TDMS Study 05210-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: I. I. T. Research Inst ETHYLBENZENE DATE: 04/23/96
EXPERIMENT: 05210 TEST: 04 TIME: 10:28:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-75193 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56393
PATHOLOGIST: TOMLINSON, MIK CAS: 100-41-4
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: I. I. T. Research Inst ETHYLBENZENE DATE: 04/23/96
EXPERIMENT: 05210 TEST: 04 TIME: 10:28:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-75193 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56393
PATHOLOGIST: TOMLINSON, MIK CAS: 100-41-4
ETHYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 1 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 29 202 289 467 519 522 544 555 568 584 |
| 585 587 610 610 616 639 642 652 698 723 |
| 725 |
| CENSORED DEATHS |
| 24 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 75 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 360 380 485 514 531 536 578 580 594 640 |
| 641 677 709 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 480 524 563 570 574 579 579 588 602 642 |
| 680 683 688 691 696 705 722 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 750 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 1 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 259 418 430 480 520 565 582 607 618 632 |
| 647 659 659 660 669 679 679 708 725 |
| CENSORED DEATHS |
| 179 |
| |
==================================================================================
ETHYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.0 98.0 95.9 93.9 93.9 91.8 85.7 75.5 63.3 57.1 |
| | |
| | |
|75 PPM | 100.0 100.0 100.0 98.0 96.0 94.0 88.0 82.0 78.0 72.0 |
| | |
| | |
|250 PPM| 100.0 100.0 100.0 100.0 100.0 98.0 96.0 82.0 80.0 64.0 |
| | |
| | |
|750 PPM| 100.0 100.0 98.0 98.0 95.9 91.8 89.8 85.7 71.4 61.2 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 75 PPM 250 PPM 750 P|M
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 57.1% 72.0% 64.0% 61.2% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.975 P=0.177N P=0.459N P=0.673N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 541.2 567.9 627.2 589.3 |
|NATURAL DEATHS (C) | (37.6) (29.5) (17.4) (27.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 636.0 683.9 692.4 664.9 |
|(STANDARD ERROR) | (23.9) (13.1) ( 9.3) (17.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ETHYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 1 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 423 501 565 578 592 597 618 629 639 688 |
| 694 715 718 725 |
| CENSORED DEATHS |
| 215 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 75 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 300 495 562 584 590 602 639 642 697 697 |
| 703 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 1 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 437 446 659 682 694 701 705 707 708 |
| CENSORED DEATHS |
| 86 |
| |
==================================================================================
ETHYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 750 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 7 169 568 612 614 666 681 711 712 712 |
| 713 718 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.0 98.0 95.9 87.8 81.6 71.4 |
| | |
| | |
|75 PPM | 100.0 100.0 100.0 98.0 98.0 98.0 96.0 88.0 84.0 76.0 |
| | |
| | |
|250 PPM| 100.0 100.0 100.0 100.0 100.0 95.9 95.9 95.9 93.9 81.6 |
| | |
| | |
|750 PPM| 98.0 96.0 96.0 96.0 96.0 96.0 96.0 94.0 90.0 74.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 75 PPM 250 PPM 750 P|M
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 71.4% 76.0% 81.6% 74.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.995N P=0.762N P=0.304N P=0.886N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 620.1 602.8 637.7 585.1 |
|NATURAL DEATHS (C) | (23.4) (33.8) (37.4) (63.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 688.9 699.5 700.5 692.3 |
|(STANDARD ERROR) | (13.5) (11.0) (15.0) (18.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ETHYLBENZENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
75 PPM = 2
250 PPM = 3
750 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 4 2 3
|
| 1 1 4 2 2 4 3 3
| 1 1 2 4 4 2 3 3
95 +
| 1 4 1 42 2 33
| 2 2
| 1 4 1
90 + 422 433
|
P | 1 21 4 24
E | 1 1 33 4
R 85 +
C | 1 123 234 4
E | 23 2
N | 1 1 4 4
T 80 + 434 3
|
S | 24 4 2
U | 233 2
R 75 + 1 1
V | 2 2
I | 33 2 2
V | 44
A 70 + 1 1 44 33
L |
| 3 3
|
65 + 1 1 4 4
| 1 1 4 3 3
|
| 1 1 4
60 +
|
| 1 1
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
ETHYLBENZENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
75 PPM = 2
250 PPM = 3
750 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 14 2 1 3
|
| 4 4 2 1 33 21
| 4 3 21 14 3
P 95 +
E | 1412 4 3 3
R | 2 2
C | 1 1 3 3
E 90 + 11 4 4 33
N |
T | 1 1 2 4 4
| 11 4 4
S 85 +
U | 1 1 233
R |
V | 1 1 3 3
I 80 + 112
V |
A | 12412
L | 42 2
75 +
| 11 4
|
| 1 1
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 13 obs hidden.