TDMS Study 05211-06 Pathology Tables
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 04/07/99
Route: DOSED FEED Time: 10:51:14
CORE STUDY; FINAL#1,REVISION#1
Facility: Southern Research Institute
Chemical CAS #: 518-82-1
Lock Date: 07/30/97
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 04/07/99
Route: DOSED FEED Time: 10:51:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 312 625 1250
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Moribund Sacrifice 7 9 2 7
Natural Death 6 2 7 7
Accidently Killed 1
Survivors
Terminal Sacrifice 37 39 40 36
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (47) (49) (48) (48)
Inflammation, Chronic 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Duodenum (48) (49) (47) (46)
Ectasia 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Necrosis, Focal 1 (2%)
Intestine Small, Jejunum (45) (48) (45) (46)
Edema 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Intestine Small, Ileum (48) (49) (47) (46)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 2 (4%) 1 (2%)
Basophilic Focus 1 (2%)
Clear Cell Focus 1 (2%)
Congestion, Focal 1 (2%) 2 (4%) 1 (2%)
Cyst 1 (2%)
Eosinophilic Focus 1 (2%)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage, Focal 1 (2%) 1 (2%) 2 (4%)
Hyperplasia, Focal, Histiocytic 1 (2%)
Hyperplasia, Focal, Lymphoid 2 (4%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Focal 5 (10%) 3 (6%)
Mineralization, Focal 1 (2%)
Mixed Cell Focus 1 (2%)
Necrosis, Focal 1 (2%) 2 (4%)
Pigmentation, Focal 1 (2%) 1 (2%)
Tension Lipidosis 1 (2%)
Bile Duct, Cyst 1 (2%)
Centrilobular, Vacuolization Cytoplasmic 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 04/07/99
Route: DOSED FEED Time: 10:51:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 312 625 1250
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Fatty Change, Diffuse 1 (2%) 3 (6%) 2 (4%) 4 (8%)
Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (2%)
Hepatocyte, Periportal, Atrophy 1 (2%) 1 (2%)
Hepatocyte, Periportal, Necrosis 1 (2%)
Hepatocyte, Periportal, Regeneration 1 (2%)
Hepatocyte, Periportal, Vacuolization
Cytoplasmic 1 (2%)
Hepatocyte, Centrilobular, Cytomegaly 1 (2%)
Mesentery (14) (16) (15) (11)
Angiectasis 1 (6%)
Inflammation, Chronic 1 (9%)
Fat, Necrosis 7 (50%) 10 (63%) 12 (80%) 6 (55%)
Pancreas (48) (49) (49) (48)
Lipomatosis 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Acinus, Atrophy, Diffuse 1 (2%)
Acinus, Atrophy, Focal 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Acinus, Focal Cellular Change 1 (2%)
Duct, Cyst 3 (6%) 1 (2%) 1 (2%) 2 (4%)
Stomach, Forestomach (50) (49) (48) (49)
Epithelium, Hyperplasia 1 (2%) 2 (4%)
Stomach, Glandular (50) (49) (48) (48)
Erosion 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Glands, Degeneration, Cystic, Focal 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Tooth (2)
Developmental Malformation 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (4) (2) (2)
Inflammation, Chronic 1 (25%)
Aorta, Mineralization 1 (50%) 1 (50%)
Pulmonary Artery, Media, Hyperplasia 3 (75%) 1 (50%)
Pulmonary Artery, Media, Hypertrophy 1 (25%) 1 (50%)
Heart (50) (50) (50) (50)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%) 1 (2%)
Angiectasis 1 (2%)
Cyst 2 (4%)
Cytoplasmic Alteration, Focal 1 (2%) 2 (4%)
Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 04/07/99
Route: DOSED FEED Time: 10:51:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 312 625 1250
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Inflammation, Chronic, Focal 1 (2%)
Capsule, Hyperplasia, Focal 1 (2%) 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (44) (47) (45) (47)
Cyst 3 (6%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Pituitary Gland (46) (45) (46) (44)
Angiectasis 1 (2%) 1 (2%)
Pars Distalis, Cyst 1 (2%) 1 (2%)
Pars Distalis, Cytoplasmic Alteration, Focal 2 (4%) 2 (4%) 3 (7%) 3 (7%)
Pars Distalis, Hyperplasia, Focal 3 (7%) 1 (2%) 3 (7%) 3 (7%)
Thyroid Gland (50) (50) (50) (48)
Cyst 1 (2%)
Degeneration, Cystic, Focal 14 (28%) 1 (2%) 5 (10%) 9 (19%)
Inflammation, Chronic, Focal 2 (4%) 1 (2%)
C-Cell, Hyperplasia 1 (2%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 9 (18%) 11 (22%) 20 (40%) 8 (17%)
Follicular Cell, Hyperplasia, Diffuse 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (2)
Mesothelium, Hyperplasia, Focal 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (48) (50) (49)
Degeneration, Cystic 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Ovary (45) (44) (48) (48)
Angiectasis 3 (7%) 4 (8%) 2 (4%)
Cyst 16 (36%) 11 (25%) 11 (23%) 11 (23%)
Hemorrhage 1 (2%)
Inflammation, Suppurative 1 (2%)
Thrombosis 1 (2%)
Bilateral, Cyst 1 (2%)
Uterus (50) (50) (49) (50)
Angiectasis 1 (2%) 1 (2%)
Atrophy 1 (2%)
Cyst 2 (4%)
Hemorrhage 1 (2%)
Hydrometra 17 (34%) 16 (32%) 13 (27%) 13 (26%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 04/07/99
Route: DOSED FEED Time: 10:51:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 312 625 1250
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Lymphangiectasis 1 (2%)
Cervix, Hyperplasia 1 (2%)
Endometrium, Hyperplasia, Cystic 47 (94%) 45 (90%) 48 (98%) 45 (90%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (50) (49) (50)
Angiectasis 1 (2%) 1 (2%)
Depletion Cellular 1 (2%)
Hyperplasia 3 (6%) 1 (2%) 1 (2%) 5 (10%)
Hyperplasia, Focal, Lymphoid 1 (2%)
Lymph Node (8) (7) (9) (7)
Bronchial, Hyperplasia 1 (13%)
Iliac, Angiectasis 2 (29%)
Iliac, Hyperplasia 1 (14%)
Inguinal, Hyperplasia, Lymphoid 1 (14%)
Mediastinal, Angiectasis 1 (14%)
Mediastinal, Hyperplasia 1 (14%)
Pancreatic, Hyperplasia, Lymphoid 1 (13%) 1 (11%)
Renal, Angiectasis 1 (14%)
Renal, Hyperplasia 1 (14%) 1 (14%)
Lymph Node, Mandibular (48) (46) (47) (47)
Angiectasis 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Lymph Node, Mesenteric (49) (48) (50) (49)
Angiectasis 1 (2%) 2 (4%)
Ectasia 1 (2%)
Hemorrhage 2 (4%)
Hyperplasia 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Spleen (48) (49) (49) (49)
Angiectasis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 9 (19%) 14 (29%) 17 (35%) 16 (33%)
Hyperplasia, Lymphoid 9 (19%) 10 (20%) 10 (20%) 12 (24%)
Pigmentation, Focal 1 (2%)
Thymus (49) (49) (46) (48)
Atrophy 1 (2%)
Cyst 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 04/07/99
Route: DOSED FEED Time: 10:51:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 312 625 1250
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (49) (50)
Ectasia 1 (2%)
Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Skin (50) (50) (50) (50)
Inflammation, Chronic, Focal 1 (2%)
Subcutaneous Tissue, Edema 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosis, Focal 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Hyperplasia, Focal,
Mast Cell 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic,
Focal 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%)
Hyperostosis 1 (2%)
Osteoporosis 1 (2%)
Skeletal Muscle (2) (2) (3)
Hemorrhage, Focal 1 (50%)
Inflammation, Suppurative 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50)
Atrophy, Focal 1 (2%) 1 (2%) 3 (6%)
Demyelination, Focal 1 (2%)
Gliosis, Focal 1 (2%)
Hemorrhage, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Hemorrhage 2 (4%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Bronchus, Glands, Cyst 1 (2%)
Mediastinum, Infiltration Cellular, Mixed
Cell 1 (2%)
Nose (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 04/07/99
Route: DOSED FEED Time: 10:51:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 312 625 1250
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cataract 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (49)
Atrophy, Focal 1 (2%)
Congestion 1 (2%)
Metaplasia, Focal, Osseous 2 (4%) 2 (4%)
Nephropathy 22 (45%) 46 (92%) 41 (82%) 48 (98%)
Pelvis, Dilatation 1 (2%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (2%) 3 (6%) 1 (2%) 2 (4%)
Renal Tubule, Dilatation 1 (2%)
Renal Tubule, Pigmentation 37 (74%) 48 (96%) 49 (100%)
Renal Tubule, Epithelium, Pigmentation 1 (2%)
Urinary Bladder (49) (50) (49) (48)
Hyperplasia, Lymphoid 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 04/07/99
Route: DOSED FEED Time: 10:51:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 160 312 625
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Natural Death 5 7 4
Moribund Sacrifice 4 6 6 7
Survivors
Terminal Sacrifice 41 37 40 43
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (48) (46) (50) (49)
Cyst 1 (2%)
Inflammation, Chronic 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Jejunum (47) (46) (49) (50)
Inflammation, Focal 2 (4%)
Ulcer 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Ileum (48) (49) (50) (50)
Inflammation, Focal 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 2 (4%) 2 (4%)
Clear Cell Focus 2 (4%) 1 (2%) 4 (8%)
Congestion, Focal 1 (2%)
Eosinophilic Focus 7 (14%) 1 (2%) 2 (4%)
Infarct 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Focal 1 (2%)
Mixed Cell Focus 1 (2%)
Necrosis, Focal 4 (8%) 2 (4%) 2 (4%)
Centrilobular, Vacuolization Cytoplasmic 1 (2%)
Hepatocyte, Fatty Change, Diffuse 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic, Focal 13 (26%) 10 (20%) 7 (14%) 6 (12%)
Mesentery (2) (4) (6) (5)
Inflammation, Chronic 1 (17%) 1 (20%)
Fat, Necrosis 2 (100%) 2 (50%) 1 (17%) 1 (20%)
Pancreas (49) (50) (50) (50)
Atrophy, Focal 1 (2%)
Lipomatosis 1 (2%)
Lipomatosis, Focal 1 (2%)
Acinus, Atrophy, Focal 1 (2%)
Salivary Glands (50) (50) (50) (50)
Vacuolization Cytoplasmic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 04/07/99
Route: DOSED FEED Time: 10:51:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 160 312 625
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (50) (50) (50) (50)
Inflammation, Chronic 1 (2%) 1 (2%)
Ulcer 1 (2%)
Epithelium, Cyst 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%) 3 (6%)
Serosa, Hemorrhage 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Erosion 1 (2%) 1 (2%)
Inflammation, Focal 1 (2%)
Pigmentation, Focal 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Glands, Degeneration, Cystic, Focal 1 (2%) 3 (6%) 5 (10%) 1 (2%)
Glands, Dysplasia, Focal 1 (2%)
Tooth (12) (17) (18) (10)
Developmental Malformation 12 (100%) 16 (94%) 18 (100%) 10 (100%)
Inflammation, Chronic, Suppurative 2 (11%)
Epithelium Alveolus, Hyperplasia 1 (6%)
Peridontal Tissue, Inflammation, Chronic 1 (6%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Inflammation, Chronic 1 (100%)
Aorta, Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 2 (4%) 1 (2%) 1 (2%)
Cyst 1 (2%)
Cytoplasmic Alteration, Focal 4 (8%) 1 (2%) 3 (6%)
Hyperplasia, Focal 3 (6%)
Hypertrophy, Focal 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Capsule, Hemorrhage 1 (2%)
Capsule, Hyperplasia, Focal 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Adrenal Medulla (50) (49) (50) (50)
Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Islets, Pancreatic (49) (50) (50) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (44) (47) (46) (45)
Cyst 1 (2%) 4 (9%) 1 (2%)
Pituitary Gland (40) (38) (42) (46)
Pars Distalis, Cyst 1 (3%) 2 (5%) 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Degeneration, Cystic, Focal 3 (6%) 6 (12%) 8 (16%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 04/07/99
Route: DOSED FEED Time: 10:51:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 160 312 625
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Inflammation, Chronic, Focal 1 (2%)
Follicle, Cyst 2 (4%) 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 11 (22%) 6 (12%) 16 (32%) 18 (36%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2)
Abdominal, Hemorrhage 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Hypertrophy 1 (2%)
Inflammation, Chronic 1 (2%)
Preputial Gland (47) (50) (50) (50)
Atrophy 1 (2%)
Degeneration, Cystic 15 (32%) 21 (42%) 24 (48%) 24 (48%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic 8 (17%) 6 (12%) 2 (4%) 2 (4%)
Prostate (50) (50) (50) (50)
Hemorrhage 1 (2%)
Seminal Vesicle (50) (50) (50) (50)
Dilatation 28 (56%) 25 (50%) 18 (36%) 19 (38%)
Inflammation, Chronic 1 (2%) 1 (2%)
Testes (50) (50) (50) (50)
Hypoplasia 1 (2%)
Germinal Epithelium, Degeneration 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Lymph Node (6) (3) (4) (1)
Iliac, Hyperplasia 1 (17%)
Inguinal, Hyperplasia, Lymphoid 1 (33%)
Inguinal, Infiltration Cellular, Mast Cell 1 (17%)
Mediastinal, Hyperplasia, Lymphoid 1 (25%)
Pancreatic, Hyperplasia 1 (25%)
Pancreatic, Hyperplasia, Lymphoid 1 (25%)
Renal, Hyperplasia 1 (17%)
Lymph Node, Mesenteric (49) (46) (50) (49)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 04/07/99
Route: DOSED FEED Time: 10:51:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 160 312 625
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage 7 (14%) 4 (9%) 3 (6%) 5 (10%)
Hyperplasia 1 (2%) 1 (2%)
Hyperplasia, Histiocytic 1 (2%) 3 (6%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 2 (4%)
Spleen (50) (50) (50) (49)
Depletion Cellular 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 13 (26%) 14 (28%) 14 (28%) 10 (20%)
Hyperplasia, Lymphoid 4 (8%) 3 (6%) 2 (4%)
Thymus (42) (45) (46) (39)
Atrophy 1 (3%)
Cyst 2 (5%) 4 (9%) 3 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Subcutaneous Tissue, Angiectasis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Hemorrhage, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Hemorrhage 3 (6%) 2 (4%)
Hyperplasia, Histiocytic 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Chronic 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 1 (2%) 4 (8%)
Bronchus, Glands, Cyst 1 (2%)
Nose (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%) 1 (2%)
Mucosa, Glands, Dilatation, Focal 1 (2%)
Nasolacrimal Duct, Cyst 1 (2%)
Squamous Epithelium, Nasolacrimal Duct,
Hyperplasia, Focal 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 04/07/99
Route: DOSED FEED Time: 10:51:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 160 312 625
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2)
Atrophy 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Congestion 1 (2%)
Cyst 4 (8%) 3 (6%) 3 (6%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Focal, Osseous 2 (4%) 1 (2%)
Nephropathy 49 (100%) 49 (98%) 50 (100%) 49 (98%)
Pelvis, Dilatation 3 (6%) 3 (6%) 1 (2%) 6 (12%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (2%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Dilatation 3 (6%)
Renal Tubule, Hyperplasia, Focal 1 (2%)
Renal Tubule, Pigmentation 46 (92%) 50 (100%) 50 (100%)
Renal Tubule, Epithelium, Pigmentation 1 (2%)
Urinary Bladder (49) (50) (50) (50)
Hyperplasia, Lymphoid 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
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