TDMS Study 05210-03 Pathology Tables
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
Facility: I. I. T. Research Institute
Chemical CAS #: 100-41-4
Lock Date: 10/02/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3|
| 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + A + + + + + +|
Inflammation | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Arteriole, Inflammation | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + A + + + + + +|
Inflammation | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + A + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + M + + + + A A + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + A + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | 1 1 2 2 2 2 1 2 1 1 1|
Clear Cell Focus | 1 |
Congestion | |
Eosinophilic Focus | 2 |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | 2 X X |
Inflammation, Chronic | 1 1 |
Mixed Cell Focus | 1 3|
Necrosis | 2 |
Vacuolization Cytoplasmic | 1 1 2 3 1 |
Centrilobular, Degeneration | 2 |
|__________________________________________________________________________|
Mesentery | + |
Artery, Inflammation | |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3|
| 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Inflammation | 2|
Acinus, Atrophy | 2 2 1 2 2 2 2 1 2 2 |
Artery, Inflammation | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + A + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia | 2 3 |
Inflammation | |
Ulcer | 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + + +|
Hyperplasia | 2 |
Necrosis | 2 2 |
Pigmentation | |
|__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + M + + + + + + + + + +|
Aorta, Inflammation | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 |
Valve, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 |
Cytoplasmic Alteration | |
Degeneration, Cystic | 2 2 |
Hemorrhage | 2 3 |
Hyperplasia | 2 2 |
Necrosis | |
Vacuolization Cytoplasmic | 2 2 2 |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3|
| 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + M + + + + + +|
Atrophy | 2 |
Hyperplasia | 2 1 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Infiltration Cellular, Mixed Cell | 3 |
Necrosis | 3 |
Pars Distalis, Angiectasis | 4 2 |
Pars Distalis, Cyst | 2 3 2 2 |
Pars Distalis, Hyperplasia | 2 3 2 2 1 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + A + + + + + + M + + + + + +|
Inflammation | |
C-Cell, Hyperplasia | 2 2 2 1 |
C-Cell, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + M + + + +|
Hyperplasia | |
Inflammation | 3 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 3 |
Corpus Luteum, Hyperplasia | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3|
| 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Hydrometra | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + + + +|
Atrophy | 3 |
Hemorrhage | 2 |
Hyperplasia | 1 2 3 |
Myelofibrosis | 3 |
|__________________________________________________________________________|
Lymph Node | + + |
|__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + + + + + M M + + + + M M + M M + +|
Atrophy | |
Hemorrhage | 3 2|
Pigmentation | 1 1 1 2|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 4 |
Hyperplasia, Plasma Cell | 3 |
Infiltration Cellular, Histiocyte | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + + +|
Amyloid Deposition | |
Atrophy | |
Hemorrhage | 3 3 3 2 1 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hemorrhage | 1 3 3 2 2 3 1 2 2|
Hyperplasia, Plasma Cell | |
Infiltration Cellular, Histiocyte | |
Necrosis | 2 |
Pigmentation | 2 2 1 2 1 2 1 1 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + A + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3|
| 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Pigmentation | |
Red Pulp, Atrophy | 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Galactocele | 3 3 3 2 2 2 |
Hyperplasia | 2 2 2 3 2 1 2 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + M + + + M + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 2 |
Fibrosis | |
Hemorrhage | |
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 1| 7| 7| 4| 7| 7| 7| 1| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 5| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 9| 2| 8| 3| 3| 3| 3|
| 6| 5| 8| 5| 5| 7| 4| 1| 5| 4| 5| 1| 5| 5| 6| 6| 4| 6| 4| 1| 7| 6| 5| 5| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic | 2 |
Inflammation, Granulomatous | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | 1 2 |
Inflammation | 1 3 2 2 3 |
Thrombosis | 2 |
Nasolacrimal Duct, Inflammation | 3 2 |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 3 |
Respiratory Epithelium, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + +|
|__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
Retina, Degeneration | 3 |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Infarct | |
Mineralization | 1 1 1 1 |
Nephropathy | 1 1 1 1 1 1 2 1 1 1 1 2 2 1 2 1 1 1 1|
Pigmentation | 3 3 |
Arteriole, Inflammation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3| |
DAY ON TEST | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1| |
| 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
CONTROL | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| 47 |
Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Arteriole, Inflammation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + A + + + + + + A + A + + + + + + +| 44 |
Inflammation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + A + A + + + A + + A| 41 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + A + + A + + + + A + A + A + + + + + + A| 41 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 | 3 1.0|
Basophilic Focus | 2 1 1 1 1 2 2 1 1 1 2 1 | 23 1.4|
Clear Cell Focus | 1 1 | 3 1.0|
Congestion | 2 | 1 2.0|
Eosinophilic Focus | 3 | 2 2.5|
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | 3 | 4 2.5|
Inflammation, Chronic | 1 | 3 1.0|
Mixed Cell Focus | 1 2 2 | 5 1.8|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 3 2 3 1 1 1 | 11 1.7|
Centrilobular, Degeneration | | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 7 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3| |
DAY ON TEST | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1| |
| 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
CONTROL | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Artery, Inflammation | 4 | 1 4.0|
Fat, Necrosis | 2 2 3 2 3 | 6 2.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 1 | 2 1.5|
Acinus, Atrophy | 1 1 2 2 1 2 2 1 | 18 1.7|
Artery, Inflammation | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | 2 3 | 2 2.5|
Hyperplasia | 3 | 3 2.7|
Inflammation | 3 | 1 3.0|
Ulcer | 4 | 3 2.7|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
Necrosis | 2 2 2 | 5 2.0|
Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Aorta, Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 | 6 1.2|
Valve, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3| |
DAY ON TEST | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1| |
| 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
CONTROL | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 3 1.7|
Cytoplasmic Alteration | 3 | 1 3.0|
Degeneration, Cystic | 1 2 2 | 5 1.8|
Hemorrhage | 2 4 | 4 2.8|
Hyperplasia | 2 | 3 2.0|
Necrosis | 3 | 1 3.0|
Vacuolization Cytoplasmic | 2 3 3 1 3 1 1 1 3| 12 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 4 1.5|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | | 1 2.0|
Hyperplasia | 1 2 1 | 5 1.4|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 3.0|
Infiltration Cellular, Mixed Cell | | 1 3.0|
Necrosis | | 1 3.0|
Pars Distalis, Angiectasis | | 2 3.0|
Pars Distalis, Cyst | 3| 5 2.4|
Pars Distalis, Hyperplasia | 3 2 2 3 3 | 11 2.4|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation | 3 | 1 3.0|
C-Cell, Hyperplasia | 1 | 5 1.6|
C-Cell, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3| |
DAY ON TEST | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1| |
| 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
CONTROL | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 3 2 2 | 4 2.3|
Inflammation | 3 2 3 2 | 6 2.7|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 | 5 2.4|
Corpus Luteum, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Hydrometra | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Hemorrhage | 4 3 | 3 3.0|
Hyperplasia | 3 2 3 3| 7 2.4|
Myelofibrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | +| 3 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M M + + + M + + M + + + M M + + + + +| 37 |
Atrophy | 2 | 1 2.0|
Hemorrhage | 2 2 | 4 2.3|
Pigmentation | 2 1 | 6 1.3|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Hemorrhage | | 3 2.7|
Hyperplasia, Plasma Cell | 3 | 2 3.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3| |
DAY ON TEST | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1| |
| 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
CONTROL | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Amyloid Deposition | 3 | 1 3.0|
Atrophy | 3 | 1 3.0|
Hemorrhage | 3 2 1 | 8 2.3|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 1 1 2 1 2 2 3 2 1 2 2 2| 21 1.9|
Hyperplasia, Plasma Cell | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Necrosis | | 1 2.0|
Pigmentation | 2 2 2 1 1 2 2 1 2 1 2 1 2 | 22 1.6|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 3 2| 6 2.5|
Pigmentation | 4 | 1 4.0|
Red Pulp, Atrophy | | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 |
Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Galactocele | 2 2 1 2 | 10 2.2|
Hyperplasia | 2 2 2 1 2 | 13 1.8|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3| |
DAY ON TEST | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1| |
| 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
CONTROL | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Hyperostosis | | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + M + + + M + + + + + + + + + + + + + + + M| 45 |
Metaplasia, Squamous | 1 | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 | 5 2.2|
Fibrosis | 1 | 1 1.0|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 2 2.0|
Inflammation, Chronic | 2 | 2 2.0|
Inflammation, Granulomatous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3| 1 3.0|
Foreign Body | 2 1 | 4 1.5|
Inflammation | 2 2 1 1 1 | 10 1.8|
Thrombosis | | 1 2.0|
Nasolacrimal Duct, Inflammation | | 2 2.5|
Nasolacrimal Duct, Metaplasia, | | |
Squamous | | 1 3.0|
Respiratory Epithelium, Hyperplasia | 2 1 1 1 | 6 1.5|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 0| 7| 6| 7| 7| 7| 4| 7| 7| 3| |
DAY ON TEST | 5| 3| 3| 3| 3| 6| 3| 3| 8| 3| 5| 2| 3| 0| 8| 1| 3| 6| 3| 3| 3| 8| 3| 3| 1| |
| 9| 5| 6| 5| 6| 8| 6| 4| 6| 5| 4| 7| 6| 4| 3| 8| 5| 5| 6| 5| 4| 6| 6| 6| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
CONTROL | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 3 |
|__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 2.0|
Retina, Degeneration | | 1 3.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Infarct | 3 | 1 3.0|
Mineralization | 1 1 1 2 | 8 1.1|
Nephropathy | 2 1 2 2 2 1 1 1 2 1 1 2 1 1 1 1 1 2 1 | 38 1.3|
Pigmentation | 1 3 | 4 2.5|
Arteriole, Inflammation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0|
| 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 1 1 2 1 1 1 1 1 3 1 2 1 1 |
Clear Cell Focus | 1 |
Degeneration | |
Eosinophilic Focus | 3 2 |
Fibrosis | |
Hepatodiaphragmatic Nodule | 3 3 |
Inflammation, Chronic | 1 3 |
Necrosis | |
Vacuolization Cytoplasmic | 1 2 2 1 1 |
Portal Vein, Thrombosis | |
|__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 1 2 2 2 2 2 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0|
| 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Ulcer | 3 4 |
|__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Endocardium, Hyperplasia | 3 |
Myocardium, Hypertrophy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cytoplasmic Alteration | 1 2 |
Degeneration, Cystic | 2 2 |
Hemorrhage | 1 1 2 |
Hyperplasia | 1 3 2 |
Vacuolization Cytoplasmic | 2 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Necrosis | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + M + + M + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + I|
Pars Distalis, Angiectasis | 3 1 1 2 2 1 3 |
Pars Distalis, Cyst | |
Pars Distalis, Degeneration | 4 |
Pars Distalis, Hemorrhage | 1 4 |
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0|
| 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Distalis, Hyperplasia | 2 2 1 2 2 |
Pars Distalis, Pigmentation | 2 3 |
Pars Intermedia, Angiectasis | 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation | 3 2 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
|__________________________________________________________________________|
Vagina | + |
Fibrosis | |
Arteriole, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Mast Cell | |
Hyperplasia | 2 3 2|
Myelostromal Proliferation | 4 |
Myeloid Cell, Hyperplasia | |
|__________________________________________________________________________|
Lymph Node | + + |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + M M + + + + M + + + + + + M M + + + + M|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0|
| 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hemorrhage | 1 3 1 1 |
Hyperplasia, Lymphoid | 2 |
Pigmentation | 2 1 2 1 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 2 |
Hyperplasia, Plasma Cell | 3 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 3 2 2 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + M|
Edema | |
Hemorrhage | 2 3 2 1 2 2 1 |
Pigmentation | 1 1 1 2 2 2 2 2 1 2 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | |
Pigmentation | 2 |
|__________________________________________________________________________|
Thymus | + + M + M + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 2 2 3 3 2 |
Hyperplasia | 2 1 1 2 2 2 1 2 2 |
Infiltration Cellular, Lymphocyte | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Subcutaneous Tissue, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0|
| 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperostosis | 3 3 3 |
Turbinate, Hyperostosis | 3 |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + M + M + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 |
Inflammation | 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Fibrosis | |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 2 2 |
Inflammation, Granulomatous | 1 |
Alveolar Epithelium, Hyperplasia | 2 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation | 2 1 3 1 |
Glands, Hyperplasia | |
Nasolacrimal Duct, Inflammation | 3 |
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
Respiratory Epithelium, Ulcer | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 4| 5|
DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 3| 3| 1| 1| 0|
| 6| 2| 6| 6| 1| 5| 6| 6| 5| 6| 6| 5| 4| 4| 6| 6| 6| 1| 5| 5| 5| 6| 0| 2| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Mineralization | 1 1 1 1 1|
Nephropathy | 1 1 2 2 1 1 2 2 1 1 1 3 1 1 2 2 1 1 1 1 |
Pigmentation | 2 |
Renal Tubule, Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 20
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3| |
| 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
75 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 2 2 1 1 1 1 1 1 1 1 2 1 1 | 29 1.3|
Clear Cell Focus | 2 1 | 3 1.3|
Degeneration | 3 | 1 3.0|
Eosinophilic Focus | 1 | 3 2.0|
Fibrosis | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | 4 2| 4 3.0|
Inflammation, Chronic | | 2 2.0|
Necrosis | 3 | 1 3.0|
Vacuolization Cytoplasmic | 2 1 1 4 2 3 1 | 12 1.8|
Portal Vein, Thrombosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Mesentery | + + +| 4 |
Fat, Necrosis | 2 3 3| 4 2.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 1 2 1 1 1 2 1 1| 18 1.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3| |
| 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
75 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
Inflammation | 3 | 1 3.0|
Ulcer | 4 4 | 4 3.8|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | 2 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 1 1.0|
Endocardium, Hyperplasia | | 1 3.0|
Myocardium, Hypertrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 | 3 2.0|
Cytoplasmic Alteration | 3 | 3 2.0|
Degeneration, Cystic | 2 | 3 2.0|
Hemorrhage | 3 3 | 5 2.0|
Hyperplasia | 1 | 4 1.8|
Vacuolization Cytoplasmic | 2 2 2| 5 2.2|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3| |
| 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
75 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia | 3 2 | 2 2.5|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 2 3 3 2 4 2 3 4| 16 2.4|
Pars Distalis, Cyst | 2 | 1 2.0|
Pars Distalis, Degeneration | | 1 4.0|
Pars Distalis, Hemorrhage | | 2 2.5|
Pars Distalis, Hyperplasia | 3 1 2 2 | 9 1.9|
Pars Distalis, Pigmentation | | 2 2.5|
Pars Intermedia, Angiectasis | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 | 5 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 3 2.0|
Inflammation | 2 3 | 5 2.4|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 4 1 | 6 2.5|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 2| 3 2.0|
|__________________________________________________________________________|____________|
Vagina | + + | 3 |
Fibrosis | 3 | 1 3.0|
Arteriole, Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3| |
| 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
75 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 2 | 2 2.5|
Hyperplasia, Mast Cell | 2 | 1 2.0|
Hyperplasia | 2 2 2 2 2 | 8 2.1|
Myelostromal Proliferation | | 1 4.0|
Myeloid Cell, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + | 3 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + + M + M M M + M M + + + M + + M + +| 34 |
Hemorrhage | 2 2 | 6 1.7|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation | 1 2 1 | 7 1.4|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 | 1 3.0|
Hemorrhage | 3 | 2 2.5|
Hyperplasia, Plasma Cell | 2 2 2 2 4 2| 9 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 | 6 1.8|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 2 | 1 2.0|
Hemorrhage | 1 2 3 1 2 2 1 3 | 15 1.9|
Pigmentation | 2 1 1 1 3 1 2 2 1 2 1| 22 1.6|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 | 3 2.3|
Hemorrhage | 3| 2 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3| |
| 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
75 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 3 2 3 3| 10 2.6|
Hyperplasia | 2 2 1 1 2 2 2 2 2 2 | 19 1.7|
Infiltration Cellular, Lymphocyte | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 4 | 1 4.0|
Subcutaneous Tissue, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 | 1 3.0|
Hyperostosis | 3 4 | 5 3.2|
Turbinate, Hyperostosis | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + M + + + + + + + + + M + + + + M + M + M +| 43 |
Infiltration Cellular, Lymphocyte | | 3 2.0|
Inflammation | | 2 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3| |
| 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
75 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Fibrosis | 2 | 1 2.0|
Hemorrhage | 1 | 2 1.5|
Infiltration Cellular, Histiocyte | 1 | 3 1.7|
Inflammation, Granulomatous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 2 | 5 1.8|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 1 | 1 1.0|
Inflammation | 3 2 2 2 3 3 | 10 2.2|
Glands, Hyperplasia | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation | | 1 3.0|
Respiratory Epithelium, Hyperplasia | 2 2 2 1 2 2 | 7 1.9|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
Respiratory Epithelium, Ulcer | 1 2 | 2 1.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Mineralization | 1 1 2 1 1 1 | 11 1.1|
Nephropathy | 1 2 4 2 2 1 1 1 2 3 2 1 2 2 1 1 1 2 2 2 1 2| 42 1.6|
Pigmentation | 2 1 3 1 1 1 1 2 1 | 10 1.5|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 6| 3| 1| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 0| 3| |
| 6| 8| 5| 9| 5| 6| 7| 4| 5| 6| 1| 5| 9| 6| 6| 1| 4| 5| 6| 4| 5| 5| 4| 9| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
75 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Urinary Bladder | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3|
| 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + A + + +|
Hyperplasia | 3 |
Inflammation | 4 |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 2 1 2 1 1 1 1 2 1 1 1 1 1 1 1|
Clear Cell Focus | |
Congestion | |
Degeneration | 2 |
Eosinophilic Focus | 2 2 3 |
Hepatodiaphragmatic Nodule | X 3 2 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 1 2 |
Mixed Cell Focus | |
Necrosis | 2 |
Vacuolization Cytoplasmic | 1 2 1 3 2 1 1 1 3|
|__________________________________________________________________________|
Mesentery | + + + + + |
Artery, Degeneration | 4 |
Artery, Inflammation | 3 |
Fat, Necrosis | 3 2 3 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Acinus, Atrophy | 1 3 2 2 2 1 3 1 2 1 1 |
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3|
| 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Arteriole, Inflammation | 3 |
Artery, Inflammation | 2|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia | 2 3 |
Ulcer | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
|__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 4 |
Inflammation | 3 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Atrium, Inflammation | 3 |
Endocardium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 |
Cytoplasmic Alteration | |
Degeneration, Cystic | |
Hemorrhage | |
Hyperplasia | 2 2 |
Hypertrophy | 2 |
Necrosis | 2 |
Pigmentation | |
Vacuolization Cytoplasmic | 2 2 2 2 3 |
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3|
| 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
Infiltration Cellular, Lymphocyte | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 1 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 2 |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 3 2 3 2 2 2 3 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
C-Cell, Hyperplasia | 1 1 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | |
Inflammation | 3 2 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3|
| 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 3 |
Myelostromal Proliferation | |
Myeloid Cell, Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node | + + |
Pancreatic, Hemorrhage | 3 |
|__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M + + + + + M + M + M + + + M + + M + + +|
Ectasia | |
Hemorrhage | 3 2 1 |
Infiltration Cellular, Histiocyte | |
Necrosis | |
Pigmentation | 2 1 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 3 |
Hyperplasia, Plasma Cell | 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 |
Hemorrhage | 2 2 2 3 |
Hyperplasia, Plasma Cell | 3 |
Inflammation | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 3 2 1 1 2 2 2 |
Pigmentation | 1 1 2 1 1 1 2 2 1 2 1 1|
|__________________________________________________________________________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3|
| 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Galactocele | 2 4 2|
Hyperplasia | 2 2 2 2 2 2 2 1 2 2 2 1 1|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Ulcer | 2 |
Epidermis, Hyperplasia | 2 |
Subcutaneous Tissue, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 4 2 |
Turbinate, Hyperostosis | 2 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + M + + + + + + + + + M + + + + + M + + +|
Infiltration Cellular, Lymphocyte | 3 |
Inflammation | 1 |
Respiratory Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 2 |
Fibrosis | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic Active | |
Inflammation, Granulomatous | |
Alveolar Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 4| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 8| 5| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 5| 3| 3| 4| 3| 6| 3|
| 5| 6| 6| 5| 5| 3| 9| 9| 6| 6| 5| 4| 5| 5| 2| 4| 5| 6| 1| 6| 4| 9| 5| 2| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Inflammation | 1 1 2 |
Necrosis | 2 |
Glands, Cyst | |
Glands, Hyperplasia | |
Respiratory Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Mineralization | 1 1 2 1 2 |
Necrosis | 4 |
Nephropathy | 2 2 1 1 1 2 1 2 2 2 2 2 1 1 2 1 2 2 3 1 2 3|
Pigmentation | 1 2 |
Renal Tubule, Degeneration | |
Renal Tubule, Hyperplasia | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 33
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8| |
| 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
250 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + A| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
Hyperplasia | | 1 3.0|
Inflammation | | 1 4.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 | 33 1.2|
Clear Cell Focus | 1 | 1 1.0|
Congestion | 2 | 1 2.0|
Degeneration | 3 | 2 2.5|
Eosinophilic Focus | 1 2 2 2 1 | 8 1.9|
Hepatodiaphragmatic Nodule | 2 | 4 2.3|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | 1 | 3 1.3|
Mixed Cell Focus | 2 | 1 2.0|
Necrosis | 2 | 2 2.0|
Vacuolization Cytoplasmic | 2 2 2 3 1 | 14 1.8|
|__________________________________________________________________________|____________|
Mesentery | + | 6 |
Artery, Degeneration | | 1 4.0|
Artery, Inflammation | | 1 3.0|
Fat, Necrosis | 3 | 5 2.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8| |
| 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
250 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Acinus, Atrophy | 2 2 2 1 1 2 2| 18 1.7|
Arteriole, Inflammation | | 1 3.0|
Artery, Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 2.0|
Hyperplasia | 3 | 3 2.7|
Ulcer | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | | 1 4.0|
Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 1 3.0|
Atrium, Inflammation | | 1 3.0|
Endocardium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 4 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8| |
| 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
250 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Cytoplasmic Alteration | 3 | 1 3.0|
Degeneration, Cystic | 1 2 | 2 1.5|
Hemorrhage | 2 2 | 2 2.0|
Hyperplasia | | 2 2.0|
Hypertrophy | 2 1 | 3 1.7|
Necrosis | | 1 2.0|
Pigmentation | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 3 2 3 1 2 1 | 12 2.1|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 1.5|
Infiltration Cellular, Lymphocyte | | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + M + M M M + + + + M + + M + + + + +| 42 |
Hyperplasia | 1 2 2 | 4 1.5|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 3 2 2| 6 2.2|
Pars Distalis, Cyst | 1 2 | 3 1.3|
Pars Distalis, Hyperplasia | 2 4 2 3 2 2 | 14 2.4|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
C-Cell, Hyperplasia | 2 1 | 5 1.2|
Follicle, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8| |
| 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
250 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Hyperplasia | 2 | 1 2.0|
Inflammation | 2 | 4 2.3|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 2 | 5 1.8|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 | 1 3.0|
Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 3 | 7 2.6|
Myelostromal Proliferation | 4 | 1 4.0|
Myeloid Cell, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Pancreatic, Hemorrhage | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + M + + + + + M + + + +| 41 |
Ectasia | 2 | 1 2.0|
Hemorrhage | 1 1 | 5 1.6|
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
Necrosis | 3 | 1 3.0|
Pigmentation | 1 1 1 1 1 | 7 1.1|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 1 2.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Plasma Cell | 2 | 4 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 1 | 3 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8| |
| 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
250 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hemorrhage | 1 2 1 3 | 8 2.0|
Hyperplasia, Plasma Cell | | 1 3.0|
Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 2 2 2 | 13 1.7|
Pigmentation | 1 2 2 2 1 1 1 2 2 1 1 1 1| 25 1.4|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 | 3 2.7|
|__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + M + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Galactocele | 2 1 2 1 2 1 2 | 10 1.9|
Hyperplasia | 3 2 2 2 1 2 1 1 | 21 1.8|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 3 | 1 3.0|
Ulcer | | 1 2.0|
Epidermis, Hyperplasia | 2 | 2 2.0|
Subcutaneous Tissue, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 3 | 5 2.6|
Turbinate, Hyperostosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8| |
| 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
250 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | M + + + + + + + + + M + + + + + + + + + + + + + M| 44 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation | | 1 1.0|
Respiratory Epithelium, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Edema | | 1 2.0|
Fibrosis | 1 | 1 1.0|
Hemorrhage | 1 1 | 2 1.0|
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Granulomatous | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Inflammation | 2 1 | 5 1.4|
Necrosis | | 1 2.0|
Glands, Cyst | 2 | 1 2.0|
Glands, Hyperplasia | 2 2 | 2 2.0|
Respiratory Epithelium, Hyperplasia | 2 1 1 1 | 5 1.2|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 3 |
Lens, Cataract | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 0| 7| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 8| |
| 5| 5| 9| 5| 6| 5| 5| 9| 4| 6| 2| 5| 6| 5| 5| 6| 5| 5| 5| 8| 6| 4| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
250 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Infarct | | 1 3.0|
Mineralization | 1 1| 7 1.3|
Necrosis | | 1 4.0|
Nephropathy | 2 2 1 2 1 1 1 2 2 2 2 2 2 2 2 1 1 2 2 2 2 | 43 1.7|
Pigmentation | 1 1 3 1 1 3| 8 1.6|
Renal Tubule, Degeneration | 3 | 1 3.0|
Renal Tubule, Hyperplasia | 3 1 | 3 2.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 4| 3| 3| 6| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 3| 2|
| 9| 3| 8| 6| 6| 2| 5| 4| 6| 6| 5| 6| 1| 6| 5| 6| 9| 4| 4| 6| 7| 6| 7| 5| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + A + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 3 |
Basophilic Focus | 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Clear Cell Focus | 1 1 |
Congestion | |
Eosinophilic Focus | 2 3 2 |
Hepatodiaphragmatic Nodule | 2 3 |
Inflammation, Acute | 1 |
Inflammation, Chronic | |
Necrosis | 4 |
Vacuolization Cytoplasmic | 3 1 1 2 1 1 2 1|
|__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 2 2 2 3 3 |
|__________________________________________________________________________|
Oral Mucosa | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 2 1 1 |
Arteriole, Inflammation | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 4| 3| 3| 6| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 3| 2|
| 9| 3| 8| 6| 6| 2| 5| 4| 6| 6| 5| 6| 1| 6| 5| 6| 9| 4| 4| 6| 7| 6| 7| 5| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia | 2 3|
Inflammation | 1|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation | |
Necrosis | |
Ulcer | |
Glands, Cyst | |
|__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 |
Fibrosis | 3 |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Degeneration, Cystic | 3 |
Degeneration | 2 |
Hemorrhage | 2 |
Hyperplasia | |
Necrosis | |
Pigmentation | 1 |
Vacuolization Cytoplasmic | 2 3 3 1 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 4| 3| 3| 6| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 3| 2|
| 9| 3| 8| 6| 6| 2| 5| 4| 6| 6| 5| 6| 1| 6| 5| 6| 9| 4| 4| 6| 7| 6| 7| 5| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 1 2 1 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2|
Pars Distalis, Cyst | 2 2 |
Pars Distalis, Hyperplasia | 2 2 3 2 3 2 3 1|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Hyperplasia | |
C-Cell, Hyperplasia | 3 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + M + + + + + + +|
Cyst | |
Hyperplasia | 2 |
Inflammation | 1 3 |
Bilateral, Hyperplasia | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 4 2 3 |
Inflammation | 2 |
Endometrium, Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hemorrhage | |
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 4| 3| 3| 6| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 3| 2|
| 9| 3| 8| 6| 6| 2| 5| 4| 6| 6| 5| 6| 1| 6| 5| 6| 9| 4| 4| 6| 7| 6| 7| 5| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia | 2 2 2 3 3 |
Erythroid Cell, Hyperplasia | |
|__________________________________________________________________________|
Lymph Node | + + + |
Pancreatic, Hemorrhage | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 3 |
Renal, Hemorrhage | 3 |
Renal, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + + + + M + + + + + M + + + + +|
Hemorrhage | 1 |
Pigmentation | 1 1 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Plasma Cell | 2 |
Pigmentation | 1 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 1 3 3 |
Hyperplasia | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 2 2 2 2 2 3 2 |
Pigmentation | 2 2 2 2 2 2 1 2 1 2 1 2 2 1|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Necrosis | 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 2 2 2 1 3 2|
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 4| 3| 3| 6| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 3| 2|
| 9| 3| 8| 6| 6| 2| 5| 4| 6| 6| 5| 6| 1| 6| 5| 6| 9| 4| 4| 6| 7| 6| 7| 5| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Hyperplasia | 2 2 3 2 1 2 2 2 2 1 3|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 2 |
Epidermis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Turbinate, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + M + + + + M M + + + + + + + + + +|
Inflammation | 2 1 |
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic | 1 1 |
Inflammation, Granulomatous | |
Alveolar Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation | |
Glands, Hyperplasia | 3 |
Goblet Cell, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 4| 3| 3| 6| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 6| 3| 2|
| 9| 3| 8| 6| 6| 2| 5| 4| 6| 6| 5| 6| 1| 6| 5| 6| 9| 4| 4| 6| 7| 6| 7| 5| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Degeneration | |
|__________________________________________________________________________|
Harderian Gland | + |
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Nephropathy | 3 3 1 2 2 1 2 1 3 3 1 4 4 3 2 4 1 1 2 3 2 3 2 4|
Pigmentation | 1 |
Renal Tubule, Hyperplasia | 1 1|
Transitional Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 46
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3| |
| 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
750 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A A + + + + + + + + + + + + + + + + + A + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 1 3 | 6 2.0|
Basophilic Focus | 1 1 1 1 1 1 1 2 2 1 2 2 1 1 1 | 29 1.2|
Clear Cell Focus | 1 1 | 4 1.0|
Congestion | 2 | 1 2.0|
Eosinophilic Focus | 2 2| 5 2.2|
Hepatodiaphragmatic Nodule | X X 1 | 5 2.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 2 2| 2 2.0|
Necrosis | 1| 2 2.5|
Vacuolization Cytoplasmic | 1 2 1 1 1 3 | 14 1.5|
|__________________________________________________________________________|____________|
Mesentery | + +| 7 |
Fat, Necrosis | 2 2| 7 2.3|
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 2 2 1 2 1 1 1 2 4 2 2 1 1| 19 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3| |
| 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
750 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Arteriole, Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
Hyperplasia | 3 1 3 3 3 2 | 8 2.5|
Inflammation | 2 3 2 2 2 | 6 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 1 2.0|
Inflammation | 1 1 | 2 1.0|
Necrosis | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
Glands, Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 2 2 | 6 1.5|
Fibrosis | | 1 3.0|
Atrium, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 1 1 | 3 1.0|
Degeneration, Cystic | 1 2 2 | 4 2.0|
Degeneration | | 1 2.0|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3| |
| 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
750 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia | 1 2 1 | 3 1.3|
Necrosis | 2 | 1 2.0|
Pigmentation | | 1 1.0|
Vacuolization Cytoplasmic | 2 | 6 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 |
Hyperplasia | 2 1 | 5 1.4|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | | 2 2.5|
Pars Distalis, Cyst | 2 | 3 2.0|
Pars Distalis, Hyperplasia | 1 3 1 2 2 2 2 3 1 | 17 2.1|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, C-Cell, Hyperplasia | 2| 1 2.0|
C-Cell, Hyperplasia | 1 | 5 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | 4 | 1 4.0|
Hyperplasia | 2 2 | 3 2.0|
Inflammation | 2 2 | 4 2.0|
Bilateral, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3| |
| 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
750 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Cyst | 2 | 5 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydrometra | 2 | 4 2.8|
Inflammation | | 1 2.0|
Endometrium, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 2.0|
Hemorrhage | 4 | 1 4.0|
Hyperplasia | 2 2 2 | 8 2.3|
Erythroid Cell, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + | 4 |
Pancreatic, Hemorrhage | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Renal, Hemorrhage | 2 | 2 2.5|
Renal, Pigmentation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + M + + + + M + + M + M M + + + M + + M| 38 |
Hemorrhage | 3 2 | 3 2.0|
Pigmentation | 1 1 | 5 1.2|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 1| 3 1.3|
Hyperplasia, Plasma Cell | 2 2 | 3 2.0|
Pigmentation | | 1 1.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 3 2 | 7 2.3|
Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3| |
| 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
750 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 1 2 2 2 1 3 3 1 2 2 2 1| 21 1.9|
Pigmentation | 1 2 2 1 2 1 1 2 2 1 1 1 2| 27 1.6|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 | 3 2.3|
Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 |
Cyst | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Galactocele | 2 3 4 3 | 11 2.4|
Hyperplasia | 3 1 3 2 1 2 2 | 18 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | | 2 2.0|
Epidermis, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperostosis | 2 | 1 2.0|
Turbinate, Hyperostosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2| 1 2.0|
Hydrocephalus | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3| |
| 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
750 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + M + + + + + + + + + + + +| 45 |
Inflammation | | 2 1.5|
Respiratory Epithelium, Hyperplasia | 2 | 2 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Histiocyte | 2 1 | 3 1.3|
Inflammation, Chronic | 1 | 3 1.0|
Inflammation, Granulomatous | 2 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 2 1 2 | 5 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 1 | 1 1.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation | 2 | 1 2.0|
Glands, Hyperplasia | | 1 3.0|
Goblet Cell, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
Lens, Cataract | 2 | 1 2.0|
Retina, Degeneration | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3| |
| 5| 6| 0| 5| 6| 5| 4| 6| 5| 5| 5| 4| 9| 6| 5| 6| 4| 5| 5| 3| 5| 5| 6| 5| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
750 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Cyst | 2 2 3| 4 2.3|
Nephropathy | 4 1 2 3 2 2 2 2 2 2 4 3 2 1 2 1 4 2 2 2 3 3| 46 2.3|
Pigmentation | 2 2 | 3 1.7|
Renal Tubule, Hyperplasia | 2 | 3 1.3|
Transitional Epithelium, Hyperplasia | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5|
DAY ON TEST | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2|
| 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | M + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + A + + + + + +|
Inflammation | |
Ulcer | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Mineralization | |
|__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + A + + + + + + + A + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 2 1 1 1 |
Clear Cell Focus | 1 |
Degeneration, Cystic | 2 2 1 1 1 3 2 2 |
Degeneration | 3 |
Eosinophilic Focus | 1 2 |
Inflammation, Chronic | 1 |
Mixed Cell Focus | 2 |
Necrosis | |
Pigmentation | |
Vacuolization Cytoplasmic | 1 2 2 1 |
|__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Oral Mucosa | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 2 2 2 1 2 3 2 1|
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5|
DAY ON TEST | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2|
| 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Acinus, Hyperplasia | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia | 2 2 3 2 2|
Inflammation | 3 |
Mineralization | |
Ulcer | 4 3 4 3 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 |
Mineralization | 2 2 |
Necrosis | 1 2 2 |
|__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 2 2 3 1 2 2 2 1 |
Mineralization | |
Atrium, Thrombosis | 3 3 3 |
Valve, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Hyperplasia | |
Pigmentation | |
Vacuolization Cytoplasmic | 3 2 1 1 1 2 2 2 |
Bilateral, Atrophy | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5|
DAY ON TEST | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2|
| 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 2 |
Bilateral, Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + M + + + + + + + + + + M + + +|
Hyperplasia | 1 3 1 1 4 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 4 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 1 2 2 3 |
Pars Distalis, Pigmentation | 2 |
Pars Intermedia, Angiectasis | 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 |
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 4 3 2 2 2 4 3 3|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation | 3 2 3 2 4 3 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 56
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5|
DAY ON TEST | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2|
| 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Mineralization | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 3 |
Hemorrhage | 2 |
Bilateral, Atrophy | 3 3 3 4 3 |
Interstitial Cell, Hyperplasia | 1 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hemorrhage | 2 |
Hyperplasia | 2 2 1 1 |
Myelofibrosis | 3 2 3 |
Myeloid Cell, Atrophy | |
|__________________________________________________________________________|
Lymph Node | + + + + + + |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + M M|
Hemorrhage | 1 2 3 |
Pigmentation | 1 1 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + + + M + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1|
Hyperplasia, Plasma Cell | 3 2 |
Pigmentation | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hemorrhage | 2 2 2 2 3 3 3 1 |
Hyperplasia, Plasma Cell | 2 |
Infiltration Cellular, Histiocyte | 3 |
Pigmentation | 2 2 1 1 2|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 57
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5|
DAY ON TEST | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2|
| 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Congestion | 3 |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 4 |
Necrosis | 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + M + + + + + + + + + + + + + +|
Galactocele | 2 3 2 1 2 2|
Hyperplasia | |
Inflammation | 2 |
Pigmentation | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 4 |
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + M|
Fibrous Osteodystrophy | |
Turbinate, Hyperostosis | |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Necrosis | 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + M + + + M + + + + + + + + + + + + + M + M|
Infiltration Cellular, Lymphocyte | |
Inflammation | |
__________________________________________|__________________________________________________________________________|
Page 58
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5|
DAY ON TEST | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2|
| 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Inflammation, Granulomatous | |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 2 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + M|
Foreign Body | 2 |
Inflammation | 3 1 2 4 |
Goblet Cell, Hyperplasia | 2 |
Nasolacrimal Duct, Inflammation | |
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, Inflammation | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 |
Respiratory Epithelium, Ulcer | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Degeneration | |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 6| 7| 7| 5| 4| 7| 6| 6| 6| 6| 7| 7| 6| 7| 5| 7| 7| 6| 6| 5| 5|
DAY ON TEST | 8| 1| 0| 4| 0| 1| 3| 4| 7| 3| 4| 5| 9| 6| 3| 3| 8| 3| 9| 3| 3| 6| 0| 5| 2|
| 9| 0| 2| 0| 9| 3| 4| 7| 9| 4| 4| 2| 2| 1| 4| 4| 9| 4| 0| 4| 4| 8| 8| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Infarct | 2 2 |
Mineralization | |
Necrosis | 2 |
Nephropathy | 2 3 2 3 3 3 2 2 3 1 2 2 2 2 1 4 2 1 2 1 2 1 4 2|
Pigmentation | 2 3 2 2 3 2 2 |
Renal Tubule, Hyperplasia | 4 |
Transitional Epithelium, Hyperplasia | 1 2 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | 2 |
__________________________________________|__________________________________________________________________________
Page 60
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5| |
DAY ON TEST | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8| |
| 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + A + + + + +| 46 |
Inflammation | 4 | 1 4.0|
Ulcer | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Mineralization | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + A A + + + + + A + + A + +| 42 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + A + + A + +| 45 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 | 6 1.2|
Clear Cell Focus | 1 | 2 1.0|
Degeneration, Cystic | 2 2 1 3 2 2 2 | 15 1.9|
Degeneration | | 1 3.0|
Eosinophilic Focus | 2 1 2 | 5 1.6|
Inflammation, Chronic | | 1 1.0|
Mixed Cell Focus | | 1 2.0|
Necrosis | 2 3 | 2 2.5|
Pigmentation | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 2 1 3 | 8 1.6|
|__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Fat, Necrosis | 2 2 | 3 2.3|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5| |
DAY ON TEST | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8| |
| 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Oral Mucosa | + | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 2 2 2 1 2 1 1 2 3 2 2 2 2| 24 1.8|
Acinus, Hyperplasia | 2 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 2.0|
Hyperplasia | 2 3 3| 8 2.4|
Inflammation | | 1 3.0|
Mineralization | 2 4 | 2 3.0|
Ulcer | 2 3 4 3| 9 3.1|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 2 2.0|
Mineralization | 3 2 | 4 2.3|
Necrosis | 2 2| 5 1.8|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | 4 4 | 2 4.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 3 3 1 2 2 3 2 3 2 2 2| 26 1.9|
Mineralization | 2 2 | 2 2.0|
Atrium, Thrombosis | 4 3 | 5 3.2|
Valve, Fibrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5| |
DAY ON TEST | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8| |
| 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | | 1 2.0|
Hyperplasia | 1 | 1 1.0|
Pigmentation | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 2 2 3 2 | 13 1.9|
Bilateral, Atrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 2 2 | 10 1.8|
Bilateral, Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + M + + +| 45 |
Hyperplasia | 4 3 2 2 4 2 | 12 2.4|
|__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 2 3 | 5 3.0|
Pars Distalis, Cyst | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 3 1 2 2 3 2 2| 12 2.2|
Pars Distalis, Pigmentation | | 1 2.0|
Pars Intermedia, Angiectasis | | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 2 1 | 6 1.3|
Follicle, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5| |
DAY ON TEST | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8| |
| 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 3 | 2 2.5|
Inflammation | 2 3 2 3 3 2 2 2 2 4 3 | 19 2.7|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
Inflammation | 3 2 2 1 | 11 2.5|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Mineralization | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 4 4 3 3 4 | 10 3.2|
Hemorrhage | | 1 2.0|
Bilateral, Atrophy | 4 2 3 2| 9 3.0|
Interstitial Cell, Hyperplasia | 1 2 2 2 2 2 2| 14 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
Hyperplasia | 2 2 3 | 7 1.9|
Myelofibrosis | | 3 2.7|
Myeloid Cell, Atrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 9 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + M M + + M + + + + + + + + + M + +| 44 |
Hemorrhage | 1 1 4 1 | 7 1.9|
Pigmentation | 1 | 3 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5| |
DAY ON TEST | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8| |
| 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 |
Hemorrhage | | 1 1.0|
Hyperplasia, Plasma Cell | 2 2 | 4 2.3|
Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Hemorrhage | 1 | 3 1.3|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + M + + + + + + + + + + + + M + + + + +| 48 |
Edema | | 1 3.0|
Hemorrhage | 2 3 4 1 | 12 2.3|
Hyperplasia, Plasma Cell | | 1 2.0|
Infiltration Cellular, Histiocyte | 3 | 2 3.0|
Pigmentation | 1 1 1 1 | 9 1.3|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Fibrosis | 2 3 | 3 2.7|
Hematopoietic Cell Proliferation | 2 3 | 3 3.0|
Necrosis | 3| 2 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + M + + + + + + M + + +| 46 |
Galactocele | 2 2 3 1 4 | 11 2.2|
Hyperplasia | 2 2 2 | 3 2.0|
Inflammation | | 1 2.0|
Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 4.0|
Hyperkeratosis | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5| |
DAY ON TEST | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8| |
| 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrous Osteodystrophy | 2 | 1 2.0|
Turbinate, Hyperostosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 2 | 1 2.0|
Necrosis | | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + M + M M + M + + + + + + M + M| 40 |
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Inflammation | 1 | 1 1.0|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Edema | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 2 | 2 2.5|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 3 2 | 2 2.5|
Inflammation, Granulomatous | 2 | 1 2.0|
Mineralization | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 1 | 2 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 4| 7| 6| 7| 6| 6| 5| 7| 7| 3| 7| 5| |
DAY ON TEST | 3| 3| 4| 1| 3| 3| 2| 8| 1| 3| 7| 3| 9| 9| 3| 3| 3| 8| 5| 7| 1| 1| 5| 3| 8| |
| 4| 0| 0| 8| 4| 4| 3| 9| 0| 4| 4| 4| 1| 7| 4| 9| 4| 5| 3| 0| 4| 5| 4| 4| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Inflammation | 2 2 2 1 | 8 2.1|
Goblet Cell, Hyperplasia | 2 | 2 2.0|
Nasolacrimal Duct, Inflammation | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 2 1 2 2 2 1 1 | 9 1.6|
Respiratory Epithelium, Inflammation | 1 | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 3.0|
Respiratory Epithelium, Ulcer | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | +| 1 |
Lens, Cataract | 4| 1 4.0|
Retina, Degeneration | 3| 1 3.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 2 2.0|
Mineralization | 1 | 1 1.0|
Necrosis | | 1 2.0|
Nephropathy | 3 2 3 2 2 3 4 4 2 1 3 1 1 3 2 3 3 2 2 4 2 2 2| 47 2.3|
Pigmentation | 2 3| 9 2.3|
Renal Tubule, Hyperplasia | 2 | 2 3.0|
Transitional Epithelium, Hyperplasia | 1 3 2 2 1 2 1 3 | 12 1.7|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Hemorrhage | 3 | 1 3.0|
Inflammation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6|
DAY ON TEST | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9|
| 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + A + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation | 4 |
Mineralization | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + A + + + + + + A + + + + + + + + + +|
Inflammation | 2 2 |
Necrosis | 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + A A + + A + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + A + + + + + + + A + + + + + + + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 |
Clear Cell Focus | 2 1 |
Cyst | |
Degeneration, Cystic | 2 2 2 2 |
Eosinophilic Focus | 2 2 2 |
Fibrosis | 1 1 |
Hemorrhage | 1 3 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 3 |
Mixed Cell Focus | 2 |
Necrosis | 1 2 2 4 |
Vacuolization Cytoplasmic | 1 1 1 2 |
Bile Duct, Inflammation, Suppurative | 3 |
|__________________________________________________________________________|
Mesentery | + + |
Inflammation | 4 |
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6|
DAY ON TEST | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9|
| 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 4 |
Acinus, Atrophy | 1 1 3 2 2 3 1 2 2 |
Artery, Degeneration | |
Artery, Inflammation | |
Artery, Mineralization | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Inflammation | 2 |
Mineralization | |
Ulcer | 1 3 3 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Mineralization | 2|
Necrosis | 1 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 1 2 3 2 |
Mineralization | |
Atrium, Thrombosis | 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 2 |
Degeneration, Cystic | 2 |
__________________________________________|__________________________________________________________________________|
Page 69
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6|
DAY ON TEST | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9|
| 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Vacuolization Cytoplasmic | 2 1 2 1 2 2 2 1 2 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 3 |
Bilateral, Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 3 2 |
Pars Distalis, Cyst | 3 3 2 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 1 2 1 |
|__________________________________________________________________________|
Thyroid Gland | + + A + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
C-Cell, Hyperplasia | 2 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Inflammation | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation | 3 3 3 2|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 70
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6|
DAY ON TEST | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9|
| 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Hyperplasia | 1 |
Infiltration Cellular, Lymphocyte | |
Inflammation | 3 4 4 2 1 4 2 2 3 2 3 2 2 2 4 3|
|__________________________________________________________________________|
Seminal Vesicle | + + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 3|
Degeneration | |
Arteriole, Inflammation | |
Bilateral, Atrophy | 3 3 3 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 2 3 2 4 4 |
Inflammation | 3 |
|__________________________________________________________________________|
Lymph Node | + + + + +|
Lumbar, Hemorrhage | 3 |
Lumbar, Hyperplasia, Plasma Cell | 4 |
Renal, Infiltration Cellular, | |
Histiocyte | |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + M + M M M + M + + M + + + M + M + M + + + M +|
Hemorrhage | 1 |
Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + A + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Plasma Cell | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage | 1 1 4 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6|
DAY ON TEST | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9|
| 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mediastinal | + + + M + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hemorrhage | 3 2 1 4 |
Hyperplasia, Plasma Cell | 2 |
Infiltration Cellular, Histiocyte | |
Pigmentation | 2 2 1 |
|__________________________________________________________________________|
Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Depletion Cellular | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 3 3 |
Pigmentation | |
|__________________________________________________________________________|
Thymus | + + + M + + + + M + + + + + + + + + + + + + + M +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M + M + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 2 3 2 1 3|
Hyperplasia | 2 2 2 |
Inflammation | 2 |
Pigmentation | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X 3 3 X|
Inflammation, Granulomatous | 3 |
Subcutaneous Tissue, Inflammation | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Turbinate, Hyperostosis | 2 |
|__________________________________________________________________________|
Skeletal Muscle | + |
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6|
DAY ON TEST | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9|
| 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | 2 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + A M + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation | 2 4 |
Necrosis | 3 |
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
Inflammation, Granulomatous | 1 |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 2 |
Interstitium, Fibrosis | |
|__________________________________________________________________________|
Nose | + + A + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2|
Infiltration Cellular, Lymphocyte | |
Inflammation | 1 3 2 2|
Glands, Cyst | |
Nasolacrimal Duct, Inflammation | 2 |
Respiratory Epithelium, Hyperplasia | 2 1 2|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 3| 5| 6| 7| 5| 4| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 2| 6| 5| 6|
DAY ON TEST | 0| 3| 0| 8| 1| 3| 9| 1| 5| 3| 3| 3| 3| 3| 3| 2| 6| 3| 3| 3| 8| 4| 6| 3| 9|
| 1| 4| 8| 4| 9| 4| 6| 6| 4| 4| 4| 4| 4| 4| 1| 0| 0| 4| 7| 4| 4| 4| 8| 8| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
75 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Hemorrhage | |
Inflammation | 1 |
Mineralization | |
Nephropathy | 1 3 2 2 2 1 3 2 3 2 3 2 3 2 2 1 2 2 1 2|
Pigmentation | 3 3 |
Renal Tubule, Hyperplasia | |
Transitional Epithelium, Hyperplasia | 2 2 3 1 2 1 |
|__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation | 3 2 |
Necrosis | 2 |
Transitional Epithelium, Hyperplasia | 2|
__________________________________________|__________________________________________________________________________
Page 74
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3| |
DAY ON TEST | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5| |
| 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 2.0|
Inflammation | | 1 4.0|
Mineralization | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + A + + + + + + + + + + + + + + + + + A| 44 |
Inflammation | | 2 2.0|
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + A + + A + + A + A + + + + + + A| 39 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + A| 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 1 1 | 5 1.0|
Clear Cell Focus | 1 | 3 1.3|
Cyst | 3 | 1 3.0|
Degeneration, Cystic | 1 1 1 2 2 1 1 2 | 12 1.6|
Eosinophilic Focus | 2 2 2 2 1 2 2 2 | 11 1.9|
Fibrosis | 1 | 3 1.0|
Hemorrhage | | 2 2.0|
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 1 3.0|
Mixed Cell Focus | 2 | 2 2.0|
Necrosis | | 4 2.3|
Vacuolization Cytoplasmic | 1 1 1 1 4 2 | 10 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3| |
DAY ON TEST | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5| |
| 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Bile Duct, Inflammation, Suppurative | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Inflammation | | 1 4.0|
Fat, Necrosis | 3 3 3 | 4 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | | 2 4.0|
Acinus, Atrophy | 2 1 2 2 2 2 2 1 1 1 3 3 | 21 1.9|
Artery, Degeneration | 4 | 1 4.0|
Artery, Inflammation | 3 | 1 3.0|
Artery, Mineralization | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 2 | 5 2.2|
Inflammation | | 1 2.0|
Mineralization | 3 | 1 3.0|
Ulcer | 3 3 3 4 2 | 9 2.7|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 2 | 1 2.0|
Mineralization | 3 1 2 | 4 2.0|
Necrosis | 2 | 2 1.5|
Ulcer | 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | 4 3 | 2 3.5|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 3 3 2 3 2 2 2 2 2 | 21 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3| |
DAY ON TEST | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5| |
| 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Mineralization | 3 | 1 3.0|
Atrium, Thrombosis | 3 4 3 3 3 | 7 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytoplasmic Alteration | | 1 2.0|
Degeneration, Cystic | 2 | 2 2.0|
Vacuolization Cytoplasmic | 3 2 2 1 2 3 1 | 18 1.8|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 1 | 7 1.7|
Bilateral, Hyperplasia | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 2 2 | 5 2.2|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + M + + + + + + + + + + + +| 46 |
Hyperplasia | 3 4 3 3 1 | 6 2.7|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 2 3 2 2 4 2 3 | 11 2.7|
Pars Distalis, Cyst | 2 1 | 6 2.2|
Pars Distalis, Hemorrhage | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 2 3 3 3 2 3 1 3 | 11 2.2|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 | 1 3.0|
C-Cell, Hyperplasia | 1 1 2 | 5 1.6|
Follicle, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3| |
DAY ON TEST | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5| |
| 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 3.0|
Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 3.0|
Inflammation | 3 2 4 | 7 2.9|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation | 3 3 3 4 2 2 2 2 1 4 2 3 2| 29 2.6|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | | 1 4.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 4 2 | 7 2.7|
Degeneration | 1 | 1 1.0|
Arteriole, Inflammation | 2 | 1 2.0|
Bilateral, Atrophy | 2 3 3 2| 7 2.7|
Interstitial Cell, Hyperplasia | 1 1 1 2 1 1 1 2 1 | 19 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 4 3 2 3 4 3 3 | 16 2.9|
Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 8 |
Lumbar, Hemorrhage | | 1 3.0|
Lumbar, Hyperplasia, Plasma Cell | | 1 4.0|
Renal, Infiltration Cellular, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3| |
DAY ON TEST | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5| |
| 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Histiocyte | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + M + + + + + M + + + M M + M + + + + + + +| 34 |
Hemorrhage | 2 3 1 | 4 1.8|
Pigmentation | 2 2 1 | 3 1.7|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Atrophy | 3 | 1 3.0|
Hyperplasia, Plasma Cell | 3| 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Hemorrhage | 2 3 | 5 2.2|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Edema | | 1 2.0|
Hemorrhage | 2 2 3 2 1 4| 10 2.4|
Hyperplasia, Plasma Cell | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
Pigmentation | 1 2 2 2 1 | 8 1.6|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | | 1 3.0|
Depletion Cellular | 3 | 2 2.5|
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 4 3.0|
Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + M + + + + + + + M| 44 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3| |
DAY ON TEST | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5| |
| 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Galactocele | 2 2 2 3 2 | 11 2.2|
Hyperplasia | | 3 2.0|
Inflammation | 2 | 2 2.0|
Pigmentation | 2 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 4 3.0|
Inflammation, Granulomatous | | 1 3.0|
Subcutaneous Tissue, Inflammation | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 | 1 3.0|
Turbinate, Hyperostosis | | 1 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Hydrocephalus | | 2 2.0|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + M + + + + + + + + + M + + + + + + M M| 44 |
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Inflammation | 2 | 3 2.7|
Necrosis | | 1 3.0|
Respiratory Epithelium, Hyperplasia | 2 2 2 | 4 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3| |
DAY ON TEST | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5| |
| 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 2 | 2 2.5|
Hemorrhage | 1 | 2 1.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | 1 2 1 | 3 1.3|
Inflammation, Granulomatous | | 1 1.0|
Mineralization | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 2 1.5|
Interstitium, Fibrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | | 2 2.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation | 2 1 2 2 | 8 1.9|
Glands, Cyst | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 1 1 2 | 7 1.4|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 | 4 2.3|
Hemorrhage | 3 | 1 3.0|
Inflammation | | 1 1.0|
Mineralization | 3 | 1 3.0|
Nephropathy | 2 1 4 2 4 2 4 2 2 2 3 4 2 1 4 3 3 2 2 4 3 3 2 | 43 2.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 6| 6| 5| 7| 6| 7| 6| 7| 7| 5| 3| |
DAY ON TEST | 3| 9| 1| 1| 0| 3| 0| 2| 3| 7| 3| 4| 0| 1| 3| 9| 8| 1| 1| 2| 1| 3| 3| 4| 5| |
| 4| 5| 8| 8| 7| 4| 0| 6| 4| 1| 4| 0| 7| 4| 9| 2| 2| 3| 5| 3| 7| 4| 4| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
75 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Pigmentation | 2 1 3 3 | 6 2.5|
Renal Tubule, Hyperplasia | 2 2 | 2 2.0|
Transitional Epithelium, Hyperplasia | 1 1 1 3 1 1 1 1 | 14 1.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 3 | 2 2.5|
Inflammation | 4 | 3 3.0|
Necrosis | | 1 2.0|
Transitional Epithelium, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5|
DAY ON TEST | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9|
| 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Thrombosis | 2 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
|__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Basophilic Focus | 1 |
Clear Cell Focus | 1 2 |
Degeneration, Cystic | 3 2 1 2 2 2 1 1 1 |
Eosinophilic Focus | 2 2 2 |
Inflammation, Chronic | 2 |
Thrombosis | 2 |
Vacuolization Cytoplasmic | 4 2 |
Kupffer Cell, Hyperplasia | 2 |
|__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Oral Mucosa | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Acinus, Atrophy | 1 1 1 2 2 2 3 1 1 1 3 |
Acinus, Hyperplasia | 2 |
Artery, Degeneration | 3 |
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5|
DAY ON TEST | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9|
| 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia | 3 2 2 |
Inflammation | 2 2 2 |
Mineralization | 3 |
Ulcer | 3 3 3 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
Inflammation | 1 |
Mineralization | 3 2 |
Necrosis | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation | 1 |
Aorta, Mineralization | 2 3 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 2 3 1 1 2 3 2 2 |
Inflammation | 3 |
Atrium, Thrombosis | 3 3 4 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Degeneration | 2 |
Hyperplasia | |
Necrosis | 2 |
Vacuolization Cytoplasmic | 3 2 1 3 2 3 3 3 1 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 2 2 1 2 2 2 |
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5|
DAY ON TEST | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9|
| 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Bilateral, Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + M|
Fibrosis | |
Hyperplasia | 3 1 1 2 1 2 4 3 2 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 4 |
Pars Distalis, Cyst | 1 1 1 2 |
Pars Distalis, Degeneration | 3 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 1 2 2 |
Pars Distalis, Necrosis | 2 |
Pars Distalis, Pigmentation | 3 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Inflammation | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Atrophy | |
Inflammation | 1 2 4 2 2|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation | 2 2 4 3 3 1 3 2 4 2 3 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5|
DAY ON TEST | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9|
| 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 2 |
Arteriole, Inflammation | 1 |
Bilateral, Atrophy | 3 2 3 3 |
Bilateral, Necrosis | 4 |
Interstitial Cell, Hyperplasia | 1 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hemorrhage | 2 4 |
Hyperplasia | 3 3 3 2 2 3 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + +|
Hemorrhage | 2 |
Pancreatic, Fibrosis | 4 |
Pancreatic, Pigmentation | 3 |
Renal, Ectasia | 3 2 |
Renal, Hemorrhage | 1 |
Renal, Hyperplasia, Plasma Cell | |
Renal, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + + M + + + + + + M M + + +|
Ectasia | |
Hemorrhage | 2 2 2 |
Infiltration Cellular, Histiocyte | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | |
Inflammation | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 1 |
__________________________________________|__________________________________________________________________________|
Page 86
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5|
DAY ON TEST | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9|
| 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Inflammation | 2 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 1 1 1 2 |
Inflammation | 3 |
Pigmentation | 2 1 2 2 1 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
Fibrosis | 2 1 2 |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | 2 |
Red Pulp, Depletion Cellular | 2 |
|__________________________________________________________________________|
Thymus | + + M M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + M +|
Fibrosis | 2 |
Galactocele | 2 2 3 2 3 4 |
Hyperplasia | 3 2 |
Inflammation | 3 |
Pigmentation | 3 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Epidermis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 1 2 |
Hyperostosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 87
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5|
DAY ON TEST | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9|
| 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Hydrocephalus | |
Mineralization | |
Necrosis | 3 2 2 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + M M + + + + + + + + + + + + + + M + + + M M M|
Foreign Body | 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation | 3 3 |
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Foreign Body | 2 |
Hemorrhage | |
Inflammation, Acute | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 3 |
Alveolar Epithelium, Hyperplasia | |
Goblet Cell, Hyperplasia | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Foreign Body | 1 |
Inflammation | 1 3 2 2 3 2 |
Goblet Cell, Hyperplasia | 2 |
Nasolacrimal Duct, Inflammation | |
Respiratory Epithelium, Hyperplasia | 1 1 1 2 2 |
Respiratory Epithelium, Ulcer | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 88
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 6| 7| 5| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 5| 5| 6| 5|
DAY ON TEST | 7| 3| 5| 9| 3| 9| 0| 3| 0| 3| 3| 3| 3| 3| 1| 6| 2| 8| 6| 0| 3| 9| 9| 6| 9|
| 1| 4| 6| 6| 4| 6| 4| 4| 9| 4| 4| 4| 4| 4| 3| 5| 9| 8| 7| 7| 4| 0| 0| 9| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
250 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Mineralization | 2 |
Nephropathy | 4 2 1 2 2 2 2 4 2 3 2 2 3 4 4 3 2 2 3 3 1 1 4 2|
Pigmentation | 3 3 3 3 |
Renal Tubule, Hyperplasia | 1 1 1 |
Transitional Epithelium, Hyperplasia | 3 1 2 1 1 1 2 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________|__________________________________________________________________________
Page 89
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6| |
DAY ON TEST | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8| |
| 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Thrombosis | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + A + + + + + + A + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + A + + + A + + + + + A + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + A A + + + + +| 45 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 1.5|
Basophilic Focus | 1| 2 1.0|
Clear Cell Focus | 2 | 3 1.7|
Degeneration, Cystic | 2 2 1 3 2 2 3 1 2 1| 19 1.8|
Eosinophilic Focus | 2| 4 2.0|
Inflammation, Chronic | | 1 2.0|
Thrombosis | | 1 2.0|
Vacuolization Cytoplasmic | 4 2 2 2 3 | 7 2.7|
Kupffer Cell, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + +| 3 |
Fat, Necrosis | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6| |
DAY ON TEST | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8| |
| 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation | | 1 2.0|
Acinus, Atrophy | 3 3 2 2 2 2 2 2 2 | 20 1.9|
Acinus, Hyperplasia | | 1 2.0|
Artery, Degeneration | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 2.0|
Hyperplasia | 2 2 3 2 3 | 8 2.4|
Inflammation | | 3 2.0|
Mineralization | | 1 3.0|
Ulcer | 4 2 3 4 3 | 9 3.2|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | | 1 3.0|
Inflammation | 2 2 | 3 1.7|
Mineralization | 2 | 3 2.3|
Necrosis | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Inflammation | | 1 1.0|
Aorta, Mineralization | 3 2 | 4 2.5|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 | 15 2.1|
Inflammation | | 1 3.0|
Atrium, Thrombosis | 3 3 | 7 3.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6| |
DAY ON TEST | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8| |
| 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Degeneration, Cystic | | 1 2.0|
Degeneration | | 1 2.0|
Hyperplasia | 2| 1 2.0|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 1 2 1 3 3 2 | 16 2.2|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 2 2 2 2 2 | 13 1.8|
Bilateral, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 4 2.3|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + M + + + + + +| 46 |
Fibrosis | 3 | 1 3.0|
Hyperplasia | 2 2 4 1 4 2 | 16 2.3|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 4 2 4 | 5 3.0|
Pars Distalis, Cyst | 2 | 5 1.4|
Pars Distalis, Degeneration | | 1 3.0|
Pars Distalis, Hemorrhage | 2| 1 2.0|
Pars Distalis, Hyperplasia | 2 2 | 12 1.9|
Pars Distalis, Necrosis | | 1 2.0|
Pars Distalis, Pigmentation | | 2 2.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2| 5 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6| |
DAY ON TEST | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8| |
| 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 3.0|
Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 4 | 1 4.0|
Inflammation | 2 2 2 | 8 2.1|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Inflammation | 2 2 2 4 2 2 2 2 3 1 | 22 2.4|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 3 3 2 2 | 10 2.4|
Arteriole, Inflammation | | 1 1.0|
Bilateral, Atrophy | 3 | 5 2.8|
Bilateral, Necrosis | | 1 4.0|
Interstitial Cell, Hyperplasia | 1 1 2 2 1 1 | 12 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Hemorrhage | | 2 3.0|
Hyperplasia | 2 3| 9 2.6|
|__________________________________________________________________________|____________|
Lymph Node | + + | 9 |
Hemorrhage | | 1 2.0|
Pancreatic, Fibrosis | | 1 4.0|
Pancreatic, Pigmentation | | 1 3.0|
Renal, Ectasia | | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6| |
DAY ON TEST | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8| |
| 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Renal, Hemorrhage | | 1 1.0|
Renal, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Renal, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M M M + + + + + M + + + M + M + + + + + M +| 39 |
Ectasia | 2 | 1 2.0|
Hemorrhage | 1 | 4 1.8|
Infiltration Cellular, Histiocyte | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Plasma Cell | 2 | 1 2.0|
Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 2.0|
Hemorrhage | 1 3 2 | 4 1.8|
Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 2 1 2 2| 10 1.6|
Inflammation | | 1 3.0|
Pigmentation | 1 1 | 7 1.4|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 2 2 | 3 2.0|
Fibrosis | 2 | 4 1.8|
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Red Pulp, Depletion Cellular | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + M +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6| |
DAY ON TEST | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8| |
| 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Mammary Gland | + + M + + + + + M + + + + + + + + + + + + + + + +| 46 |
Fibrosis | | 1 2.0|
Galactocele | 3 1 2 2 3 | 11 2.5|
Hyperplasia | 2 2 | 4 2.3|
Inflammation | | 1 3.0|
Pigmentation | | 2 2.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 2 |
Epidermis, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 2 | 5 2.0|
Hyperostosis | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 3 | 1 3.0|
Mineralization | 1 | 1 1.0|
Necrosis | | 3 2.3|
|__________________________________________________________________________|____________|
Peripheral Nerve | + +| 2 |
|__________________________________________________________________________|____________|
Spinal Cord | + + +| 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + M + + + + + M + + + + M +| 41 |
Foreign Body | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation | 1 | 3 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6| |
DAY ON TEST | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8| |
| 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Respiratory Epithelium, Hyperplasia | | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 1.0|
Foreign Body | | 1 2.0|
Hemorrhage | 1 | 1 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | | 2 2.5|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Goblet Cell, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Foreign Body | 2 | 2 1.5|
Inflammation | 2 2 2 | 9 2.1|
Goblet Cell, Hyperplasia | | 1 2.0|
Nasolacrimal Duct, Inflammation | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 2 1 1 | 9 1.3|
Respiratory Epithelium, Ulcer | | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | +| 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 6| 6| 7| 6| 5| 7| 6| 7| 4| 2| 7| 7| 7| 5| 5| 7| 6| 7| 7| 7| 5| 6| |
DAY ON TEST | 4| 3| 9| 6| 2| 2| 1| 8| 0| 7| 2| 2| 6| 1| 3| 3| 2| 2| 0| 4| 0| 3| 0| 9| 8| |
| 4| 4| 1| 8| 4| 0| 9| 9| 3| 1| 3| 0| 6| 2| 4| 4| 8| 7| 8| 3| 3| 4| 3| 1| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
250 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Cyst | | 1 2.0|
Mineralization | | 1 2.0|
Nephropathy | 2 2 1 1 4 2 2 1 2 4 1 1 2 4 2 3 2 2 2 3 2 1 3| 47 2.3|
Pigmentation | 1 2 2 2 2 | 9 2.3|
Renal Tubule, Hyperplasia | 2 | 4 1.3|
Transitional Epithelium, Hyperplasia | 2 2 2 1 1 2 | 15 1.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5|
DAY ON TEST | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8|
| 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + A A + + + + + + + A + + + + + + A +|
Inflammation | 2 |
Mineralization | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + A A A + + A + + + + A + + + + + + + +|
Inflammation | 4 |
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + A A + + + A + + + + A + + + + + + A +|
Inflammation | 3 |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 1 |
Degeneration, Cystic | 2 1 1 2 2 2 2 2 2 2 2 1 2 2 2 1 2 1 1|
Eosinophilic Focus | 1 2 1 2 1 2 |
Hepatodiaphragmatic Nodule | |
Mineralization | 2 |
Necrosis | 2 1 2 2 1 |
Vacuolization Cytoplasmic | 4 |
Bile Duct, Hyperplasia | 2|
|__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 3 |
|__________________________________________________________________________|
Oral Mucosa | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
__________________________________________|__________________________________________________________________________|
Page 98
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5|
DAY ON TEST | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8|
| 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Acinus, Atrophy | 2 1 2 2 2 2 2 2 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 3 |
Inflammation | 1 2 2 |
Mineralization | 2 |
Ulcer | 3 3 4 4 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Inflammation | |
Mineralization | 2 3 2 2 2 2 3 2 4 2|
Ulcer | 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Aorta, Inflammation | 2 |
Aorta, Mineralization | 3 3 3 3 3 3 3|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 2 3 3 2 2 3 2 3 2 2 3 2 |
Mineralization | 1 2 2 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hyperplasia | |
Hypertrophy | 2 |
Necrosis | 4 |
Vacuolization Cytoplasmic | 2 1 2 3 2 1|
Capsule, Inflammation | 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 99
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5|
DAY ON TEST | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8|
| 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hyperplasia | 1 1 1 1 2|
Necrosis | 4 |
Bilateral, Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 2 4 1 2 1 4 3 2 3 4 2 2 3 4 2|
|__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + M +|
Pars Distalis, Angiectasis | 3 2 1 4 |
Pars Distalis, Cyst | 2|
Pars Distalis, Hyperplasia | 2 2 2 1 2 2 2 2 2 3 2|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Mineralization | 2 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 2 4 2 3 2 2 4|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 3 1 2 2 3 2 2 2 2 4 2 3 4 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 1 2 4 |
Degeneration | |
__________________________________________|__________________________________________________________________________|
Page 100
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5|
DAY ON TEST | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8|
| 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Mineralization | 2 2 |
Bilateral, Atrophy | 3 3 2|
Interstitial Cell, Hyperplasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hemorrhage | 2 |
Hyperplasia | 2 2 3 3 2 4 2 2 2 2 |
Myelofibrosis | 2 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Renal, Ectasia | 3 |
Renal, Hemorrhage | 2 1 3 4 |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | 2 |
Renal, Pigmentation | 2 2 |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + M + + M M M + + + M + M M + M M M +|
Hemorrhage | 3 2 |
Pigmentation | 2 2 1 1 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Plasma Cell | 3 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 2 2 |
Inflammation | 4 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + M + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hemorrhage | 2 2 4 3 2 |
Infiltration Cellular, Histiocyte | 2 |
Pigmentation | 2 1 1 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 101
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5|
DAY ON TEST | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8|
| 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Atrophy | |
Depletion Cellular | 2 2 3 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 |
Necrosis | 4 2 |
|__________________________________________________________________________|
Thymus | + + + + + M + + + + M + M + + + + + + + + + + + +|
Cyst | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 1 1 1 3 |
Hyperplasia | 2 |
Mineralization | 2 |
Pigmentation | 2 2 3|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Inflammation | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 1 2 2 2 3 3|
Turbinate, Hyperostosis | |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + M + M + + + M + + M + M + + + + + M M + + M|
__________________________________________|__________________________________________________________________________|
Page 102
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5|
DAY ON TEST | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8|
| 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Infiltration Cellular, Lymphocyte | |
Inflammation | 1 |
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Edema | 3 2 1 |
Fibrosis | |
Hemorrhage | 1 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 1 |
Inflammation, Chronic Active | 1 3 1 |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 1 2 |
Artery, Mineralization | |
Interstitium, Inflammation | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | |
Inflammation | 3 1 |
Necrosis | 3 |
Olfactory Epithelium, Inflammation | |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Hyperplasia | 2 1 1 |
Respiratory Epithelium, Inflammation | 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Zymbal's Gland | |
Cyst | |
__________________________________________|__________________________________________________________________________|
Page 103
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 5| 5|
DAY ON TEST | 0| 6| 3| 6| 4| 8| 1| 5| 4| 3| 8| 8| 8| 9| 3| 4| 7| 1| 8| 5| 6| 5| 8| 8| 8|
| 2| 8| 4| 7| 3| 8| 9| 5| 7| 4| 7| 1| 6| 0| 8| 6| 2| 6| 7| 1| 3| 2| 0| 4| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 |
Infarct | 3 |
Mineralization | 2 2 2 2 2 3|
Necrosis | 4 |
Nephropathy | 4 4 3 4 4 4 4 4 4 3 2 4 4 3 2 4 4 4 4 2 3 4 4 4|
Pigmentation | |
Renal Tubule, Hyperplasia | 2 2 2 2 1 2 |
Transitional Epithelium, Hyperplasia | 2 2 2 2 2 1 2 1 1 2 2 2 2 2 2 2 2 1|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________|__________________________________________________________________________
Page 104
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5| |
DAY ON TEST | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3| |
| 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
750 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | A + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Mineralization | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A A + A + + + + A + A + + A + + + + + + + + + + +| 39 |
Inflammation | | 1 2.0|
Mineralization | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A A A + + A + A + A + + + A + + A + + + A + + +| 34 |
Inflammation | | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + A + + + + + + A + + A + + + A + + + A + + +| 37 |
Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | 2 1 | 4 1.3|
Degeneration, Cystic | 1 3 2 2 2 2 2 2 3 1 1| 30 1.8|
Eosinophilic Focus | 2 4 1 | 9 1.8|
Hepatodiaphragmatic Nodule | X | 1 |
Mineralization | | 1 2.0|
Necrosis | 2 2 3 | 8 1.9|
Vacuolization Cytoplasmic | 2 1 1 | 4 2.0|
Bile Duct, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | 2 | 3 2.7|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5| |
DAY ON TEST | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3| |
| 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
750 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Oral Mucosa | + | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 4.0|
Acinus, Atrophy | 2 2 2 1 2 2 2 2| 18 1.8|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 8 2.1|
Inflammation | | 3 1.7|
Mineralization | 3 2 2 2 | 5 2.2|
Ulcer | 2 2 4 3 2 | 10 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | | 1 2.0|
Inflammation | 2 | 1 2.0|
Mineralization | 2 2 3 3 2 3 2 3| 18 2.4|
Ulcer | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 | 1 3.0|
Aorta, Inflammation | | 1 2.0|
Aorta, Mineralization | 3 2 2 2 3 3 4| 14 2.9|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 3 1 2 3 2 2 1 1 3 3 2 2 3| 30 2.2|
Mineralization | 2 3 | 7 2.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5| |
DAY ON TEST | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3| |
| 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
750 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Degeneration, Cystic | 3 2 1 | 3 2.0|
Hyperplasia | 2 1 | 2 1.5|
Hypertrophy | | 1 2.0|
Necrosis | 2 | 2 3.0|
Vacuolization Cytoplasmic | 2 3 1 2 1| 11 1.8|
Capsule, Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 1 2| 8 1.4|
Necrosis | | 1 4.0|
Bilateral, Hyperplasia | 2 | 4 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + M + + + + + + +| 46 |
Hyperplasia | 3 3 3 2 2 3 4 3 3 4 4 3 4 3 3 2 4| 35 2.9|
|__________________________________________________________________________|____________|
Pituitary Gland | M M + + + + + + + + + + + + + + + M + + + + + + +| 45 |
Pars Distalis, Angiectasis | | 4 2.5|
Pars Distalis, Cyst | 3 1 2 | 4 2.0|
Pars Distalis, Hyperplasia | 3 | 12 2.1|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | 4 2 | 2 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
Mineralization | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5| |
DAY ON TEST | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3| |
| 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
750 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Inflammation | 3 4 4 | 10 3.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 3 4 2 3 2 1 3 3 3 4 | 25 2.6|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 6 2.7|
Degeneration | 2 | 1 2.0|
Mineralization | | 2 2.0|
Bilateral, Atrophy | 3 | 4 2.8|
Interstitial Cell, Hyperplasia | 1 1 2 1 | 8 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Hemorrhage | 3 3 1 | 4 2.3|
Hyperplasia | 2 3 2 1 2 3 2 4 2| 19 2.4|
Myelofibrosis | 2 2 2| 5 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 14 |
Renal, Ectasia | | 1 3.0|
Renal, Hemorrhage | 2 2 3 2 | 8 2.4|
Renal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Renal, Hyperplasia, Plasma Cell | | 1 2.0|
Renal, Pigmentation | | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M + + M M M M + + M + + M + M + + M + + + + +| 28 |
Hemorrhage | 1 2 2 3 1| 7 2.0|
Pigmentation | 1 | 5 1.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5| |
DAY ON TEST | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3| |
| 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
750 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Hyperplasia, Plasma Cell | 2 | 4 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 3 1 | 8 1.9|
Inflammation | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 |
Edema | 2 2 | 3 2.0|
Hemorrhage | 2 2 3 1 1 3 2 4 2 2 1 2| 17 2.2|
Infiltration Cellular, Histiocyte | | 1 2.0|
Pigmentation | 1 1 1 1 | 7 1.1|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 | 2 3.0|
Depletion Cellular | 3 | 4 2.5|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Necrosis | | 2 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + M + + + M + + + + + + + + + + + + + + M| 44 |
Cyst | 2 | 1 2.0|
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Galactocele | 2 3 1 1 | 9 1.7|
Hyperplasia | 1 2 | 3 1.7|
Mineralization | | 1 2.0|
Pigmentation | 2 2 2 | 6 2.2|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5| |
DAY ON TEST | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3| |
| 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
750 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 2.0|
Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 3 | 9 2.2|
Turbinate, Hyperostosis | 2| 1 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | M + + + + + + M + + + M + + + + + M M M + + + M +| 35 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation | | 1 1.0|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 3 3 | 6 2.8|
Edema | 3 2 2| 6 2.2|
Fibrosis | 2 | 1 2.0|
Hemorrhage | 2 2 2 3 2 2| 8 2.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 2 1.5|
Inflammation, Chronic Active | 2 2 2 1| 7 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5| |
DAY ON TEST | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3| |
| 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
750 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Mineralization | 1 1 1| 3 1.0|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
Artery, Mineralization | 2 | 1 2.0|
Interstitium, Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 | 1 4.0|
Foreign Body | 1 | 1 1.0|
Inflammation | 1 2 2 2 2 1 3 | 9 1.9|
Necrosis | | 1 3.0|
Olfactory Epithelium, Inflammation | 1 | 1 1.0|
Olfactory Epithelium, Metaplasia | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | 2 1 2 | 6 1.5|
Respiratory Epithelium, Inflammation | 1 | 3 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Cyst | 4 | 1 4.0|
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 2 3 3 2 3 | 10 2.7|
Infarct | | 1 3.0|
Mineralization | 2 2 2| 9 2.1|
Necrosis | | 1 4.0|
Nephropathy | 4 4 4 4 3 4 3 4 3 2 3 4 4 4 4 4 2 2 4 3 2 4 2 4| 48 3.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 111
NTP Experiment-Test: 05210-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLBENZENE Date: 01/27/05
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:49
__________________________________________________________________________________________________________________________________
| 5| 4| 6| 3| 6| 6| 6| 5| 6| 6| 5| 5| 7| 6| 6| 5| 6| 5| 3| 5| 6| 3| 6| 5| 5| |
DAY ON TEST | 6| 8| 6| 9| 7| 7| 6| 9| 2| 6| 0| 9| 0| 2| 4| 9| 4| 0| 7| 9| 9| 8| 9| 9| 3| |
| 9| 3| 1| 3| 9| 2| 3| 6| 6| 5| 7| 0| 9| 7| 1| 7| 5| 0| 7| 1| 6| 3| 6| 4| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
750 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Pigmentation | 2 3 | 2 2.5|
Renal Tubule, Hyperplasia | 1 1 1 2 2 3 | 12 1.8|
Transitional Epithelium, Hyperplasia | 2 2 2 2 1 2 2 2 1 2 2 2 1 3 1 2| 34 1.8|
|__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
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---------- END OF REPORT ----------
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