https://ntp.niehs.nih.gov/go/3671

TDMS Study 05211-05 Pathology Tables

NTP Experiment-Test: 05211-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 03/26/99
Route: DOSED FEED                                                                                                 Time: 08:33:59
                                                          27 WEEK SSAC
       Facility:  Southern Research Institute
       Chemical CAS #:  518-82-1
       Lock Date:  07/30/97
       Cage Range:  All
       Reasons For Removal:    25017 Scheduled Sacrifice
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                              Page   1
NTP Experiment-Test: 05211-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 03/26/99  
Route: DOSED FEED                                                                                                 Time: 08:33:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (10)         (10)         (10)                                   
      Basophilic Focus                                 2 (20%)                   1 (10%)      1 (10%)                               
      Infiltration Cellular, Mixed Cell                             1 (10%)                                                         
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 03/26/99  
Route: DOSED FEED                                                                                                 Time: 08:33:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Nephropathy                                      1 (10%)      2 (20%)      1 (10%)      3 (30%)                               
      Renal Tubule, Hyaline Droplet                    6 (60%)     10 (100%)    10 (100%)    10 (100%)                              
      Renal Tubule, Pigmentation                      10 (100%)    10 (100%)    10 (100%)    10 (100%)                              
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 03/26/99  
Route: DOSED FEED                                                                                                 Time: 08:33:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (10)         (10)         (10)                                   
      Basophilic Focus                                                           1 (10%)                                            
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 03/26/99  
Route: DOSED FEED                                                                                                 Time: 08:33:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            280          830          2500                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Nephropathy                                      9 (90%)      9 (90%)     10 (100%)     8 (80%)                               
      Renal Tubule, Hyaline Droplet                                10 (100%)    10 (100%)    10 (100%)                              
      Renal Tubule, Pigmentation                      10 (100%)    10 (100%)    10 (100%)    10 (100%)                              
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------