https://ntp.niehs.nih.gov/go/2806

TDMS Study 05211-06 Pathology Tables

NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98
Route: DOSED FEED                                                                                                 Time: 10:12:26
                                                       53 WEEK SSAC MICE
       Facility:  Southern Research Institute
       Chemical CAS #:  518-82-1
       Lock Date:  07/30/97
       Cage Range:  All
       Reasons For Removal:    25017 Scheduled Sacrifice
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98  
Route: DOSED FEED                                                                                                 Time: 10:12:26  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0            312          625          1250                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (10)         (10)         (10)                                   
      Basophilic Focus                                 2 (20%)                                                                      
      Congestion, Focal                                                                       1 (10%)                               
      Inflammation, Focal                             10 (100%)     8 (80%)      8 (80%)      9 (90%)                               
      Mineralization, Focal                                                      1 (10%)                                            
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 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98  
Route: DOSED FEED                                                                                                 Time: 10:12:26  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0            312          625          1250                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Cyst                                             1 (10%)                                                                      
      Nephropathy                                      4 (40%)      4 (40%)      5 (50%)      9 (90%)                               
      Renal Tubule, Dilatation                                      1 (10%)                                                         
      Renal Tubule, Pigmentation                                                 7 (70%)     10 (100%)                              
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98  
Route: DOSED FEED                                                                                                 Time: 10:12:26  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0            160          312          625                                       
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (10)         (10)         (10)                                   
      Inflammation, Focal                              5 (50%)      4 (40%)      2 (20%)      6 (60%)                               
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 12/02/98  
Route: DOSED FEED                                                                                                 Time: 10:12:26  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0            160          312          625                                       
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                                                         (1)                                                 
      Hyperostosis                                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Cyst                                             1 (10%)      1 (10%)                                                         
      Mineralization, Focal                            1 (10%)      1 (10%)                                                         
      Nephropathy                                     10 (100%)    10 (100%)    10 (100%)    10 (100%)                              
      Renal Tubule, Dilatation                                      1 (10%)      2 (20%)                                            
      Renal Tubule, Pigmentation                                    7 (70%)     10 (100%)    10 (100%)                              
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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