TDMS Study 05211-05 Pathology Tables
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:56
FINAL#3;REVISION#1
Facility: Southern Research Institute
Chemical CAS #: 518-82-1
Lock Date: 07/30/97
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Early Deaths
Moribund Sacrifice 12 8 11 15
Natural Death 5 3 4 1
Survivors
Terminal Sacrifice 33 39 35 34
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Ileum (48) (50) (49) (50)
Liver (49) (50) (50) (50)
Hemangioma 1 (2%)
Hepatocellular Adenoma, Multiple 1 (2%)
Pancreas (49) (50) (49) (50)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Stomach, Forestomach (49) (50) (50) (50)
Stomach, Glandular (49) (50) (50) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Adrenal Medulla (47) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 1 (2%) 4 (8%) 1 (2%)
Islets, Pancreatic (49) (50) (49) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 1 (2%) 1 (2%)
Pituitary Gland (49) (50) (49) (49)
Pars Distalis, Adenoma 15 (31%) 21 (42%) 25 (51%) 25 (51%)
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NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Pars Intermedia, Carcinoma 1 (2%)
Thyroid Gland (49) (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 4 (8%) 5 (10%) 4 (8%) 3 (6%)
C-Cell, Carcinoma 2 (4%) 2 (4%) 3 (6%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
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GENITAL SYSTEM
Clitoral Gland (49) (50) (49) (49)
Adenoma 10 (20%) 10 (20%) 8 (16%) 9 (18%)
Carcinoma 2 (4%) 3 (6%) 2 (4%)
Bilateral, Adenoma 2 (4%) 1 (2%)
Ovary (49) (50) (50) (50)
Bilateral, Granulosa Cell Tumor Benign 1 (2%)
Uterus (49) (50) (50) (50)
Leiomyoma 1 (2%)
Polyp Stromal 10 (20%) 7 (14%) 7 (14%) 10 (20%)
Polyp Stromal, Multiple 1 (2%)
Sarcoma Stromal 1 (2%)
Vagina (2) (3) (3) (5)
Granular Cell Tumor Benign 1 (33%)
Squamous Cell Papilloma 1 (33%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Lymph Node (5) (3) (4) (3)
Lymph Node, Mandibular (49) (50) (50) (50)
Lymph Node, Mesenteric (49) (50) (49) (50)
Spleen (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Thymus (47) (49) (49) (50)
Page 3
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Thymoma Benign 1 (2%) 1 (2%)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (50) (50)
Carcinoma 2 (4%)
Fibroadenoma 18 (37%) 13 (26%) 20 (40%) 16 (32%)
Fibroadenoma, Multiple 5 (10%) 5 (10%) 1 (2%)
Skin (49) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Keratoacanthoma 1 (2%)
Schwannoma Malignant 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50) (50)
Osteosarcoma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Glioma Malignant 1 (2%)
Granular Cell Tumor Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Adrenal Cortex 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Lacrimal Gland (1)
Carcinoma 1 (100%)
Zymbal's Gland (3)
Carcinoma 3 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (49) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
Urinary Bladder (49) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 14 (28%) 17 (34%) 16 (32%) 3 (6%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 47 48 43
Total Primary Neoplasms 94 99 98 85
Total Animals with Benign Neoplasms 41 39 41 37
Total Benign Neoplasms 70 70 75 70
Total Animals with Malignant Neoplasms 22 24 22 15
Total Malignant Neoplasms 24 29 23 15
Total Animals with Metastatic Neoplasms 1 1 1 2
Total Metastatic Neoplasm 2 1 1 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Early Deaths
Moribund Sacrifice 17 26 27 16
Natural Death 3 3 2 4
Survivors
Terminal Sacrifice 30 21 21 30
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (50) (50) (49)
Intestine Small, Duodenum (48) (50) (49) (50)
Carcinoma 1 (2%)
Intestine Small, Jejunum (49) (48) (50) (49)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Intestine Small, Ileum (50) (50) (48) (49)
Sarcoma 1 (2%)
Liver (50) (50) (50) (50)
Cholangiocarcinoma 1 (2%)
Fibrosarcoma, Metastatic, Spleen 1 (2%)
Hepatocellular Carcinoma 3 (6%) 3 (6%)
Hepatocellular Adenoma 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mesentery (8) (7) (13) (15)
Sarcoma 2 (13%)
Pancreas (50) (50) (50) (50)
Fibrosarcoma, Metastatic, Spleen 1 (2%)
Mixed Tumor Benign 2 (4%)
Salivary Glands (50) (50) (50) (49)
Schwannoma Malignant 1 (2%)
Stomach, Forestomach (50) (50) (49) (48)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (49) (48)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Adrenal Medulla (50) (49) (50) (50)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 1 (2%)
Pheochromocytoma Benign 6 (12%) 11 (22%) 5 (10%) 9 (18%)
Bilateral, Pheochromocytoma Benign 1 (2%) 2 (4%) 1 (2%)
Islets, Pancreatic (50) (50) (49) (50)
Adenoma 2 (4%) 5 (10%) 1 (2%) 1 (2%)
Carcinoma 3 (6%) 1 (2%) 1 (2%)
Parathyroid Gland (48) (45) (45) (47)
Adenoma 1 (2%)
Pituitary Gland (49) (50) (48) (50)
Pars Distalis, Adenoma 15 (31%) 9 (18%) 10 (21%) 13 (26%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Adenoma 3 (6%) 5 (10%) 3 (6%) 3 (6%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (2) (1) (3) (1)
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GENITAL SYSTEM
Preputial Gland (50) (50) (50) (50)
Adenoma 5 (10%) 1 (2%) 2 (4%) 3 (6%)
Carcinoma 3 (6%) 2 (4%) 1 (2%) 3 (6%)
Prostate (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 3 (6%)
Seminal Vesicle (50) (50) (50) (50)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 34 (68%) 30 (60%) 37 (74%) 35 (70%)
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NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Interstitial Cell, Adenoma 7 (14%) 13 (26%) 7 (14%) 13 (26%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Lymph Node (12) (21) (18) (11)
Lymph Node, Mandibular (49) (50) (48) (50)
Lymph Node, Mesenteric (50) (50) (50) (50)
Spleen (50) (50) (50) (50)
Fibrosarcoma 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Thymus (46) (47) (48) (48)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (47) (49) (49)
Fibroadenoma 1 (2%) 2 (4%) 2 (4%) 3 (6%)
Skin (50) (50) (49) (49)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%) 1 (2%)
Keratoacanthoma 3 (6%) 3 (6%) 3 (6%) 3 (6%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 2 (4%)
Trichoepithelioma 1 (2%) 1 (2%)
Sebaceous Gland, Adenoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 3 (6%) 2 (4%) 5 (10%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Hemangiopericytoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%) 1 (2%)
Skeletal Muscle (1) (2)
Schwannoma Malignant, Metastatic, Skin 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 2 (4%) 1 (2%)
Oligodendroglioma Malignant 1 (2%)
Pineal Gland, Meningioma Malignant 1 (2%)
Spinal Cord (2) (5) (8) (3)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Nose (50) (50) (50) (50)
Squamous Cell Carcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Renal Tubule, Stromal Nephroma 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Page 10
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leukemia Mononuclear 28 (56%) 31 (62%) 29 (58%) 18 (36%)
Mesothelioma Malignant 2 (4%) 1 (2%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05211-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 12:57:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 50 50
Total Primary Neoplasms 131 141 124 133
Total Animals with Benign Neoplasms 45 46 47 49
Total Benign Neoplasms 87 91 79 98
Total Animals with Malignant Neoplasms 36 38 36 28
Total Malignant Neoplasms 44 50 45 35
Total Animals with Metastatic Neoplasms 1 2
Total Metastatic Neoplasm 2 7
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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