TDMS Study 05210-04 Pathology Tables
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
CORE STUDY
Facility: I. I. T. Research Institute
Chemical CAS #: 100-41-4
Lock Date: 10/02/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 6| 3| 1| 7| 3| 3| 3| 3| 3| 2| 3| 9|
| 1| 1| 2| 2| 1| 0| 2| 5| 1| 8| 1| 1| 2| 5| 9| 5| 8| 1| 1| 2| 0| 1| 9| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + A + + + + M + + + + + + + + + +|
Infiltration Cellular | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + M + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 |
Clear Cell Focus | |
Eosinophilic Focus | 2 |
Infiltration Cellular | 2 2 2 |
Inflammation | 1 |
Necrosis | |
Pigmentation, Hemosiderin | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 2 1 1 |
Acinus, Hyperplasia | 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 1 1 2 2 1 2 1 2 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | |
Glands, Cyst | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | M + + + + + + + + + M + + + + + + + + + + + M + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + M + + + + + + M + +|
Accessory Adrenal Cortical Nodule | |
Degeneration | 3 1 1 1 2 |
Hemorrhage | 2 |
Hyperplasia | 1 2 |
Necrosis | 3|
Vacuolization Cytoplasmic | 3 |
Capsule, Hyperplasia | 2 2 2 2 1 1 3 2 1 2 2 3 3 2 1 2 2 2 2 2 3 2 3|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 6| 3| 1| 7| 3| 3| 3| 3| 3| 2| 3| 9|
| 1| 1| 2| 2| 1| 0| 2| 5| 1| 8| 1| 1| 2| 5| 9| 5| 8| 1| 1| 2| 0| 1| 9| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + M + +|
Hemorrhage | 2 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | |
__________________________________________________________________________|
Parathyroid Gland | M M M + M M + M M + + M M + + + M + + M + M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + M + +|
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 2 1 1 1 |
Pars Intermedia, Hyperplasia | 3 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Degeneration | 1 |
Follicular Cell, Hyperplasia | 1 2 1 3 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M M + + M + + + + M + M M + + + + + + +|
__________________________________________________________________________|
Ovary | + + M + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Cyst | 1 1 2 4 |
Hemorrhage | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
Inflammation | |
Endometrium, Hyperplasia | 3 3 2 3 2 3 3 3 4 2 4 4 3 3 2 3 3 3 3 2 3 3|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + M + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Pigmentation, Hemosiderin | 2 1 |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + +|
Inguinal, Pigmentation, Hemosiderin | 2|
Lumbar, Hyperplasia | 2 |
Renal, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M M + + + M + + + + + M M + M + M M + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 6| 3| 1| 7| 3| 3| 3| 3| 3| 2| 3| 9|
| 1| 1| 2| 2| 1| 0| 2| 5| 1| 8| 1| 1| 2| 5| 9| 5| 8| 1| 1| 2| 0| 1| 9| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Granulomatous | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + M + + M + M M + + + M + + M M + M|
Hyperplasia, Histiocytic | 2 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 1 |
Hyperplasia | |
Pigmentation, Hemosiderin | 2 1 2 |
Lymphoid Follicle, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + M + + + + + M M + + + + + M + M|
Atrophy | 3 3 |
Thymocyte, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2|
Necrosis | |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + M + + + + + + + + + + + + + + + + +|
Periosteum, Femur, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mineralization | 1 1 1 1 1 1 1 1 |
Cerebellum, Atrophy | 2 |
Cerebrum, Atrophy | |
Medulla, Atrophy | 2 |
Medulla, Hemorrhage | 2|
__________________________________________________________________________|
Spinal Cord | +|
Hemorrhage | 3|
Myelin, Degeneration | 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + M + + + + + + + + + +|
Infiltration Cellular | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 |
Vein, Thrombosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 6| 3| 1| 7| 3| 3| 3| 3| 3| 2| 3| 9|
| 1| 1| 2| 2| 1| 0| 2| 5| 1| 8| 1| 1| 2| 5| 9| 5| 8| 1| 1| 2| 0| 1| 9| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | 2 |
Inflammation | 1 |
Nasolacrimal Duct, Inflammation | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Pleura | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 |
Nephropathy | 1 1 1 2 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hemorrhage | 3 |
Infiltration Cellular | 2 2 2 |
Inflammation | 1 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 4| 7| 6| 7| |
DAY ON TEST | 3| 1| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 3| 1| 3| 3| 2| 3| 9| 3| |
| 0| 8| 1| 0| 5| 2| 1| 2| 1| 1| 1| 2| 2| 1| 1| 2| 2| 1| 8| 0| 2| 3| 2| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
CONTROL | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A M + + + + + + + + + + A + + + + + + + +| 44 |
Infiltration Cellular | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + M + + + + + + + + + + + + + + + + + + A +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + A + + + + + + + + + + + + + + + + + + A +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 | 3 1.7|
Clear Cell Focus | 1 | 1 1.0|
Eosinophilic Focus | 2 2 2 1 | 5 1.8|
Infiltration Cellular | | 3 2.0|
Inflammation | | 1 1.0|
Necrosis | 1 | 1 1.0|
Pigmentation, Hemosiderin | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 4 | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular | 1 1 3 | 7 1.4|
Acinus, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular | 1 2 1 2 1 1 2 1 1 1 1 1 2 2 | 30 1.3|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular | 1 | 1 1.0|
Glands, Cyst | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + M + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 2 1 | 10 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + M + + + + + + + + + + + + + + + + + + + +| 47 |
Accessory Adrenal Cortical Nodule | 1 1 | 2 1.0|
Degeneration | 1 2 1 2 2 2 2| 12 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 4| 7| 6| 7| |
DAY ON TEST | 3| 1| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 3| 1| 3| 3| 2| 3| 9| 3| |
| 0| 8| 1| 0| 5| 2| 1| 2| 1| 1| 1| 2| 2| 1| 1| 2| 2| 1| 8| 0| 2| 3| 2| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
CONTROL | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hemorrhage | 2 | 2 2.0|
Hyperplasia | 1 | 3 1.3|
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic | | 1 3.0|
Capsule, Hyperplasia | 2 2 2 1 2 2 2 3 2 3 3 2 1 2 1 2 1 2 2 2 2 2 2| 46 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +| 47 |
Hemorrhage | | 1 2.0|
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + + M M M + + M M M + M + M + + + + +| 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hemorrhage | 2 2 | 3 2.3|
Pars Distalis, Hyperplasia | 1 2 2 1 1 2 | 10 1.4|
Pars Intermedia, Hyperplasia | | 2 3.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Degeneration | | 1 1.0|
Follicular Cell, Hyperplasia | 3 1 1 2 1 1 1 1 3| 18 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + + + + + + + M + + + + + + + + M +| 41 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 | 2 2.0|
Cyst | 3 1 2 2 | 8 2.0|
Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 2 | 2 2.5|
Inflammation | 2 1 2 | 3 1.7|
Endometrium, Hyperplasia | 3 3 4 3 3 3 3 2 2 3 2 4 2 4 3 3 2 3 3 3 2 2| 44 2.9|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation | | 1 2.0|
Pigmentation, Hemosiderin | 2 | 3 1.7|
Myeloid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 4| 7| 6| 7| |
DAY ON TEST | 3| 1| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 3| 1| 3| 3| 2| 3| 9| 3| |
| 0| 8| 1| 0| 5| 2| 1| 2| 1| 1| 1| 2| 2| 1| 1| 2| 2| 1| 8| 0| 2| 3| 2| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
CONTROL | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Inguinal, Pigmentation, Hemosiderin | | 1 2.0|
Lumbar, Hyperplasia | | 1 2.0|
Renal, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + M M M + + + + + + + M + + M + M + + M M M| 32 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +| 47 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 2 2 3 2 | 4 2.3|
Inflammation, Granulomatous | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + + + + + M + + M + M M M + M + + + + +| 34 |
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia | 3 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 | 4 1.8|
Hyperplasia | 3 | 1 3.0|
Pigmentation, Hemosiderin | 1| 4 1.5|
Lymphoid Follicle, Hyperplasia | 4 2 3 3 2 2 | 9 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + + + + + M + + + + + +| 42 |
Atrophy | 3 2 2| 5 2.6|
Thymocyte, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 2.0|
Necrosis | 2 | 1 2.0|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Periosteum, Femur, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 | 2 1.5|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1| 19 1.0|
Cerebellum, Atrophy | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 4| 7| 6| 7| |
DAY ON TEST | 3| 1| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 3| 1| 3| 3| 2| 3| 9| 3| |
| 0| 8| 1| 0| 5| 2| 1| 2| 1| 1| 1| 2| 2| 1| 1| 2| 2| 1| 8| 0| 2| 3| 2| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
CONTROL | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Cerebrum, Atrophy | 2 2| 2 2.0|
Medulla, Atrophy | | 1 2.0|
Medulla, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Hemorrhage | | 1 3.0|
Myelin, Degeneration | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Vein, Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
Inflammation | 2 1 | 3 1.3|
Nasolacrimal Duct, Inflammation | | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 3 | 2 2.5|
__________________________________________________________________________|____________|
Pleura | + | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts Protein | | 1 1.0|
Nephropathy | 1 1 1 1 1 1 | 13 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + M M +| 47 |
Hemorrhage | | 1 3.0|
Infiltration Cellular | 2 | 4 2.0|
Inflammation | | 1 1.0|
Ulcer | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 3| 4| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 9| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 0| 5| 1| 0| 2| 1| 2| 2| 0| 2| 2| 2| 2| 2| 1| 3| 2| 1| 1| 0| 1| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M A + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + A + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + A + + + + + A + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Eosinophilic Focus | 2 1 1 1 |
Inflammation | 1 2 |
Necrosis | 1 2 1 |
Pigmentation, Hemosiderin | |
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Atrophy | 3 1 |
Cyst | 4 |
Degeneration | |
Fibrosis | 3 |
Infiltration Cellular | 2 1 2 3 2 2 2|
Necrosis | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Infiltration Cellular | 2 1 1 2 1 1 2 2 1 1 1 2 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration | 2 1 1 |
Hemorrhage | 2 |
Hyperplasia | 2 |
Infiltration Cellular | |
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 3| 4| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 9| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 0| 5| 1| 0| 2| 1| 2| 2| 0| 2| 2| 2| 2| 2| 1| 3| 2| 1| 1| 0| 1| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Hyperplasia | 2 1 3 3 2 2 2 2 1 2 2 1 1 2 2 2 1 1 2 2 2 1 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + M + + + + M M + + + M M + + M M + + M + M +|
Infiltration Cellular | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 2 2 3 1 1 3 2 2|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 3 2 1 2 1 1 3 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + +|
Fat, Necrosis | 2 3 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + M + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Atrophy | 4 |
Cyst | 1 2|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
Endometrium, Hyperplasia | 4 3 2 3 4 4 4 4 2 4 4 4 4 2 4 4 4 2 3 4 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hyperplasia | 2 |
Lumbar, Hyperplasia | 2 3 |
Renal, Necrosis | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + M + + M + + + + + M + + + + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Granulomatous | 4 |
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 3| 4| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 9| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 0| 5| 1| 0| 2| 1| 2| 2| 0| 2| 2| 2| 2| 2| 1| 3| 2| 1| 1| 0| 1| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Necrosis | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + M + + + + M M + + + + + + + + + + + + + +|
Hyperplasia | 3 3 4|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 2 2 |
Necrosis | 3 |
Pigmentation, Hemosiderin | |
Lymphoid Follicle, Hyperplasia | 4 3 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + M + + + + + + + + + + + + + +|
Atrophy | 4 3 4 |
Thymocyte, Hyperplasia | 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | 2 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 |
Cerebrum, Atrophy | 2 |
Meninges, Infiltration Cellular | 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Degeneration | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 3| 4| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 9| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 0| 5| 1| 0| 2| 1| 2| 2| 0| 2| 2| 2| 2| 2| 1| 3| 2| 1| 1| 0| 1| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular | |
Nephropathy | 2 1 3 1|
Cortex, Metaplasia, Osseous | |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + M +|
Infiltration Cellular | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 9| 2| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| |
| 1| 0| 7| 2| 2| 2| 2| 7| 3| 1| 1| 2| 4| 1| 2| 2| 2| 1| 9| 1| 2| 2| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
75 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + M + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M + + + + + + + + + + M M + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + M + + + + + + A + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Eosinophilic Focus | 2 1 2 | 7 1.4|
Inflammation | 2 | 3 1.7|
Necrosis | 2 | 4 1.5|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Hepatocyte, Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Atrophy | | 2 2.0|
Cyst | | 1 4.0|
Degeneration | 1 | 1 1.0|
Fibrosis | | 1 3.0|
Infiltration Cellular | 2 1 1 1 2 | 12 1.8|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
Infiltration Cellular | 2 2 1 1 2 1 1 1 2 2 1 1 1 2 1 1 1 2 1| 32 1.4|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 | 23 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 9| 2| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| |
| 1| 0| 7| 2| 2| 2| 2| 7| 3| 1| 1| 2| 4| 1| 2| 2| 2| 1| 9| 1| 2| 2| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
75 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Degeneration | 1 | 4 1.3|
Hemorrhage | | 1 2.0|
Hyperplasia | 1 1 2 1 | 5 1.4|
Infiltration Cellular | 1 1 | 2 1.0|
Inflammation | 2 2 2 | 3 2.0|
Capsule, Hyperplasia | 2 1 2 1 2 1 1 2 2 2 2 2 2 2 2 1 1 2 2 1 3 2 3 2 3| 49 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M M M + + M + M + M + M M + + + + M M M M M| 24 |
Infiltration Cellular | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Hyperplasia | 2 2 2 2 | 12 2.0|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 2 1 1 1 1 1 2 2 1 1 1| 23 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 6 |
Fat, Necrosis | 3 | 4 2.5|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Atrophy | | 1 4.0|
Cyst | 2 2 2 3 4 1 | 8 2.1|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | | 1 2.0|
Endometrium, Hyperplasia | 3 4 2 3 3 3 4 3 2 2 2 3 4 3 4 4 4 1 3 3 3 3 3 3| 46 3.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 4.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Iliac, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 9| 2| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| |
| 1| 0| 7| 2| 2| 2| 2| 7| 3| 1| 1| 2| 4| 1| 2| 2| 2| 1| 9| 1| 2| 2| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
75 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Hyperplasia | | 2 2.5|
Renal, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + + M + M + + M + + + + + M + + + + + + + +| 40 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 3 2 | 3 2.3|
Inflammation, Granulomatous | | 1 4.0|
Inflammation | 2 3 | 2 2.5|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + + + M M + + + + + + + + + + + M + + +| 42 |
Hyperplasia | 2 | 4 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 4 3 | 7 3.0|
Necrosis | | 1 3.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Lymphoid Follicle, Hyperplasia | 2 2 | 5 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + M M + M + + + +| 44 |
Atrophy | 3 3 | 5 3.4|
Thymocyte, Hyperplasia | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fracture | | 2 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 1 1 1 1 1 | 17 1.0|
Cerebrum, Atrophy | | 1 2.0|
Meninges, Infiltration Cellular | | 2 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 9| 2| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| |
| 1| 0| 7| 2| 2| 2| 2| 7| 3| 1| 1| 2| 4| 1| 2| 2| 2| 1| 9| 1| 2| 2| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
75 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Glands, Degeneration | 1 | 2 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 1| 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular | 4 | 1 4.0|
Nephropathy | 1 1 2 | 7 1.6|
Cortex, Metaplasia, Osseous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular | 2 | 4 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 8| 3|
| 1| 1| 2| 2| 1| 1| 2| 1| 1| 6| 2| 2| 2| 2| 1| 2| 1| 6| 1| 2| 1| 0| 0| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + A + + + M + M +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 |
Clear Cell Focus | |
Eosinophilic Focus | 2 2 1 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | |
Inflammation | 1 |
Mixed Cell Focus | 3 |
Necrosis | 1 2 |
Hepatocyte, Syncytial Alteration | 1 |
Hepatocyte, Vacuolization Cytoplasmic| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 2 2 1 2 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 2 1 2 1 1 2 2 2 2 1 2 1 2 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + M + + + + + M +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 2 2 1 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 2 |
Hemorrhage | |
Hyperplasia | 1 |
Capsule, Hyperplasia | 1 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 3 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Infiltration Cellular | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + M + + M + + M + + + M + + + + + M M + M +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 8| 3|
| 1| 1| 2| 2| 1| 1| 2| 1| 1| 6| 2| 2| 2| 2| 1| 2| 1| 6| 1| 2| 1| 0| 0| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Angiectasis | 2 3 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 3 2 2 2 3 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 |
Follicular Cell, Hyperplasia | 1 2 1 1 2 2 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + + |
Fat, Necrosis | 1 2 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | 3 2 2 2 |
Hemorrhage | |
Infiltration Cellular | 2 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hemorrhage | |
Thrombosis | 2 |
Endometrium, Hyperplasia | 3 3 4 3 3 4 3 4 3 2 3 3 2 3 2 3 3 2 3 3 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node | +|
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M M M M M + + M + + + M M + M + + + M + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + M + M + + + + + + +|
Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + M + + + + + + M M + M + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Pigmentation, Hemosiderin | 1 |
Lymphoid Follicle, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + A + + + + + + + + + + + + + + +|
Atrophy | 4 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 8| 3|
| 1| 1| 2| 2| 1| 1| 2| 1| 1| 6| 2| 2| 2| 2| 1| 2| 1| 6| 1| 2| 1| 0| 0| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Galactocele | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + M + + + + + + +|
Fibrosis | 4 |
Inflammation | 3 3 |
Ulcer | 2 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arthrosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Cerebrum, Atrophy | 1|
Meninges, Infiltration Cellular | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + A + + + + + + + + + + + + + + +|
Degeneration | 1 |
Infiltration Cellular | 1 |
Glands, Degeneration | |
Glands, Inflammation | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | 1 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 2 1 1 1 1 |
Cortex, Cyst | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + + +|
Infiltration Cellular | 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 0| 3| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 3| 3| 3| 3| |
| 8| 1| 1| 7| 7| 1| 2| 1| 0| 1| 5| 2| 1| 1| 1| 1| 1| 4| 9| 2| 2| 1| 2| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
250 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + + A + + + + + + + A + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + M A + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + A + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 3 2 | 4 2.3|
Clear Cell Focus | 2 | 1 2.0|
Eosinophilic Focus | 2 1 | 6 1.5|
Hemorrhage | 3 | 1 3.0|
Hepatodiaphragmatic Nodule | 2 1 | 2 1.5|
Inflammation | | 1 1.0|
Mixed Cell Focus | | 1 3.0|
Necrosis | 1 | 3 1.3|
Hepatocyte, Syncytial Alteration | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular | 1 1 1 1 | 12 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular | 2 1 2 1 2 1 1 1 1 1 1 1 2 1 1 1 1| 33 1.4|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A + + + + A + + + + + + + + + + + + + + +| 48 |
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + A + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1 1 2 1 4 1 1 | 23 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 1 | 4 1.3|
Hemorrhage | 1 2 | 2 1.5|
Hyperplasia | 1 1 | 3 1.0|
Capsule, Hyperplasia | 2 1 2 2 2 2 2 2 2 1 2 2 1 2 2 1 1 2 1 1 2 2 2 1| 48 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 0| 3| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 3| 3| 3| 3| |
| 8| 1| 1| 7| 7| 1| 2| 1| 0| 1| 5| 2| 1| 1| 1| 1| 1| 4| 9| 2| 2| 1| 2| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
250 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 2 2.0|
Infiltration Cellular | 1 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M M + + M + + + + + M + M + + + + + + M + + M| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Angiectasis | 3 2 | 4 2.5|
Pars Distalis, Hemorrhage | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 1 2 2 2 2 3 2 2 3 3 | 23 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular | | 1 1.0|
Follicular Cell, Hyperplasia | 2 3 1 1 2 2 2 1 1 1 1 1 1| 25 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 4 |
Fat, Necrosis | | 3 1.7|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Atrophy | 3 | 1 3.0|
Cyst | 4 1 2 1 1 2 | 10 2.0|
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular | | 2 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Thrombosis | | 1 2.0|
Endometrium, Hyperplasia | 3 3 3 2 3 4 4 4 3 4 3 3 3 4 4 4 3 2 4 4 3 4 4 4| 47 3.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M M M + + + + + + + M M M + + M M + + +| 29 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +| 46 |
Hyperplasia | | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 0| 3| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 3| 3| 3| 3| |
| 8| 1| 1| 7| 7| 1| 2| 1| 0| 1| 5| 2| 1| 1| 1| 1| 1| 4| 9| 2| 2| 1| 2| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
250 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + + + + + + M M + + + + M + + + + + + +| 41 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2| 2 2.5|
Pigmentation, Hemosiderin | | 1 1.0|
Lymphoid Follicle, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + M + + M + + + + + + M| 45 |
Atrophy | 4 4 3 | 5 3.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Galactocele | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | | 1 4.0|
Inflammation | | 2 3.0|
Ulcer | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arthrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 26 1.0|
Cerebrum, Atrophy | 3 | 2 2.0|
Meninges, Infiltration Cellular | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + M M + + + + + + + + + + + + + + + + + + + +| 47 |
Degeneration | | 1 1.0|
Infiltration Cellular | | 1 1.0|
Glands, Degeneration | 1 1 | 2 1.0|
Glands, Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 1 | 3 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 0| 3| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 3| 3| 3| 3| |
| 8| 1| 1| 7| 7| 1| 2| 1| 0| 1| 5| 2| 1| 1| 1| 1| 1| 4| 9| 2| 2| 1| 2| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
250 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 1 1 | 9 1.1|
Cortex, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | M + + + + + + + + M + + + + + + + + + + + + + + +| 47 |
Infiltration Cellular | 2 | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 1| 1| 1| 1| 3| 1| 3| 3| 3| 3| 3| 1| 1| 3| 0| 3| 3| 3|
| 0| 2| 2| 1| 1| 1| 2| 2| 2| 8| 1| 1| 4| 2| 2| 2| 2| 2| 2| 3| 2| 7| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + A + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + M + + A + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + A + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + A A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 3 |
Eosinophilic Focus | 1 4 3 1 2 2 2 2 2 2 2|
Hemorrhage | 2 |
Inflammation | 2 |
Mineralization | 1 |
Mixed Cell Focus | 4 |
Necrosis | 1 2 2 |
Bile Duct, Cyst | 2 |
Hepatocyte, Hypertrophy | |
Hepatocyte, Vacuolization Cytoplasmic| 3 |
Serosa, Inflammation | 2 |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 1 1 2 |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 1 2 1 1 1 1 1 2 2 1 1 2 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Epithelium, Cyst | 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Hyperplasia | |
Serosa, Infiltration Cellular | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 4 1 2 1 1 2 1 2 2 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 |
Hemorrhage | 2 1 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 1| 1| 1| 1| 3| 1| 3| 3| 3| 3| 3| 1| 1| 3| 0| 3| 3| 3|
| 0| 2| 2| 1| 1| 1| 2| 2| 2| 8| 1| 1| 4| 2| 2| 2| 2| 2| 2| 3| 2| 7| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 3 |
Capsule, Hyperplasia | 3 2 2 2 2 1 2 1 1 1 2 3 2 2 3 2 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M M M M + M M M + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hemorrhage | 3|
Pars Distalis, Hyperplasia | 2 2 2 2 2 1 2 1 1 2 2 |
Pars Distalis, Necrosis | |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 2 1 3 1 1 1 2 2 2 3 2 2 2 1 1 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Fat, Necrosis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + M + + + + + + + + + + + + + +|
Degeneration | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Mineralization | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 4 |
Hemorrhage | |
Infiltration Cellular | |
Inflammation | 3 |
Endometrium, Hyperplasia | 4 2 3 2 3 3 3 2 3 3 2 3 4 3 2 3 2 1 2 2 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 |
Myelofibrosis | |
Pigmentation, Hemosiderin | |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + |
Inguinal, Hyperplasia | |
Pancreatic, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M M + M M M M M + + + + + M + M +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + M + + + M +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 1| 1| 1| 1| 3| 1| 3| 3| 3| 3| 3| 1| 1| 3| 0| 3| 3| 3|
| 0| 2| 2| 1| 1| 1| 2| 2| 2| 8| 1| 1| 4| 2| 2| 2| 2| 2| 2| 3| 2| 7| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + M + M +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M + + + + M + M M + M + + M M M M + + M M + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Pigmentation, Hemosiderin | 2 2 2 |
Lymphoid Follicle, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + M + + + + + +|
Atrophy | 3 4 2 4 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1|
Cerebrum, Gliosis | |
Cerebrum, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + M + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 |
Glands, Degeneration | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 3 |
Alveolar Epithelium, Metaplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | |
Mineralization | |
Nephropathy | 1 1 1 1 1 3 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 1| 1| 1| 1| 3| 1| 3| 3| 3| 3| 3| 1| 1| 3| 0| 3| 3| 3|
| 0| 2| 2| 1| 1| 1| 2| 2| 2| 8| 1| 1| 4| 2| 2| 2| 2| 2| 2| 3| 2| 7| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cortex, Cyst | |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| |
| 2| 1| 1| 1| 9| 2| 1| 1| 8| 1| 1| 1| 1| 2| 2| 1| 2| 0| 1| 0| 3| 2| 2| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
750 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + + + + + + + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + M + + + + + + + + + + + + + + + A| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + A| 46 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + M + + + + + + + + + + + + + + + A + + + A| 45 |
Peyer's Patch, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 | 3 2.7|
Eosinophilic Focus | 2 2 2 1 2 1 3 1 1 3 2 | 22 2.0|
Hemorrhage | | 1 2.0|
Inflammation | | 1 2.0|
Mineralization | | 1 1.0|
Mixed Cell Focus | | 1 4.0|
Necrosis | 2 | 4 1.8|
Bile Duct, Cyst | | 1 2.0|
Hepatocyte, Hypertrophy | 1 | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| | 1 3.0|
Serosa, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular | 1 2 2 1 1 1 | 10 1.3|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular | 1 2 1 1 1 1 2 1 2 1 2 1 1 1 | 30 1.3|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 3.0|
Epithelium, Cyst | 2 | 2 2.0|
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Hyperplasia | 2 | 1 2.0|
Serosa, Infiltration Cellular | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 2 | 15 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| |
| 2| 1| 1| 1| 9| 2| 1| 1| 8| 1| 1| 1| 1| 2| 2| 1| 2| 0| 1| 0| 3| 2| 2| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
750 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Degeneration | 1 1 1| 5 1.0|
Hemorrhage | 3 | 3 2.0|
Hyperplasia | 2 2 | 3 2.3|
Capsule, Hyperplasia | 2 3 2 1 1 2 2 3 2 2 2 2 2 2 2 2 2 2 1 1 2 2 2| 46 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + M + + + + M M M M M M M M + M M + M M +| 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 | 2 2.0|
Pars Distalis, Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia | 2 1 2 2 1 4 1 2 2 3 1 | 22 1.8|
Pars Distalis, Necrosis | 1 | 1 1.0|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 3 2 1 1 1 1 3 1 1 2 2 2 1 1 1 1 1 | 35 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Fat, Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Cyst | 2 2 2 1 2 3 1 2 3 | 10 2.0|
Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | | 1 4.0|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular | 3 | 1 3.0|
Inflammation | | 1 3.0|
Endometrium, Hyperplasia | 4 4 3 3 3 4 4 2 4 4 4 3 4 3 3 4 4 4 2 2 3 3 4 2| 46 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| |
| 2| 1| 1| 1| 9| 2| 1| 1| 8| 1| 1| 1| 1| 2| 2| 1| 2| 0| 1| 0| 3| 2| 2| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
750 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Infiltration Cellular, Histiocyte | | 1 1.0|
Myelofibrosis | 1 2 | 2 1.5|
Pigmentation, Hemosiderin | 1 | 1 1.0|
Myeloid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + +| 5 |
Inguinal, Hyperplasia | 3 | 1 3.0|
Pancreatic, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + M + + + + + + + + + + + + + + + M + + + +| 38 |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + M + + + + + + + + + + + M +| 44 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + A + + M + + + + + + + + + + + + + + + +| 44 |
Hyperplasia | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + M + + + M + M M + M + + + + + + + + + + +| 31 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Pigmentation, Hemosiderin | 1 | 4 1.8|
Lymphoid Follicle, Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M + + + + + M + + + +| 46 |
Atrophy | 4 | 6 3.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1| 25 1.0|
Cerebrum, Gliosis | 1| 1 1.0|
Cerebrum, Hemorrhage | 1| 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular | | 1 1.0|
Glands, Degeneration | 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| |
| 2| 1| 1| 1| 9| 2| 1| 1| 8| 1| 1| 1| 1| 2| 2| 1| 2| 0| 1| 0| 3| 2| 2| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
750 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | | 1 3.0|
Alveolar Epithelium, Metaplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts Protein | 1 | 1 1.0|
Mineralization | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 | 21 1.1|
Cortex, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ureter | +| 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular | 1 | 5 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 9| 2| 3| 2| 2| 3| 2| 3| 2| 2| 6| 2| 1| 1| 2| 2| 8| 3| 3| 2| 2| 2| 8| 3|
| 0| 8| 9| 0| 3| 9| 0| 5| 0| 9| 2| 7| 9| 0| 6| 9| 9| 9| 0| 0| 9| 9| 9| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + A + + A + + M M + A M + + M + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + A + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + A + + + A + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 |
Clear Cell Focus | 1 1|
Cyst | 2 |
Eosinophilic Focus | 3 2 1 |
Eosinophilic Focus, Multiple | |
Mixed Cell Focus | 1 1 |
Necrosis | 2 1 2 |
Hepatocyte, Hypertrophy | 1 |
Hepatocyte, Necrosis | 1|
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Vein, Thrombosis | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Duct, Cyst | 2 |
Duct, Fibrosis | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 1 1 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 |
Metaplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 1 1 1 1 1 2 3 1|
Inflammation | 3 1 |
Myocardium, Mineralization | |
Pericardium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 9| 2| 3| 2| 2| 3| 2| 3| 2| 2| 6| 2| 1| 1| 2| 2| 8| 3| 3| 2| 2| 2| 8| 3|
| 0| 8| 9| 0| 3| 9| 0| 5| 0| 9| 2| 7| 9| 0| 6| 9| 9| 9| 0| 0| 9| 9| 9| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + M + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration | 1 |
Hemorrhage | 1 |
Hyperplasia | 1 1 1 1 3 2 1 2 2|
Vacuolization Cytoplasmic | |
Capsule, Hyperplasia | 1 2 2 1 1 1 2 1 2 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | M M + M M + M M M M + + M + M + + + M M M M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + M M +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 1 1 2 1 2 1 1 1 2 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 1 |
Cyst | 1 |
Granuloma Sperm | |
Inflammation | |
Mineralization | 1 |
__________________________________________________________________________|
Penis | + |
Inflammation | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 2 |
Hyperplasia | |
Infiltration Cellular | 2 |
Inflammation | 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + M + + + M + + + + + +|
Atrophy | 3 |
Infiltration Cellular | 1 |
Inflammation | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
Degeneration | 2 2 2 2 2 2 2 3|
Inflammation | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 9| 2| 3| 2| 2| 3| 2| 3| 2| 2| 6| 2| 1| 1| 2| 2| 8| 3| 3| 2| 2| 2| 8| 3|
| 0| 8| 9| 0| 3| 9| 0| 5| 0| 9| 2| 7| 9| 0| 6| 9| 9| 9| 0| 0| 9| 9| 9| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Pigmentation, Hemosiderin | 2 |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + |
Inguinal, Hyperplasia | |
Lumbar, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M M + + M + M M + M + M M + M M + M M M + M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + M + + + + + M + + + + + + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + M + + + + + + + + + + M + + + + + + + +|
Congestion | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M + M M + + M M + M + + M + + M + M + M M M|
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 4 2 |
Lymphoid Follicle, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + M + + M + + M M + M + + + M + + + + + + + M + +|
Atrophy | 3 4 4 2 4 |
Cyst | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
Atrophy | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
Necrosis | 2 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Degeneration | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + M + + + + + + + + + + + + + +|
Infiltration Cellular | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 2 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 9| 2| 3| 2| 2| 3| 2| 3| 2| 2| 6| 2| 1| 1| 2| 2| 8| 3| 3| 2| 2| 2| 8| 3|
| 0| 8| 9| 0| 3| 9| 0| 5| 0| 9| 2| 7| 9| 0| 6| 9| 9| 9| 0| 0| 9| 9| 9| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | 1 1 |
Polyp, Inflammatory | 3 |
Nasolacrimal Duct, Inflammation | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
Infarct | |
Inflammation | 3 |
Nephropathy | 1 4 1 2 1 2 2 1 1 1 1 1 1 1 1 1 3 1|
Pigmentation, Bile | |
Cortex, Cyst | 1 |
Papilla, Inflammation | 2 2 |
Pelvis, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation | 3 2 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 0| 5| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 5| 7| 5| 5| 5| 0| 7| |
DAY ON TEST | 2| 2| 8| 2| 8| 0| 3| 3| 2| 2| 5| 2| 2| 4| 2| 1| 3| 3| 6| 2| 5| 1| 4| 2| 2| |
| 9| 9| 7| 4| 4| 2| 0| 0| 9| 9| 2| 9| 9| 2| 9| 0| 0| 9| 8| 9| 5| 9| 4| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + A + + +| 47 |
__________________________________________________________________________|____________|
Gallbladder | + + M A + A + + + + + + + + + M + + M + M A + A +| 33 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + A + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + A + + + + A + + + + + + + + + + A + A +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + A + + + + + + + + + + A + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + A + + + + A + + + + + A + M +| 44 |
Peyer's Patch, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + A + + + + A + + + + + + M + + + A + + +| 42 |
Peyer's Patch, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 2 | 3 1.3|
Clear Cell Focus | 1 2 1| 5 1.2|
Cyst | | 1 2.0|
Eosinophilic Focus | 1 1 2| 6 1.7|
Eosinophilic Focus, Multiple | 2 | 1 2.0|
Mixed Cell Focus | 1 | 3 1.0|
Necrosis | 3 2 1 1 | 7 1.7|
Hepatocyte, Hypertrophy | | 1 1.0|
Hepatocyte, Necrosis | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 2| 4 1.8|
Vein, Thrombosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Inflammation | 2 | 1 2.0|
Duct, Cyst | | 1 2.0|
Duct, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular | 1 1 2 1 2 1 1 1 1 1 2 | 21 1.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + A + + +| 48 |
Ulcer | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + A + + +| 48 |
Infiltration Cellular | | 1 1.0|
Metaplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + M + + + + + + + + + M +| 48 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 3 2 1 1 1 | 18 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 0| 5| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 5| 7| 5| 5| 5| 0| 7| |
DAY ON TEST | 2| 2| 8| 2| 8| 0| 3| 3| 2| 2| 5| 2| 2| 4| 2| 1| 3| 3| 6| 2| 5| 1| 4| 2| 2| |
| 9| 9| 7| 4| 4| 2| 0| 0| 9| 9| 2| 9| 9| 2| 9| 0| 0| 9| 8| 9| 5| 9| 4| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Inflammation | | 2 2.0|
Myocardium, Mineralization | 2 | 1 2.0|
Pericardium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + M + + M + + +| 47 |
Accessory Adrenal Cortical Nodule | 1 | 1 1.0|
Degeneration | | 1 1.0|
Hemorrhage | | 1 1.0|
Hyperplasia | 2 1 2 3 | 13 1.7|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Capsule, Hyperplasia | 2 1 2 1 1 1 1 1 | 19 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + M + + M + + +| 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Hyperplasia | 1 2 1 2 | 5 1.6|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + M + M M + M + M + + + M + M M M M M +| 22 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + M + M + + + +| 44 |
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 2 1 2 2 2 2 1 1 | 21 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Atypia Cellular | | 1 1.0|
Cyst | | 1 1.0|
Granuloma Sperm | 2 1 | 2 1.5|
Inflammation | 1 | 1 1.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + A + + + + + + + + + + + + M +| 48 |
Degeneration | 2| 3 1.7|
Hyperplasia | 2 | 1 2.0|
Infiltration Cellular | | 1 2.0|
Inflammation | 4 2 2 4 | 6 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + M + + + + + + + + + M +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 0| 5| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 5| 7| 5| 5| 5| 0| 7| |
DAY ON TEST | 2| 2| 8| 2| 8| 0| 3| 3| 2| 2| 5| 2| 2| 4| 2| 1| 3| 3| 6| 2| 5| 1| 4| 2| 2| |
| 9| 9| 7| 4| 4| 2| 0| 0| 9| 9| 2| 9| 9| 2| 9| 0| 0| 9| 8| 9| 5| 9| 4| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | | 1 3.0|
Infiltration Cellular | | 1 1.0|
Inflammation | 2 1 2 1 3 | 6 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Atrophy | | 2 3.0|
Degeneration | 1 2 2 2 1 2 2 3 3 3 3| 19 2.2|
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
Pigmentation, Hemosiderin | 1 | 2 1.5|
Myeloid Cell, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Inguinal, Hyperplasia | 3 | 1 3.0|
Lumbar, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + M M + M M M M M M M M M M M + M M M + M + M| 14 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + M + M + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + M + + +| 45 |
Congestion | 3 | 1 3.0|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + M + + M + M + M + + M + M M + M M M + M| 24 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 3 2.7|
Lymphoid Follicle, Atrophy | 3 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + M + M + + M M + M + + +| 37 |
Atrophy | 2 2 3 2 3 2 2 3 2 4 4 4 2 | 18 2.9|
Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M + M M M M M M M + M + M M M| 3 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 2 | 3 2.0|
Necrosis | | 1 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 0| 5| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 5| 7| 5| 5| 5| 0| 7| |
DAY ON TEST | 2| 2| 8| 2| 8| 0| 3| 3| 2| 2| 5| 2| 2| 4| 2| 1| 3| 3| 6| 2| 5| 1| 4| 2| 2| |
| 9| 9| 7| 4| 4| 2| 0| 0| 9| 9| 2| 9| 9| 2| 9| 0| 0| 9| 8| 9| 5| 9| 4| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vertebra, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 2 1 1| 21 1.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Infiltration Cellular | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | | 2 2.0|
Inflammation | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Inflammation | 1 2 2 1 1 | 7 1.3|
Polyp, Inflammatory | 3 | 2 3.0|
Nasolacrimal Duct, Inflammation | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | | 1 1.0|
Infarct | 2 | 1 2.0|
Inflammation | 3 3 | 3 3.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 2 1 2 1 3 2| 34 1.4|
Pigmentation, Bile | 3 | 1 3.0|
Cortex, Cyst | | 1 1.0|
Papilla, Inflammation | 2 | 3 2.0|
Pelvis, Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + M +| 48 |
Calculus Micro Observation Only | 1 | 1 1.0|
Inflammation | 3 4 3 3 2 | 7 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5| 3| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 2| 2| 2| 3| 2| 2| 2| 3| 4| 2| 1| 6| 3| 2| 3| 3| 3| 9| 3| 2| 3| 3| 0| 2|
| 7| 9| 9| 9| 0| 9| 9| 9| 1| 0| 5| 4| 0| 0| 9| 0| 0| 0| 4| 6| 9| 0| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A M + + + + + + + + + M M + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + A + + + + + + + + + + + + +|
Cyst | 1 |
Epithelium, Dysplasia | 2 |
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 2 |
Clear Cell Focus | 2 2 1 |
Cyst | 1|
Eosinophilic Focus | 1 1 2 |
Fibrosis | 1 |
Inflammation, Chronic | 2 2 |
Mixed Cell Focus | |
Necrosis | 2 2 1 |
Hepatocyte, Necrosis | 2 |
Hepatocyte, Syncytial Alteration | 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 1 1 1 1 2 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 1 1 1 1 2 1 1 3 1 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + M + + M + + + + + + + M + + + + +|
Degeneration | 2 |
Hyperplasia | 2 2 2 |
Capsule, Hyperplasia | 2 2 1 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | M + + + + + + + M + + M + + + + + + + M + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M M M + M + M + + + M + + + M M + + + M M +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5| 3| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 2| 2| 2| 3| 2| 2| 2| 3| 4| 2| 1| 6| 3| 2| 3| 3| 3| 9| 3| 2| 3| 3| 0| 2|
| 7| 9| 9| 9| 0| 9| 9| 9| 1| 0| 5| 4| 0| 0| 9| 0| 0| 0| 4| 6| 9| 0| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + M + + + + + +|
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 3 1 2 1 3 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Cyst | |
Fat, Necrosis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
Fibrosis | 2 |
Granuloma Sperm | 2 |
Infiltration Cellular | 2 |
__________________________________________________________________________|
Penis | + |
Concretion | 3 |
Inflammation | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Degeneration | 2 |
Infiltration Cellular | 1 1 1 |
Inflammation | 3 3 2 2 2 1|
Mineralization | 1 |
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 2 |
Inflammation | 2 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Degeneration | 2 2 2 2 3 3 3 2 2 2 2 3 3 2 2 2 |
Inflammation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Germinal Epithelium, Atrophy | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Pigmentation, Hemosiderin | |
Myeloid Cell, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5| 3| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 2| 2| 2| 3| 2| 2| 2| 3| 4| 2| 1| 6| 3| 2| 3| 3| 3| 9| 3| 2| 3| 3| 0| 2|
| 7| 9| 9| 9| 0| 9| 9| 9| 1| 0| 5| 4| 0| 0| 9| 0| 0| 0| 4| 6| 9| 0| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Hyperplasia | |
Inguinal, Pigmentation | |
Lumbar, Hyperplasia | 2 3 4 |
Lumbar, Pigmentation | |
Renal, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M + + + M + + M M M M + M + + + M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + M + + + + + + + + + + + + + + M + + +|
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + M +|
Congestion | 3 3 |
Hematopoietic Cell Proliferation | 2 3 |
Hyperplasia | 2 |
Inflammation | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + M M M M + + M M + M M M M M M M M + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 |
__________________________________________________________________________|
Thymus | M + + M + + + + M + + M M + + + + M M M + + + M +|
Atrophy | 3 4 4 4 4 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M + M M M M M M M M M M M M M M M M|
Atrophy | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infiltration Cellular, Melanocyte | |
Inflammation | 4 4 3 2 |
Ulcer | 2 4 3 4 |
Hair Follicle, Atrophy | |
Sebaceous Gland, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 2 1 1 |
Glands, Degeneration | |
Glands, Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5| 3| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 2| 2| 2| 3| 2| 2| 2| 3| 4| 2| 1| 6| 3| 2| 3| 3| 3| 9| 3| 2| 3| 3| 0| 2|
| 7| 9| 9| 9| 0| 9| 9| 9| 1| 0| 5| 4| 0| 0| 9| 0| 0| 0| 4| 6| 9| 0| 0| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Metaplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2|
Polyp, Inflammatory | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 4 2 |
Metaplasia, Osseous | 1 |
Mineralization | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 |
Cortex, Cyst | 1 2 1 2 1|
Papilla, Inflammation | 2 2 |
Pelvis, Dilatation | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation | 2 4 4 3 2 2 4 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 3| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 2| 2| 8| 8| 3| 2| 3| 8| 3| 4| 2| 2| 2| 3| 3| 3| 2| 2| 3| 2| 3| 7| 2| 3| |
| 0| 9| 9| 5| 0| 0| 9| 0| 0| 0| 1| 9| 9| 9| 0| 0| 0| 9| 9| 0| 9| 0| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + M + + M + A + + + + + + M + + + + A + +| 39 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + A + +| 46 |
Cyst | | 1 1.0|
Epithelium, Dysplasia | | 1 2.0|
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 3 | 3 2.0|
Clear Cell Focus | 2 | 4 1.8|
Cyst | | 1 1.0|
Eosinophilic Focus | 1 1 2 1 2 | 8 1.4|
Fibrosis | | 1 1.0|
Inflammation, Chronic | | 2 2.0|
Mixed Cell Focus | 2 3 | 2 2.5|
Necrosis | 1 3 1 2 1 | 8 1.6|
Hepatocyte, Necrosis | | 1 2.0|
Hepatocyte, Syncytial Alteration | 1 1 1| 5 1.0|
Hepatocyte, Vacuolization Cytoplasmic| | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular | 1 1 1 1 1 1 2 1 1 1 1 1 1 | 26 1.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 2 2 2 1 1 1 1 3 1 2 2 2| 36 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Degeneration | 3 | 2 2.5|
Hyperplasia | 1 2 2 3 2| 8 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 3| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 2| 2| 8| 8| 3| 2| 3| 8| 3| 4| 2| 2| 2| 3| 3| 3| 2| 2| 3| 2| 3| 7| 2| 3| |
| 0| 9| 9| 5| 0| 0| 9| 0| 0| 0| 1| 9| 9| 9| 0| 0| 0| 9| 9| 0| 9| 0| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Capsule, Hyperplasia | 2 1 2 2 1 1 1 1 1 2 1 1| 22 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 | 5 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + + + + M + + + M M + + + + + + + + + + M| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M M + + + + + + + + + + + + + + + + M + +| 45 |
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 4 1 1 1 2 3 2 1 | 21 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + +| 3 |
Cyst | 2 | 1 2.0|
Fat, Necrosis | 2 2| 2 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | 3 | 1 3.0|
Fibrosis | | 1 2.0|
Granuloma Sperm | | 1 2.0|
Infiltration Cellular | | 1 2.0|
__________________________________________________________________________|____________|
Penis | + | 2 |
Concretion | | 1 3.0|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | | 1 2.0|
Degeneration | 3 4 | 3 3.0|
Infiltration Cellular | 2 1 | 5 1.2|
Inflammation | 3 2 2 1 1 | 11 2.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular | | 2 1.5|
Inflammation | 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Degeneration | 3 2 3 2 3 2 3 3 2 2| 26 2.4|
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 3| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 2| 2| 8| 8| 3| 2| 3| 8| 3| 4| 2| 2| 2| 3| 3| 3| 2| 2| 3| 2| 3| 7| 2| 3| |
| 0| 9| 9| 5| 0| 0| 9| 0| 0| 0| 1| 9| 9| 9| 0| 0| 0| 9| 9| 0| 9| 0| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | | 1 2.0|
Germinal Epithelium, Atrophy | 3 | 1 3.0|
Interstitial Cell, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 4.0|
Pigmentation, Hemosiderin | 1 1 | 2 1.0|
Myeloid Cell, Hyperplasia | 2 | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + | 7 |
Inguinal, Hyperplasia | 2 | 1 2.0|
Inguinal, Pigmentation | 2 | 1 2.0|
Lumbar, Hyperplasia | 2 | 4 2.8|
Lumbar, Pigmentation | 2 | 1 2.0|
Renal, Hyperplasia | 3 2 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + + M M M + + M M + M M M M M M + + + + + +| 24 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M M +| 45 |
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + A + +| 46 |
Congestion | 3 | 3 3.0|
Hematopoietic Cell Proliferation | 2 | 3 2.3|
Hyperplasia | 2 | 2 2.0|
Inflammation | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + M M M + + + M M + M + + M M M + +| 25 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + M M + + + + + + + + + + + M + +| 37 |
Atrophy | 3 3 4 3 3 | 11 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M M M M M M M M M M M M M M M M M M M M M| 2 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Infiltration Cellular, Melanocyte | 2 | 1 2.0|
Inflammation | 2 4 | 6 3.2|
Ulcer | 4 | 5 3.4|
Hair Follicle, Atrophy | 2 | 1 2.0|
Sebaceous Gland, Cyst | 1| 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 3| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 2| 2| 8| 8| 3| 2| 3| 8| 3| 4| 2| 2| 2| 3| 3| 3| 2| 2| 3| 2| 3| 7| 2| 3| |
| 0| 9| 9| 5| 0| 0| 9| 0| 0| 0| 1| 9| 9| 9| 0| 0| 0| 9| 9| 0| 9| 0| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 1 1 1 1 1 | 18 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular | 1 | 4 1.3|
Glands, Degeneration | 1 | 1 1.0|
Glands, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 1 4 3 3 | 5 2.6|
Alveolar Epithelium, Metaplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 3 1.7|
Polyp, Inflammatory | | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 4 2 | 5 2.8|
Metaplasia, Osseous | | 1 1.0|
Mineralization | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1| 38 1.1|
Cortex, Cyst | 1 1 1 | 8 1.3|
Papilla, Inflammation | 3 2 | 4 2.3|
Pelvis, Dilatation | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | 2 | 1 2.0|
Inflammation | 3 4 4 3 2 | 12 3.1|
Ulcer | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 5| 5|
DAY ON TEST | 9| 2| 7| 2| 2| 3| 2| 3| 2| 0| 2| 2| 3| 0| 8| 2| 3| 4| 9| 2| 8| 8| 2| 7| 8|
| 6| 9| 9| 9| 2| 0| 9| 0| 4| 5| 9| 9| 0| 2| 8| 9| 0| 2| 1| 9| 3| 0| 9| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M M A + + + + + + + + + + + M + + A + M + A + + M|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + A + + + + M + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + A + + + + + + + + + + + A + A + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + A + + + + + + + + A + + A + + + A|
Parasite Metazoan | 1 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + A + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + A + + + + + + + + A + + A + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 1 |
Clear Cell Focus | 1 |
Eosinophilic Focus | 3 3 3 1 |
Hepatodiaphragmatic Nodule | |
Mineralization | |
Necrosis | 2 2 2 2 1 3|
Hepatocyte, Necrosis | 1 2 |
Hepatocyte, Syncytial Alteration | 1 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| |
Vein, Thrombosis | 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + A + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 1 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Mineralization | |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 1 2 1 2 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + M + + + + + + + + M +|
Degeneration | |
Hyperplasia | 1 3 2 |
Capsule, Hyperplasia | 2 1 2 2 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 5| 5|
DAY ON TEST | 9| 2| 7| 2| 2| 3| 2| 3| 2| 0| 2| 2| 3| 0| 8| 2| 3| 4| 9| 2| 8| 8| 2| 7| 8|
| 6| 9| 9| 9| 2| 0| 9| 0| 4| 5| 9| 9| 0| 2| 8| 9| 0| 2| 1| 9| 3| 0| 9| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration | |
Hyperplasia | |
Mineralization | |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + + + + + + + + + + + + + M + + + + + + +|
Degeneration | 1 |
Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Parathyroid Gland | M + M M M + + + M + + M + M + + M M M + M M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 1 |
Follicular Cell, Hyperplasia | 1 1 2 1 2 1 2 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Bilateral, Fibrosis | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Cyst | |
Degeneration | 2 2 2 2 |
Fibrosis | |
Hyperplasia | |
Infiltration Cellular | 1 |
Inflammation | 4 2 4 3 |
Necrosis | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | |
Inflammation | 1 2 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Degeneration | 2 2 1 1 2 2 2 2 |
Inflammation | 4 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tunic, Fibrosis | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 2 4 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Lumbar, Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 5| 5|
DAY ON TEST | 9| 2| 7| 2| 2| 3| 2| 3| 2| 0| 2| 2| 3| 0| 8| 2| 3| 4| 9| 2| 8| 8| 2| 7| 8|
| 6| 9| 9| 9| 2| 0| 9| 0| 4| 5| 9| 9| 0| 2| 8| 9| 0| 2| 1| 9| 3| 0| 9| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lumbar, Hyperplasia | 3 2 3 |
Lumbar, Inflammation | 1 |
Renal, Congestion | 3 3 |
Renal, Hyperplasia | 2 3 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M + + M + + M M + M + M + M + + + M M M M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M M + + + + + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M M + + + + + + + + + + + + + M + + + + + + +|
Congestion | 3|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + M M + + + + + + M M + + M + M M + M + + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + M + + M + + + + + + + + + + + M M + + + + M M|
Atrophy | 4 3 2 4 4 3 3 3 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M + M|
Atrophy | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 4 |
Ulcer | 3 4 |
Prepuce, Degeneration | |
Prepuce, Hyperplasia, Lymphoid | 4 |
Prepuce, Inflammation | 4 |
Prepuce, Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | M + + + + + + + + + + + + + + + + + + + M + M + M|
Foreign Body | |
Infiltration Cellular | |
Glands, Degeneration | 1 2 2 |
Glands, Inflammation | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 5| 5|
DAY ON TEST | 9| 2| 7| 2| 2| 3| 2| 3| 2| 0| 2| 2| 3| 0| 8| 2| 3| 4| 9| 2| 8| 8| 2| 7| 8|
| 6| 9| 9| 9| 2| 0| 9| 0| 4| 5| 9| 9| 0| 2| 8| 9| 0| 2| 1| 9| 3| 0| 9| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | |
Pigmentation, Hemosiderin | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolar Epithelium, Metaplasia | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Polyp, Inflammatory | 2 |
Nasolacrimal Duct, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 3 4 4 |
Nephropathy | 1 1 1 2 1 2 1 3 1 2 1 2 1 1 3 1 1 1 2 |
Cortex, Cyst | 2 1 1 |
Papilla, Inflammation | 1 1 |
Papilla, Necrosis | 3 |
Pelvis, Dilatation | 2 |
Renal Tubule, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Ureter | + + |
Degeneration | 2 |
Inflammation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | 4 |
Infiltration Cellular | |
Inflammation | 2 4 |
Muscularis, Inflammation | 3 |
Muscularis, Necrosis | 3 |
Serosa, Fibrosis | 4 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 3| 7| 3| 2| 3| 6| 3| 2| 3| 3| 3| |
| 9| 9| 0| 9| 4| 9| 9| 9| 9| 4| 9| 9| 9| 9| 0| 9| 0| 9| 0| 3| 0| 9| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + A + A + + + + A + + + + + M + + + M + + + + +| 37 |
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + A + + + + + + + + + + + + + + + + + + + +| 43 |
Parasite Metazoan | | 1 1.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + A + + + + + + + + + + + + + + A + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 2 1 | 5 1.4|
Clear Cell Focus | 2 2 1 1 2 3 | 7 1.7|
Eosinophilic Focus | 1 2 2 2 | 8 2.1|
Hepatodiaphragmatic Nodule | 2 | 1 2.0|
Mineralization | 2 | 1 2.0|
Necrosis | 3 4 2 3 | 10 2.4|
Hepatocyte, Necrosis | 1 | 3 1.3|
Hepatocyte, Syncytial Alteration | 1 3 1 2 1 | 8 1.4|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 2 | 4 1.8|
Vein, Thrombosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular | 1 1 1 1 1 1 1 1 | 17 1.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
Mineralization | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 2 1 2 1 2 3 1 2 1 1 3 | 29 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 3| 7| 3| 2| 3| 6| 3| 2| 3| 3| 3| |
| 9| 9| 0| 9| 4| 9| 9| 9| 9| 4| 9| 9| 9| 9| 0| 9| 0| 9| 0| 3| 0| 9| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Degeneration | 1 | 1 1.0|
Hyperplasia | 1 2 1 2 1 2 | 9 1.7|
Capsule, Hyperplasia | 1 1 1 1 2 1 2 1 1 1 1 2 2 1 | 20 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Degeneration | 2 | 1 2.0|
Hyperplasia | 2 1 | 2 1.5|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Degeneration | | 1 1.0|
Hyperplasia | 1 2 2 1 1 | 8 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + + + + M M + + M + + + + M M + + M + M| 28 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + M + + + + M + + + + + M + M + + + + + + +| 45 |
Pars Distalis, Cyst | 1 | 2 1.0|
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | | 1 1.0|
Follicular Cell, Hyperplasia | 1 3 1 3 1 2 1 1 2 1 3 2| 29 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 | 1 2.0|
Bilateral, Fibrosis | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Cyst | 2 | 1 2.0|
Degeneration | 2 4 2 4 2 | 9 2.4|
Fibrosis | 3 | 1 3.0|
Hyperplasia | 2 | 1 2.0|
Infiltration Cellular | 2 2 1 1 2| 6 1.5|
Inflammation | 4 2 2 1 3 2 1 | 11 2.5|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular | 1 | 1 1.0|
Inflammation | 2 | 5 1.4|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 3| 7| 3| 2| 3| 6| 3| 2| 3| 3| 3| |
| 9| 9| 0| 9| 4| 9| 9| 9| 9| 4| 9| 9| 9| 9| 0| 9| 0| 9| 0| 3| 0| 9| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Degeneration | 3 2 3 2 2 2 2 2 | 16 2.0|
Inflammation | | 2 3.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tunic, Fibrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia | 3 2 2 3 | 9 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + | 11 |
Lumbar, Congestion | | 1 2.0|
Lumbar, Hyperplasia | 3 | 4 2.8|
Lumbar, Inflammation | 2 | 2 1.5|
Renal, Congestion | | 2 3.0|
Renal, Hyperplasia | | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M M + + + M + + M M + + M + M M + + + + + +| 27 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Congestion | | 1 3.0|
Hyperplasia | 4 2| 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M + + M + M M + + M M M M M + M M + + + M +| 27 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 2 | 2 2.5|
Lymphoid Follicle, Atrophy | | 1 3.0|
Lymphoid Follicle, Hyperplasia | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + M + M + + + + + + + M + + + + + + + + + + M M| 39 |
Atrophy | 3 3 2 4 3 2 3 4 3 2 | 20 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + M + M M M M M M M M M M M M M M M M M M| 3 |
Atrophy | 4 | 2 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 4 2.8|
Ulcer | | 2 3.5|
Prepuce, Degeneration | 3 | 1 3.0|
Prepuce, Hyperplasia, Lymphoid | | 1 4.0|
Prepuce, Inflammation | 4 | 2 4.0|
Prepuce, Ulcer | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 3| 7| 3| 2| 3| 6| 3| 2| 3| 3| 3| |
| 9| 9| 0| 9| 4| 9| 9| 9| 9| 4| 9| 9| 9| 9| 0| 9| 0| 9| 0| 3| 0| 9| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1| 19 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Foreign Body | 2 | 1 2.0|
Infiltration Cellular | 1 1 1 2 | 4 1.3|
Glands, Degeneration | | 3 1.7|
Glands, Inflammation | 2 | 2 1.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
Thrombosis | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 2 1.5|
Alveolar Epithelium, Metaplasia | | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 3 1 | 4 2.0|
Polyp, Inflammatory | 2 | 2 2.0|
Nasolacrimal Duct, Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 5 3.6|
Nephropathy | 1 1 2 1 1 1 1 1 1 1 3 1 3 1 1 1 2 1 1 1 1| 40 1.4|
Cortex, Cyst | 2 1 | 5 1.4|
Papilla, Inflammation | 2 | 3 1.3|
Papilla, Necrosis | | 1 3.0|
Pelvis, Dilatation | | 1 2.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 3| 7| 3| 2| 3| 6| 3| 2| 3| 3| 3| |
| 9| 9| 0| 9| 4| 9| 9| 9| 9| 4| 9| 9| 9| 9| 0| 9| 0| 9| 0| 3| 0| 9| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ureter | | 2 |
Degeneration | | 1 2.0|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Calculus Micro Observation Only | 2| 2 3.0|
Infiltration Cellular | 2 | 1 2.0|
Inflammation | 3 2 1 2 | 6 2.3|
Muscularis, Inflammation | | 1 3.0|
Muscularis, Necrosis | | 1 3.0|
Serosa, Fibrosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 2| 3| 2| 1| 6| 8| 3| 3| 0| 3| 2| 2| 6| 5| 2| 3| 2| 7| 2| 3| 2| 3| 3| 3|
| 9| 9| 0| 9| 8| 5| 2| 0| 0| 8| 0| 9| 9| 9| 9| 9| 0| 9| 9| 0| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A M + + + + + + A + + + + A + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + M + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + A + + + + A + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + A + + + + + + + + + + + + A + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + A + + + + + + + + + + + + A + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + A + + + + + + + A + + + + A + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | 2 |
Clear Cell Focus | 1 2 |
Eosinophilic Focus | 2 3 2 1 2 |
Fibrosis | |
Hemorrhage | 2 |
Mixed Cell Focus | |
Necrosis | 2 3 1 2 |
Thrombosis | |
Hepatocyte, Hyperplasia | 4 |
Hepatocyte, Hypertrophy | 2 1 1 1 1 1 1 1 1|
Hepatocyte, Necrosis | 2 1 1 1 3 1 |
Hepatocyte, Syncytial Alteration | 1 1 1 1 1 2 1 1 1 2 1 2 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 2 |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + + + + + + + + + + M + + + + +|
Acinus, Hyperplasia | |
Duct, Degeneration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 1 1 2 1 2 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + A + + + + + + + + + + + + A + + + + +|
Cyst | |
Epithelium, Hyperplasia | |
Serosa, Inflammation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Tongue | + |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + M + + + + + M|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 2 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 2| 3| 2| 1| 6| 8| 3| 3| 0| 3| 2| 2| 6| 5| 2| 3| 2| 7| 2| 3| 2| 3| 3| 3|
| 9| 9| 0| 9| 8| 5| 2| 0| 0| 8| 0| 9| 9| 9| 9| 9| 0| 9| 9| 0| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia | 2 |
Capsule, Hyperplasia | 1 1 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M M M M + + M + M + + M M M + + M M M M M M M + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + M + + + M +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 1 2 2 1 1 2 2 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Fat, Necrosis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Degeneration | 2 3 3 2 |
Infiltration Cellular | 1 |
Inflammation | 4 4 2 3 1 2 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 1 |
Inflammation | 1 3 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Degeneration | 1 3 3 2 2 2 3 2 2 3 2 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Mineralization | |
Germinal Epithelium, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 1 |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Hyperplasia | 3 2 |
Lumbar, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M M + + + + M M M M M M + + + M + + + M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + M + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 2| 3| 2| 1| 6| 8| 3| 3| 0| 3| 2| 2| 6| 5| 2| 3| 2| 7| 2| 3| 2| 3| 3| 3|
| 9| 9| 0| 9| 8| 5| 2| 0| 0| 8| 0| 9| 9| 9| 9| 9| 0| 9| 9| 0| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + A + + + + +|
Atrophy | |
Congestion | |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + M M + M + + M + + + M M + + M + M M M M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + M + + + + +|
Lymphoid Follicle, Atrophy | |
__________________________________________________________________________|
Thymus | M + M + + M M + + + M + + + A M + + + M + + + + +|
Atrophy | 3 4 3 4 3 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M + M M M M M M M M M M + M M M M M|
Atrophy | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Degeneration | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Glands, Degeneration | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 |
Alveolar Epithelium, Hyperplasia | 1 1 |
Alveolar Epithelium, Metaplasia | 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | |
Inflammation | |
Nasolacrimal Duct, Inflammation | 2 |
Respiratory Epithelium, Inflammation | |
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Cyst | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 6| 5| 7| 7| 7| 4| 7|
DAY ON TEST | 5| 2| 3| 2| 1| 6| 8| 3| 3| 0| 3| 2| 2| 6| 5| 2| 3| 2| 7| 2| 3| 2| 3| 3| 3|
| 9| 9| 0| 9| 8| 5| 2| 0| 0| 8| 0| 9| 9| 9| 9| 9| 0| 9| 9| 0| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Glands, Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Cortex, Cyst | 1 1 |
Papilla, Inflammation | 2 3 |
Pelvis, Dilatation | 2 2|
__________________________________________________________________________|
Ureter | + |
Degeneration | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +|
Calculus Micro Observation Only | 2 |
Infiltration Cellular | 2 |
Inflammation | 3 2 3 4 3 |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 1| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 7| 2| 3| 2| 3| 3| 2| 7| 0| 2| 3| 6| 1| 8| 3| 3| 2| 3| 3| 3| 4| 5| 2| 3| 3| |
| 9| 9| 2| 5| 0| 0| 9| 9| 7| 9| 0| 0| 8| 0| 0| 0| 9| 0| 0| 0| 7| 9| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
750 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + M + + + + + A + + + M A A + + + + M + A + + + +| 38 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + A + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + M A + + + + + + A + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + A + + + +| 45 |
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + M A + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + M + + + + M A + + + + + + A + + + +| 41 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Basophilic Focus | 1 1 2 | 4 1.5|
Clear Cell Focus | 1 | 3 1.3|
Eosinophilic Focus | 2 2 2 3 1 1 2 | 12 1.9|
Fibrosis | 3 | 1 3.0|
Hemorrhage | 4 | 2 3.0|
Mixed Cell Focus | 1 | 1 1.0|
Necrosis | 2 1 3 4 1 2 | 10 2.1|
Thrombosis | 2 | 1 2.0|
Hepatocyte, Hyperplasia | | 1 4.0|
Hepatocyte, Hypertrophy | 1 1 1 1 1 1 1 1 | 17 1.1|
Hepatocyte, Necrosis | 3 1 3 2| 10 1.8|
Hepatocyte, Syncytial Alteration | 1 1 1 1 1 1 1 1 1 1 | 23 1.1|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 3 1.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Hyperplasia | 1 | 1 1.0|
Duct, Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular | 2 1 1 1 1 1 1 1 1 1| 20 1.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
Cyst | 1 | 1 1.0|
Epithelium, Hyperplasia | 1 | 1 1.0|
Serosa, Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 1| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 7| 2| 3| 2| 3| 3| 2| 7| 0| 2| 3| 6| 1| 8| 3| 3| 2| 3| 3| 3| 4| 5| 2| 3| 3| |
| 9| 9| 2| 5| 0| 0| 9| 9| 7| 9| 0| 0| 8| 0| 0| 0| 9| 0| 0| 0| 7| 9| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
750 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 1 1 3 2 1 3 3 2 2 2 1| 25 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 1.0|
Hyperplasia | 1 2 1 | 4 1.5|
Capsule, Hyperplasia | 1 2 1 1 1 2 1 2 | 17 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + M + + M M + + + + + M M M + + M + M +| 25 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 2 1 1 1 2 4 3 1 1 2 3 3 1 2 3| 32 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 2 |
Fat, Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration | 4 3 | 6 2.8|
Infiltration Cellular | 3 2 2 | 4 2.0|
Inflammation | 2 4 3 2 2 3| 13 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular | 2 | 2 1.5|
Inflammation | 3 1 1 | 6 2.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Degeneration | 3 2 2 1 2 2 2 2 2| 22 2.1|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Mineralization | 2 | 1 2.0|
Germinal Epithelium, Degeneration | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
__________________________________________________________________________________________________________________________________
| 1| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 7| 2| 3| 2| 3| 3| 2| 7| 0| 2| 3| 6| 1| 8| 3| 3| 2| 3| 3| 3| 4| 5| 2| 3| 3| |
| 9| 9| 2| 5| 0| 0| 9| 9| 7| 9| 0| 0| 8| 0| 0| 0| 9| 0| 0| 0| 7| 9| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
750 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation, Hemosiderin | | 1 1.0|
Myeloid Cell, Hyperplasia | 3 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node | | 3 |
Lumbar, Hyperplasia | | 2 2.5|
Lumbar, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + + + M M M + M + M + + + + M M M M M + +| 27 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + M + + + + + + + + + + M + + + + + +| 44 |
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 3 | 1 3.0|
Congestion | 2 2 | 2 2.0|
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M + + + M M M M + + + M + + M M + M + + + +| 25 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoid Follicle, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + M + M M + M + + M + + + M + M + +| 34 |
Atrophy | 3 3 4 3 3 | 11 3.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M M M M M M M M M M M M M M M M M M M M M M| 3 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 3 | 3 2.7|
Ulcer | 1 3 | 3 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vertebra, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 | 19 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05210-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 04/24/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:49:38
____________