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https://ntp.niehs.nih.gov/go/4657

TDMS Study 05212-03 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                              OXAZEPAM


NTP Experiment-Test: 05212-03                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: DOSED FEED                                                                                                 Time: 09:53:45




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  604-75-1

       Lock Date:  02/20/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05212-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      3            2           26           35                                     
    Moribund Sacrifice                                 8            7           22           15                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           41            2                                                  
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (60)         (60)         (60)         (60)                                   
      Inflammation, Granulomatous                                                             1 (2%)                                
   Intestine Small, Jejunum                           (60)         (60)         (60)         (60)                                   
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                    1 (2%)                                             
   Liver                                              (60)         (60)         (60)         (60)                                   
      Basophilic Focus                                 4 (7%)                                                                       
      Clear Cell Focus                                 2 (3%)       3 (5%)                                                          
      Congestion                                                                              1 (2%)                                
      Developmental Malformation                                    1 (2%)                                                          
      Eosinophilic Focus                              10 (17%)     19 (32%)     10 (17%)     12 (20%)                               
      Hematopoietic Cell Proliferation, Focal                                                 1 (2%)                                
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Infarct                                                                                 1 (2%)                                
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Mixed Cell Focus                                                                        1 (2%)                                
      Necrosis, Multifocal                             2 (3%)                                 1 (2%)                                
      Thrombosis                                                                              2 (3%)                                
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
      Bile Duct, Hyperplasia, Focal                                 1 (2%)                                                          
      Centrilobular, Hypertrophy                                    2 (3%)      11 (18%)     29 (48%)                               
      Hepatocyte, Centrilobular, Hypertrophy                                    10 (17%)     10 (17%)                               
   Mesentery                                          (3)          (3)                                                              
      Artery, Inflammation, Chronic                                 1 (33%)                                                         
      Fat, Inflammation, Chronic                                    1 (33%)                                                         
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Ectopic Liver                                                              1 (2%)                                             
      Infarct, Focal                                                                          1 (2%)                                
      Inflammation, Granulomatous                                                             1 (2%)                                
      Acinus, Atrophy                                  1 (2%)       1 (2%)                                                          
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Dysplasia                                        1 (2%)                                                                       
      Hyperplasia, Diffuse, Squamous                                             1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05212-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia, Focal, Squamous                     1 (2%)       1 (2%)                                                          
      Hyperplasia, Multifocal, Squamous                                          1 (2%)                                             
      Ulcer                                            2 (3%)       1 (2%)                                                          
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Congestion, Multifocal                                                                  1 (2%)                                
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (60)         (60)         (59)                                   
      Aorta, Mineralization                            1 (2%)                                                                       
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
   Heart                                              (60)         (60)         (60)         (60)                                   
      Mineralization                                   1 (2%)                                                                       
      Atrium, Inflammation, Chronic                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Cyst                                                          1 (2%)                                                          
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
      Hypertrophy                                      2 (3%)       1 (2%)                    2 (3%)                                
      Vacuolization Cytoplasmic                        2 (3%)                                                                       
      Capsule, Accessory Adrenal Cortical Nodule                    1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (60)         (59)         (53)         (59)                                   
      Pars Distalis, Angiectasis                       2 (3%)       2 (3%)                                                          
      Pars Distalis, Cyst                              2 (3%)                    1 (2%)                                             
      Pars Distalis, Hyperplasia                       6 (10%)      9 (15%)      6 (11%)      3 (5%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Infiltration Cellular, Lymphocyte                                                       1 (2%)                                
      Inflammation, Chronic Active, Focal                           1 (2%)                                                          
      Follicular Cell, Hyperplasia                    16 (27%)     34 (57%)     59 (98%)     54 (90%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (58)         (57)         (57)         (56)                                   
      Duct, Ectasia                                                 1 (2%)                    1 (2%)                                
   Ovary                                              (60)         (60)         (58)         (60)                                   
      Atrophy                                         39 (65%)     39 (65%)     44 (76%)     38 (63%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05212-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                             2 (3%)                                                                       
      Mineralization                                                             1 (2%)                                             
      Bilateral, Follicle, Cyst                                     1 (2%)                                                          
      Follicle, Cyst                                  15 (25%)     16 (27%)      4 (7%)       5 (8%)                                
      Periovarian Tissue, Cyst                                      1 (2%)       1 (2%)                                             
   Uterus                                             (60)         (60)         (60)         (59)                                   
      Endometrium, Hyperplasia, Cystic                46 (77%)     50 (83%)     19 (32%)     14 (24%)                               
      Endometrium, Hyperplasia, Cystic, Glandular     10 (17%)     10 (17%)     10 (17%)      8 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Myelofibrosis                                                              1 (2%)                                             
      Calvarium, Myelofibrosis                                      1 (2%)                                                          
      Myeloid Cell, Erythroid Cell, Atrophy                         1 (2%)                                                          
   Lymph Node                                         (3)          (2)          (1)                                                 
      Bronchial, Hyperplasia, Lymphoid                 1 (33%)                                                                      
   Lymph Node, Mandibular                             (58)         (57)         (58)         (54)                                   
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
   Lymph Node, Mesenteric                             (58)         (56)         (48)         (47)                                   
      Atrophy                                                                    1 (2%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Lymph Node, Mediastinal                            (1)          (2)          (3)                                                 
      Angiectasis                                                                1 (33%)                                            
   Spleen                                             (60)         (60)         (60)         (59)                                   
      Developmental Malformation                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation                13 (22%)      4 (7%)      13 (22%)      4 (7%)                                
      Hyperplasia, Focal, Reticulum Cell               1 (2%)                                                                       
      Hyperplasia, Lymphoid                            2 (3%)       1 (2%)                                                          
      Capsule, Mineralization                          1 (2%)                                                                       
      Lymphoid Follicle, Atrophy                       2 (3%)                                                                       
      Lymphoid Follicle, Degeneration                               1 (2%)                                                          
      Red Pulp, Atrophy                                2 (3%)       1 (2%)                                                          
   Thymus                                             (60)         (58)         (44)         (43)                                   
      Atrophy                                         41 (68%)     44 (76%)     30 (68%)     22 (51%)                               
      Hyperplasia, Focal, Lymphoid                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05212-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (59)         (57)         (53)                                   
      Hyperplasia, Cystic                              1 (2%)                                                                       
   Skin                                               (59)         (60)         (60)         (60)                                   
      Ulcer, Multifocal                                             1 (2%)                                                          
      Dermis, Sebaceous Gland, Hyperplasia                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Femur, Hyperostosis, Focal                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Compression                                                   1 (2%)                                                          
   Peripheral Nerve                                   (2)          (3)          (2)          (1)                                    
      Sciatic, Axon, Degeneration                      2 (100%)     3 (100%)     1 (50%)      1 (100%)                              
   Spinal Cord                                        (2)          (3)          (2)          (1)                                    
      Degeneration                                     1 (50%)      1 (33%)      1 (50%)                                            
      Nerve, Degeneration                              1 (50%)      3 (100%)     1 (50%)      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Foreign Body                                                               1 (2%)                                             
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal                                                 1 (2%)                                
      Arteriole, Infiltration Cellular, Lymphocyte                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)                                                              
      Phthisis Bulbi                                   1 (50%)      1 (100%)                                                        
   Harderian Gland                                    (3)          (3)          (1)          (1)                                    
      Cyst                                             1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05212-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Inflammation, Subacute                                                                  1 (2%)                                
      Nephropathy, Chronic                            17 (28%)     15 (25%)     10 (17%)      5 (8%)                                
      Artery, Pelvis, Inflammation, Chronic                         1 (2%)                                                          
      Renal Tubule, Necrosis, Acute, Diffuse                        1 (2%)                                                          
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05212-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            4           22           30                                     
    Natural Death                                      3            2           13           20                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                45           44           15                                                  
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (59)         (60)         (60)         (60)                                   
      Peyer's Patch, Hyperplasia, Lymphoid             2 (3%)       1 (2%)                                                          
   Liver                                              (59)         (60)         (60)         (60)                                   
      Angiectasis                                                                2 (3%)                                             
      Basophilic Focus                                 2 (3%)       1 (2%)                    1 (2%)                                
      Clear Cell Focus                                 9 (15%)      5 (8%)       1 (2%)       1 (2%)                                
      Clear Cell Focus, Multifocal                     4 (7%)       1 (2%)                                                          
      Eosinophilic Focus                              18 (31%)     13 (22%)     17 (28%)     10 (17%)                               
      Infarct                                                                                 1 (2%)                                
      Mixed Cell Focus                                 2 (3%)       1 (2%)       1 (2%)                                             
      Necrosis                                         2 (3%)                                                                       
      Necrosis, Multifocal                             1 (2%)                                                                       
      Thrombosis                                                                 1 (2%)       5 (8%)                                
      Vacuolization Cytoplasmic                        9 (15%)      8 (13%)      1 (2%)       1 (2%)                                
      Artery, Angiectasis                                                                     1 (2%)                                
      Centrilobular, Hypertrophy                                    2 (3%)      26 (43%)     43 (72%)                               
      Hepatocyte, Centrilobular, Hypertrophy                       10 (17%)     10 (17%)     10 (17%)                               
   Mesentery                                          (2)          (2)          (2)          (2)                                    
      Congestion                                                                              1 (50%)                               
      Fat, Inflammation, Chronic                       1 (50%)      1 (50%)                                                         
   Pancreas                                           (59)         (60)         (60)         (60)                                   
      Acinus, Atrophy                                                                         1 (2%)                                
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Hyperplasia, Focal, Squamous                     2 (3%)       4 (7%)       1 (2%)                                             
      Hyperplasia, Multifocal, Squamous                                          1 (2%)                                             
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Necrosis, Multifocal                                                                    2 (3%)                                
   Tooth                                              (1)                       (1)                                                 
      Gingiva, Hyperplasia, Focal, Squamous            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05212-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Angiectasis, Focal                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (60)         (59)         (60)                                   
      Hypertrophy                                     13 (22%)      7 (12%)      1 (2%)       2 (3%)                                
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
      Capsule, Hyperplasia                             3 (5%)       2 (3%)       1 (2%)                                             
   Islets, Pancreatic                                 (59)         (60)         (60)         (60)                                   
      Hyperplasia, Focal                               1 (2%)                                                                       
   Pituitary Gland                                    (58)         (60)         (52)         (47)                                   
      Pars Distalis, Cyst                              4 (7%)       3 (5%)       3 (6%)                                             
      Pars Distalis, Vacuolization Cytoplasmic                                                3 (6%)                                
   Thyroid Gland                                      (59)         (60)         (60)         (60)                                   
      Inflammation, Chronic Active, Focal                                                     1 (2%)                                
      Follicle, Dilatation, Multiple                                             1 (2%)                                             
      Follicular Cell, Hyperplasia                     4 (7%)      22 (37%)     54 (90%)     54 (90%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
      Granuloma Sperm                                  1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                2 (3%)      14 (23%)     33 (55%)     21 (35%)                               
      Inflammation, Chronic                                                      1 (2%)                                             
      Spermatocele                                     2 (3%)                                                                       
   Preputial Gland                                    (60)         (60)         (60)         (59)                                   
      Ectasia                                          2 (3%)                                                                       
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Chronic                            7 (12%)      7 (12%)      8 (13%)      5 (8%)                                
      Duct, Ectasia                                   40 (67%)     31 (52%)     10 (17%)      7 (12%)                               
      Duct, Hemorrhage                                                           1 (2%)                                             
   Testes                                             (60)         (60)         (60)         (60)                                   
      Atrophy                                          1 (2%)                   25 (42%)     38 (63%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05212-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (2)          (1)          (1)          (2)                                    
      Inguinal, Hyperplasia, Lymphoid                  1 (50%)                                1 (50%)                               
      Lumbar, Hyperplasia, Lymphoid                                                           1 (50%)                               
   Lymph Node, Mandibular                             (54)         (54)         (52)         (52)                                   
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
   Lymph Node, Mesenteric                             (58)         (57)         (55)         (50)                                   
      Angiectasis                                                                1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)                                             
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
   Spleen                                             (59)         (60)         (60)         (60)                                   
      Atrophy                                                                                 1 (2%)                                
      Hematopoietic Cell Proliferation                 3 (5%)       2 (3%)       6 (10%)      7 (12%)                               
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Thymus                                             (52)         (52)         (46)         (40)                                   
      Atrophy                                         39 (75%)     40 (77%)     35 (76%)     24 (60%)                               
      Cyst                                                                                    1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)                                   
      Edema, Subacute                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Cartilage, Vertebra, Fracture                                 1 (2%)                                                          
      Joint, Cartilage, Fracture                                    1 (2%)                                                          
      Vertebra, Hyperostosis                                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Peripheral Nerve                                                (1)          (2)                                                 
      Sciatic, Axon, Degeneration                                   1 (100%)     2 (100%)                                           
   Spinal Cord                                                     (1)          (2)                                                 
      Nerve, Degeneration                                           1 (100%)     2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05212-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:45  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Hemorrhage, Focal                                                                       1 (2%)                                
      Infiltration Cellular, Multifocal, Histiocyte                 1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 4 (7%)       2 (3%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (2)                                                              
      Bilateral, Inflammation, Chronic                 1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Hydronephrosis                                   1 (2%)                                                                       
      Nephropathy, Chronic                            53 (88%)     50 (83%)      8 (13%)     25 (42%)                               
      Cortex, Cyst                                     2 (3%)       1 (2%)                                                          
   Urinary Bladder                                    (59)         (60)         (60)         (59)                                   
      Calculus Gross Observation                                                              1 (2%)                                
      Dilatation                                                                 1 (2%)                                             
      Inflammation, Chronic Active                                                            1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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