TDMS Study 05211-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst EMODIN DATE: 12/02/98
EXPERIMENT: 05211 TEST: 06 TIME: 13:48:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-85216 ROUTE: DOSED FEED NTP C#: C62408
PATHOLOGIST: FARNELL, D. CAS: 518-82-1
------------------------------------------------------------------------------------------------------------------------------------
CORE STUDY MICE
REASONS FOR REMOVAL: 25022 Accidently Killed
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst EMODIN DATE: 12/02/98
EXPERIMENT: 05211 TEST: 06 TIME: 13:48:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-85216 ROUTE: DOSED FEED NTP C#: C62408
PATHOLOGIST: FARNELL, D. CAS: 518-82-1
EMODIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 556 636 636 639 639 656 680 699 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 160 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 446 461 554 631 632 636 639 645 677 695 |
| 699 705 715 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 312 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 497 541 572 579 581 639 688 688 726 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
EMODIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 625 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 281 604 632 633 684 723 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
EMODIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM| 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 88.0 82.0 |
| | |
| | |
|160 PPM| 100.0 100.0 100.0 100.0 100.0 96.0 96.0 94.0 84.0 74.0 |
| | |
| | |
|312 PPM| 100.0 100.0 100.0 100.0 100.0 100.0 96.0 90.0 88.0 80.0 |
| | |
| | |
|625 PPM| 100.0 100.0 100.0 98.0 98.0 98.0 98.0 96.0 92.0 86.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 160 PPM 312 PPM 625 P|M
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 82.0% 74.0% 80.0% 86.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.471N P=0.428 P=0.949 P=0.796N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 652.1 625.8 623.8 611.7 |
|NATURAL DEATHS (C) | (16.2) (24.3) (25.6) (57.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 715.2 702.2 708.0 712.6 |
|(STANDARD ERROR) | ( 5.0) ( 8.9) ( 7.8) ( 9.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
EMODIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 484 541 548 587 592 606 608 643 645 681 |
| 684 699 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 312 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 391 461 490 527 552 633 659 681 707 720 |
| 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 625 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 1 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 461 625 658 673 698 719 720 730 730 |
| CENSORED DEATHS |
| 90 |
| |
==================================================================================
EMODIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 445 515 525 604 608 646 670 680 681 681 |
| 693 695 709 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
EMODIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM| 100.0 100.0 100.0 100.0 100.0 98.0 96.0 90.0 82.0 74.0 |
| | |
| | |
|312 PPM| 100.0 100.0 100.0 100.0 98.0 96.0 92.0 90.0 86.0 78.0 |
| | |
| | |
|625 PPM| 100.0 100.0 100.0 100.0 100.0 98.0 98.0 98.0 93.9 81.6 |
| | |
| | |
|1250 PPM| 100.0 100.0 100.0 100.0 100.0 98.0 94.0 92.0 88.0 72.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 312 PPM 625 PPM 1250 P|M
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.0% 78.0% 81.6% 72.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.880 P=0.805N P=0.405N P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 618.4 595.3 668.2 634.0 |
|NATURAL DEATHS (C) | (19.2) (35.1) (28.6) (22.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 701.7 701.1 706.9 703.8 |
|(STANDARD ERROR) | ( 8.6) (10.9) (13.9) ( 8.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
EMODIN
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
160 PPM = 2
312 PPM = 3
625 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 3 1
|
| 4 2 2 3 3 1 4 1
|
96 + 2 3 2 3 4 4
|
P | 2 33 11
E |
R 92 + 4 4
C |
E | 3 1 1 4 4
N |
T 88 + 22 1 13
|
S | 22 1 1 4 4
U |
R 84 + 2 2 31 1
V |
I | 2 2 1 1
V |
A 80 + 3 3
L |
| 22
|
76 + 2 2
|
| 2 2
|
72 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.
EMODIN
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
312 PPM = 2
625 PPM = 3
1250 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 4 3 1
|
| 2 4 2 1 4 1 3
|
96 + 2 2 4 4 11 3 3
|
P | 2 42 1 1 4 3 3
E |
R 92 + 2 2 1 1 3 3
C |
E | 2 1 1 2 4 3 3
N |
T 88 + 2 4 24
|
S | 1 1 24 2 3 3
U |
R 84 + 11 2 2
V |
I | 1 1 2 2 3
V |
A 80 + 44 22
L |
| 141 2 2
|
76 + 1 41
|
| 414 1
|
72 + 4 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.