TDMS Study 05211-06 Pathology Tables
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:12:26
53 WEEK SSAC MICE
Facility: Southern Research Institute
Chemical CAS #: 518-82-1
Lock Date: 07/30/97
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:12:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 312 625 1250
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Basophilic Focus 2 (20%)
Congestion, Focal 1 (10%)
Inflammation, Focal 10 (100%) 8 (80%) 8 (80%) 9 (90%)
Mineralization, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:12:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 312 625 1250
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Cyst 1 (10%)
Nephropathy 4 (40%) 4 (40%) 5 (50%) 9 (90%)
Renal Tubule, Dilatation 1 (10%)
Renal Tubule, Pigmentation 7 (70%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:12:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 160 312 625
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Inflammation, Focal 5 (50%) 4 (40%) 2 (20%) 6 (60%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 12/02/98
Route: DOSED FEED Time: 10:12:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 160 312 625
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (1)
Hyperostosis 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Cyst 1 (10%) 1 (10%)
Mineralization, Focal 1 (10%) 1 (10%)
Nephropathy 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Renal Tubule, Dilatation 1 (10%) 2 (20%)
Renal Tubule, Pigmentation 7 (70%) 10 (100%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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