TDMS Study 05211-05 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Southern Research Inst EMODIN DATE: 03/26/99
EXPERIMENT: 05211 TEST: 05 TIME: 08:30:21
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP: C62408
CONT: NO1-ES-85216 CAS: 518-82-1
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: SOUTHERN RESEARCH INSTITUTE EMODIN DATE: 03/26/99
EXPERIMENT: 05211 TEST: 05 TIME: 8:44:25
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP: C62408
CONT: NO1-ES-85216 CAS: 518-82-1
FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED FEED STUDY OF EMODIN
==================================================================================================================================
0 PPM 280 PPM 830 PPM 2500 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
2 16.3 178.4 16.0 174.5 0.98 256 15.8 171.1 0.97 766 14.4 160.3 0.88 2245
5 18.0 263.9 18.5 259.9 1.03 200 17.4 252.5 0.97 573 17.4 236.4 0.97 1842
9 17.1 325.0 17.3 319.3 1.01 152 16.6 310.4 0.97 443 16.0 290.6 0.94 1373
13 16.5 358.8 16.6 356.1 1.01 130 16.0 343.5 0.97 387 15.9 330.0 0.96 1206
17 16.2 385.9 16.0 382.0 0.99 118 15.7 372.6 0.97 349 15.6 355.6 0.96 1097
21 16.6 404.7 16.8 399.9 1.01 117 16.2 389.6 0.98 345 15.9 369.4 0.96 1080
25 16.1 419.6 16.0 416.0 0.99 108 15.7 404.1 0.98 324 15.8 387.1 0.98 1019
29 16.8 437.5 16.9 430.6 1.01 110 16.8 423.2 1.00 330 16.5 398.2 0.98 1037
33 17.7 448.0 17.9 442.8 1.01 113 17.4 433.5 0.98 333 17.4 412.3 0.98 1052
37 15.7 460.5 15.5 457.1 0.99 95 15.4 445.2 0.98 288 14.9 426.8 0.95 875
41 16.0 463.6 16.0 456.8 1.00 98 15.7 448.6 0.98 290 15.3 431.3 0.96 890
45 16.7 466.5 16.1 464.9 0.96 97 16.0 457.5 0.96 291 15.8 436.2 0.95 905
49 15.3 470.6 15.3 468.2 1.00 91 14.8 459.5 0.97 268 14.7 439.8 0.96 833
53 15.2 472.5 14.7 469.0 0.97 88 14.7 458.2 0.97 266 15.0 440.7 0.99 850
57 15.0 473.5 16.2 471.8 1.08 96 16.2 463.5 1.08 291 15.8 443.6 1.05 888
61 15.1 472.4 15.1 467.9 1.00 90 15.5 459.3 1.03 281 14.8 440.2 0.98 843
65 14.9 470.6 14.8 464.5 0.99 89 15.2 458.1 1.02 275 15.2 439.9 1.02 863
69 15.2 471.6 15.0 465.1 0.99 90 15.7 458.5 1.03 283 15.4 440.4 1.01 876
73 15.0 470.7 15.2 464.2 1.01 92 15.4 456.9 1.03 280 15.4 443.1 1.03 867
77 15.2 471.3 14.6 464.0 0.96 88 14.8 456.6 0.97 268 14.2 441.6 0.93 806
81 15.5 471.7 14.8 462.0 0.95 89 14.9 453.6 0.96 273 15.2 442.6 0.98 857
85 15.1 465.4 14.9 460.1 0.99 91 15.9 456.3 1.05 289 15.9 442.5 1.05 899
89 15.2 459.4 14.2 449.4 0.93 89 14.2 444.2 0.93 265 14.4 434.4 0.95 831
93 14.5 456.1 14.4 444.6 0.99 91 13.2 430.9 0.91 255 14.2 430.0 0.98 823
97 13.4 452.0 13.2 432.4 0.99 85 13.5 429.4 1.01 261 13.8 427.4 1.03 805
101 14.2 448.8 13.9 426.9 0.98 91 13.5 420.4 0.95 267 12.9 417.2 0.91 775
1 TO 13 WEEKS
----------------
MEAN 16.9 281.5 17.1 277.4 1.01 185 16.5 269.4 0.97 542 15.9 254.3 0.94 1666
SD(D) 0.8 1.1 0.02 56 0.7 0.00 168 1.2 0.04 470
CV(E) 4.5 6.4 1.9 30.3 4.4 0.2 31.0 7.7 4.1 28.2
14 TO 52 WEEKS
----------------
MEAN 16.3 439.7 16.3 435.4 1.00 105 16.0 426.0 0.98 313 15.8 406.3 0.96 976
SD(D) 0.7 0.8 0.01 10 0.8 0.01 29 0.8 0.01 100
CV(E) 4.3 5.0 1.5 9.6 4.8 1.2 9.3 5.1 1.5 10.2
> 52 WEEKS
----------------
MEAN 14.9 465.8 14.7 457.1 0.99 90 14.8 449.7 1.00 273 14.8 437.2 0.99 845
SD(D) 0.6 0.7 0.03 3 1.0 0.05 11 0.8 0.04 36
CV(E) 3.7 4.9 3.5 2.8 6.5 5.0 4.0 5.7 4.5 4.2
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
CHRONIC DOSED FEED STUDY OF EMODIN
==================================================================================================================================
0 PPM 280 PPM 830 PPM 2500 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
2 11.8 131.1 11.7 129.1 0.99 254 11.6 127.7 0.98 753 11.2 123.9 0.95 2260
5 11.6 163.2 12.0 161.4 1.03 209 11.4 157.2 0.98 603 11.0 151.7 0.95 1816
9 10.4 182.8 10.3 179.9 0.99 160 10.1 177.4 0.97 473 9.9 173.2 0.95 1428
13 10.0 194.8 9.8 191.9 0.98 143 9.3 188.6 0.93 411 9.8 185.9 0.98 1320
17 9.7 204.7 9.7 203.2 1.00 134 9.9 198.7 1.02 415 9.9 197.8 1.02 1247
21 10.0 211.3 9.8 208.7 0.98 132 9.7 205.4 0.97 390 9.2 202.0 0.92 1136
25 9.7 219.3 9.4 214.0 0.97 124 9.4 210.9 0.97 368 9.8 209.2 1.01 1166
29 10.0 226.0 10.1 222.2 1.01 127 9.8 217.3 0.98 373 10.6 216.7 1.06 1227
33 10.6 234.6 10.6 228.3 1.00 129 10.4 226.2 0.98 380 10.3 221.7 0.97 1157
37 9.7 240.9 9.6 232.8 0.99 115 9.5 230.0 0.98 344 9.5 224.3 0.98 1055
41 10.3 247.3 9.7 239.6 0.94 114 9.9 237.2 0.96 348 10.1 232.4 0.98 1091
45 10.1 254.9 10.2 247.2 1.01 115 10.1 242.6 1.00 345 10.0 237.1 0.99 1055
49 10.5 264.5 9.9 253.1 0.94 110 10.0 250.0 0.95 331 9.8 245.0 0.93 1002
53 10.3 268.4 10.1 255.9 0.98 111 10.1 253.2 0.98 330 10.0 247.3 0.97 1013
57 10.8 273.7 10.7 262.8 0.99 114 10.9 260.1 1.01 348 11.0 253.4 1.02 1081
61 10.9 282.2 10.9 268.6 1.00 114 10.7 267.9 0.98 332 10.9 259.9 1.00 1045
65 11.1 292.2 10.5 277.3 0.95 106 11.0 278.1 0.99 328 10.9 272.2 0.98 1001
69 11.3 301.4 11.5 286.4 1.02 112 11.3 287.1 1.00 326 11.6 279.1 1.03 1039
73 11.5 308.1 11.1 293.3 0.97 106 11.3 294.0 0.98 319 11.5 289.4 1.00 991
77 11.5 319.0 11.0 302.1 0.96 102 11.2 299.9 0.97 311 11.2 296.3 0.97 946
81 11.3 323.9 10.1 302.5 0.89 94 11.5 308.1 1.02 310 10.7 295.8 0.95 906
85 12.0 330.6 12.3 315.9 1.03 109 11.5 314.2 0.96 304 11.8 303.7 0.98 971
89 11.8 332.9 11.6 316.9 0.98 102 11.9 318.4 1.01 311 11.1 301.8 0.94 922
93 10.8 330.0 11.6 318.7 1.07 102 11.5 316.8 1.06 300 11.7 307.6 1.08 949
97 11.6 336.3 11.5 326.1 0.99 99 11.2 319.7 0.97 291 11.1 310.1 0.96 896
101 11.2 335.9 11.9 330.5 1.06 101 12.0 330.5 1.07 300 11.4 314.2 1.02 907
1 TO 13 WEEKS
----------------
MEAN 10.9 168.0 10.9 165.6 1.00 191 10.6 162.7 0.97 560 10.5 158.7 0.96 1706
SD(D) 0.9 1.1 0.02 50 1.1 0.03 151 0.7 0.02 427
CV(E) 8.2 10.0 2.4 26.3 10.1 2.6 27.0 7.0 1.6 25.0
14 TO 52 WEEKS
----------------
MEAN 10.1 233.7 9.9 227.7 0.98 122 9.8 224.2 0.98 366 9.9 220.7 0.99 1126
SD(D) 0.3 0.3 0.03 9 0.3 0.02 27 0.4 0.04 82
CV(E) 3.4 3.4 2.7 7.3 3.1 2.1 7.3 4.3 4.3 7.3
> 52 WEEKS
----------------
MEAN 11.2 310.3 11.1 296.7 0.99 106 11.2 296.0 1.00 316 11.1 287.0 0.99 974
SD(D) 0.5 0.7 0.05 6 0.5 0.03 16 0.5 0.04 60
CV(E) 4.2 6.1 4.8 5.9 4.5 3.5 5.1 4.3 3.9 6.1
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED FEED STUDY OF EMODIN
=========================================================================================================
0 PPM 280 PPM 830 PPM 2500 PPM
---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
==========================================================================================================
B 138.5 60 134.5 60 134.2 60 133.0 60
1 138.5 60 134.5 60 134.2 60 133.0 60
2 16.3 10046 178.4 60 16.0 9912 174.5 60 15.8 9823 171.1 60 14.4 9760 160.3 60
3 214.1 60 208.3 60 204.0 60 192.1 60
4 242.0 60 234.7 60 230.1 60 211.4 60
5 18.0 10110 263.9 60 18.5 9925 259.9 60 17.4 10046 252.5 60 17.4 9808 236.4 60
6 282.6 60 277.6 60 269.4 60 253.4 60
7 299.4 60 293.8 60 286.2 60 268.7 60
8 313.1 60 307.3 60 298.1 60 277.8 60
9 17.1 10084 325.0 60 17.3 10064 319.3 60 16.6 10080 310.4 60 16.0 10108 290.6 60
10 328.1 60 323.2 60 321.1 60 302.3 60
11 342.2 60 337.7 60 329.5 60 314.2 60
12 351.5 60 345.4 60 335.6 60 318.9 60
13 16.5 10194 358.8 60 16.6 10092 356.1 60 16.0 10090 343.5 60 15.9 9985 330.0 60
17 16.2 9957 385.9 60 16.0 9860 382.0 60 15.7 9805 372.6 60 15.6 9734 355.6 60
21 16.6 9801 404.7 59 16.8 9815 399.9 60 16.2 9826 389.6 60 15.9 9746 369.4 60
25 16.1 9932 419.6 59 16.0 10084 416.0 60 15.7 10017 404.1 60 15.8 9958 387.1 60
29 16.8 8089 437.5 49 16.9 8151 430.6 50 16.8 8098 423.2 50 16.5 8078 398.2 50
33 17.7 7890 448.0 48 17.9 8210 442.8 50 17.4 8160 433.5 50 17.4 8207 412.3 50
37 15.7 8103 460.5 48 15.5 8414 457.1 50 15.4 8372 445.2 50 14.9 8308 426.8 50
41 16.0 8004 463.6 48 16.0 8325 456.8 50 15.7 8311 448.6 50 15.3 8161 431.3 49
45 16.7 7850 466.5 47 16.1 8320 464.9 50 16.0 8205 457.5 50 15.8 7985 436.2 49
49 15.3 7843 470.6 47 15.3 8329 468.2 50 14.8 8294 459.5 50 14.7 8069 439.8 49
53 15.2 7786 472.5 47 14.7 8186 469.0 50 14.7 8142 458.2 50 15.0 7881 440.7 49
56 15.1 3637 15.4 3768 15.1 3612 14.4 3805
57 15.0 4345 473.5 47 16.2 4615 471.8 50 16.2 4374 463.5 48 15.8 4484 443.6 49
61 15.1 7814 472.4 46 15.1 8399 467.9 50 15.5 8056 459.3 48 14.8 8171 440.2 49
65 14.9 7721 470.6 46 14.8 8360 464.5 50 15.2 7999 458.1 48 15.2 8040 439.9 49
69 15.2 7695 471.6 45 15.0 8051 465.1 48 15.7 7975 458.5 48 15.4 7911 440.4 48
73 15.0 7537 470.7 45 15.2 7797 464.2 47 15.4 7797 456.9 47 15.4 7768 443.1 47
77 15.2 7515 471.3 44 14.6 7639 464.0 45 14.8 7768 456.6 45 14.2 7956 441.6 47
81 15.5 7367 471.7 44 14.8 7258 462.0 42 14.9 7249 453.6 44 15.2 7535 442.6 46
85 15.1 7444 465.4 44 14.9 6952 460.1 41 15.9 7229 456.3 43 15.9 7665 442.5 46
89 15.2 6372 459.4 38 14.2 6187 449.4 37 14.2 6324 444.2 38 14.4 6630 434.4 39
93 14.5 6204 456.1 37 14.4 5348 444.6 32 13.2 5515 430.9 33 14.2 6275 430.0 38
97 13.4 6119 452.0 36 13.2 5242 432.4 31 13.5 5046 429.4 30 13.8 5892 427.4 35
101 14.2 5618 448.8 33 13.9 4299 426.9 26 13.5 4333 420.4 25 12.9 5833 417.2 34
105 14.3 5046 15.0 3449 13.6 3437 13.8 4896
MEAN BODY WGT FOR WEEKS
1 TO 13 279.8 274.8 268.1 253.0
14 TO 52 439.7 435.4 426.0 406.3
> 52 465.8 457.1 449.7 437.2
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
CHRONIC DOSED FEED STUDY OF EMODIN
=========================================================================================================
0 PPM 280 PPM 830 PPM 2500 PPM
---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
==========================================================================================================
B 110.8 60 109.4 60 109.0 60 107.9 60
1 110.8 60 109.4 60 109.0 60 107.9 60
2 11.8 9873 131.1 60 11.7 9740 129.1 60 11.6 9697 127.7 60 11.2 9628 123.9 60
3 144.5 60 140.7 60 139.2 60 134.4 60
4 152.5 60 150.2 60 147.8 60 141.7 60
5 11.6 9329 163.2 60 12.0 9200 161.4 60 11.4 10140 157.2 60 11.0 9882 151.7 60
6 168.9 60 165.4 60 162.7 60 156.8 60
7 176.0 60 172.5 60 170.2 60 164.3 60
8 180.3 60 175.8 60 174.8 60 169.5 60
9 10.4 10061 182.8 60 10.3 10056 179.9 60 10.1 10032 177.4 60 9.9 10062 173.2 60
10 185.2 60 182.5 60 179.9 60 176.0 60
11 189.5 60 187.2 60 184.7 60 180.2 60
12 191.8 60 189.5 60 187.2 60 184.7 60
13 10.0 10152 194.8 60 9.8 10158 191.9 60 9.3 10062 188.6 60 9.8 10020 185.9 60
17 9.7 9984 204.7 60 9.7 9870 203.2 60 9.9 9754 198.7 60 9.9 9797 197.8 60
21 10.0 9924 211.3 60 9.8 9879 208.7 60 9.7 9713 205.4 60 9.2 9872 202.0 60
25 9.7 10116 219.3 60 9.4 10039 214.0 60 9.4 10044 210.9 60 9.8 9948 209.2 60
29 10.0 8256 226.0 50 10.1 8131 222.2 50 9.8 8153 217.3 50 10.6 8076 216.7 50
33 10.6 8077 234.6 50 10.6 8065 228.3 50 10.4 8069 226.2 50 10.3 8049 221.7 50
37 9.7 8445 240.9 50 9.6 8437 232.8 50 9.5 8108 230.0 49 9.5 8289 224.3 50
41 10.3 8238 247.3 50 9.7 8227 239.6 50 9.9 8081 237.2 49 10.1 8224 232.4 50
45 10.1 8394 254.9 50 10.2 8323 247.2 50 10.1 8073 242.6 49 10.0 8088 237.1 50
49 10.5 8262 264.5 50 9.9 8242 253.1 50 10.0 8057 250.0 49 9.8 8179 245.0 50
53 10.3 8237 268.4 50 10.1 8134 255.9 50 10.1 7947 253.2 49 10.0 7956 247.3 49
56 9.4 3856 10.5 3769 10.3 3703 10.1 3802
57 10.8 4518 273.7 50 10.7 4498 262.8 50 10.9 4441 260.1 49 11.0 4364 253.4 49
61 10.9 8337 282.2 50 10.9 8028 268.6 49 10.7 8048 267.9 49 10.9 7958 259.9 49
65 11.1 8283 292.2 49 10.5 8080 277.3 49 11.0 8046 278.1 49 10.9 7938 272.2 49
69 11.3 8207 301.4 49 11.5 8123 286.4 49 11.3 8100 287.1 49 11.6 7976 279.1 49
73 11.5 8029 308.1 48 11.1 8146 293.3 49 11.3 8114 294.0 49 11.5 8122 289.4 49
77 11.5 7910 319.0 47 11.0 8221 302.1 49 11.2 8055 299.9 48 11.2 8104 296.3 48
81 11.3 7660 323.9 46 10.1 8192 302.5 49 11.5 7753 308.1 47 10.7 7894 295.8 48
85 12.0 7702 330.6 46 12.3 7860 315.9 47 11.5 7755 314.2 47 11.8 7910 303.7 47
89 11.8 7188 332.9 44 11.6 7305 316.9 45 11.9 7466 318.4 45 11.1 6783 301.8 42
93 10.8 6942 330.0 40 11.6 7081 318.7 43 11.5 7389 316.8 45 11.7 6654 307.6 41
97 11.6 6517 336.3 39 11.5 6785 326.1 41 11.2 6920 319.7 42 11.1 6247 310.1 38
101 11.2 6114 335.9 37 11.9 6587 330.5 40 12.0 6440 330.5 39 11.4 5755 314.2 35
105 11.0 5609 11.8 6395 12.2 5849 12.5 5527
MEAN BODY WGT FOR WEEKS
1 TO 13 167.0 164.3 162.0 157.7
14 TO 52 233.7 227.7 224.2 220.7
> 52 310.3 296.7 296.0 287.0
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.