TDMS Study 05211-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst EMODIN DATE: 01/25/01
EXPERIMENT: 05211 TEST: 05 TIME: 13:06:30
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-85216 ROUTE: DOSED FEED NTP C#: C62408
PATHOLOGIST: HEATH, JAMES CAS: 518-82-1
------------------------------------------------------------------------------------------------------------------------------------
FINAL#3;REVISION#1
REASONS FOR REMOVAL: 25022 Accidently Killed
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst EMODIN DATE: 01/25/01
EXPERIMENT: 05211 TEST: 05 TIME: 13:06:30
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-85216 ROUTE: DOSED FEED NTP C#: C62408
PATHOLOGIST: HEATH, JAMES CAS: 518-82-1
EMODIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 122 216 284 406 472 528 590 590 597 599 |
| 604 617 617 646 679 686 700 704 711 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 280 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 462 464 491 506 511 555 557 561 584 596 |
| 610 610 617 630 631 632 636 638 665 673 |
| 679 679 679 690 704 704 714 716 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 830 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 368 373 483 510 533 550 575 602 603 605 |
| 609 617 617 624 631 638 644 645 645 648 |
| 673 689 696 700 700 704 704 720 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
EMODIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 266 449 492 539 590 597 602 605 607 617 |
| 617 634 645 654 668 700 702 711 711 720 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
EMODIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM| 100.0 98.0 96.0 94.0 92.0 90.0 88.0 78.0 72.0 60.0 |
| | |
| | |
|280 PPM| 100.0 100.0 100.0 100.0 100.0 96.0 90.0 80.0 62.0 42.0 |
| | |
| | |
|830 PPM| 100.0 100.0 100.0 100.0 96.0 94.0 90.0 80.0 60.0 42.0 |
| | |
| | |
|2500 PPM| 100.0 100.0 98.0 98.0 98.0 96.0 92.0 84.0 72.0 60.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 280 PPM 830 PPM 2500 P|M
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.0% 42.0% 42.0% 60.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.396N P=0.145 P=0.154 P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 554.7 617.9 614.9 606.3 |
|NATURAL DEATHS (C) | (38.4) (14.4) (17.0) (24.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 659.3 664.6 662.8 679.9 |
|(STANDARD ERROR) | (19.4) (11.4) (12.7) (12.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
EMODIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 448 497 527 544 596 610 630 630 645 646 |
| 648 685 686 704 704 725 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 280 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 396 572 575 600 605 624 634 646 656 690 |
| 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 830 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 232 527 539 592 617 648 665 665 674 674 |
| 677 702 711 725 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
EMODIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 360 529 590 592 597 602 603 610 618 646 |
| 657 665 674 689 690 716 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
EMODIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM| 100.0 100.0 100.0 100.0 100.0 98.0 92.0 90.0 78.0 66.0 |
| | |
| | |
|280 PPM| 100.0 100.0 100.0 100.0 98.0 98.0 98.0 90.0 82.0 78.0 |
| | |
| | |
|830 PPM| 100.0 100.0 98.0 98.0 98.0 98.0 94.0 92.0 84.0 70.0 |
| | |
| | |
|2500 PPM| 100.0 100.0 100.0 98.0 98.0 98.0 96.0 86.0 76.0 68.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 280 PPM 830 PPM 2500 P|M
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 78.0% 70.0% 68.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.762 P=0.285N P=0.761N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 626.5 610.4 624.9 614.9 |
|NATURAL DEATHS (C) | (19.8) (25.3) (32.2) (20.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 694.8 703.7 698.5 693.2 |
|(STANDARD ERROR) | ( 9.6) ( 8.9) (11.7) (10.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
EMODIN
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
280 PPM = 2
830 PPM = 3
2500 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 1 4 3 2
| 1 1 4 33 422
96 + 1 1 3 4 2 3 2
| 1 1 3 2 2 4
| 1 1 3 3 4
| 1 2 13 32 44
P 88 + 1 3 3 1
E | 22 3 34
R | 2 2 113
C | 2 24 4
E 80 + 112
N | 1 1 4
T | 22 4 4
| 12 14
S 72 + 22 14 41
U | 33 411 4
R | 1 14
V | 223 114
I 64 + 2 2 11
V | 2 2 141
A | 3 3 41 1
L | 3 3
56 + 33
| 2 2
| 2 2
| 33
48 + 22
| 322
| 22
| 2 2
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 29 obs hidden.
EMODIN
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
280 PPM = 2
830 PPM = 3
2500 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 4 2 1
|
| 3 4 2 1 1 3 2
| 1 13 22 4
95 +
| 131 2 32
P | 1 312 3
E |
R 90 + 12132 3
C |
E | 441 12 3 3
N | 44 2 2
T 85 +
| 441 12 3 3
S | 4 42 2
U |
R 80 + 44 2 2
V |
I | 14 4 31 3 2 2
V | 4 4 33
A 75 +
L | 414 13 3
|
|
70 + 4 1 41 3
|
| 4 4
| 1 1
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.