TDMS Study 05210-03 Pathology Tables
NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 Facility: I. I. T. Research Institute Chemical CAS #: 100-41-4 Lock Date: 10/02/92 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3| | 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + A + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + A + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + A + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + A + M + + + + A A + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + A + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + A + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Lymphoma Malignant | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Lymphoma Malignant | | Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X X X X| Pars Distalis, Adenoma, Multiple | X | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3| | 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Leukemia Mononuclear | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + A + + + + + + M + + + + + +| C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + M + + + + + + + + + + M + + + +| Adenoma | X X | Carcinoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node | + + | Inguinal, Lymphoma Malignant | | Lumbar, Histiocytic Sarcoma | X | Lumbar, Leukemia Mononuclear | X | Lumbar, Lymphoma Malignant | | Renal, Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + + + + + + + + M M + + + + M M + M M + +| Leukemia Mononuclear | X | Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + M + + + + + + + +| Leukemia Mononuclear | X X X X X | Lymphoma Malignant | | __________________________________________________________________________| Spleen | + + + + + + + + + + + A + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3| | 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Adenoma | X | Carcinoma | X | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X | Fibroadenoma, Multiple | X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Subcutaneous Tissue, Fibroma | X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | X | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + M + + + M + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + +| External Ear, Sarcoma | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Zymbal's Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + A + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3| | 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3| | DAY ON TEST | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1| | | 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | CONTROL | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + A + + A + + + + + + A + A + + + + + + +| 44 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| 47 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + A + A + + + A + + A| 41 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | A + + + + A + + A + + + + A + A + A + + + + + + A| 41 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X X | 13 | __________________________________________________________________________|____________| Mesentery | + + + + + + | 7 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | Lymphoma Malignant | X| 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | Lymphoma Malignant | X| 1 | Pheochromocytoma Benign | | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3| | DAY ON TEST | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1| | | 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | CONTROL | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 3 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X | 27 | Pars Distalis, Adenoma, Multiple | X X | 3 | Pars Distalis, Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | C-Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 47 | Adenoma | | 2 | Carcinoma | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Polyp Stromal | | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X | 8 | __________________________________________________________________________|____________| Lymph Node | +| 3 | Inguinal, Lymphoma Malignant | X| 1 | Lumbar, Histiocytic Sarcoma | | 1 | Lumbar, Leukemia Mononuclear | | 1 | Lumbar, Lymphoma Malignant | X| 1 | Renal, Lymphoma Malignant | X| 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + M M + + + M + + M + + + M M + + + + +| 37 | Leukemia Mononuclear | X | 2 | Lymphoma Malignant | X| 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 4 | Lymphoma Malignant | X| 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3| | DAY ON TEST | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1| | | 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | CONTROL | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 7 | Lymphoma Malignant | X| 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X | 13 | __________________________________________________________________________|____________| Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 | Adenoma | | 1 | Carcinoma | X | 2 | Carcinoma, Multiple | | 1 | Fibroadenoma | X X X X X X X | 13 | Fibroadenoma, Multiple | X X X | 6 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Subcutaneous Tissue, Fibroma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | | 1 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + M + + + M + + + + + + + + + + + + + + + M| 45 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 1 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X | 9 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3| | DAY ON TEST | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1| | | 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | CONTROL | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Ear | + | 3 | External Ear, Sarcoma | X | 1 | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 2 | Leukemia Mononuclear | X X X X X X | 13 | Lymphoma Malignant | X| 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5| DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0| | 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + A + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + A| Leukemia Mononuclear | X X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | X| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Mesentery | + | Leukemia Mononuclear | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Pheochromocytoma Malignant | | Bilateral, Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + + + + + + + M + + M + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + I| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X | Pars Distalis, Adenoma, Multiple | | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5| DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0| | 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Carcinoma | | Pars Distalis, Leukemia Mononuclear | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X | Endometrium, Sarcoma Stromal | X | __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node | + + | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + M M + + + + M + + + + + + M M + + + + M| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + M| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | X| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Thymus | + + M + M + + + + + + + + + + + + + + + + + + + M| Leukemia Mononuclear | X X | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5| DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0| | 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Carcinoma | X | Fibroadenoma | X X X X X X | Fibroadenoma, Multiple | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Lipoma | | Subcutaneous Tissue, Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + M + M + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma, | | Multiple | | Leukemia Granulocytic | X| Leukemia Mononuclear | X X X X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | Mediastinum, Sarcoma, Metastatic, | | Uncertain Primary Site | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Glands, Adenoma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5| DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0| | 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | X| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | X| Leukemia Mononuclear | X X X X X X X X X | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3| | | 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 75 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Granulocytic | | 1 | Leukemia Mononuclear | X X X X X X X X X| 18 | __________________________________________________________________________|____________| Mesentery | + + +| 4 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 8 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Leukemia Mononuclear | X X X X X X| 11 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 9 | Pheochromocytoma Malignant | X | 1 | Bilateral, Pheochromocytoma Benign | X X | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3| | | 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 75 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 2 | Pars Distalis, Adenoma | X X X X X X X X | 17 | Pars Distalis, Adenoma, Multiple | X X X X X X | 6 | Pars Distalis, Carcinoma | X | 1 | Pars Distalis, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, C-Cell, Adenoma | X | 1 | C-Cell, Adenoma | X X X | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 5 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Polyp Stromal | X X | 3 | Endometrium, Sarcoma Stromal | | 1 | __________________________________________________________________________|____________| Vagina | + + | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 9 | __________________________________________________________________________|____________| Lymph Node | + | 3 | Pancreatic, Leukemia Mononuclear | X | 2 | Renal, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + M + + + M + M M M + M M + + + M + + M + +| 34 | Leukemia Mononuclear | X | 5 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 10 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3| | | 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 75 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Granulocytic | | 1 | Leukemia Mononuclear | X X X X X X X X X| 18 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X | 3 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 2 | Carcinoma | | 1 | Fibroadenoma | X X X X X X X X X X X X| 18 | Fibroadenoma, Multiple | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Lipoma | X | 1 | Subcutaneous Tissue, Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pituitary | | | Gland | X | 1 | Leukemia Mononuclear | X X X | 4 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + M + + + + + + + + + M + + + + M + M + M +| 43 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Leukemia Granulocytic | | 1 | Leukemia Mononuclear | X X X X X | 9 | Sarcoma, Metastatic, Uncertain | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| | DAY ON TEST | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3| | | 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 75 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Primary Site | | 1 | Mediastinum, Sarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | Glands, Adenoma | X | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 9 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | Leukemia Granulocytic | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Granulocytic | | 1 | Leukemia Mononuclear | X X X X X X X X X| 18 | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3| | 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 250 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + A + + +| Polyp Adenomatous | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + A A + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + A + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + A + + +| Leukemia Mononuclear | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Mesentery | + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | Leukemia Mononuclear | X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Malignant | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3| | 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 250 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X X | Pars Distalis, Adenoma, Multiple | X | Pars Distalis, Carcinoma | X| Pars Distalis, Leukemia Mononuclear | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | C-Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| Carcinoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X | Bilateral, Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node | + + | Leukemia Mononuclear | | Inguinal, Leukemia Mononuclear | | Lumbar, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | + M + + M + + + + + M + M + M + + + M + + M + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Rhabdomyosarcoma, Metastatic, | | Uncertain Primary Site | X | __________________________________________________________________________| Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3| | 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 250 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +| Leukemia Mononuclear | X X | Rhabdomyosarcoma, Metastatic, | | Uncertain Primary Site | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| Carcinoma | X X | Fibroadenoma | X X X X X X | Fibroadenoma, Multiple | X X X| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + M + + + + + + + + + M + + + + + M + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Carcinoma, Metastatic, Mammary Gland | X | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3| | 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 250 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| | DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8| | | 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 250 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 | Polyp Adenomatous | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + A| 47 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X| 16 | __________________________________________________________________________|____________| Mesentery | + | 6 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 4 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 5 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Carcinoma | X | 1 | Leukemia Mononuclear | X X X X X X | 9 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| | DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8| | | 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 250 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X | 6 | Pheochromocytoma Malignant | | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + M + M M M + + + + M + + M + + + + +| 42 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 4 | Pars Distalis, Adenoma | X X X X X X X X X X X X X | 24 | Pars Distalis, Adenoma, Multiple | | 1 | Pars Distalis, Carcinoma | | 1 | Pars Distalis, Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | C-Cell, Adenoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 | Carcinoma | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 6 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Polyp Stromal | X X X | 4 | Bilateral, Polyp Stromal | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X| 10 | __________________________________________________________________________|____________| Lymph Node | + + | 4 | Leukemia Mononuclear | X | 1 | Inguinal, Leukemia Mononuclear | X | 1 | Lumbar, Leukemia Mononuclear | X | 1 | Pancreatic, Leukemia Mononuclear | | 2 | Renal, Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + + + + + M + + + + + M + + + +| 41 | Leukemia Mononuclear | X X X X X | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| | DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8| | | 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 250 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 7 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 10 | Rhabdomyosarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X X| 16 | __________________________________________________________________________|____________| Thymus | + M + + + + + + + + M + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X X | 5 | Rhabdomyosarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma | | 2 | Fibroadenoma | X X X X X X X X X X X X | 18 | Fibroadenoma, Multiple | | 3 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma | | 1 | Squamous Cell Papilloma | X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | M + + + + + + + + + M + + + + + + + + + + + + + M| 44 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 1 | Carcinoma, Metastatic, Mammary Gland | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| | DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8| | | 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 250 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X X X X| 13 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 4 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 9 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X| 16 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 6| 7| 4| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| DAY ON TEST | 2| 2| 4| 3| 3| 6| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 3| 2| | 9| 3| 8| 6| 6| 2| 5| 4| 6| 6| 5| 6| 1| 6| 5| 6| 9| 4| 4| 6| 7| 6| 7| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 750 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Mesentery | + + + + + | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tongue | + | Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X | Pars Distalis, Adenoma, Multiple | | Pars Distalis, Leukemia Mononuclear | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 6| 7| 4| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| DAY ON TEST | 2| 2| 4| 3| 3| 6| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 3| 2| | 9| 3| 8| 6| 6| 2| 5| 4| 6| 6| 5| 6| 1| 6| 5| 6| 9| 4| 4| 6| 7| 6| 7| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 750 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X | C-Cell, Adenoma | X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + M + + + + + + + M + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node | + + + | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + M + + + + M + + + + + M + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + M + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X| Fibroadenoma, Multiple | X X X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Sebaceous Gland, Carcinoma | | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 6| 7| 4| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| DAY ON TEST | 2| 2| 4| 3| 3| 6| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 3| 2| | 9| 3| 8| 6| 6| 2| 5| 4| 6| 6| 5| 6| 1| 6| 5| 6| 9| 4| 4| 6| 7| 6| 7| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 750 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + M + + + + M M + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3| | | 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 750 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A A + + + + + + + + + + + + + + + + + A + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X | 11 | __________________________________________________________________________|____________| Mesentery | + +| 7 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Tongue | | 1 | Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 5 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 6 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 5 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3| | | 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 750 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Leukemia Mononuclear | X X | 4 | Pars Distalis, Adenoma | X X X X X X X X X| 24 | Pars Distalis, Adenoma, Multiple | X X X | 3 | Pars Distalis, Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | C-Cell, Adenoma | X X | 3 | C-Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | Polyp Stromal | X | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 7 | __________________________________________________________________________|____________| Lymph Node | + | 4 | Renal, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + + + + M + + + + M + + M + M M + + + M + + M| 38 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 5 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 5 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X | 7 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X | 11 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3| | | 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 750 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | | 1 | Carcinoma, Multiple | | 1 | Fibroadenoma | X X X X X X X X | 15 | Fibroadenoma, Multiple | X | 6 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 2 | Sebaceous Gland, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 4 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + M + + + + + + + + + + + +| 45 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X | 10 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X | 9 | Renal Tubule, Adenoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| | DAY ON TEST | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3| | | 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 750 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5| DAY ON TEST | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2| | 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | M + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Sarcoma | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + A + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + A + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + + + A + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | Osteosarcoma, Metastatic, Spleen | X | __________________________________________________________________________| Mesentery | + | Sarcoma | | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Osteosarcoma, Metastatic, Spleen | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Osteosarcoma, Metastatic, Spleen | X | Pheochromocytoma Benign | X | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5| DAY ON TEST | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2| | 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Bilateral, Pheochromocytoma Benign | X X X X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + M + + + + + + + + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X| Pars Distalis, Adenoma, Multiple | X X | Pars Distalis, Leukemia Mononuclear | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X | C-Cell, Carcinoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Leukemia Mononuclear | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X | Interstitial Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + M| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + | Deep Cervical, Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | X | Lumbar, Leukemia Mononuclear | X X | Pancreatic, Leukemia Mononuclear | X X | Renal, Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5| DAY ON TEST | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2| | 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Thoracic, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + M M| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | M + + + M + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | Osteosarcoma | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + M + + + + M M| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + M + + + + + M + + + + + + + + + + + + + +| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X X| Leukemia Mononuclear | X X X | Squamous Cell Papilloma | | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Leukemia | | Mononuclear | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Skeletal Muscle | + | Osteosarcoma, Metastatic, Spleen | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + M + + + M + + + + + + + + + + + + + M + M| Leukemia Mononuclear | X X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | X | Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X X X X X X X X | Osteosarcoma, Metastatic, Spleen | X | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5| DAY ON TEST | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2| | 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Mediastinum, Osteosarcoma, | | Metastatic, Spleen | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + M| Leukemia Mononuclear | X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Lipoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5| | DAY ON TEST | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8| | | 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Sarcoma | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + A + + + + +| 46 | Leukemia Mononuclear | X X X| 5 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + + + A A + + + + + A + + A + +| 42 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + A + + A + +| 45 | Leukemia Mononuclear | X X X | 4 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| 27 | Osteosarcoma, Metastatic, Spleen | | 1 | __________________________________________________________________________|____________| Mesentery | + + + | 4 | Sarcoma | X | 1 | __________________________________________________________________________|____________| Oral Mucosa | + | 2 | Pharyngeal, Squamous Cell Papilloma | X | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 7 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 5 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 5 | __________________________________________________________________________|____________| Tongue | + | 1 | Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X| 18 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5| | DAY ON TEST | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8| | | 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Osteosarcoma, Metastatic, Spleen | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 10 | Osteosarcoma, Metastatic, Spleen | | 1 | Pheochromocytoma Benign | X X X X X| 6 | Bilateral, Pheochromocytoma Benign | | 7 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 3 | Carcinoma | X | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + M + + +| 45 | __________________________________________________________________________|____________| Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X| 5 | Pars Distalis, Adenoma | X X X X X X X X X X | 23 | Pars Distalis, Adenoma, Multiple | | 2 | Pars Distalis, Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Bilateral, C-Cell, Adenoma | X X | 2 | C-Cell, Adenoma | | 1 | C-Cell, Carcinoma | X | 2 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Adenoma | X | 3 | Leukemia Mononuclear | X X X| 4 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X | 27 | Interstitial Cell, Adenoma | X X X X X| 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5| | DAY ON TEST | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8| | | 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X X| 17 | __________________________________________________________________________|____________| Lymph Node | + + + | 9 | Deep Cervical, Leukemia Mononuclear | | 1 | Iliac, Leukemia Mononuclear | | 1 | Lumbar, Leukemia Mononuclear | | 2 | Pancreatic, Leukemia Mononuclear | X X | 4 | Renal, Leukemia Mononuclear | X | 4 | Thoracic, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + M M + + M + + + + + + + + + M + +| 44 | Leukemia Mononuclear | X X X X X X X| 15 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X X X X X X X X| 14 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X| 16 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + M + + + + + + + + + + + + M + + + + +| 48 | Leukemia Mononuclear | X X X X X X X X| 17 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| 27 | Osteosarcoma | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| 46 | Leukemia Mononuclear | X X X X X| 11 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + M + + + + + + M + + +| 46 | Fibroadenoma | X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X | 3 | Leukemia Mononuclear | | 3 | Squamous Cell Papilloma | X X | 2 | Subcutaneous Tissue, Fibroma | X | 1 | Subcutaneous Tissue, Leukemia | | | Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5| | DAY ON TEST | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8| | | 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | Osteosarcoma, Metastatic, Spleen | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X| 4 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + M + M M + M + + + + + + M + M| 40 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X | 2 | Alveolar/Bronchiolar Carcinoma | | 1 | Carcinoma, Metastatic, Thyroid Gland | X | 2 | Leukemia Mononuclear | X X X X X X X X X X| 18 | Osteosarcoma, Metastatic, Spleen | | 1 | Mediastinum, Osteosarcoma, | | | Metastatic, Spleen | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X| 5 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | +| 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X| 20 | Lipoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Leukemia Mononuclear | X X X| 6 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| 27 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6| DAY ON TEST | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9| | 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + A + + + + A + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + A + + + + + + A + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + A A + + A + + + A + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Ileum | + + A + + + A + + + + + + + A + + + + + + + + A +| Leukemia Mononuclear | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X X | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X| __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| Duct, Carcinoma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + M + + +| _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6| DAY ON TEST | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9| | 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Adenoma | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X X X | Pars Distalis, Adenoma, Multiple | X | Pars Distalis, Leukemia Mononuclear | X| __________________________________________________________________________| Thyroid Gland | + + A + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Seminal Vesicle | + + A + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + A + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X| __________________________________________________________________________| Lymph Node | + + + + +| Pancreatic, Leukemia Mononuclear | X X| Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | + + M + M M M + M + + M + + + M + M + M + + + M +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X| __________________________________________________________________________| Lymph Node, Mandibular | + + A + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6| DAY ON TEST | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9| | 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Lymph Node, Mediastinal | + + + M + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X| __________________________________________________________________________| Thymus | + + + M + + + + M + + + + + + + + + + + + + + M +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + M + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X | Fibroadenoma, Multiple | X | Fibroma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Leukemia Mononuclear | | Squamous Cell Papilloma | X | Pinna, Schwannoma Benign | | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Skeletal Muscle | + | Histiocytic Sarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + A M + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Nose | + + A + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6| DAY ON TEST | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9| | 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Leukemia Mononuclear | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X| Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| Transitional Epithelium, Papilloma | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X| Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3| | DAY ON TEST | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5| | | 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + A + + + + + + + + + + + + + + + + + A| 44 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + A + + A + + A + A + + + + + + A| 39 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + A| 44 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Adenoma | X | 3 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X X | 26 | __________________________________________________________________________|____________| Mesentery | + + + | 5 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 4 | Duct, Carcinoma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 14 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 9 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X X X X X X | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3| | DAY ON TEST | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5| | | 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Bilateral, Pheochromocytoma Benign | X X | 3 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X | 4 | Carcinoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M + + + M + + + + + + + + + + + +| 46 | Adenoma | X | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 2 | Pars Distalis, Adenoma | X X X X X X X | 18 | Pars Distalis, Adenoma, Multiple | | 1 | Pars Distalis, Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Adenoma | X X X | 6 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + | 1 | Mesothelioma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Mesothelioma Malignant | X X | 2 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 4 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Mesothelioma Malignant | X X | 2 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X | 23 | Interstitial Cell, Adenoma | X X X X X X X | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3| | DAY ON TEST | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5| | | 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X X X X X | 15 | __________________________________________________________________________|____________| Lymph Node | + + + | 8 | Pancreatic, Leukemia Mononuclear | X | 3 | Renal, Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + M + + + + + M + + + M M + M + + + + + + +| 34 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X | 11 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 | Leukemia Mononuclear | X X X X X X | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X | 13 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X | 19 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X X | 26 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + M + + M + + + + + + + M| 44 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 | Fibroadenoma | X | 2 | Fibroadenoma, Multiple | | 1 | Fibroma | X X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X | 2 | Leukemia Mononuclear | X X | 2 | Squamous Cell Papilloma | | 1 | Pinna, Schwannoma Benign | X | 1 | Subcutaneous Tissue, Fibroma | X | 1 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Sarcoma | X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 47 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3| | DAY ON TEST | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5| | | 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Histiocytic Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + M + + + + + + + + + M + + + + + + M M| 44 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 1 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X | 20 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X | 16 | Renal Tubule, Adenoma | X X X | 3 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 3 | Transitional Epithelium, Papilloma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X X | 26 | Mesothelioma Malignant | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5| DAY ON TEST | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9| | 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 250 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + A + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + A +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X| __________________________________________________________________________| Mesentery | + | Lipoma | | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +| Leukemia Mononuclear | X X X X X X X| Pheochromocytoma Benign | X X X | Bilateral, Pheochromocytoma Benign | X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X | __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + M| _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5| DAY ON TEST | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9| | 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 250 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pars Distalis, Adenoma | X X X X X X X X| Pars Distalis, Adenoma, Multiple | X | Pars Distalis, Leukemia Mononuclear | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | C-Cell, Adenoma | X X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| Mesothelioma Malignant | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| __________________________________________________________________________| Lymph Node | + + + + + + +| Pancreatic, Leukemia Mononuclear | X X X| Renal, Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + + + + + + + + + M + + + + + + M M + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5| DAY ON TEST | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9| | 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 250 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thymus | + + M M + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Thymoma Benign | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + M +| Adenoma | | Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Keratoacanthoma | X | Leukemia Mononuclear | X X X X| Squamous Cell Papilloma | X | Pinna, Schwannoma Malignant | | Sebaceous Gland, Adenoma | | Subcutaneous Tissue, Fibroma | X X X | Subcutaneous Tissue, Myxoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Turbinate, Chondroma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Glioma Malignant | | Leukemia Mononuclear | X X X X| __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + M M + + + + + + + + + + + + + + M + + + M M M| Leukemia Mononuclear | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | X | Leukemia Mononuclear | X| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5| DAY ON TEST | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9| | 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 250 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Carcinoma | | __________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X| Renal Tubule, Adenoma | | Renal Tubule, Carcinoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X| Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6| | DAY ON TEST | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8| | | 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Leukemia Mononuclear | X X X | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + + + + + A + + + + + + A + + + + +| 46 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 6 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + A + + + A + + + + + A + + + + + +| 44 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + A A + + + + +| 45 | Leukemia Mononuclear | X X X | 6 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X | 32 | __________________________________________________________________________|____________| Mesentery | + +| 3 | Lipoma | X| 1 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X | 12 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 13 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 6 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X | 18 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X | 19 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X X X | 18 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6| | DAY ON TEST | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8| | | 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pheochromocytoma Benign | X X X | 6 | Bilateral, Pheochromocytoma Benign | | 3 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 4 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + + + + + + + + + + M + + + + + +| 46 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 10 | Pars Distalis, Adenoma | X X X X X X X X X X | 18 | Pars Distalis, Adenoma, Multiple | | 1 | Pars Distalis, Leukemia Mononuclear | X X X X | 6 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | C-Cell, Adenoma | X | 3 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 6 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | | 1 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 8 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 5 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 6 | Mesothelioma Malignant | X | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X| 32 | Interstitial Cell, Adenoma | X X X X X | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X | 25 | __________________________________________________________________________|____________| Lymph Node | + + | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6| | DAY ON TEST | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8| | | 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Pancreatic, Leukemia Mononuclear | | 3 | Renal, Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M M M + + + + + M + + + M + M + + + + + M +| 39 | Leukemia Mononuclear | X X X X X X X X X | 17 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X | 15 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 17 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X | 23 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X | 32 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + M + + + + + + + + + + + M +| 46 | Leukemia Mononuclear | X X X X X X | 11 | Thymoma Benign | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + + + M + + + + + + + + + + + + + + + +| 46 | Adenoma | X | 1 | Fibroadenoma | X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Adenoma | | 1 | Keratoacanthoma | X | 2 | Leukemia Mononuclear | X | 5 | Squamous Cell Papilloma | | 1 | Pinna, Schwannoma Malignant | X | 1 | Sebaceous Gland, Adenoma | X | 1 | Subcutaneous Tissue, Fibroma | | 3 | Subcutaneous Tissue, Myxoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Turbinate, Chondroma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Glioma Malignant | X | 1 | Leukemia Mononuclear | X X X X X X | 10 | __________________________________________________________________________|____________| Peripheral Nerve | + +| 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 55 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6| | DAY ON TEST | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8| | | 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spinal Cord | + + +| 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + M + + + + + M + + + + M +| 41 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X | 28 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X | 14 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leiomyosarcoma | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | +| 1 | Carcinoma | X| 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X | 26 | Renal Tubule, Adenoma | X X | 2 | Renal Tubule, Carcinoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 8 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X | 32 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 56 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5| DAY ON TEST | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8| | 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 750 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + A +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Cecum | + A + + + + + A A + + + + + + + A + + + + + + A +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + A A A + + A + + + + A + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Ileum | + A + + + + A A + + + A + + + + A + + + + + + A +| Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Oral Mucosa | | Pharyngeal, Squamous Cell Papilloma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +| Leukemia Mononuclear | X X| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X X | Bilateral, Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + M +| _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5| DAY ON TEST | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8| | 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 750 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X X| Pars Distalis, Adenoma | X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | C-Cell, Adenoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X | Bilateral, Adenoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Lymph Node | + + + + + + + +| Leukemia Mononuclear | X X | Lumbar, Leukemia Mononuclear | X X X| Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X X X X| __________________________________________________________________________| Lymph Node, Bronchial | + + M + + + + M + + M M M + + + M + M M + M M M +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Lymph Node, Mediastinal | + + + M + + + M + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5| DAY ON TEST | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8| | 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 750 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | + + + + + M + + + + M + M + + + + + + + + + + + +| Leukemia Mononuclear | X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | X | Keratoacanthoma | X | Leukemia Mononuclear | X X X X| Subcutaneous Tissue, Lipoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Sarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Glioma Malignant | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + M + M + + + M + + M + M + + + + + M M + + M| Leukemia Mononuclear | X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Leukemia Mononuclear | X X X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Renal Tubule, Adenoma | X X X | Renal Tubule, Carcinoma | X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 _____________________________________________________________________________________________________________________ | 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5| DAY ON TEST | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8| | 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 750 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Leukemia Mononuclear | X X X X X| _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5| | DAY ON TEST | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3| | | 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 750 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | A + + A + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | A A + A + + + + A + A + + A + + + + + + + + + + +| 39 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Intestine Small, Jejunum | A A A A + + A + A + A + + + A + + A + + + A + + +| 34 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | A A + A + + + + + + A + + A + + + A + + + A + + +| 37 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X | 9 | __________________________________________________________________________|____________| Mesentery | + | 3 | __________________________________________________________________________|____________| Oral Mucosa | + | 1 | Pharyngeal, Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 3 | Pheochromocytoma Malignant | X | 2 | Pheochromocytoma Benign | X X X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5| | DAY ON TEST | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3| | | 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 750 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Bilateral, Pheochromocytoma Benign | X | 3 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 4 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M + + + + + + + + + M + + + + + + +| 46 | __________________________________________________________________________|____________| Pituitary Gland | M M + + + + + + + + + + + + + + + M + + + + + + +| 45 | Leukemia Mononuclear | X | 3 | Pars Distalis, Adenoma | X X X X X X X X X | 18 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | C-Cell, Adenoma | X X | 2 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | Leukemia Mononuclear | X | 2 | Bilateral, Adenoma | X | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X| 40 | Interstitial Cell, Adenoma | X | 4 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 7 | __________________________________________________________________________|____________| Lymph Node | + + + + + + | 14 | Leukemia Mononuclear | | 2 | Lumbar, Leukemia Mononuclear | | 3 | Pancreatic, Leukemia Mononuclear | | 1 | Renal, Leukemia Mononuclear | X X | 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 62 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5| | DAY ON TEST | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3| | | 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 750 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Bronchial | M M M + + M M M M + + M + + M + M + + M + + + + +| 28 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 5 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 7 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X | 6 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 9 | __________________________________________________________________________|____________| Thymus | + + + + + M + + + M + + + + + + + + + + + + + + M| 44 | Leukemia Mononuclear | X | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Carcinoma | | 1 | Keratoacanthoma | X | 2 | Leukemia Mononuclear | | 4 | Subcutaneous Tissue, Lipoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Glioma Malignant | X | 1 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | M + + + + + + M + + + M + + + + + M M M + + + M +| 35 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 1 | Leukemia Mononuclear | X X X | 7 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 63 NTP Experiment-Test: 05210-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ETHYLBENZENE Date: 03/17/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:55:34 __________________________________________________________________________________________________________________________________ | 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5| | DAY ON TEST | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3| | | 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 750 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | Renal Tubule, Adenoma | X | 4 | Renal Tubule, Carcinoma | X | 3 | __________________________________________________________________________|____________| Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 64 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------