TDMS Study 05211-05 Pathology Tables
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:48
FINAL#3;REVISION#1
Facility: Southern Research Institute
Chemical CAS #: 518-82-1
Lock Date: 07/30/97
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Moribund Sacrifice 12 8 11 15
Natural Death 5 3 4 1
Survivors
Terminal Sacrifice 33 39 35 34
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (50) (49) (50)
Edema 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%)
Intestine Small, Duodenum (48) (50) (49) (50)
Epithelium, Hyperplasia 1 (2%)
Liver (49) (50) (50) (50)
Angiectasis 2 (4%) 4 (8%)
Basophilic Focus 39 (80%) 44 (88%) 41 (82%) 45 (90%)
Clear Cell Focus 2 (4%) 10 (20%) 4 (8%) 11 (22%)
Eosinophilic Focus 18 (37%) 10 (20%) 18 (36%) 27 (54%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%) 2 (4%)
Hemorrhage 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 3 (6%) 9 (18%) 7 (14%) 7 (14%)
Infiltration Cellular, Mixed Cell 15 (31%) 12 (24%) 9 (18%) 11 (22%)
Mixed Cell Focus 4 (8%) 5 (10%) 6 (12%) 1 (2%)
Necrosis, Focal 4 (8%) 4 (8%) 3 (6%)
Bile Duct, Hyperplasia 1 (2%) 4 (8%) 1 (2%)
Centrilobular, Necrosis 1 (2%) 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 3 (6%) 2 (4%) 2 (4%) 2 (4%)
Kupffer Cell, Pigmentation 2 (4%) 2 (4%) 3 (6%) 1 (2%)
Mesentery (1) (6) (1) (6)
Accessory Spleen 2 (33%) 2 (33%)
Fat, Necrosis 1 (100%) 4 (67%) 1 (100%) 5 (83%)
Pancreas (49) (50) (49) (50)
Atrophy 13 (27%) 15 (30%) 18 (37%) 13 (26%)
Metaplasia, Hepatocyte 1 (2%)
Salivary Glands (49) (50) (50) (50)
Atrophy 1 (2%) 1 (2%) 2 (4%)
Stomach, Forestomach (49) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Edema 1 (2%) 1 (2%) 1 (2%)
Erosion 1 (2%)
Perforation 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Stomach, Glandular (49) (50) (50) (50)
Edema 1 (2%)
Erosion 1 (2%) 1 (2%) 1 (2%)
Tongue (1)
Epithelium, Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (50) (50)
Cardiomyopathy 22 (45%) 16 (32%) 17 (34%) 16 (32%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Accessory Adrenal Cortical Nodule 6 (12%) 4 (8%) 7 (14%) 10 (20%)
Atrophy 2 (4%)
Degeneration, Fatty 12 (24%) 9 (18%) 14 (28%) 10 (20%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Diffuse 1 (2%)
Hyperplasia, Focal 3 (6%) 3 (6%) 8 (16%) 7 (14%)
Hypertrophy 1 (2%)
Hypertrophy, Focal 12 (24%) 7 (14%) 12 (24%) 10 (20%)
Necrosis 2 (4%)
Adrenal Medulla (47) (50) (50) (50)
Hyperplasia 2 (4%) 2 (4%) 2 (4%) 3 (6%)
Islets, Pancreatic (49) (50) (49) (50)
Hyperplasia 1 (2%)
Pituitary Gland (49) (50) (49) (49)
Pars Distalis, Angiectasis 9 (18%) 10 (20%) 6 (12%) 5 (10%)
Pars Distalis, Cyst 22 (45%) 11 (22%) 13 (27%) 16 (33%)
Pars Distalis, Hyperplasia, Focal 13 (27%) 10 (20%) 3 (6%) 5 (10%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (49) (50) (50) (50)
Ultimobranchial Cyst 1 (2%) 1 (2%)
C-Cell, Hyperplasia 21 (43%) 9 (18%) 11 (22%) 12 (24%)
Follicle, Cyst 1 (2%) 1 (2%) 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (50) (49) (49)
Cyst 1 (2%) 4 (8%) 1 (2%)
Hyperplasia 3 (6%) 2 (4%) 6 (12%) 3 (6%)
Inflammation, Chronic 5 (10%) 5 (10%) 6 (12%) 5 (10%)
Ovary (49) (50) (50) (50)
Cyst 10 (20%) 6 (12%) 6 (12%) 7 (14%)
Uterus (49) (50) (50) (50)
Angiectasis 1 (2%)
Hydrometra 5 (10%) 3 (6%) 5 (10%) 6 (12%)
Hyperplasia, Cystic 1 (2%) 5 (10%) 4 (8%) 7 (14%)
Inflammation, Chronic 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Hyperplasia 5 (10%) 3 (6%) 4 (8%) 6 (12%)
Infiltration Cellular, Histiocyte 2 (4%) 4 (8%) 2 (4%)
Lymph Node (5) (3) (4) (3)
Mediastinal, Hemorrhage 2 (50%) 1 (33%)
Mediastinal, Hyperplasia, Lymphoid 1 (25%) 1 (33%)
Mediastinal, Pigmentation 1 (20%) 1 (33%) 1 (25%)
Pancreatic, Hematopoietic Cell Proliferation 1 (25%)
Pancreatic, Hemorrhage 1 (25%)
Lymph Node, Mandibular (49) (50) (50) (50)
Ectasia 1 (2%) 2 (4%) 6 (12%) 6 (12%)
Hemorrhage 2 (4%) 4 (8%) 4 (8%) 4 (8%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%) 1 (2%)
Pigmentation 18 (37%) 19 (38%) 21 (42%) 25 (50%)
Lymph Node, Mesenteric (49) (50) (49) (50)
Hemorrhage 2 (4%) 5 (10%) 2 (4%) 4 (8%)
Pigmentation 2 (4%) 2 (4%) 2 (4%)
Spleen (50) (50) (50) (50)
Angiectasis 1 (2%)
Depletion Cellular 1 (2%)
Developmental Malformation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Fibrosis 2 (4%)
Hematopoietic Cell Proliferation 27 (54%) 24 (48%) 31 (62%) 40 (80%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Necrosis 1 (2%) 1 (2%)
Pigmentation 30 (60%) 30 (60%) 35 (70%) 43 (86%)
Thymus (47) (49) (49) (50)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (50) (50)
Hyperplasia 44 (90%) 44 (88%) 42 (84%) 42 (84%)
Skin (49) (50) (50) (50)
Hyperkeratosis 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Inflammation, Chronic 1 (2%) 1 (2%)
Ulcer 2 (4%) 1 (2%) 4 (8%) 3 (6%)
Epidermis, Hyperplasia 4 (8%) 2 (4%) 5 (10%) 5 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50) (50)
Cranium, Osteopetrosis 7 (14%) 5 (10%) 6 (12%) 8 (16%)
Femur, Osteopetrosis 6 (12%) 8 (16%) 7 (14%) 7 (14%)
Skeletal Muscle (1)
Atrophy 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Compression 8 (16%) 7 (14%) 10 (20%) 7 (14%)
Hydrocephalus 3 (6%) 3 (6%) 7 (14%)
Peripheral Nerve (2) (1) (3)
Atrophy 1 (33%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50) (50)
Hemorrhage 3 (6%) 1 (2%) 2 (4%) 5 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Infiltration Cellular, Histiocyte 38 (78%) 37 (74%) 34 (68%) 32 (64%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 4 (8%) 4 (8%)
Nose (49) (50) (50) (50)
Foreign Body 1 (2%) 1 (2%) 2 (4%)
Inflammation, Chronic 6 (12%) 3 (6%) 5 (10%) 5 (10%)
Goblet Cell, Hyperplasia 1 (2%) 1 (2%)
Respiratory Epithelium, Hyperplasia 6 (12%) 4 (8%) 4 (8%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (5) (2) (4) (2)
Cataract 4 (80%) 2 (100%) 3 (75%) 1 (50%)
Hemorrhage 2 (50%)
Inflammation, Chronic 1 (25%) 1 (50%)
Retina, Degeneration 4 (80%) 2 (100%) 3 (75%) 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (49) (50)
Cyst 1 (2%)
Glomerulosclerosis 1 (2%)
Hydronephrosis 1 (2%)
Infarct 2 (4%) 3 (6%)
Inflammation, Chronic 1 (2%) 1 (2%) 3 (6%)
Nephropathy 46 (94%) 43 (86%) 45 (92%) 49 (98%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Hyaline Droplet 22 (45%) 49 (98%) 49 (100%) 50 (100%)
Renal Tubule, Hyperplasia, Oncocytic 2 (4%)
Renal Tubule, Necrosis 1 (2%)
Renal Tubule, Pigmentation 45 (92%) 49 (98%) 49 (100%) 50 (100%)
Transitional Epithelium, Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Urinary Bladder (49) (50) (50) (50)
Hemorrhage 1 (2%)
Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Moribund Sacrifice 17 26 27 16
Natural Death 3 3 2 4
Survivors
Terminal Sacrifice 30 21 21 30
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (50) (50) (50)
Congestion 1 (2%)
Edema 1 (2%)
Inflammation, Chronic 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Large, Cecum (49) (50) (50) (49)
Congestion 1 (2%)
Edema 2 (4%) 2 (4%) 3 (6%) 2 (4%)
Inflammation, Chronic 2 (4%)
Epithelium, Hyperplasia 2 (4%)
Intestine Small, Jejunum (49) (48) (50) (49)
Congestion 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 5 (10%) 5 (10%) 11 (22%)
Basophilic Focus 20 (40%) 18 (36%) 18 (36%) 23 (46%)
Clear Cell Focus 7 (14%) 7 (14%) 9 (18%) 13 (26%)
Degeneration, Cystic 7 (14%) 10 (20%) 11 (22%) 10 (20%)
Eosinophilic Focus 6 (12%) 8 (16%) 6 (12%) 10 (20%)
Hematopoietic Cell Proliferation 2 (4%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 3 (6%) 5 (10%) 2 (4%) 4 (8%)
Infiltration Cellular, Mixed Cell 2 (4%) 2 (4%) 2 (4%)
Mixed Cell Focus 6 (12%) 4 (8%) 3 (6%) 9 (18%)
Necrosis, Focal 2 (4%) 2 (4%) 2 (4%)
Bile Duct, Hyperplasia 33 (66%) 24 (48%) 20 (40%) 14 (28%)
Centrilobular, Necrosis 1 (2%) 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 3 (6%) 3 (6%) 4 (8%) 2 (4%)
Kupffer Cell, Pigmentation 1 (2%) 1 (2%) 2 (4%) 4 (8%)
Mesentery (8) (7) (13) (15)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Accessory Spleen 4 (50%) 2 (29%) 2 (15%)
Fat, Necrosis 5 (63%) 6 (86%) 11 (85%) 12 (80%)
Pancreas (50) (50) (50) (50)
Atrophy 23 (46%) 19 (38%) 16 (32%) 23 (46%)
Metaplasia, Hepatocyte 1 (2%) 1 (2%)
Acinus, Hyperplasia, Focal 1 (2%) 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50) (49)
Edema 1 (2%)
Stomach, Forestomach (50) (50) (49) (48)
Diverticulum 1 (2%)
Edema 4 (8%) 3 (6%) 2 (4%) 5 (10%)
Perforation 1 (2%)
Ulcer 6 (12%) 2 (4%) 4 (8%) 4 (8%)
Epithelium, Hyperplasia 5 (10%) 4 (8%) 7 (14%) 5 (10%)
Stomach, Glandular (50) (50) (49) (48)
Edema 1 (2%) 3 (6%)
Erosion 1 (2%) 2 (4%) 3 (6%) 1 (2%)
Ulcer 2 (4%) 3 (6%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 34 (68%) 31 (62%) 35 (70%) 36 (72%)
Thrombosis 2 (4%) 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 13 (26%) 18 (36%) 16 (32%) 10 (20%)
Degeneration, Fatty 7 (14%) 9 (18%) 10 (20%) 8 (16%)
Hyperplasia, Diffuse 2 (4%) 1 (2%) 1 (2%)
Hyperplasia, Focal 3 (6%) 4 (8%) 2 (4%)
Hypertrophy 1 (2%)
Hypertrophy, Focal 6 (12%) 9 (18%) 7 (14%) 3 (6%)
Necrosis 1 (2%)
Adrenal Medulla (50) (49) (50) (50)
Hyperplasia 10 (20%) 9 (18%) 7 (14%) 17 (34%)
Islets, Pancreatic (50) (50) (49) (50)
Hyperplasia 5 (10%) 1 (2%) 2 (4%)
Parathyroid Gland (48) (45) (45) (47)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia, Focal 1 (2%)
Pituitary Gland (49) (50) (48) (50)
Pars Distalis, Angiectasis 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Cyst 7 (14%) 9 (18%) 5 (10%) 3 (6%)
Pars Distalis, Hyperplasia, Focal 6 (12%) 3 (6%) 5 (10%) 1 (2%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Ultimobranchial Cyst 1 (2%) 1 (2%)
C-Cell, Hyperplasia 7 (14%) 2 (4%) 7 (14%) 4 (8%)
Follicle, Cyst 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Atypia Cellular 29 (58%) 26 (52%) 25 (50%) 29 (58%)
Preputial Gland (50) (50) (50) (50)
Cyst 1 (2%) 1 (2%)
Inflammation, Chronic 17 (34%) 20 (40%) 13 (26%) 20 (40%)
Prostate (50) (50) (50) (50)
Fibrosis 5 (10%) 5 (10%) 4 (8%) 6 (12%)
Inflammation, Chronic 27 (54%) 24 (48%) 28 (56%) 29 (58%)
Epithelium, Hyperplasia 12 (24%) 3 (6%) 10 (20%) 9 (18%)
Testes (50) (50) (50) (50)
Germinal Epithelium, Atrophy 7 (14%) 12 (24%) 3 (6%) 8 (16%)
Interstitial Cell, Hyperplasia 4 (8%) 8 (16%) 3 (6%) 5 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 3 (6%) 5 (10%) 3 (6%) 11 (22%)
Lymph Node (12) (21) (18) (11)
Iliac, Pigmentation 1 (5%) 1 (9%)
Mediastinal, Hemorrhage 1 (8%) 1 (5%) 2 (11%) 4 (36%)
Mediastinal, Hyperplasia, Lymphoid 1 (8%) 1 (6%)
Mediastinal, Pigmentation 2 (10%) 4 (22%) 2 (18%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pancreatic, Hemorrhage 1 (9%)
Pancreatic, Pigmentation 1 (5%)
Renal, Hemorrhage 1 (6%)
Renal, Pigmentation 1 (6%) 1 (9%)
Lymph Node, Mandibular (49) (50) (48) (50)
Ectasia 3 (6%) 2 (4%) 1 (2%)
Hemorrhage 1 (2%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Pigmentation 2 (4%) 2 (4%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Atrophy 1 (2%)
Ectasia 6 (12%)
Hemorrhage 2 (4%) 2 (4%) 2 (4%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
Spleen (50) (50) (50) (50)
Accessory Spleen 1 (2%) 1 (2%)
Fibrosis 8 (16%) 9 (18%) 3 (6%) 3 (6%)
Hematopoietic Cell Proliferation 3 (6%) 5 (10%) 4 (8%) 8 (16%)
Necrosis 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Pigmentation 1 (2%) 2 (4%) 4 (8%) 4 (8%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (47) (49) (49)
Hyperplasia 14 (29%) 23 (49%) 10 (20%) 13 (27%)
Skin (50) (50) (49) (49)
Cyst Epithelial Inclusion 3 (6%) 2 (4%)
Hyperkeratosis 2 (4%) 3 (6%) 1 (2%)
Hyperplasia, Basal Cell 1 (2%)
Inflammation, Chronic 2 (4%) 2 (4%) 1 (2%)
Ulcer 2 (4%)
Epidermis, Hyperplasia 1 (2%) 3 (6%)
Subcutaneous Tissue, Fibrosis 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Cranium, Osteopetrosis 1 (2%)
Skeletal Muscle (1) (2)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Hemorrhage 1 (50%)
Necrosis 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Angiectasis 1 (2%)
Compression 4 (8%) 2 (4%) 5 (10%) 5 (10%)
Hydrocephalus 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Necrosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Hemorrhage 1 (2%) 2 (4%) 1 (2%)
Infiltration Cellular, Histiocyte 26 (52%) 28 (56%) 27 (54%) 35 (70%)
Inflammation, Chronic 1 (2%) 2 (4%)
Alveolar Epithelium, Hyperplasia 5 (10%) 1 (2%) 2 (4%) 5 (10%)
Nose (50) (50) (50) (50)
Foreign Body 4 (8%) 3 (6%) 1 (2%) 2 (4%)
Inflammation, Chronic 9 (18%) 8 (16%) 9 (18%) 8 (16%)
Respiratory Epithelium, Hyperplasia 6 (12%) 7 (14%) 8 (16%) 5 (10%)
Respiratory Epithelium, Metaplasia, Squamous 4 (8%) 3 (6%) 5 (10%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (1) (1)
Atrophy 1 (33%)
Cataract 2 (67%) 1 (100%) 1 (100%)
Retina, Degeneration 2 (67%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 1 (2%) 2 (4%) 1 (2%)
Hydronephrosis 2 (4%)
Infarct 3 (6%)
Inflammation, Chronic 15 (30%) 11 (22%) 13 (26%) 25 (50%)
Nephropathy 48 (96%) 50 (100%) 50 (100%) 50 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Hyaline Droplet 3 (6%) 45 (90%) 43 (86%) 43 (86%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Necrosis 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 35 (70%) 47 (94%) 49 (98%) 50 (100%)
Transitional Epithelium, Hyperplasia 4 (8%) 4 (8%) 3 (6%) 2 (4%)
Urinary Bladder (50) (50) (50) (50)
Edema 1 (2%)
Hemorrhage 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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