TDMS Study 05212-05 Pathology Tables
NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 10/25/96
Route: DOSED FEED Time: 07:56:27
CONTROL VS 10,000 PPM STOP
Facility: Battelle Columbus Laboratory
Chemical CAS #: 604-75-1
Lock Date: 05/12/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 001 0 PPM
Include 002 0 PPM
Include 011 10,000 PPM STOP
Include 012 10,000 PPM STOP
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 10/25/96
Route: DOSED FEED Time: 07:56:27
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50
Early Deaths
Natural Death 6 6
Moribund Sacrifice 11 19
Accidently Killed 1
Survivors
Terminal Sacrifice 32 25
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50)
Polyp Adenomatous 1 (2%)
Liver (50) (49)
Histiocytic Sarcoma, Metastatic, Skin 1 (2%)
Mesentery (10) (13)
Salivary Glands (50) (1)
Myoepithelioma 1 (100%)
Stomach, Forestomach (50) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (2)
Adenoma 1 (50%)
Adrenal Medulla (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (50)
Adenoma 1 (2%)
Pituitary Gland (50) (35)
Pars Distalis, Adenoma 30 (60%) 23 (66%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Thyroid Gland (50) (50)
Bilateral, C-Cell, Adenoma 2 (4%)
C-Cell, Adenoma 6 (12%) 2 (4%)
C-Cell, Carcinoma 1 (2%)
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NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 10/25/96
Route: DOSED FEED Time: 07:56:27
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (11)
Adenoma 6 (12%) 7 (64%)
Carcinoma 1 (2%)
Bilateral, Adenoma 1 (2%)
Ovary (50) (4)
Granulosa Cell Tumor Benign 1 (2%)
Uterus (50) (5)
Polyp Stromal 2 (4%)
Sarcoma Stromal 1 (2%) 1 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (4) (4)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (25%)
Renal, Pheochromocytoma Malignant,
Metastatic, Adrenal Medulla 1 (25%)
Lymph Node, Mandibular (50) (3)
Squamous Cell Carcinoma, Metastatic, Skin 1 (33%)
Lymph Node, Mesenteric (50) (2)
Spleen (50) (12)
Thymus (50)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (23)
Adenoma 1 (2%)
Carcinoma 2 (4%)
Carcinoma, Multiple 1 (4%)
Fibroadenoma 11 (22%) 17 (74%)
Fibroadenoma, Multiple 14 (29%) 6 (26%)
Skin (50) (6)
Fibroma 2 (33%)
Squamous Cell Carcinoma 1 (17%)
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NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 10/25/96
Route: DOSED FEED Time: 07:56:27
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Histiocytic Sarcoma 1 (17%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (1)
Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50)
Oligodendroglioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (1)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 14 (28%) 15 (30%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 10/25/96
Route: DOSED FEED Time: 07:56:27
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 43
Total Primary Neoplasms 101 80
Total Animals with Benign Neoplasms 43 38
Total Benign Neoplasms 77 61
Total Animals with Malignant Neoplasms 21 17
Total Malignant Neoplasms 24 19
Total Animals with Metastatic Neoplasms 2 2
Total Metastatic Neoplasm 2 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 10/25/96
Route: DOSED FEED Time: 07:56:27
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50
Early Deaths
Moribund Sacrifice 25 39
Natural Death 8 11
Survivors
Terminal Sacrifice 17
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (49)
Carcinoma 2 (4%)
Leiomyosarcoma 1 (2%)
Liver (50) (50)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%)
Mesentery (7) (5)
Leiomyosarcoma, Metastatic, Intestine Small,
Jejunum 1 (14%)
Pancreas (50)
Acinus, Adenoma 1 (2%)
Acinus, Adenoma, Mixed Cell 1 (2%)
Stomach, Forestomach (50) (49)
Stomach, Glandular (50) (47)
Tooth (1)
Odontoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Medulla (50) (1)
Pheochromocytoma Malignant 1 (100%)
Pheochromocytoma Benign 9 (18%)
Bilateral, Pheochromocytoma Benign 5 (10%)
Islets, Pancreatic (50)
Adenoma 1 (2%)
Carcinoma 2 (4%)
Pituitary Gland (49) (5)
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NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 10/25/96
Route: DOSED FEED Time: 07:56:27
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Distalis, Adenoma 17 (35%) 5 (100%)
Thyroid Gland (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 9 (18%) 1 (2%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 2 (4%)
Follicular Cell, Carcinoma 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (2) (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (1)
Preputial Gland (48) (14)
Adenoma 6 (13%) 7 (50%)
Carcinoma 1 (2%)
Bilateral, Adenoma 1 (2%) 3 (21%)
Testes (50) (48)
Bilateral, Interstitial Cell, Adenoma 35 (70%) 44 (92%)
Interstitial Cell, Adenoma 10 (20%) 4 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (5) (9)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (11%)
Lymph Node, Mandibular (50) (4)
Lymph Node, Mesenteric (49) (4)
Spleen (50) (33)
Fibroma 1 (2%)
Thymus (49)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (2)
Adenoma 1 (50%)
Carcinoma 1 (50%)
Fibroadenoma 4 (8%)
Skin (50) (8)
Fibroma 3 (6%) 2 (25%)
Fibrosarcoma 2 (4%) 1 (13%)
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NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 10/25/96
Route: DOSED FEED Time: 07:56:27
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Keratoacanthoma 3 (6%) 2 (25%)
Sarcoma 1 (2%)
Schwannoma Malignant 3 (6%)
Squamous Cell Papilloma 2 (4%)
Sebaceous Gland, Adenoma 1 (2%) 2 (25%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (2)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (3)
Alveolar/Bronchiolar Adenoma 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (42)
Renal Tubule, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50)
Leukemia Mononuclear 27 (54%) 34 (68%)
Lymphoma Malignant 1 (2%)
Mesothelioma Malignant 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 10/25/96
Route: DOSED FEED Time: 07:56:27
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 48
Total Primary Neoplasms 160 116
Total Animals with Benign Neoplasms 47 48
Total Benign Neoplasms 115 74
Total Animals with Malignant Neoplasms 38 35
Total Malignant Neoplasms 45 42
Total Animals with Metastatic Neoplasms 3 1
Total Metastatic Neoplasm 3 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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