TDMS Study 05212-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/18/94
EXP: 05212 OXAZEPAM TIME: 10:10:23
TEST: 03 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 62453
CONT: N01-ES-85213 CAS: 604-75-1
PATHOLOGIST: R. PERSING
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/18/94
EXP: 05212 OXAZEPAM TIME: 10:10:23
TEST: 03 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 62453
CONT: N01-ES-85213 CAS: 604-75-1
PATHOLOGIST: R. PERSING
OXAZEPAM
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 5 CENSORED DEATHS 10 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 117 586 624 627 707 |
| CENSORED DEATHS |
| 460 460 460 460 460 460 460 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 125 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 6 CENSORED DEATHS 10 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 453 508 527 625 701 715 |
| CENSORED DEATHS |
| 460 460 460 460 460 460 460 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 35 CENSORED DEATHS 10 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| 486 523 540 567 594 598 608 615 616 628 |
| 638 639 642 645 646 665 666 667 669 673 |
| 673 679 679 682 697 700 703 710 714 720 |
| 720 720 722 722 727 |
| CENSORED DEATHS |
| 460 460 460 460 460 460 460 460 460 460 |
| |
==================================================================================
OXAZEPAM
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 50 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 401 413 434 450 451 461 464 479 479 507 |
| 514 531 535 537 539 542 547 566 567 567 |
| 568 569 569 569 575 575 587 589 593 595 |
| 596 596 596 598 609 612 614 615 617 617 |
| 622 622 623 623 624 624 625 625 628 628 |
| CENSORED DEATHS |
| 460 460 460 460 460 460 460 460 460 460 |
| |
==================================================================================
OXAZEPAM
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 98.3 98.3 98.3 98.3 98.3 98.3 96.3 92.3 90.3 |
| | |
| | |
|125 PPM | 100.0 100.0 100.0 100.0 100.0 98.3 94.3 94.3 92.3 88.3 |
| | |
| | |
|2500 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 88.0 68.0 30.0 |
| | |
| | |
|5000 PPM | 100.0 100.0 100.0 100.0 96.7 83.5 69.3 32.6 0.0 0.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 125 PPM 2500 PPM 5000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 90.3% 88.3% 30.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.987 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 532.2 588.2 654.1 561.7 |
|NATURAL DEATHS (C) | ( 106) (44.2) (10.2) ( 8.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 667.8 670.1 640.5 544.8 |
|(STANDARD ERROR) | (16.1) (14.0) (12.7) ( 8.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
OXAZEPAM
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 10 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 357 516 576 598 622 624 630 638 652 659 |
| 670 |
| CENSORED DEATHS |
| 460 460 460 460 460 460 460 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 125 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 9 CENSORED DEATHS 10 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 391 471 490 492 649 662 701 714 732 |
| CENSORED DEATHS |
| 460 460 460 460 460 460 460 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 48 CENSORED DEATHS 10 TERMINAL 2 |
| |
| UNCENSORED DEATHS |
| 393 396 470 575 596 614 615 622 630 634 |
| 635 636 638 642 644 645 648 663 664 665 |
| 666 667 677 689 691 692 699 700 701 702 |
| 706 706 710 711 711 712 712 712 712 712 |
| 719 719 719 719 719 719 719 719 |
| CENSORED DEATHS |
| 460 460 460 460 460 460 460 460 460 460 |
| |
==================================================================================
OXAZEPAM
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 50 CENSORED DEATHS 10 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 6 7 7 403 410 412 414 415 450 454 |
| 457 470 471 478 479 491 494 499 504 526 |
| 533 535 541 547 554 562 563 566 567 568 |
| 569 569 570 570 577 582 583 589 594 595 |
| 596 596 600 612 613 614 614 617 617 617 |
| CENSORED DEATHS |
| 460 460 460 460 460 460 460 460 460 460 |
| |
==================================================================================
OXAZEPAM
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 98.3 98.3 98.3 96.3 92.3 80.3 78.3 |
| | |
| | |
|125 PPM | 100.0 100.0 100.0 100.0 98.3 96.3 92.3 92.3 88.3 82.3 |
| | |
| | |
|2500 PPM | 100.0 100.0 100.0 100.0 96.7 94.7 94.7 90.6 60.4 4.0 |
| | |
| | |
|5000 PPM | 95.0 95.0 95.0 95.0 86.7 73.3 56.5 14.7 0.0 0.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 125 PPM 2500 PPM 5000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.3% 82.3% 4.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.761N P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 594.7 589.1 661.8 505.5 |
|NATURAL DEATHS (C) | (27.1) (42.5) (10.8) (20.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 663.5 667.3 630.6 498.0 |
|(STANDARD ERROR) | (14.5) (15.1) (13.2) (16.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
OXAZEPAM
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
125 PPM = 2
2500 PPM = 3
5000 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 4 2 3
| 1 44 4 2 3 2 32 1 1
| 4 4 32 3 3 2
| 44 3 3 1 1
90 + 44 33 1 2 1
| 4 4 33 2 2
| 33
| 4 44 3 3
80 + 4 4 3 3
| 44
| 33
| 44
P 70 + 44 3 3
E | 4 4 33
R |
C | 33
E 60 + 44
N |
T | 33
| 44 3 3
S 50 + 44
U | 4 4 33
R | 33
V | 33
I 40 + 44
V |
A | 33
L | 44
30 + 44 3 3
|
| 44
|
20 +
|
|
| 44
10 +
|
|
|
0 + 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.
OXAZEPAM
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
125 PPM = 2
2500 PPM = 3
5000 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 14 1 23
| 1 23 2 2 1 1
| 4 4 3 22 1 1
| 44 2 3 1 1 2
90 + 44 3 311 2 2
| 4 4 331 1 2 22
| 33 1 1 2 2
| 44 4 33 1 1 2
80 + 11
| 44 33 1 1
|
| 4 4
P 70 + 44 33
E | 3 3
R | 4 4
C | 44
E 60 + 33
N | 444 33
T | 44 3 3
| 44
S 50 +
U | 33
R | 44 33
V |
I 40 +
V | 33
A |
L | 444
30 +
| 4 4
|
|
20 + 44 33
|
| 4 4
|
10 +
| 44
| 3 3
|
0 + 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.