TDMS Study 05212-04 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
OXAZEPAM
NTP Experiment-Test: 05212-04 Report: PEIRPT05
Study Type: CHRONIC Date: 09/18/94
Route: DOSED FEED Time: 11:54:34
Facility: Battelle Columbus Laboratory
Chemical CAS #: 604-75-1
Lock Date: 02/06/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05212-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 09/18/94
Route: DOSED FEED Time: 11:54:34
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Early Deaths
Moribund Sacrifice 9 13 11
Natural Death 4 18 31
Survivors
Terminal Sacrifice 47 27 17
Natural Death 1
Missing 1 1
Animals Examined Microscopically 60 59 59
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ALIMENTARY SYSTEM
Gallbladder (60) (58) (56)
Intestine Large, Cecum (58) (56) (51)
Intestine Small, Duodenum (59) (56) (56)
Adenoma 1 (2%)
Intestine Small, Jejunum (59) (59) (56)
Carcinoma 1 (2%)
Liver (60) (59) (59)
Hepatocellular Carcinoma 1 (2%) 1 (2%) 6 (10%)
Hepatocellular Carcinoma, Multiple 5 (8%)
Hepatocellular Adenoma 9 (15%) 8 (14%)
Hepatocellular Adenoma, Multiple 13 (22%) 39 (66%)
Histiocytic Sarcoma 1 (2%)
Pancreas (60) (59) (59)
Salivary Glands (60) (59) (59)
Stomach, Glandular (59) (59) (57)
Tooth (2) (2)
Adamantinoma NOS 1 (50%)
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CARDIOVASCULAR SYSTEM
Heart (60) (59) (59)
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ENDOCRINE SYSTEM
Adrenal Cortex (60) (59) (59)
Adenoma 1 (2%)
Adrenal Medulla (59) (58) (57)
Pituitary Gland (57) (58) (58)
Thyroid Gland (60) (59) (59)
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NTP Experiment-Test: 05212-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 09/18/94
Route: DOSED FEED Time: 11:54:34
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Follicular Cell, Adenoma 1 (2%) 1 (2%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (59) (58) (55)
Hemangioma 1 (2%) 1 (2%)
Uterus (60) (59) (57)
Polyp Stromal 1 (2%) 1 (2%)
Sarcoma Stromal 1 (2%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (60) (59) (59)
Lymph Node (8) (10) (7)
Pancreatic, Histiocytic Sarcoma 1 (14%)
Lymph Node, Mandibular (58) (57) (58)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (60) (57) (56)
Histiocytic Sarcoma 1 (2%)
Spleen (60) (59) (59)
Histiocytic Sarcoma 1 (2%)
Thymus (56) (57) (55)
Histiocytic Sarcoma 1 (2%)
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
Skeletal Muscle (60) (59) (59)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
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NTP Experiment-Test: 05212-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 09/18/94
Route: DOSED FEED Time: 11:54:34
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (59) (59)
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RESPIRATORY SYSTEM
Lung (60) (59) (59)
Alveolar/Bronchiolar Adenoma 6 (10%) 4 (7%) 6 (10%)
Alveolar/Bronchiolar Carcinoma 5 (8%) 3 (5%) 1 (2%)
Nose (60) (59) (59)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (60) (59) (59)
Urinary Bladder (59) (59) (59)
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SYSTEMIC LESIONS
Multiple Organs *(60) *(59) *(59)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%)
Lymphoma Malignant Mixed 6 (10%) 8 (14%) 1 (2%)
Lymphoma Malignant Undifferentiated Cell 3 (5%) 4 (7%) 5 (8%)
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* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05212-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 09/18/94
Route: DOSED FEED Time: 11:54:34
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 24 37 49
Total Primary Neoplasms 26 46 75
Total Animals with Benign Neoplasms 9 26 47
Total Benign Neoplasms 9 29 55
Total Animals with Malignant Neoplasms 16 16 17
Total Malignant Neoplasms 16 17 20
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 05212-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 09/18/94
Route: DOSED FEED Time: 11:54:34
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Early Deaths
Moribund Sacrifice 10 13 24
Natural Death 5 28 26
Survivors
Terminal Sacrifice 45 19 10
Animals Examined Microscopically 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (60) (57) (58)
Adenoma 1 (2%)
Intestine Small, Jejunum (59) (59) (56)
Liver (60) (60) (60)
Hepatoblastoma 1 (2%)
Hepatocellular Carcinoma 4 (7%) 13 (22%)
Hepatocellular Carcinoma, Multiple 1 (2%) 6 (10%)
Hepatocellular Adenoma 1 (2%) 14 (23%) 8 (13%)
Hepatocellular Adenoma, Multiple 21 (35%) 42 (70%)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Pancreas (60) (60) (60)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Salivary Glands (60) (60) (60)
Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Stomach, Glandular (60) (59) (60)
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CARDIOVASCULAR SYSTEM
Heart (60) (60) (60)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
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ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60)
Adenoma 1 (2%)
Capsule, Adenoma 1 (2%)
Adrenal Medulla (60) (58) (56)
Thyroid Gland (60) (60) (60)
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NTP Experiment-Test: 05212-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 09/18/94
Route: DOSED FEED Time: 11:54:34
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Epididymis (60) (58) (60)
Histiocytic Sarcoma 1 (2%)
Testes (60) (60) (60)
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HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60)
Lymph Node (7) (7) (4)
Inguinal, Sarcoma, Metastatic, Skeletal
Muscle 1 (14%)
Lumbar, Histiocytic Sarcoma 1 (14%)
Mediastinal, Histiocytic Sarcoma 1 (14%)
Pancreatic, Sarcoma, Metastatic, Skeletal
Muscle 1 (14%)
Renal, Histiocytic Sarcoma 1 (14%)
Lymph Node, Mandibular (57) (56) (55)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (59) (55) (57)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Spleen (60) (60) (60)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Thymus (59) (57) (51)
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INTEGUMENTARY SYSTEM
Skin (60) (60) (59)
Hemangiosarcoma 1 (2%) 1 (2%)
Neurofibrosarcoma 1 (2%)
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MUSCULOSKELETAL SYSTEM
Skeletal Muscle (60) (60) (60)
Sarcoma 1 (2%)
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Page 7
NTP Experiment-Test: 05212-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 09/18/94
Route: DOSED FEED Time: 11:54:34
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60)
Alveolar/Bronchiolar Adenoma 10 (17%) 5 (8%) 7 (12%)
Alveolar/Bronchiolar Adenoma, Multiple 2 (3%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 5 (8%) 3 (5%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Nose (60) (60) (60)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Urinary Bladder (60) (59) (59)
Histiocytic Sarcoma 1 (2%)
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SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant 1 (2%)
Lymphoma Malignant Lymphocytic 2 (3%) 2 (3%) 2 (3%)
Lymphoma Malignant Mixed 3 (5%) 3 (5%)
Lymphoma Malignant Undifferentiated Cell 4 (7%) 5 (8%) 1 (2%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05212-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXAZEPAM Date: 09/18/94
Route: DOSED FEED Time: 11:54:34
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0 PPM 2500 PPM 5000 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 26 42 54
Total Primary Neoplasms 33 61 83
Total Animals with Benign Neoplasms 14 36 51
Total Benign Neoplasms 14 43 57
Total Animals with Malignant Neoplasms 17 17 25
Total Malignant Neoplasms 19 18 26
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 9
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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