TDMS Study 05211-06 Pathology Tables
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:33:41
CORE STUDY MICE
Facility: Southern Research Institute
Chemical CAS #: 518-82-1
Lock Date: 07/30/97
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:33:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 312 625 1250
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Early Deaths
Moribund Sacrifice 7 9 2 7
Natural Death 6 2 7 7
Accidently Killed 1
Survivors
Terminal Sacrifice 37 39 40 36
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (47) (49) (48) (48)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Intestine Large, Rectum (47) (49) (48) (47)
Intestine Large, Cecum (47) (49) (47) (45)
Leiomyosarcoma 1 (2%)
Intestine Small, Jejunum (45) (48) (45) (46)
Leiomyosarcoma 1 (2%)
Intestine Small, Ileum (48) (49) (47) (46)
Liver (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 3 (6%) 6 (12%) 8 (16%) 1 (2%)
Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Hepatocellular Adenoma 8 (16%) 6 (12%) 10 (20%) 7 (14%)
Hepatocellular Adenoma, Multiple 1 (2%) 1 (2%) 2 (4%)
Histiocytic Sarcoma 1 (2%) 2 (4%) 4 (8%) 2 (4%)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Mesentery (14) (16) (15) (11)
Hemangiosarcoma 1 (7%) 1 (7%) 1 (9%)
Histiocytic Sarcoma 1 (7%) 2 (13%) 1 (7%) 1 (9%)
Leiomyosarcoma, Metastatic, Uterus 1 (7%)
Leiomyosarcoma, Metastatic, Intestine Small,
Jejunum 1 (9%)
Sarcoma 1 (7%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (7%)
Pancreas (48) (49) (49) (48)
Acinus, Adenoma 1 (2%)
Salivary Glands (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Stomach, Forestomach (50) (49) (48) (49)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:33:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 312 625 1250
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Stomach, Glandular (50) (49) (48) (48)
Tooth (2)
Adamantinoma Malignant 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Rhabdomyosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Capsule, Adenoma 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%)
Pituitary Gland (46) (45) (46) (44)
Pars Distalis, Adenoma 4 (9%) 4 (9%) 9 (20%) 8 (18%)
Pars Intermedia, Adenoma 1 (2%)
Pars Intermedia, Carcinoma 1 (2%)
Thyroid Gland (50) (50) (50) (48)
C-Cell, Adenoma 1 (2%)
Follicular Cell, Adenoma 2 (4%) 5 (10%) 2 (4%) 2 (4%)
Follicular Cell, Adenoma, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (2)
Sarcoma, Metastatic, Mesentery 1 (50%)
Tissue NOS (2) (3) (1)
Abdominal, Leiomyosarcoma, Metastatic,
Intestine Small, Jejunum 1 (100%)
Abdominal, Rhabdomyosarcoma, Metastatic,
Heart 1 (33%)
Abdominal, Schwannoma Malignant 1 (33%)
Pelvic, Fibrosarcoma 1 (50%)
Thoracic, Rhabdomyosarcoma 1 (50%) 1 (33%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:33:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 312 625 1250
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (45) (44) (48) (48)
Cystadenoma 1 (2%) 2 (5%) 2 (4%) 1 (2%)
Histiocytic Sarcoma 2 (5%)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Luteoma 1 (2%)
Oviduct (1) (1) (1)
Uterus (50) (50) (49) (50)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Leiomyoma 1 (2%)
Leiomyosarcoma 1 (2%)
Endometrium, Polyp Stromal 2 (4%) 2 (4%) 2 (4%) 2 (4%)
Vagina (1)
Histiocytic Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (50) (49) (50)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Lymph Node (8) (7) (9) (7)
Histiocytic Sarcoma 1 (14%)
Axillary, Histiocytic Sarcoma 1 (14%)
Bronchial, Histiocytic Sarcoma 1 (14%)
Deep Cervical, Histiocytic Sarcoma 1 (14%)
Iliac, Histiocytic Sarcoma 1 (14%) 2 (22%)
Inguinal, Histiocytic Sarcoma 1 (14%)
Mediastinal, Histiocytic Sarcoma 1 (14%) 1 (11%) 1 (14%)
Mediastinal, Leiomyosarcoma, Metastatic,
Uterus 1 (13%)
Mediastinal, Sarcoma, Metastatic, Peritoneum 1 (13%)
Pancreatic, Histiocytic Sarcoma 1 (14%) 1 (11%)
Popliteal, Histiocytic Sarcoma 1 (14%)
Renal, Histiocytic Sarcoma 1 (11%) 1 (14%)
Lymph Node, Mandibular (48) (46) (47) (47)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Lymph Node, Mesenteric (49) (48) (50) (49)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 2 (4%) 4 (8%) 1 (2%)
Rhabdomyosarcoma, Metastatic, Heart 1 (2%)
Spleen (48) (49) (49) (49)
Hemangiosarcoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 2 (4%) 2 (4%) 1 (2%)
Thymus (49) (49) (46) (48)
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:33:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 312 625 1250
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Histiocytic Sarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (49) (50)
Carcinoma 1 (2%)
Myoepithelioma 1 (2%)
Skin (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Sebaceous Gland, Carcinoma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Rhabdomyosarcoma,
Metastatic, Heart 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%) 1 (2%)
Skeletal Muscle (2) (2) (3)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (33%)
Hemangiosarcoma 1 (33%)
Leiomyosarcoma, Metastatic, Uterus 1 (50%)
Rhabdomyosarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 4 (8%) 1 (2%) 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 3 (6%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 2 (4%) 1 (2%) 2 (4%)
Rhabdomyosarcoma, Metastatic, Heart 1 (2%)
Schwannoma Malignant, Metastatic, Tissue NOS 1 (2%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (2%)
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:33:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 312 625 1250
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Mediastinum, Histiocytic Sarcoma 1 (2%) 2 (4%)
Nose (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Pleura (1)
Sarcoma, Metastatic, Mesentery 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (3) (4) (3)
Adenoma 3 (100%) 3 (75%) 1 (33%)
Carcinoma 1 (100%) 2 (67%)
Bilateral, Carcinoma 1 (25%)
Zymbal's Gland (1) (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (49)
Histiocytic Sarcoma 1 (2%) 2 (4%) 1 (2%)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Urinary Bladder (49) (50) (49) (48)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 2 (4%) 5 (10%) 3 (6%)
Lymphoma Malignant 9 (18%) 10 (20%) 8 (16%) 10 (20%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:33:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 312 625 1250
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 34 33 43 37
Total Primary Neoplasms 54 52 64 59
Total Animals with Benign Neoplasms 21 23 25 19
Total Benign Neoplasms 25 27 34 26
Total Animals with Malignant Neoplasms 22 22 25 25
Total Malignant Neoplasms 29 25 30 33
Total Animals with Metastatic Neoplasms 3 2 4
Total Metastatic Neoplasm 12 5 6
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:33:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 160 312 625
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Early Deaths
Natural Death 5 7 4
Moribund Sacrifice 4 6 6 7
Survivors
Terminal Sacrifice 41 37 40 43
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (48) (46) (50) (49)
Adenoma 1 (2%)
Intestine Large, Cecum (47) (49) (50) (50)
Carcinoma 1 (2%)
Intestine Small, Duodenum (47) (49) (50) (50)
Polyp Adenomatous 1 (2%)
Intestine Small, Jejunum (47) (46) (49) (50)
Carcinoma 4 (8%)
Leiomyosarcoma 1 (2%) 1 (2%)
Intestine Small, Ileum (48) (49) (50) (50)
Liver (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Hemangiosarcoma 2 (4%) 1 (2%) 1 (2%)
Hemangiosarcoma, Multiple 1 (2%)
Hepatoblastoma 1 (2%)
Hepatocellular Carcinoma 13 (26%) 15 (30%) 17 (34%) 12 (24%)
Hepatocellular Carcinoma, Multiple 7 (14%) 10 (20%) 5 (10%) 4 (8%)
Hepatocellular Adenoma 7 (14%) 5 (10%) 5 (10%) 7 (14%)
Hepatocellular Adenoma, Multiple 2 (4%) 5 (10%) 7 (14%) 4 (8%)
Leiomyosarcoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Mesentery (2) (4) (6) (5)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (25%)
Carcinoma, Metastatic, Pancreas 1 (20%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (17%) 1 (20%)
Leiomyosarcoma, Metastatic, Intestine Small,
Jejunum 1 (17%)
Pancreas (49) (50) (50) (50)
Hemangioma 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small,
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:33:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 160 312 625
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Jejunum 1 (2%)
Duct, Carcinoma 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Capsule, Adenoma 1 (2%) 5 (10%) 4 (8%) 2 (4%)
Adrenal Medulla (50) (49) (50) (50)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (49) (50) (50) (50)
Adenoma 1 (2%)
Parathyroid Gland (44) (47) (46) (45)
Carcinoma 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Follicular Cell, Adenoma 1 (2%) 4 (8%)
Follicular Cell, Adenoma, Multiple 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:33:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 160 312 625
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Mast Cell Tumor Malignant 1 (2%)
Lymph Node (6) (3) (4) (1)
Mediastinal, Hepatocellular Carcinoma,
Metastatic, Liver 1 (33%)
Pancreatic, Hepatocellular Carcinoma,
Metastatic, Liver 1 (17%)
Lymph Node, Mandibular (49) (49) (50) (48)
Lymph Node, Mesenteric (49) (46) (50) (49)
Spleen (50) (50) (50) (49)
Hemangiosarcoma 1 (2%) 1 (2%)
Thymus (42) (45) (46) (39)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Mast Cell Tumor Malignant 1 (2%)
Pinna, Fibrosarcoma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Hepatocellular
Carcinoma, Metastatic, Liver 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (3) (1) (2)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (33%)
Carcinoma, Metastatic, Pancreas 1 (50%)
Hemangiosarcoma, Metastatic, Liver 1 (50%)
Leiomyosarcoma, Metastatic, Intestine Small,
Jejunum 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:33:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 160 312 625
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 9 (18%) 9 (18%) 5 (10%) 7 (14%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 9 (18%) 6 (12%) 6 (12%) 5 (10%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) 3 (6%)
Carcinoma, Metastatic, Pancreas 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 3 (6%) 5 (10%) 3 (6%)
Leiomyosarcoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Mediastinum, Leiomyosarcoma, Metastatic,
Intestine Small, Jejunum 1 (2%)
Nose (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
External Ear, Histiocytic Sarcoma 1 (100%)
Harderian Gland (4) (3) (4) (7)
Adenoma 4 (100%) 2 (67%) 3 (75%) 4 (57%)
Carcinoma 1 (33%) 1 (25%) 3 (43%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Carcinoma, Metastatic, Pancreas 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Renal Tubule, Carcinoma 1 (2%) 1 (2%)
Urethra (1)
Urinary Bladder (49) (50) (50) (50)
Hemangioma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant 5 (10%) 3 (6%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:33:41
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 160 312 625
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 43 46 43 37
Total Primary Neoplasms 74 76 71 56
Total Animals with Benign Neoplasms 24 27 24 22
Total Benign Neoplasms 29 36 30 24
Total Animals with Malignant Neoplasms 31 33 32 26
Total Malignant Neoplasms 45 40 41 32
Total Animals with Metastatic Neoplasms 3 4 6 5
Total Metastatic Neoplasm 5 11 11 10
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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