TDMS Study 05210-03 Pathology Tables
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:43
CORE STUDY
Facility: I. I. T. Research Institute
Chemical CAS #: 100-41-4
Lock Date: 10/02/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 7 14 8 6
Natural Death 12 5 8 8
Survivors
Terminal Sacrifice 30 31 34 35
Natural Death 1
Missing 1
Animals Examined Microscopically 50 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (47) (49) (48) (49)
Intestine Large, Rectum (49) (50) (47) (49)
Polyp Adenomatous 1 (2%)
Intestine Large, Cecum (44) (50) (47) (49)
Intestine Small, Duodenum (47) (48) (47) (48)
Intestine Small, Jejunum (41) (49) (47) (45)
Intestine Small, Ileum (41) (48) (47) (46)
Liver (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Mesentery (7) (4) (6) (7)
Oral Mucosa (1)
Pharyngeal, Squamous Cell Papilloma 1 (100%)
Pancreas (49) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Salivary Glands (50) (50) (50) (49)
Stomach, Forestomach (49) (50) (50) (49)
Stomach, Glandular (49) (49) (49) (49)
Tongue (1) (1)
Schwannoma Malignant 1 (100%)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (49)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Adrenal Medulla (50) (50) (50) (49)
Pheochromocytoma Malignant 1 (2%) 2 (4%)
Pheochromocytoma Benign 2 (4%)
Bilateral, Pheochromocytoma Benign 2 (4%)
Islets, Pancreatic (50) (50) (50) (49)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (49) (49) (50) (49)
Pars Distalis, Adenoma 27 (55%) 17 (35%) 24 (48%) 24 (49%)
Pars Distalis, Adenoma, Multiple 3 (6%) 6 (12%) 1 (2%) 3 (6%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Thyroid Gland (48) (50) (50) (49)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 2 (4%) 3 (6%) 2 (4%) 3 (6%)
C-Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (49) (48) (47)
Adenoma 2 (4%)
Carcinoma 1 (2%) 1 (2%)
Ovary (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Uterus (50) (50) (50) (49)
Polyp Stromal 2 (4%) 3 (6%) 4 (8%) 3 (6%)
Bilateral, Polyp Stromal 1 (2%)
Endometrium, Sarcoma Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (49)
Lymph Node (3) (3) (4) (4)
Lumbar, Histiocytic Sarcoma 1 (33%)
Lymph Node, Bronchial (37) (34) (41) (38)
Lymph Node, Mandibular (49) (50) (50) (49)
Lymph Node, Mesenteric (49) (50) (50) (49)
Lymph Node, Mediastinal (49) (49) (50) (49)
Page 3
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Rhabdomyosarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
Spleen (49) (50) (49) (49)
Thymus (48) (47) (47) (47)
Rhabdomyosarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (50) (49) (49)
Adenoma 1 (2%) 2 (4%) 1 (2%)
Carcinoma 2 (4%) 1 (2%) 2 (4%)
Carcinoma, Multiple 1 (2%) 1 (2%)
Fibroadenoma 13 (27%) 18 (36%) 18 (37%) 15 (31%)
Fibroadenoma, Multiple 6 (13%) 1 (2%) 3 (6%) 6 (12%)
Skin (50) (50) (50) (49)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 2 (4%)
Sebaceous Gland, Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (49)
Astrocytoma Malignant 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (45) (43) (44) (45)
Lung (50) (50) (50) (49)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Page 4
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Mediastinum, Sarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
Nose (50) (50) (50) (49)
Glands, Adenoma 1 (2%)
Trachea (50) (50) (50) (49)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (3)
External Ear, Sarcoma 1 (33%)
Zymbal's Gland (1) (1)
Adenoma 1 (100%)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (49)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (48) (49) (49) (48)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(49)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Leukemia Granulocytic 1 (2%)
Leukemia Mononuclear 13 (26%) 18 (36%) 16 (32%) 11 (22%)
Lymphoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 42 45 43 46
Total Primary Neoplasms 84 84 84 74
Total Animals with Benign Neoplasms 37 39 37 39
Total Benign Neoplasms 62 57 60 58
Total Animals with Malignant Neoplasms 20 24 21 14
Total Malignant Neoplasms 22 27 24 16
Total Animals with Metastatic Neoplasms 2 3
Total Metastatic Neoplasm 3 4
Total Animals with Malignant Neoplasms 1 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 7 16 11 22
Moribund Sacrifice 28 20 26 26
Survivors
Terminal Sacrifice 15 14 13 2
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Intestine Large, Colon (50) (48) (48) (48)
Sarcoma 1 (2%)
Intestine Large, Rectum (48) (49) (48) (48)
Intestine Large, Cecum (46) (44) (46) (39)
Intestine Small, Duodenum (48) (48) (50) (50)
Intestine Small, Jejunum (42) (39) (44) (34)
Intestine Small, Ileum (45) (44) (45) (37)
Liver (50) (50) (50) (49)
Hepatocellular Adenoma 3 (6%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Mesentery (4) (5) (3) (3)
Lipoma 1 (33%)
Sarcoma 1 (25%)
Oral Mucosa (2) (1) (1)
Pharyngeal, Squamous Cell Papilloma 2 (100%) 1 (100%) 1 (100%)
Pancreas (50) (49) (50) (50)
Duct, Carcinoma 1 (2%)
Salivary Glands (50) (49) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Stomach, Glandular (50) (49) (50) (50)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Adrenal Medulla (50) (50) (49) (48)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Pheochromocytoma Malignant 1 (2%) 2 (4%)
Pheochromocytoma Benign 6 (12%) 10 (20%) 6 (12%) 9 (19%)
Bilateral, Pheochromocytoma Benign 7 (14%) 3 (6%) 3 (6%) 3 (6%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 3 (6%) 4 (8%) 4 (8%) 4 (8%)
Carcinoma 2 (4%) 1 (2%)
Parathyroid Gland (45) (46) (46) (46)
Adenoma 1 (2%)
Pituitary Gland (49) (50) (50) (45)
Pars Distalis, Adenoma 23 (47%) 18 (36%) 18 (36%) 18 (40%)
Pars Distalis, Adenoma, Multiple 2 (4%) 1 (2%) 1 (2%)
Thyroid Gland (50) (49) (50) (50)
Bilateral, C-Cell, Adenoma 2 (4%)
C-Cell, Adenoma 1 (2%) 6 (12%) 3 (6%) 2 (4%)
C-Cell, Carcinoma 2 (4%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (49) (50) (49) (50)
Adenoma 3 (6%) 1 (2%) 1 (2%) 2 (4%)
Bilateral, Adenoma 2 (4%)
Prostate (50) (50) (50) (50)
Seminal Vesicle (49) (49) (50) (50)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 27 (54%) 23 (46%) 32 (64%) 40 (80%)
Interstitial Cell, Adenoma 9 (18%) 10 (20%) 8 (16%) 4 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (9) (8) (9) (14)
Lymph Node, Bronchial (44) (34) (39) (28)
Page 8
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Histiocytic Sarcoma 1 (3%)
Lymph Node, Mandibular (47) (48) (49) (50)
Lymph Node, Mesenteric (49) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mediastinal (48) (48) (50) (47)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (49) (50) (50)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma 1 (2%)
Thymus (46) (44) (46) (44)
Histiocytic Sarcoma 1 (2%)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (47) (46) (49)
Adenoma 1 (2%)
Fibroadenoma 2 (4%) 2 (4%) 2 (4%)
Fibroadenoma, Multiple 1 (2%)
Fibroma 2 (4%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 3 (6%) 2 (4%) 2 (4%) 2 (4%)
Squamous Cell Papilloma 2 (4%) 1 (2%) 1 (2%)
Pinna, Schwannoma Benign 1 (2%)
Pinna, Schwannoma Malignant 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%) 3 (6%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Myxoma 1 (2%)
Subcutaneous Tissue, Sarcoma 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Turbinate, Chondroma 1 (2%)
Skeletal Muscle (1) (1) (1)
Histiocytic Sarcoma 1 (100%)
Osteosarcoma, Metastatic, Spleen 1 (100%)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Glioma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (40) (44) (41) (35)
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 2 (4%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Spleen 1 (2%)
Mediastinum, Osteosarcoma, Metastatic, Spleen 1 (2%)
Nose (49) (49) (50) (50)
Trachea (50) (50) (50) (50)
Leiomyosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1)
Carcinoma 1 (100%)
Zymbal's Gland (1) (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lipoma 1 (2%)
Renal Tubule, Adenoma 3 (6%) 2 (4%) 4 (8%)
Renal Tubule, Carcinoma 1 (2%) 3 (6%)
Urinary Bladder (49) (49) (50) (49)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 27 (54%) 26 (52%) 32 (64%) 9 (18%)
Mesothelioma Malignant 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:28:43
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 45 50 50
Total Primary Neoplasms 134 131 134 111
Total Animals with Benign Neoplasms 48 44 48 48
Total Benign Neoplasms 97 95 94 93
Total Animals with Malignant Neoplasms 33 32 37 17
Total Malignant Neoplasms 37 36 40 18
Total Animals with Metastatic Neoplasms 3
Total Metastatic Neoplasm 8
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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