TDMS Study 05211-07 Pathology Tables
NTP Experiment-Test: 05211-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/08/99
Route: DOSED FEED Time: 10:50:55
53 WEEK SPECIAL STUDY RATS
Facility: Southern Research Institute
Chemical CAS #: 518-82-1
Lock Date: 07/30/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05211-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/08/99
Route: DOSED FEED Time: 10:50:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 5 5 5 5
Early Deaths
Survivors
Terminal Sacrifice 5 5 5 5
Animals Examined Microscopically 5 5 5 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (5) (5) (5) (5)
Basophilic Focus 4 (80%) 1 (20%) 2 (40%) 4 (80%)
Infiltration Cellular, Mixed Cell 1 (20%) 1 (20%) 1 (20%)
Bile Duct, Hyperplasia 1 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/08/99
Route: DOSED FEED Time: 10:50:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (5) (5) (5) (5)
Nephropathy 3 (60%) 3 (60%) 4 (80%) 4 (80%)
Renal Tubule, Hyaline Droplet 3 (60%) 5 (100%) 5 (100%) 5 (100%)
Renal Tubule, Pigmentation 5 (100%) 5 (100%) 5 (100%) 5 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/08/99
Route: DOSED FEED Time: 10:50:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 5 5 5 5
Early Deaths
Survivors
Terminal Sacrifice 5 5 5 5
Animals Examined Microscopically 5 5 5 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (5) (5) (5) (5)
Basophilic Focus 1 (20%) 1 (20%) 1 (20%)
Infiltration Cellular, Mixed Cell 2 (40%) 1 (20%) 1 (20%)
Mixed Cell Focus 1 (20%)
Bile Duct, Hyperplasia 1 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 05211-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EMODIN Date: 01/08/99
Route: DOSED FEED Time: 10:50:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 280 830 2500
PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (5) (5) (5) (5)
Inflammation, Chronic 1 (20%) 1 (20%)
Nephropathy 5 (100%) 5 (100%) 5 (100%) 5 (100%)
Renal Tubule, Hyaline Droplet 5 (100%) 5 (100%) 5 (100%)
Renal Tubule, Pigmentation 5 (100%) 5 (100%) 5 (100%) 4 (80%)
a Number of animals examined microscopically at site and number of animals with lesion
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