16%) |
|ADJUSTED (b) | 15.1% 22.7% 27.4% 47.3% | 10.9% 10.5% 11.4% 21.6% |
|TERMINAL (d) | 2/28 (7%) 6/36 (17%) 6/32 (19%) 13/30 (43%) | 3/35 (9%) 4/38 (11%) 2/40 (5%) 8/37 (22%) |
|FIRST INCIDENCE (DAYS) | 616 531 602 418 | 694 730 (T) 682 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005 ** P=0.341 P=0.218 P=0.014 * | P=0.106 P=0.598N P=0.579 P=0.206 |
|INCIDENTAL TUMOR | P=0.008 ** P=0.179 P=0.205 P=0.006 ** | P=0.141 P=0.619N P=0.642 P=0.222 |
|LOGISTIC REGRESSION | P=0.006 ** P=0.234 P=0.193 P=0.009 ** | P=0.111 P=0.618N P=0.525 P=0.218 |
|COCHRAN-ARMITAGE | P=0.006 ** | P=0.096 |
|FISHER EXACT | P=0.194 P=0.131 P=0.006 ** | P=0.643N P=0.487 P=0.178 |
|=================================================================================================================================|
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 75 PPM 250 750 | CONTROL 75 PPM 250 750 |
| | PPM PPM | PPM PPM |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 5/50 (10%) 3/50 (6%) | 0/50 (0%) 2/50 (4%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 6.2% 2.8% 13.1% 9.6% | 0.0% 4.7% 0.0% 0.0% |
|TERMINAL (d) | 1/28 (4%) 1/36 (3%) 2/32 (6%) 2/30 (7%) | 0/35 (0%) 1/38 (3%) 0/40 (0%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 610 729 (T) 588 708 | --- 590 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.341 P=0.430N P=0.285 P=0.534 | P=0.364N P=0.251 (e) (e) |
|INCIDENTAL TUMOR | P=0.356 P=0.520N P=0.238 P=0.529 | P=0.461N P=0.232 (e) (e) |
|LOGISTIC REGRESSION | P=0.351 P=0.474N P=0.227 P=0.529 | P=0.358N P=0.225 (e) (e) |
|COCHRAN-ARMITAGE | P=0.348 | P=0.369N |
|FISHER EXACT | P=0.500N P=0.218 P=0.500 | P=0.247 (e) (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 10/50 (20%) 15/50 (30%) 19/50 (38%) | 4/50 (8%) 6/50 (12%) 5/49 (10%) 8/50 (16%) |
|ADJUSTED (b) | 20.6% 25.2% 37.9% 55.0% | 10.9% 15.0% 11.4% 21.6% |
|TERMINAL (d) | 3/28 (11%) 7/36 (19%) 8/32 (25%) 15/30 (50%) | 3/35 (9%) 5/38 (13%) 2/40 (5%) 8/37 (22%) |
|FIRST INCIDENCE (DAYS) | 610 531 588 418 | 694 590 682 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.004 ** P=0.482 P=0.114 P=0.014 * | P=0.184 P=0.419 P=0.579 P=0.206 |
|INCIDENTAL TUMOR | P=0.006 ** P=0.272 P=0.078 P=0.006 ** | P=0.209 P=0.388 P=0.642 P=0.222 |
|LOGISTIC REGRESSION | P=0.004 ** P=0.355 P=0.064 P=0.008 ** | P=0.181 P=0.386 P=0.525 P=0.218 |
|COCHRAN-ARMITAGE | P=0.004 ** | P=0.169 |
|FISHER EXACT | P=0.298 P=0.045 * P=0.006 ** | P=0.370 P=0.487 P=0.178 |
|=================================================================================================================================|
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 75 PPM 250 750 | CONTROL 75 PPM 250 750 |
| | PPM PPM | PPM PPM |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 3/50 (6%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.9% 7.3% 0.0% 0.0% |
|TERMINAL (d) | 0/28 (0%) 0/36 (0%) 0/32 (0%) 0/30 (0%) | 1/35 (3%) 1/38 (3%) 0/40 (0%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 730 (T) 642 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.144N P=0.336 P=0.473N P=0.489N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.164N P=0.289 P=0.473N P=0.489N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.149N P=0.311 P=0.473N P=0.489N |
|COCHRAN-ARMITAGE | (e) | P=0.150N |
|FISHER EXACT | (e) (e) (e) | P=0.309 P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/49 (4%) 0/50 (0%) 0/49 (0%) 2/49 (4%) |
|ADJUSTED (b) | | 5.9% 0.0% 0.0% 5.0% |
|TERMINAL (d) | | 2/34 (6%) 0/38 (0%) 0/40 (0%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | | 730 (T) --- --- 712 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.396 P=0.214N P=0.203N P=0.661N |
|INCIDENTAL TUMOR | | P=0.424 P=0.214N P=0.203N P=0.640N |
|LOGISTIC REGRESSION | | P=0.396 P=0.214N P=0.203N P=0.665N |
|COCHRAN-ARMITAGE | | P=0.378 |
|FISHER EXACT | | P=0.242N P=0.247N P=0.691N |
|=================================================================================================================================|
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 75 PPM 250 750 | CONTROL 75 PPM 250 750 |
| | PPM PPM | PPM PPM |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/44 (0%) 0/45 (0%) 0/45 (0%) 0/47 (0%) | 4/48 (8%) 8/49 (16%) 7/47 (15%) 5/49 (10%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 11.1% 19.8% 17.0% 13.5% |
|TERMINAL (d) | 0/27 (0%) 0/35 (0%) 0/30 (0%) 0/30 (0%) | 3/35 (9%) 6/38 (16%) 5/38 (13%) 5/37 (14%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 725 697 659 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.445N P=0.223 P=0.322 P=0.533 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.357N P=0.177 P=0.326 P=0.563 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.425N P=0.203 P=0.276 P=0.542 |
|COCHRAN-ARMITAGE | (e) | P=0.459N |
|FISHER EXACT | (e) (e) (e) | P=0.188 P=0.249 P=0.513 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/44 (0%) 0/45 (0%) 1/45 (2%) 0/47 (0%) | 4/48 (8%) 8/49 (16%) 7/47 (15%) 5/49 (10%) |
|ADJUSTED (b) | 0.0% 0.0% 2.4% 0.0% | 11.1% 19.8% 17.0% 13.5% |
|TERMINAL (d) | 0/27 (0%) 0/35 (0%) 0/30 (0%) 0/30 (0%) | 3/35 (9%) 6/38 (16%) 5/38 (13%) 5/37 (14%) |
|FIRST INCIDENCE (DAYS) | --- --- 642 --- | 725 697 659 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.776N (e) P=0.543 (e) | P=0.445N P=0.223 P=0.322 P=0.533 |
|INCIDENTAL TUMOR | P=0.781N (e) P=0.500 (e) | P=0.357N P=0.177 P=0.326 P=0.563 |
|LOGISTIC REGRESSION | P=0.779N (e) P=0.485 (e) | P=0.425N P=0.203 P=0.276 P=0.542 |
|COCHRAN-ARMITAGE | P=0.777N | P=0.459N |
|FISHER EXACT | (e) P=0.506 (e) | P=0.188 P=0.249 P=0.513 |
|=================================================================================================================================|
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 75 PPM 250 750 | CONTROL 75 PPM 250 750 |
| | PPM PPM | PPM PPM |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 3.6% 0.0% 0.0% 0.0% | 0.0% 5.3% 0.0% 5.4% |
|TERMINAL (d) | 1/28 (4%) 0/36 (0%) 0/32 (0%) 0/30 (0%) | 0/35 (0%) 2/38 (5%) 0/40 (0%) 2/37 (5%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- --- | --- 730 (T) --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.481N P=0.450N P=0.473N P=0.486N | P=0.290 P=0.257 (e) P=0.251 |
|INCIDENTAL TUMOR | P=0.481N P=0.450N P=0.473N P=0.486N | P=0.290 P=0.257 (e) P=0.251 |
|LOGISTIC REGRESSION | P=0.481N P=0.450N P=0.473N P=0.486N | P=0.290 P=0.257 (e) P=0.251 |
|COCHRAN-ARMITAGE | P=0.474N | P=0.287 |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | P=0.247 (e) P=0.247 |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.6% 0.0% 0.0% 0.0% | 0.0% 5.3% 0.0% 0.0% |
|TERMINAL (d) | 1/28 (4%) 0/36 (0%) 0/32 (0%) 0/30 (0%) | 0/35 (0%) 2/38 (5%) 0/40 (0%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- --- | --- 730 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.481N P=0.450N P=0.473N P=0.486N | P=0.364N P=0.257 (e) (e) |
|INCIDENTAL TUMOR | P=0.481N P=0.450N P=0.473N P=0.486N | P=0.364N P=0.257 (e) (e) |
|LOGISTIC REGRESSION | P=0.481N P=0.450N P=0.473N P=0.486N | P=0.364N P=0.257 (e) (e) |
|COCHRAN-ARMITAGE | P=0.474N | P=0.369N |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | P=0.247 (e) (e) |
|=================================================================================================================================|
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 75 PPM 250 750 | CONTROL 75 PPM 250 750 |
| | PPM PPM | PPM PPM |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 3.6% 0.0% 0.0% 0.0% | 0.0% 5.3% 0.0% 2.7% |
|TERMINAL (d) | 1/28 (4%) 0/36 (0%) 0/32 (0%) 0/30 (0%) | 0/35 (0%) 2/38 (5%) 0/40 (0%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- --- | --- 730 (T) --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.481N P=0.450N P=0.473N P=0.486N | P=0.628 P=0.257 (e) P=0.511 |
|INCIDENTAL TUMOR | P=0.481N P=0.450N P=0.473N P=0.486N | P=0.628 P=0.257 (e) P=0.511 |
|LOGISTIC REGRESSION | P=0.481N P=0.450N P=0.473N P=0.486N | P=0.628 P=0.257 (e) P=0.511 |
|COCHRAN-ARMITAGE | P=0.474N | P=0.622 |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | P=0.247 (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 3.0% 0.0% | 0.0% 2.6% 5.0% 0.0% |
|TERMINAL (d) | 0/28 (0%) 0/36 (0%) 0/32 (0%) 0/30 (0%) | 0/35 (0%) 1/38 (3%) 2/40 (5%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 724 --- | --- 730 (T) 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.795N (e) P=0.526 (e) | P=0.510N P=0.516 P=0.268 (e) |
|INCIDENTAL TUMOR | P=0.661N (e) P=0.638 (e) | P=0.510N P=0.516 P=0.268 (e) |
|LOGISTIC REGRESSION | P=0.792N (e) P=0.533 (e) | P=0.510N P=0.516 P=0.268 (e) |
|COCHRAN-ARMITAGE | P=0.786N | P=0.515N |
|FISHER EXACT | (e) P=0.500 (e) | P=0.500 P=0.247 (e) |
|=================================================================================================================================|
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 75 PPM 250 750 | CONTROL 75 PPM 250 750 |
| | PPM PPM | PPM PPM |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 2/50 (4%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 2.8% 0.0% 0.0% | 2.8% 4.7% 2.5% 2.7% |
|TERMINAL (d) | 0/28 (0%) 1/36 (3%) 0/32 (0%) 0/30 (0%) | 0/35 (0%) 1/38 (3%) 1/40 (3%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- --- | 725 562 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.585N P=0.550 (e) (e) | P=0.530N P=0.518 P=0.734N P=0.751N |
|INCIDENTAL TUMOR | P=0.585N P=0.550 (e) (e) | P=0.551N P=0.466 P=0.708N P=0.702N |
|LOGISTIC REGRESSION | P=0.585N P=0.550 (e) (e) | P=0.535N P=0.489 P=0.738N P=0.744N |
|COCHRAN-ARMITAGE | P=0.576N | P=0.535N |
|FISHER EXACT | P=0.500 (e) (e) | P=0.500 P=0.753N P=0.753N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 1/50 (2%) 6/50 (12%) | 5/50 (10%) 6/50 (12%) 3/50 (6%) 4/50 (8%) |
|ADJUSTED (b) | 10.7% 5.1% 3.1% 17.8% | 13.7% 15.2% 7.1% 10.8% |
|TERMINAL (d) | 3/28 (11%) 1/36 (3%) 1/32 (3%) 4/30 (13%) | 4/35 (11%) 5/38 (13%) 2/40 (5%) 4/37 (11%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 640 729 (T) 647 | 694 697 682 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.069 P=0.390N P=0.257N P=0.294 | P=0.355N P=0.557 P=0.288N P=0.462N |
|INCIDENTAL TUMOR | P=0.088 P=0.469N P=0.257N P=0.362 | P=0.301N P=0.519 P=0.261N P=0.437N |
|LOGISTIC REGRESSION | P=0.072 P=0.437N P=0.257N P=0.278 | P=0.339N P=0.532 P=0.320N P=0.449N |
|COCHRAN-ARMITAGE | P=0.073 | P=0.372N |
|FISHER EXACT | P=0.500N P=0.309N P=0.243 | P=0.500 P=0.357N P=0.500N |
|=================================================================================================================================|
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 75 PPM 250 750 | CONTROL 75 PPM 250 750 |
| | PPM PPM | PPM PPM |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | | 4.9% 2.6% 2.5% 0.0% |
|TERMINAL (d) | | 1/35 (3%) 1/38 (3%) 1/40 (3%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | | 565 730 (T) 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.189N P=0.481N P=0.469N P=0.231N |
|INCIDENTAL TUMOR | | P=0.239N P=0.499N P=0.732N P=0.322N |
|LOGISTIC REGRESSION | | P=0.194N P=0.510N P=0.505N P=0.232N |
|COCHRAN-ARMITAGE | | P=0.194N |
|FISHER EXACT | | P=0.500N P=0.500N P=0.247N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 3/50 (6%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 3.6% 0.0% 5.7% 0.0% | 0.0% 7.9% 7.0% 0.0% |
|TERMINAL (d) | 1/28 (4%) 0/36 (0%) 0/32 (0%) 0/30 (0%) | 0/35 (0%) 3/38 (8%) 2/40 (5%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 691 --- | --- 730 (T) 659 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.469N P=0.450N P=0.551 P=0.486N | P=0.280N P=0.136 P=0.149 (e) |
|INCIDENTAL TUMOR | P=0.304N P=0.450N P=0.675 P=0.486N | P=0.256N P=0.136 P=0.161 (e) |
|LOGISTIC REGRESSION | P=0.453N P=0.450N P=0.554 P=0.486N | P=0.281N P=0.136 P=0.123 (e) |
|COCHRAN-ARMITAGE | P=0.455N | P=0.291N |
|FISHER EXACT | P=0.500N P=0.500 P=0.500N | P=0.121 P=0.121 (e) |
|=================================================================================================================================|
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 75 PPM 250 750 | CONTROL 75 PPM 250 750 |
| | PPM PPM | PPM PPM |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 2.8% 0.0% 0.0% | 0.0% 5.3% 0.0% 0.0% |
|TERMINAL (d) | 0/28 (0%) 1/36 (3%) 0/32 (0%) 0/30 (0%) | 0/35 (0%) 2/38 (5%) 0/40 (0%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- --- | --- 730 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.585N P=0.550 (e) (e) | P=0.364N P=0.257 (e) (e) |
|INCIDENTAL TUMOR | P=0.585N P=0.550 (e) (e) | P=0.364N P=0.257 (e) (e) |
|LOGISTIC REGRESSION | P=0.585N P=0.550 (e) (e) | P=0.364N P=0.257 (e) (e) |
|COCHRAN-ARMITAGE | P=0.576N | P=0.369N |
|FISHER EXACT | P=0.500 (e) (e) | P=0.247 (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 4/50 (8%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 3.6% 2.8% 5.7% 0.0% | 0.0% 10.5% 7.0% 0.0% |
|TERMINAL (d) | 1/28 (4%) 1/36 (3%) 0/32 (0%) 0/30 (0%) | 0/35 (0%) 4/38 (11%) 2/40 (5%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 691 --- | --- 730 (T) 659 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.345N P=0.705N P=0.551 P=0.486N | P=0.212N P=0.074 P=0.149 (e) |
|INCIDENTAL TUMOR | P=0.220N P=0.705N P=0.675 P=0.486N | P=0.193N P=0.074 P=0.161 (e) |
|LOGISTIC REGRESSION | P=0.330N P=0.705N P=0.554 P=0.486N | P=0.211N P=0.074 P=0.123 (e) |
|COCHRAN-ARMITAGE | P=0.333N | P=0.222N |
|FISHER EXACT | P=0.753N P=0.500 P=0.500N | P=0.059 P=0.121 (e) |
|=================================================================================================================================|
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 75 PPM 250 750 | CONTROL 75 PPM 250 750 |
| | PPM PPM | PPM PPM |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 3/50 (6%) 2/50 (4%) | 3/50 (6%) 6/50 (12%) 5/50 (10%) 5/50 (10%) |
|ADJUSTED (b) | 4.8% 4.8% 8.4% 6.5% | 7.1% 13.4% 10.7% 12.2% |
|TERMINAL (d) | 0/28 (0%) 1/36 (3%) 1/32 (3%) 1/30 (3%) | 1/35 (3%) 2/38 (5%) 1/40 (3%) 3/37 (8%) |
|FIRST INCIDENCE (DAYS) | 522 514 680 725 | 423 300 437 666 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.608 P=0.655N P=0.564 P=0.673N | P=0.496 P=0.278 P=0.416 P=0.393 |
|INCIDENTAL TUMOR | P=0.501N P=0.698N P=0.554 P=0.682N | P=0.434 P=0.187 P=0.283 P=0.235 |
|LOGISTIC REGRESSION | P=0.609N P=0.629 P=0.474 P=0.691 | P=0.237 P=0.175 P=0.340 P=0.358 |
|COCHRAN-ARMITAGE | P=0.606N | P=0.469 |
|FISHER EXACT | P=0.691N P=0.500 P=0.691N | P=0.243 P=0.357 P=0.357 |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 20/50 (40%) 25/50 (50%) 26/50 (52%) 30/50 (60%) | 20/50 (40%) 26/50 (52%) 27/50 (54%) 28/50 (56%) |
|ADJUSTED (b) | 56.4% 56.4% 68.1% 78.3% | 50.8% 63.2% 59.9% 71.6% |
|TERMINAL (d) | 13/28 (46%) 17/36 (47%) 20/32 (63%) 22/30 (73%) | 16/35 (46%) 23/38 (61%) 22/40 (55%) 26/37 (70%) |
|FIRST INCIDENCE (DAYS) | 522 360 579 418 | 565 562 659 614 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.045 * P=0.564 P=0.364 P=0.100 | P=0.163 P=0.260 P=0.284 P=0.122 |
|INCIDENTAL TUMOR | P=0.054 P=0.244 P=0.354 P=0.058 | P=0.172 P=0.200 P=0.180 P=0.088 |
|LOGISTIC REGRESSION | P=0.046 * P=0.304 P=0.341 P=0.053 | P=0.176 P=0.190 P=0.163 P=0.116 |
|COCHRAN-ARMITAGE | P=0.046 * | P=0.132 |
|FISHER EXACT | P=0.211 P=0.158 P=0.036 * | P=0.158 P=0.115 P=0.080 |
|=================================================================================================================================|
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 75 PPM 250 750 | CONTROL 75 PPM 250 750 |
| | PPM PPM | PPM PPM |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 21/50 (42%) 15/50 (30%) 21/50 (42%) 16/50 (32%) | 13/50 (26%) 20/50 (40%) 9/50 (18%) 18/50 (36%) |
|ADJUSTED (b) | 46.4% 35.2% 44.5% 36.4% | 28.5% 40.5% 19.3% 39.7% |
|TERMINAL (d) | 5/28 (18%) 9/36 (25%) 7/32 (22%) 4/30 (13%) | 4/35 (11%) 9/38 (24%) 4/40 (10%) 10/37 (27%) |
|FIRST INCIDENCE (DAYS) | 289 514 480 259 | 423 300 437 568 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.349N P=0.082N P=0.381N P=0.184N | P=0.380 P=0.181 P=0.191N P=0.279 |
|INCIDENTAL TUMOR | P=0.207N P=0.275N P=0.479 P=0.192N | P=0.161 P=0.031 * P=0.555N P=0.093 |
|LOGISTIC REGRESSION | P=0.287N P=0.179N P=0.448 P=0.212N | P=0.075 P=0.045 * P=0.265N P=0.192 |
|COCHRAN-ARMITAGE | P=0.309N | P=0.322 |
|FISHER EXACT | P=0.149N P=0.580N P=0.204N | P=0.101 P=0.235N P=0.194 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 35/50 (70%) 34/50 (68%) 40/50 (80%) 41/50 (82%) | 29/50 (58%) 38/50 (76%) 31/50 (62%) 38/50 (76%) |
|ADJUSTED (b) | 76.0% 70.8% 80.0% 89.0% | 62.9% 76.0% 64.5% 80.8% |
|TERMINAL (d) | 17/28 (61%) 22/36 (61%) 22/32 (69%) 25/30 (83%) | 18/35 (51%) 26/38 (68%) 23/40 (58%) 28/37 (76%) |
|FIRST INCIDENCE (DAYS) | 289 360 480 259 | 423 300 437 568 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.131 P=0.159N P=0.549N P=0.379 | P=0.229 P=0.187 P=0.466N P=0.161 |
|INCIDENTAL TUMOR | P=0.094 P=0.570N P=0.276 P=0.186 | P=0.081 P=0.030 * P=0.376 P=0.032 * |
|LOGISTIC REGRESSION | P=0.069 P=0.423N P=0.248 P=0.162 | P=0.042 * P=0.041 * P=0.431 P=0.045 * |
|COCHRAN-ARMITAGE | P=0.063 | P=0.116 |
|FISHER EXACT | P=0.500N P=0.178 P=0.121 | P=0.044 * P=0.419 P=0.044 * |
|=================================================================================================================================|
DATE: 04/24/96 EXPERIMENT: 05210 TEST: 04 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLBENZENE
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).