TDMS Study 05210-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: I. I. T. Research Inst ETHYLBENZENE DATE: 03/14/96
EXPERIMENT: 05210 TEST: 03 TIME: 12:54:34
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-75193 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56393
PATHOLOGIST: BRENNECKE, LUK CAS: 100-41-4
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: I. I. T. Research Inst ETHYLBENZENE DATE: 03/14/96
EXPERIMENT: 05210 TEST: 03 TIME: 12:54:34
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-75193 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56393
PATHOLOGIST: BRENNECKE, LUK CAS: 100-41-4
ETHYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 35 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| 354 391 479 497 528 547 553 570 574 584 |
| 590 602 608 609 618 623 630 639 640 640 |
| 644 652 653 661 668 685 689 689 689 692 |
| 710 710 713 714 715 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 75 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 36 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 244 308 352 416 518 538 549 560 582 584 |
| 584 596 600 601 607 615 617 619 626 631 |
| 634 637 639 640 654 668 671 692 693 695 |
| 707 713 714 718 720 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 266 420 467 496 509 527 528 556 589 590 |
| 590 591 591 596 619 624 629 643 644 665 |
| 668 669 671 671 686 688 696 703 703 703 |
| 704 707 708 712 713 720 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 750 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 48 CENSORED DEATHS 0 TERMINAL 2 |
| |
| UNCENSORED DEATHS |
| 377 383 393 483 500 507 538 539 546 547 |
| 555 563 567 569 572 584 586 587 587 587 |
| 588 590 590 591 594 596 597 616 626 627 |
| 641 643 645 651 652 661 663 665 668 672 |
| 679 680 681 696 696 702 709 719 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 96.0 94.0 90.0 76.0 52.0 30.0 |
| | |
| | |
|75 PPM | 100.0 100.0 98.0 94.0 92.0 92.0 88.0 72.0 50.0 28.0 |
| | |
| | |
|250 PPM| 100.0 100.0 98.0 98.0 96.0 94.0 86.0 72.0 60.0 26.0 |
| | |
| | |
|750 PPM| 100.0 100.0 100.0 100.0 94.0 92.0 84.0 46.0 24.0 4.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 75 PPM 250 PPM 750 P|M
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 30.0% 28.0% 26.0% 4.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.888 P=0.953 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 616.0 601.8 621.2 598.1 |
|NATURAL DEATHS (C) | (14.7) (18.9) (16.2) (11.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 651.4 638.8 650.5 603.5 |
|(STANDARD ERROR) | (12.8) (16.0) (13.9) (11.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ETHYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 18 111 194 318 486 496 507 638 651 654 |
| 659 665 668 683 686 687 704 721 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 75 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 412 462 475 506 531 601 609 609 610 636 |
| 646 647 668 686 719 724 724 731 731 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 393 449 486 502 602 624 651 658 659 662 |
| 674 685 689 694 699 709 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ETHYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 750 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 1 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 448 462 604 629 646 655 667 690 699 703 |
| 709 711 722 723 |
| CENSORED DEATHS |
| 527 |
| |
==================================================================================
ETHYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.0 96.0 94.0 92.0 92.0 92.0 86.0 86.0 76.0 62.0 |
| | |
| | |
|75 PPM | 100.0 100.0 100.0 100.0 98.0 94.0 90.0 88.0 76.0 62.0 |
| | |
| | |
|250 PPM| 100.0 100.0 100.0 100.0 98.0 96.0 92.0 90.0 80.0 68.0 |
| | |
| | |
|750 PPM| 100.0 100.0 100.0 100.0 100.0 96.0 96.0 94.0 87.8 71.5 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 75 PPM 250 PPM 750 P|M
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.0% 62.0% 68.0% 71.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.248N P=1.000N P=0.620N P=0.326N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 540.7 617.2 614.8 647.7 |
|NATURAL DEATHS (C) | (50.5) (22.6) (25.0) (23.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 660.5 689.6 695.8 705.7 |
|(STANDARD ERROR) | (23.1) (11.7) (11.1) ( 9.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ETHYLBENZENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
75 PPM = 2
250 PPM = 3
750 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 2 3 1 4
| 2 3 2 1 4 41 3
| 2 2 414 2 3 1 1
| 2 4 1432 1
90 + 432 12 1
| 4 2 2
| 34412 1 2 3
| 44 1 1
80 + 44 1 1
| 44 2 11
| 44 311
| 21 1
P 70 + 4 4 2233
E | 211
R | 21 1
C | 223 3
E 60 + 33
N | 4 4 1 1
T | 22 1 1
| 2 2 11 3
S 50 + 44 2 1 13
U | 113
R | 4 4 4 2 233
V | 22
I 40 + 4 4 1221
V | 22
A | 44 322
L | 44 11
30 + 4 4 312 1
| 32 2
| 44 3 3
|
20 + 44
| 44
| 4 4
|
10 + 44
| 44
| 44 4
|
0 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 37 obs hidden.
ETHYLBENZENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
75 PPM = 2
250 PPM = 3
750 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 3 2 4
|
| 1 1 3 2 4 32
|
96 + 1 1 32 2 3 4
|
| 1 1 2 3 32 4 4
|
92 + 1 1 32 2 3 4 4
|
| 11 2 2 3 44
|
P 88 + 1 1 22 3 34 4
E |
R | 1 133 4 4
C |
E 84 + 22 113 3 44
N |
T | 2 2 11 44
|
S 80 + 2 21 1 3 44
U |
R | 33
V |
I 76 + 2 11 33 4 4
V |
A | 1 133
L |
72 + 2 2
| 4 4
| 113 322
|
68 + 1 13 3
|
| 1 12 2
|
64 + 11
|
| 1 1
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.